Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0049 | 0.0459 | 0.0459 |
Onchocerca volvulus | 0.0297 | 0.7837 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0461 | 0.0461 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.037 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2767 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.2767 | 0.2767 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.2767 | 0.2767 |
Brugia malayi | hypothetical protein | 0.0297 | 0.7837 | 0.7837 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.2767 | 0.2767 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0049 | 0.0459 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2767 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0049 | 0.0459 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2767 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0049 | 0.0459 | 0.0459 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2767 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.2767 | 0.2767 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0049 | 0.0459 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0049 | 0.0459 | 0.0459 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0049 | 0.0459 | 0.5 |
Brugia malayi | RNA binding protein | 0.0126 | 0.2767 | 0.2767 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0049 | 0.0459 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.2767 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.2767 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0461 | 0.0461 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.7837 | 0.7837 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0049 | 0.0459 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0049 | 0.0459 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0461 | 0.0461 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.2767 | 0.2767 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0049 | 0.0459 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0049 | 0.0459 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0049 | 0.0459 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2767 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.037 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0461 | 0.0461 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0049 | 0.0459 | 0.166 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 83 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected erythrocytes | ChEMBL. | 18619713 |
Ki (binding) | > 1 mM | Inhibition of human dUTPase | ChEMBL. | 18619713 |
Ki (binding) | > 1 mM | Inhibition of Plasmodium falciparum dUTPase | ChEMBL. | 18619713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.