Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0219 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0219 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0202 | 0.9081 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0219 | 1 | 1 |
Leishmania major | stearic acid desaturase, putative | 0.0202 | 0.9081 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0186 | 0.8182 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0219 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0219 | 1 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0202 | 0.9081 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0219 | 1 | 1 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0177 | 0.7663 | 0.7663 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0219 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0177 | 0.7663 | 0.7663 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0037 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0037 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0186 | 0.8182 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0186 | 0.8182 | 0.8182 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0037 | 0 | 0.5 |
Onchocerca volvulus | 0.0202 | 0.9081 | 1 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0177 | 0.7663 | 0.7663 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 1 | 1 |
Brugia malayi | acyl-CoA desaturase | 0.0186 | 0.8182 | 0.8182 |
Brugia malayi | Choline O-acetyltransferase | 0.0177 | 0.7663 | 0.7663 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0177 | 0.7663 | 0.7663 |
Onchocerca volvulus | 0.0202 | 0.9081 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.0219 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0037 | 0 | 0.5 |
Brugia malayi | Choline O-acetyltransferase | 0.0177 | 0.7663 | 0.7663 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.7663 | 0.7663 |
Leishmania major | fatty-acid desaturase, putative | 0.0202 | 0.9081 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 6.08 % | Agonist activity at human thyroid hormone receptor alpha expressed in CV1 cells at 0.01 uM by TRE-luciferase assay | ChEMBL. | 18585912 |
Activity (functional) | = 6.12 % | Agonist activity at human thyroid hormone receptor alpha expressed in CV1 cells at 0.001 uM by TRE-luciferase assay | ChEMBL. | 18585912 |
Activity (functional) | = 9.36 % | Agonist activity at human thyroid hormone receptor alpha expressed in CV1 cells at 1 uM by TRE-luciferase assay | ChEMBL. | 18585912 |
Activity (functional) | = 14.6 % | Agonist activity at human thyroid hormone receptor beta expressed in CV1 cells at 0.001 uM by TRE-luciferase assay | ChEMBL. | 18585912 |
Activity (functional) | = 15.1 % | Agonist activity at human thyroid hormone receptor beta expressed in CV1 cells at 0.01 uM by TRE-luciferase assay | ChEMBL. | 18585912 |
Activity (functional) | = 30.9 % | Agonist activity at human thyroid hormone receptor beta expressed in CV1 cells at 1 uM by TRE-luciferase assay | ChEMBL. | 18585912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.