Detailed information for compound 979353

Basic information

Technical information
  • TDR Targets ID: 979353
  • Name: 2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyac etyl]amino]benzoic acid
  • MW: 365.358 | Formula: C16H15NO7S
  • H donors: 3 H acceptors: 6 LogP: 2.2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(c(c1)O)C(=O)O)COS(=O)(=O)c1ccc(cc1)C
  • InChi: 1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
  • InChiKey: HWNUSGNZBAISFM-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxy-1-oxoethyl]amino]benzoic acid
  • 2-hydroxy-4-[2-(4-methylphenyl)sulfonyloxyethanoylamino]benzoic acid
  • NSC74859
  • NCIOpen2_008987

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens sirtuin 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe Get druggable targets OG5_127825 All targets in OG5_127825
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei transcriptional regulatory protein sir2a Get druggable targets OG5_127825 All targets in OG5_127825
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_127825 All targets in OG5_127825
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) Get druggable targets OG5_127825 All targets in OG5_127825
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe Get druggable targets OG5_127825 All targets in OG5_127825
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe Get druggable targets OG5_127825 All targets in OG5_127825
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans similar to archaebacterial Sir2 family protein Get druggable targets OG5_127825 All targets in OG5_127825
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi transcriptional regulatory protein sir2 homologue, putative Get druggable targets OG5_127825 All targets in OG5_127825
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium falciparum transcriptional regulatory protein sir2a Get druggable targets OG5_127825 All targets in OG5_127825
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_127825 All targets in OG5_127825
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii histone deacetylase SIR2 Get druggable targets OG5_127825 All targets in OG5_127825
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_127825 All targets in OG5_127825
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi Silent information regulator 2 related protein 3 Get druggable targets OG5_127825 All targets in OG5_127825
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe Get druggable targets OG5_127825 All targets in OG5_127825
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to archaebacterial Sir2 family protein Get druggable targets OG5_127825 All targets in OG5_127825
Mycobacterium tuberculosis Transcriptional regulatory protein Get druggable targets OG5_127825 All targets in OG5_127825
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe Get druggable targets OG5_127825 All targets in OG5_127825
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi Silent information regulator 2 related protein 3 Get druggable targets OG5_127825 All targets in OG5_127825
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani Silent information regulator 2 related protein 3 Get druggable targets OG5_127825 All targets in OG5_127825
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans NAD-dependent deacetylase Get druggable targets OG5_127825 All targets in OG5_127825
Giardia lamblia Transcriptional regulator, Sir2 family Get druggable targets OG5_127825 All targets in OG5_127825
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense Silent information regulator 2 related protein 3 Get druggable targets OG5_127825 All targets in OG5_127825
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica Sir2 family transcriptional regulator, putative Get druggable targets OG5_127825 All targets in OG5_127825
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni chromatin regulatory protein sir2 Get druggable targets OG5_127825 All targets in OG5_127825
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium yoelii transcriptional regulatory protein, Sir2 family Get druggable targets OG5_127825 All targets in OG5_127825
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum NAD-dependent deacetylase, putative Get druggable targets OG5_127825 All targets in OG5_127825
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K01463 sirtuin 5 (silent mating type information regulation 2 homolog) 5 [EC:3.5.1.-], putative Get druggable targets OG5_127825 All targets in OG5_127825
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei Silent information regulator 2 related protein 3 Get druggable targets OG5_127825 All targets in OG5_127825
Plasmodium vivax NAD-dependent deacetylase, putative Get druggable targets OG5_127825 All targets in OG5_127825
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei SIR2-like protein 4, putative sirtuin 5 292 aa 272 aa 29.0 %
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi UDP-galactopyranose mutase 0.014 0.9532 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.6305 1
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.063 0.0661
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0045 0.0047
Schistosoma mansoni chromatin regulatory protein sir2 0.0062 0.378 0.3965
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0269 0.0282
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.063 0.0598
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.6305 0.6614
Mycobacterium ulcerans dehydrogenase 0.014 0.9532 1
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0062 0.378 0.3965
Mycobacterium ulcerans protoporphyrinogen oxidase 0.014 0.9532 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0012 0.0067 0.007
Echinococcus granulosus dna polymerase eta 0.0095 0.6205 0.6509
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0612 0.0642
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0634 0.1005
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.2082 0.2185
Trypanosoma brucei DNA polymerase eta, putative 0.0095 0.6205 0.9841
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0062 0.378 0.5995
Loa Loa (eye worm) hypothetical protein 0.014 0.9532 0.9532
Trichomonas vaginalis rotamase, putative 0.0039 0.2082 0.3004
Loa Loa (eye worm) hypothetical protein 0.0095 0.6205 0.6205
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.063 0.0598
Leishmania major DNA polymerase kappa, putative 0.002 0.0634 0.0665
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0634 0.1005
Brugia malayi amine oxidase, flavin-containing family protein 0.014 0.9532 0.9658
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.014 0.9532 1
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0634 0.0665
Brugia malayi PHD-finger family protein 0.0035 0.1772 0.1795
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.014 0.9532 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.002 0.063 0.099
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.987 0.987
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.014 0.9532 1
Toxoplasma gondii histone deacetylase SIR2-like 0.002 0.063 0.0661
Trypanosoma brucei SIR2-like protein 4, putative 0.002 0.063 0.1
Entamoeba histolytica hypothetical protein, conserved 0.002 0.063 0.099
Plasmodium falciparum protoporphyrinogen oxidase 0.014 0.9532 1
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0634 0.0665
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0634 0.0665
Schistosoma mansoni hypothetical protein 0.0015 0.0255 0.0268
Giardia lamblia Transcriptional regulator, Sir2 family 0.0062 0.378 0.8364
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0064 0.3918 0.4111
Leishmania major silent information regulator 2, putative 0.002 0.063 0.0661
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0269 0.0282
Toxoplasma gondii histone lysine-specific demethylase 0.014 0.9532 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.2082 0.3303
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.2322 0.2436
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.292 0.3063
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0011 0.0011
Loa Loa (eye worm) transcriptional regulator 0.002 0.063 0.063
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.2082 0.2185
Mycobacterium ulcerans oxidoreductase 0.014 0.9532 1
Schistosoma mansoni DNA helicase recq1 0.0012 0.0045 0.0047
Brugia malayi ImpB/MucB/SamB family protein 0.0095 0.6205 0.6286
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.6305 0.6614
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.0269 0.0282
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0306 0.0062
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.063 0.0598
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0012 0.0011 0.0017
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0012 0.0011 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.3032 0.4809
Brugia malayi SWIRM domain containing protein 0.014 0.9532 0.9658
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.2797 0.2934
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0045 0.0047
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.6305 0.6374
Echinococcus multilocularis bloom syndrome protein 0.0029 0.131 0.1374
Echinococcus granulosus lysine specific histone demethylase 1A 0.014 0.9532 1
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0015 0.0269 0.0427
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0012 0.0067 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0255 0.0255
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0015 0.0269 0.0282
Brugia malayi jmjC domain containing protein 0.0115 0.7725 0.7827
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.6305 0.6614
Trypanosoma cruzi UDP-galactopyranose mutase 0.014 0.9532 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.002 0.063 0.0639
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0306 0.0486
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0067 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.451 0.7154
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.002 0.063 0.1311
Echinococcus granulosus jumonji domain containing protein 0.0049 0.2797 0.2934
Plasmodium vivax hypothetical protein, conserved 0.014 0.9532 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0306 0.0321
Loa Loa (eye worm) hypothetical protein 0.014 0.9532 0.9532
Loa Loa (eye worm) hypothetical protein 0.002 0.063 0.063
Plasmodium falciparum transcriptional regulatory protein sir2b 0.002 0.063 0.0661
Loa Loa (eye worm) hypothetical protein 0.0052 0.302 0.302
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0064 0.3918 0.4111
Trichomonas vaginalis DNA polymerase eta, putative 0.0096 0.6305 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.002 0.063 0.0661
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.063 0.0598
Mycobacterium tuberculosis Conserved hypothetical protein 0.014 0.9532 1
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0634 0.1005
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.1048 0.11
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.7725 0.8104
Brugia malayi transcriptional regulator, Sir2 family protein 0.002 0.063 0.0639
Echinococcus granulosus chromatin regulatory protein sir2 0.002 0.063 0.0661
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.002 0.063 0.099
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.0269 0.0282
Loa Loa (eye worm) hypothetical protein 0.014 0.9532 0.9532
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0011 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.6305 1
Plasmodium falciparum phd finger protein, putative 0.0035 0.1772 0.1859
Echinococcus multilocularis chromatin regulatory protein sir2 0.002 0.063 0.0661
Brugia malayi transcriptional regulator, Sir2 family protein 0.002 0.063 0.0639
Schistosoma mansoni Lysine-specific histone demethylase 1 0.014 0.9532 1
Loa Loa (eye worm) hypothetical protein 0.014 0.9532 0.9532
Mycobacterium ulcerans hypothetical protein 0.002 0.0634 0.0004
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0045 0.0045
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0064 0.3918 0.4111
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0634 0.0665
Loa Loa (eye worm) RecQ helicase 0.0029 0.131 0.131
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.014 0.9532 0.9532
Schistosoma mansoni amine oxidase 0.014 0.9532 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.014 0.9532 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.302 0.479
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.4558 0.4558
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0634 0.1005
Schistosoma mansoni DNA polymerase eta 0.0095 0.6205 0.6509
Schistosoma mansoni rotamase 0.004 0.2153 0.2259
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0634 0.0665
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.0634 0.0665
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0634 0.0665
Leishmania major DNA polymerase eta, putative 0.0095 0.6205 0.6509
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0062 0.378 0.5817
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.002 0.063 0.0661
Brugia malayi jmjC domain containing protein 0.0043 0.2322 0.2353
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.006 0.3641 0.3641
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0634 0.0665
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.002 0.063 0.0661
Leishmania major DNA polymerase kappa, putative 0.0072 0.451 0.4732
Schistosoma mansoni terminal deoxycytidyl transferase 0.0064 0.3918 0.4111
Trypanosoma cruzi DNA polymerase eta, putative 0.0095 0.6205 0.6509
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.1772 0.1859
Plasmodium vivax hypothetical protein, conserved 0.0035 0.1772 0.1859
Toxoplasma gondii PHD-finger domain-containing protein 0.0012 0.0011 0.0011
Brugia malayi AF-10 protein 0.0012 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0035 0.1772 0.1859
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.063 0.0661
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.063 0.0661
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.063 0.0598
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0015 0.0269 0.0282
Brugia malayi PHD-finger family protein 0.0012 0.0011 0.0011
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.1772 0.1859
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0067 0.0106
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0634 0.1005
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.6305 0.6374
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.2082 0.2185
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0062 0.378 0.5817
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.987 0.987
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0011 0.0011
Mycobacterium ulcerans NAD-dependent deacetylase 0.0062 0.378 0.3538
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.7725 0.8104
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.131 0.1724
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.6305 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.6305 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0045
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0045 0.0047
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0045 0.0047
Leishmania major DNA damage repair protein, putative 0.002 0.0634 0.0665
Echinococcus granulosus bloom syndrome protein 0.0029 0.131 0.1374
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.6305 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.292 0.3063
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.2153 0.2153
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0012 0.0011 0.0011
Giardia lamblia DNA damage repair protein 0.002 0.0634 0.1319
Onchocerca volvulus 0.014 0.9532 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.002 0.063 0.0661
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.2322 0.2436
Echinococcus multilocularis 0.0015 0.0269 0.0282
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.3918 0.024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0595 0.0624
Echinococcus granulosus CTD small phosphatase protein like 0.0015 0.0269 0.0282
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0062 0.378 0.3965
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.002 0.063 0.0661
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.2322 0.2322
Echinococcus granulosus expressed protein 0.004 0.2153 0.2259
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0062 0.378 0.3965
Schistosoma mansoni jumonji domain containing protein 0.0092 0.5964 0.6256
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0045 0.0047
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.6305 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.002 0.063 0.0661
Echinococcus multilocularis expressed protein 0.004 0.2153 0.2259
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0072 0.451 0.4732
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0015 0.0269 0.0502
Echinococcus granulosus dna polymerase kappa 0.0096 0.6305 0.6614
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0045 0.0047
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.002 0.063 0.0661
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.3918 0.397
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.063 0.0598
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.002 0.063 0.0661
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.063 0.0661
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0306 0.0321
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.014 0.9532 1
Echinococcus multilocularis dna polymerase eta 0.0095 0.6205 0.6509
Brugia malayi MH2 domain containing protein 0.0144 0.987 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.2082 0.4969
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0096 0.6305 1
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.2082 0.2185
Loa Loa (eye worm) sirtuin 4 0.002 0.063 0.063
Toxoplasma gondii histone deacetylase SIR2 0.0062 0.378 0.3965
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0015 0.0269 0.0282
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.6305 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.014 0.9532 1
Loa Loa (eye worm) transcriptional regulator 0.002 0.063 0.063
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0269 0.0282
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0062 0.378 0.9621
Giardia lamblia PHD finger protein 15 0.0035 0.1772 0.3868
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0012 0.0067 0.007
Brugia malayi NAD-dependent deacetylase SIRT1 0.002 0.063 0.0639
Plasmodium vivax NAD-dependent deacetylase, putative 0.0062 0.378 0.3965
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.6305 0.6614
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0064 0.3918 0.3918
Schistosoma mansoni amine oxidase 0.014 0.9532 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.002 0.063 0.0661
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0067 0.007
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0062 0.378 0.3965
Brugia malayi hypothetical protein 0.014 0.9532 0.9658
Loa Loa (eye worm) hypothetical protein 0.0035 0.1772 0.1772
Trypanosoma brucei unspecified product 0.0044 0.244 0.387
Trypanosoma brucei Silent information regulator 2 related protein 1 0.002 0.063 0.1
Leishmania major sir2-family protein-like protein 0.002 0.063 0.0661
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.002 0.063 0.099
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.2322 0.2436
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0015 0.0269 0.0282
Giardia lamblia Sirtuin type 2 0.002 0.063 0.1311
Plasmodium vivax hypothetical protein, conserved 0.014 0.9532 1
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.063 0.0661
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.1772 0.1859
Giardia lamblia DINP protein human, muc B family 0.0072 0.451 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.6305 1
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.131 0.1327
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0045 0.0045
Echinococcus granulosus lysine specific histone demethylase 1A 0.014 0.9532 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.6305 1
Loa Loa (eye worm) transcriptional regulator 0.002 0.063 0.063
Echinococcus granulosus peregrin 0.0035 0.1772 0.1859
Plasmodium vivax hypothetical protein, conserved 0.002 0.063 0.0661
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.6305 1
Brugia malayi Bromodomain containing protein 0.0035 0.1772 0.1795
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.1772 0.1859
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.014 0.9532 1
Trypanosoma brucei DNA polymerase IV, putative 0.0088 0.5713 0.9061
Echinococcus multilocularis 0.014 0.9532 1
Trypanosoma brucei unspecified product 0.0044 0.244 0.387
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.2153 0.2181
Leishmania major hypothetical protein, conserved 0.0015 0.0269 0.0282
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.131 0.1724
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.014 0.9532 1
Trichomonas vaginalis rotamase, putative 0.004 0.2153 0.3121
Echinococcus multilocularis lysine specific histone demethylase 1A 0.014 0.9532 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.3032 0.4809
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.6305 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.063 0.0598
Echinococcus multilocularis dna polymerase kappa 0.0096 0.6305 0.6614
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.063 0.0598
Schistosoma mansoni hypothetical protein 0.0012 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.004 0.2153 0.3121
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0045 0.0047
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0015 0.0269 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.3032 0.4809
Loa Loa (eye worm) hypothetical protein 0.0015 0.0269 0.0269
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.063 0.0661
Loa Loa (eye worm) hypothetical protein 0.014 0.9532 0.9532
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.2322 0.2436
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0857 0.0899
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.1772 0.1859
Trypanosoma brucei unspecified product 0.0088 0.5713 0.9061
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0062 0.378 0.5817
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0072 0.451 0.127
Entamoeba histolytica deoxycytidyl transferase, putative 0.0064 0.3918 1
Giardia lamblia Hypothetical protein 0.002 0.063 0.1311
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.302 0.479
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0028 0.1226 0.1286
Schistosoma mansoni DNA helicase recq5 0.0012 0.0045 0.0047
Mycobacterium ulcerans monoamine oxidase 0.014 0.9532 1
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0306 0.0102
Mycobacterium tuberculosis Possible oxidoreductase 0.014 0.9532 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.014 0.9532 1
Leishmania major DNA polymerase eta, putative 0.0051 0.292 0.3063
Echinococcus multilocularis peregrin 0.0035 0.1772 0.1859
Brugia malayi polk-prov protein 0.0052 0.302 0.306
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.002 0.063 0.0661
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.1772 0.1772
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.014 0.9532 1
Leishmania major UDP-galactopyranose mutase 0.014 0.9532 1
Echinococcus multilocularis protoporphyrinogen oxidase 0.014 0.9532 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) 4.19 uM PubChem BioAssay. MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_Dose_CherryPick_Activity_Set5. (Class of assay: confirmatory) ChEMBL. No reference
Activity (functional) = 50 % Induction of apoptosis in mock pcDNA3 transfected human MDA-MB-231 cells at 100 uM after 24 hrs ChEMBL. 17463090
Activity (functional) = 50 % Induction of apoptosis in human MDA-MB-231 cells at 100 uM after 24 hrs ChEMBL. 17463090
GI (functional) = 20 % Cytotoxicity against human SNU449 cells with intact TGFbeta pathway assessed as growth inhibition at 250 uM after 72 hrs by MTT assay ChEMBL. 22650325
IC50 (functional) = 4.636 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
IC50 (functional) 75.277 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 84 uM Binding affinity to Stat3 (unknown origin) using hSIE as probe preincubated for 30 mins followed by hSIE addition by electrophoretic mobility shift assay ChEMBL. 23968501
IC50 (binding) = 86 uM Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction in nucleus after 30 mins by EMSA ChEMBL. 22650325
IC50 (binding) = 86 uM Inhibition of STAT3 dimerization in EGF-stimulated mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction after 30 mins by EMSA ChEMBL. 22650325
IC50 (binding) = 86 uM Inhibition of STAT3 (unknown origin) dimerization by EMSA ChEMBL. 24073326
IC50 (binding) = 86 uM Inhibition of STAT3 (unknown origin) DNA-binding activity by electrophoretic mobility shift assay ChEMBL. No reference
IC50 (functional) = 86 uM Inhibition of Stat3 DNA binding activity in EGF-stimulated mouse NIH3T3 cells expressing hEGFR with activated Stat1, Stat3, Stat5 ChEMBL. 17463090
IC50 (functional) = 86 uM Inhibition of Stat3:Stat3 dimerization in EGF-stimulated mouse NIH3T3 cells expressing hEGFR with activated Stat1, Stat3, Stat5 ChEMBL. 17463090
IC50 (functional) = 160 uM Inhibition of Stat1:Stat3 dimerization in EGF-stimulated mouse NIH3T3 cells expressing hEGFR with activated Stat1, Stat3, Stat5 ChEMBL. 17463090
IC50 (functional) = 166 uM Inhibition of Stat5:Stat5 dimerization in EGF-stimulated mouse NIH3T3 cells expressing hEGFR with activated Stat1, Stat3, Stat5 ChEMBL. 17463090
IC50 (binding) > 300 uM Inhibition of STAT1 dimerization in EGF-stimulated mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT1-DNA interaction after 30 mins by EMSA ChEMBL. 22650325
IC50 (functional) > 300 uM Inhibition of Stat1:Stat1 dimerization in EGF-stimulated mouse NIH3T3 cells expressing hEGFR with activated Stat1, Stat3, Stat5 ChEMBL. 17463090
Ki (binding) = 80 uM Inhibition of STAT3 SH2 domain assessed as inhibition of STAT3 SH2-phosphotyrosine interaction after 15 mins by fluorescence polarization assay ChEMBL. 22650325
Potency (functional) 0.4467 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 3.3587 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.691 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.8876 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.0115 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.