Detailed information for compound 978952

Basic information

Technical information
  • TDR Targets ID: 978952
  • Name: 6-(6-methoxy-1,3-benzodioxol-5-yl)pyrano[5,6- f][1]benzoxol-7-one
  • MW: 336.295 | Formula: C19H12O6
  • H donors: 0 H acceptors: 1 LogP: 3.73 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2OCOc2cc1c1cc2cc3ccoc3cc2oc1=O
  • InChi: 1S/C19H12O6/c1-21-16-8-18-17(23-9-24-18)6-12(16)13-5-11-4-10-2-3-22-14(10)7-15(11)25-19(13)20/h2-8H,9H2,1H3
  • InChiKey: PENSQRMNZZWMGV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-(6-methoxy-1,3-benzodioxol-5-yl)pyrano[5,6-f]benzofuran-7-one
  • 6-(6-methoxy-1,3-benzodioxol-5-yl)-7-pyrano[5,6-f]benzofuranone
  • 10091-01-7
  • NCGC00095223-02
  • BSPBio_002549
  • Spectrum2_000410
  • DivK1c_006295
  • Spectrum_001845
  • KBio3_002049
  • KBio1_001239
  • SDCCGMLS-0066383.P001
  • AIDS-154303
  • Spectrum3_000875
  • KBioSS_002355
  • KBio2_004920
  • 6-(6-Methoxy-1,3-benzodioxol-5-yl)-7H-furo(3,2-g)(1)benzopyran-7-one
  • 7H-Furo(3,2-g)(1)benzopyran-7-one, 6-(6-methoxy-1,3-benzodioxol-5-yl)-
  • 7H-Furo[3,2-g][1]benzopyran-7-one, 6-(6-methoxy-1,3-benzodioxol-5-yl)-
  • KBio2_002352
  • Pachyrhizin
  • Pachyrrhizin
  • KBio2_007488
  • SPBio_000340
  • Spectrum4_000715
  • AIDS154303
  • Spectrum5_000921
  • KBioGR_001269
  • SPECTRUM201602
  • SpecPlus_000199
  • NSC404570
  • NCGC00095223-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens caspase 7, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cell death protein 3 precursor caspase 7, apoptosis-related cysteine peptidase 303 aa 256 aa 37.1 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0215 0.0168
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0416 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0047 0.003
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.005 0.0416 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0416 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.012 0.1225 0.1183
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0047 0.0756
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0139 0.3049
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0076 0.1487
Brugia malayi polk-prov protein 0.0038 0.0278 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0416 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0215 1
Echinococcus multilocularis caspase 0.012 0.1225 0.1183
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0416 1
Echinococcus multilocularis sodium bile acid cotransporter 0.0883 1 1
Trypanosoma cruzi metacaspase, putative 0.0032 0.0215 0.4951
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0325 0.7706
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.0139 0.6159
Plasmodium falciparum metacaspase 1 0.0032 0.0215 0.5
Brugia malayi Cell death protein 3 precursor 0.0032 0.0215 0.0198
Trypanosoma brucei metacaspase MCA2 0.0032 0.0215 0.4951
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0215 0.4951
Echinococcus granulosus caspase 3 0.0088 0.0856 0.0813
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0416 1
Echinococcus granulosus sodium bile acid cotransporter 0.0883 1 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0032 0.0215 0.0168
Echinococcus granulosus caspase 2 0.0032 0.0215 0.0168
Trypanosoma cruzi metacaspase, putative 0.0032 0.0215 0.4951
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0076 0.1487
Trypanosoma cruzi metacaspase, putative 0.0032 0.0215 0.4951
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0047 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0416 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0416 1
Echinococcus multilocularis sodium bile acid cotransporter 0.0883 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0416 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0215 0.0198
Trichomonas vaginalis DNA polymerase eta, putative 0.005 0.0416 1
Leishmania major DNA polymerase kappa, putative 0.0025 0.0139 0.6159
Schistosoma mansoni sodium-bile acid cotransporter related 0.0358 0.3963 0.3935
Schistosoma mansoni caspase-3 (C14 family) 0.012 0.1225 0.1183
Echinococcus multilocularis caspase 2 0.0032 0.0215 0.0168
Echinococcus multilocularis caspase 8 0.0032 0.0215 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0416 1
Schistosoma mansoni caspase-7 (C14 family) 0.012 0.1225 0.1183
Trypanosoma brucei metacaspase 0.0032 0.0215 0.4951
Giardia lamblia DINP protein human, muc B family 0.0025 0.0139 0.5
Echinococcus multilocularis dna polymerase kappa 0.005 0.0416 0.0371
Plasmodium vivax metacaspase 1, putative 0.0032 0.0215 0.5
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0047 0.0756
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0047 0.003
Schistosoma mansoni sodium-bile acid cotransporter 0.0525 0.5883 0.5863
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0416 1
Loa Loa (eye worm) hypothetical protein 0.0883 1 1
Echinococcus granulosus caspase 0.012 0.1225 0.1183
Trypanosoma cruzi metacaspase, putative 0.0032 0.0215 0.4951
Echinococcus granulosus sodium bile acid cotransporter 0.0883 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0416 1
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0416 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0278 0.653
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.0139 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0416 1
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0215 0.4951
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0416 1
Trypanosoma brucei unspecified product 0.0042 0.0325 0.7706
Loa Loa (eye worm) hypothetical protein 0.0032 0.0215 0.0198
Schistosoma mansoni sodium-bile acid cotransporter related 0.0883 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0416 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0076 0.1487
Echinococcus granulosus caspase 8 0.0032 0.0215 0.0168
Onchocerca volvulus 0.0883 1 1
Echinococcus multilocularis sodium bile acid cotransporter 0.0883 1 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.012 0.1225 0.1183
Trypanosoma brucei metacaspase MCA3 0.0032 0.0215 0.4951
Leishmania major DNA polymerase eta, putative 0.0017 0.0047 0.1526
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0278 0.653
Echinococcus multilocularis caspase 3 0.0088 0.0856 0.0813
Leishmania major metacaspase, putative 0.0032 0.0215 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0416 1
Trypanosoma brucei metacaspase 5, putative 0.0032 0.0215 0.4951
Echinococcus granulosus dna polymerase kappa 0.005 0.0416 0.0371
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0215 1
Plasmodium falciparum metacaspase-like protein 0.0032 0.0215 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0278 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0416 1
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0215 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0047 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.003
Trypanosoma brucei Metacaspase-4 0.0032 0.0215 0.4951
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0215 1
Echinococcus granulosus sodium bile acid cotransporter 0.0883 1 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0032 0.0215 0.0198

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.6 ug ml-1 Cytotoxicity against human MCF7 cells after 3 days by SRB assay ChEMBL. 16562843
IC50 (functional) > 5 ug ml-1 Cytotoxicity against human A549 cells after 3 days by SRB assay ChEMBL. 16562843
Inhibition (ADMET) = 121.3516639 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 139.60159 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Potency (ADMET) = 0.3981 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 0.3981 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16562843

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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