Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.2279 | 0.2279 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.3514 | 0.3514 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.3514 | 0.3514 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.3514 | 0.3514 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3514 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3514 | 1 |
Brugia malayi | RNA binding protein | 0.0071 | 0.3514 | 0.3514 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.3514 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1188 | 0.3382 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.3514 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3514 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.3514 | 0.3514 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.2279 | 0.2279 |
Onchocerca volvulus | 0.017 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2279 | 0.2279 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.3514 | 0.3514 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1188 | 0.1188 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1188 | 0.1188 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3514 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.2279 | 0.2279 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3514 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.