Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | leukotriene A4 hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma japonicum | ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus granulosus | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | leukotriene A4 hydrolase | 611 aa | 508 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0142 | 0.4542 | 0.3719 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.4542 | 0.4542 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.4542 | 0.4542 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0135 | 0.4267 | 0.3403 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.4267 | 0.3403 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0279 | 1 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0142 | 0.4542 | 0.3719 |
Onchocerca volvulus | 0.0135 | 0.4267 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.131 | 0.131 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0135 | 0.4267 | 0.3403 |
Brugia malayi | hypothetical protein | 0.0061 | 0.131 | 0.307 |
Brugia malayi | hypothetical protein | 0.0128 | 0.3978 | 0.9323 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0279 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0135 | 0.4267 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.131 | 0.131 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.4267 | 0.4267 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0279 | 1 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0142 | 0.4542 | 0.3719 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.4267 | 0.4267 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0142 | 0.4542 | 0.3719 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0135 | 0.4267 | 0.3403 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0135 | 0.4267 | 0.3403 |
Onchocerca volvulus | Deterin homolog | 0.0135 | 0.4267 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0061 | 0.131 | 0.307 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0135 | 0.4267 | 0.3403 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0135 | 0.4267 | 1 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0135 | 0.4267 | 0.3403 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 21 nM | Inhibition of human recombinant LTA4-h by peptidase assay | ChEMBL. | 18394906 |
IC50 (functional) | = 110 nM | Inhibition of calcium ionophore-induced LTB4 synthesis in human whole blood after 15 mins by ELISA | ChEMBL. | 18394906 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18394906 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.