Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Brugia malayi | ADAM-TS Spacer 1 family protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FAD binding domain containing protein | 0.0033 | 0.0741 | 0.0228 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0054 | 0.3233 | 0.3119 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0054 | 0.3233 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0054 | 0.3233 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0054 | 0.3233 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0054 | 0.3233 | 0.2859 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0046 | 0.2265 | 0.2004 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0103 | 0.9208 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0054 | 0.3233 | 0.3511 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0048 | 0.2493 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0033 | 0.0741 | 0.0228 |
Brugia malayi | flavodoxin family protein | 0.0054 | 0.3233 | 0.2859 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0911 | 0.0407 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0054 | 0.3233 | 0.5 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0046 | 0.2265 | 0.2004 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.9208 | 0.9164 |
Schistosoma mansoni | amidase | 0.0103 | 0.9208 | 1 |
Onchocerca volvulus | Papilin homolog | 0.0035 | 0.0911 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0054 | 0.3233 | 0.5 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0046 | 0.2265 | 0.246 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0054 | 0.3233 | 0.3119 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0054 | 0.3233 | 0.5 |
Brugia malayi | angiogenesis inhibito | 0.0034 | 0.0791 | 0.0281 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0031 | 0.0525 | 0.057 |
Brugia malayi | ADAMTS-like protease | 0.0034 | 0.0791 | 0.0281 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0054 | 0.3233 | 0.3119 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0103 | 0.9208 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0033 | 0.0741 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0103 | 0.9208 | 1 |
Giardia lamblia | Hypothetical protein | 0.0048 | 0.2493 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3233 | 0.2859 |
Brugia malayi | amidase | 0.0103 | 0.9208 | 0.9164 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0054 | 0.3233 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0103 | 0.9208 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0054 | 0.3233 | 0.5 |
Echinococcus granulosus | methionine synthase reductase | 0.0033 | 0.0741 | 0.0249 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0054 | 0.3233 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0054 | 0.3233 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0054 | 0.3233 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0054 | 0.3233 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0033 | 0.0741 | 0.0805 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0054 | 0.3233 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0054 | 0.3233 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0054 | 0.3233 | 0.2859 |
Echinococcus multilocularis | methionine synthase reductase | 0.0033 | 0.0741 | 0.0249 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0103 | 0.9208 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0054 | 0.3233 | 0.3119 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.