Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FAD binding domain containing protein | 0.0058 | 0.5525 | 0.5525 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0095 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0095 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0084 | 0.867 | 0.8159 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0095 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0058 | 0.5525 | 0.5525 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0095 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0095 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0036 | 0.2776 | 0.5 |
Echinococcus multilocularis | methionine synthase reductase | 0.0058 | 0.5525 | 0.5525 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0036 | 0.2776 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0095 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0036 | 0.2776 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0095 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Schistosoma mansoni | diflavin oxidoreductase | 0.0047 | 0.4106 | 0.4106 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0095 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0095 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0095 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0036 | 0.2776 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0036 | 0.2776 | 0.2776 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0095 | 1 | 1 |
Onchocerca volvulus | Putative nachr subunit | 0.0014 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0036 | 0.2776 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0095 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0084 | 0.867 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0048 | 0.4195 | 0.4195 |
Echinococcus granulosus | methionine synthase reductase | 0.0058 | 0.5525 | 0.5525 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0058 | 0.5525 | 0.5525 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0084 | 0.867 | 0.8159 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0095 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Leishmania major | p450 reductase, putative | 0.0095 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0047 | 0.4106 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0095 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0058 | 0.5525 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0095 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0084 | 0.867 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0095 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0095 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0084 | 0.867 | 0.8159 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0047 | 0.4106 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.0036 | 0.2776 | 0.2776 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0095 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Entamoeba histolytica | type A flavoprotein, putative | 0.0036 | 0.2776 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antifungal activity against Candida albicans at 1 mM by almar blue dye reduction assay | ChEMBL. | 18585037 | |
Activity (functional) | Antibacterial activity against Escherichia coli at 1 mM by almar blue dye reduction assay | ChEMBL. | 18585037 | |
Activity (functional) | Antifungal activity against Saccharomyces cerevisiae at 1 mM by almar blue dye reduction assay | ChEMBL. | 18585037 | |
Activity (functional) | Antifungal activity against Cryptococcus neoformans at 1 mM by almar blue dye reduction assay | ChEMBL. | 18585037 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.