Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 0.5 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 0.5 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | > 1 10'-4M | Cytotoxicity against human PC3 cells | ChEMBL. | 18605720 |
GI50 (functional) | = 1 10'-4M | Cytotoxicity against human HCT15 cells | ChEMBL. | 18605720 |
GI50 (functional) | > 1 10'-4M | Cytotoxicity against human SW620 cells | ChEMBL. | 18605720 |
GI50 (functional) | = 1.52 10'-5M | Cytotoxicity against human ACHN cells | ChEMBL. | 18605720 |
GI50 (functional) | = 1.94 10'-5M | Cytotoxicity against human MOLT4 cells | ChEMBL. | 18605720 |
GI50 (functional) | = 1.61 10'-6M | Cytotoxicity against human SF268 cells | ChEMBL. | 18605720 |
GI50 (functional) | = 9.58 10'-6M | Cytotoxicity against human HT29 cells | ChEMBL. | 18605720 |
GI50 (functional) | = 1.64 10'-7M | Cytotoxicity against human MCF7 cells | ChEMBL. | 18605720 |
GI50 (functional) | = 2.67 10'-7M | Cytotoxicity against human NCI-H460 cells | ChEMBL. | 18605720 |
GI50 (functional) | = 3.76 10'-7M | Cytotoxicity against human CAKI1 cells | ChEMBL. | 18605720 |
GI50 (functional) | = 9.52 10'-7M | Cytotoxicity against human K562 cells | ChEMBL. | 18605720 |
GI50 (functional) | < 1 10'-8M | Cytotoxicity against human LOXIMVI cells | ChEMBL. | 18605720 |
GI50 (functional) | = 1.28 10'-8M | Cytotoxicity against human 786-0 cells | ChEMBL. | 18605720 |
IC50 (binding) | = 0.00311 uM | Inhibition of Pneumocystis carinii DHFR using dihydrofolic acid substrate and NADPH cofactor | ChEMBL. | 18605720 |
IC50 (binding) | = 0.06 uM | Inhibition of rat liver DHFR using dihydrofolic acid substrate and NADPH cofactor | ChEMBL. | 18605720 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.