Detailed information for compound 980149

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.46 | Formula: C21H20N2O3S
  • H donors: 1 H acceptors: 2 LogP: 3.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)/C=N/NC(=O)Cc1cc(=O)oc2c1cc(C)c(c2)C
  • InChi: 1S/C21H20N2O3S/c1-13-8-18-16(11-21(25)26-19(18)9-14(13)2)10-20(24)23-22-12-15-4-6-17(27-3)7-5-15/h4-9,11-12H,10H2,1-3H3,(H,23,24)/b22-12+
  • InChiKey: DIOVAXXFUYSCGS-WSDLNYQXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ecdysone induced protein 78C 0.0182 0.518 0.518
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0557 0.0657
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0718 0.0718
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0182 0.518 0.6907
Loa Loa (eye worm) hypothetical protein 0.0146 0.4011 0.5328
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0086 0.2055 0.2055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0182 0.518 0.518
Schistosoma mansoni nuclear receptor 0.0086 0.2055 0.2424
Echinococcus granulosus FTZ F1 alpha 0.0182 0.518 0.518
Brugia malayi Steroid receptor seven-up type 2 0.0182 0.518 0.6907
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0182 0.518 0.518
Schistosoma mansoni bromodomain containing protein 0.0065 0.1388 0.1638
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1278 0.1637
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.747 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.2055 0.2687
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0182 0.518 0.6907
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0182 0.518 0.6907
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0096 0.239 0.3139
Brugia malayi Nuclear hormone receptor-like 1 0.0182 0.518 0.6907
Brugia malayi nuclear hormone receptor family member nhr-6 0.0086 0.2055 0.2687
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.2055 0.2055
Echinococcus granulosus muscleblind protein 0.0146 0.4011 0.4011
Onchocerca volvulus Bile acid receptor homolog 0.0182 0.518 1
Echinococcus multilocularis muscleblind protein 0.0146 0.4011 0.4011
Loa Loa (eye worm) hypothetical protein 0.0069 0.1512 0.1953
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.4649 0.6026
Loa Loa (eye worm) steroid hormone receptor 0.0182 0.518 0.6907
Brugia malayi orphan nuclear receptor NR2E1 0.0086 0.2055 0.2687
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0182 0.518 0.518
Brugia malayi ecdysteroid receptor 0.0182 0.518 0.6907
Loa Loa (eye worm) hypothetical protein 0.0047 0.0781 0.0965
Loa Loa (eye worm) hypothetical protein 0.0086 0.2055 0.2687
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.099 0.1248
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0182 0.518 0.518
Brugia malayi hypothetical protein 0.0096 0.239 0.3139
Loa Loa (eye worm) hypothetical protein 0.0086 0.2055 0.2687
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.4649 0.6026
Schistosoma mansoni retinoic acid receptor RXR 0.0182 0.518 0.611
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0086 0.2055 0.2055
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0407 0.0407
Loa Loa (eye worm) hypothetical protein 0.0038 0.0484 0.0565
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0066 0.5
Brugia malayi conserved hypotetical protein 0.0086 0.2055 0.2687
Loa Loa (eye worm) hypothetical protein 0.0048 0.0836 0.1041
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.747 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0182 0.518 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.3945 0.4654
Schistosoma mansoni hypothetical protein 0.0166 0.4649 0.5483
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.747 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0695 0.0695
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0182 0.518 0.611
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0182 0.518 0.6907
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0182 0.518 0.518
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0182 0.518 0.518
Brugia malayi nuclear receptor NHR-67 0.0086 0.2055 0.2687
Onchocerca volvulus 0.0086 0.2055 0.2897
Brugia malayi nuclear hormone receptor 0.0182 0.518 0.6907
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0448 0.0516
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0695 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0448 0.0516
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0182 0.518 0.6907
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0182 0.518 0.611
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0182 0.518 0.518
Echinococcus granulosus geminin 0.0166 0.4649 0.4649
Onchocerca volvulus 0.0182 0.518 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.518 0.6907
Loa Loa (eye worm) hypothetical protein 0.0182 0.518 0.6907
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1278 0.1507
Loa Loa (eye worm) hypothetical protein 0.0182 0.518 0.6907
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0182 0.518 0.6907
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.1889 1
Loa Loa (eye worm) nuclear hormone receptor 0.0086 0.2055 0.2687
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0718 0.0847
Schistosoma mansoni zinc finger protein 0.0086 0.2055 0.2424
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0182 0.518 0.518
Brugia malayi photoreceptor-specific nuclear receptor 0.0182 0.518 0.6907
Loa Loa (eye worm) nuclear receptor NHR-67 0.0086 0.2055 0.2687
Brugia malayi steroid hormone receptor 0.0182 0.518 0.6907
Brugia malayi nuclear receptor NHR-88 0.0086 0.2055 0.2687
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0718 0.0718
Brugia malayi Nuclear hormone receptor-like 1 0.0096 0.239 0.3139
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0096 0.239 0.2819
Loa Loa (eye worm) hypothetical protein 0.0182 0.518 0.6907
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0182 0.518 0.6907
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0695 0.0457
Leishmania major hypothetical protein, conserved 0.0025 0.0066 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0672 0.0819
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0182 0.518 0.6907
Loa Loa (eye worm) DR-78 0.0086 0.2055 0.2687
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0557 0.0657
Onchocerca volvulus 0.0086 0.2055 0.2897
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1278 0.1507
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.099 0.099
Schistosoma mansoni nuclear hormone receptor 0.0086 0.2055 0.2424
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.4649 0.6026
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1278 0.1507
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0718 0.0881
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0182 0.518 0.611
Brugia malayi nuclear receptor NHR-88 0.0182 0.518 0.6907
Schistosoma mansoni nuclear hormone receptor 0.0086 0.2055 0.2424
Loa Loa (eye worm) hypothetical protein 0.0045 0.0733 0.0901
Echinococcus multilocularis tumor protein p63 0.0331 1 1
Brugia malayi nuclear receptor RXR 0.0096 0.239 0.3139
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0695 0.0457
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0066 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0086 0.2055 0.2055
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0695 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0086 0.2055 0.2897
Echinococcus multilocularis muscleblind protein 1 0.0146 0.4011 0.4011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0182 0.518 0.6907
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.4938 0.6434
Loa Loa (eye worm) hypothetical protein 0.0086 0.2055 0.2687
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0448 0.0448
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0182 0.518 0.6907
Loa Loa (eye worm) RNA binding protein 0.0062 0.1278 0.1637
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0182 0.518 0.6907
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.099 0.099
Loa Loa (eye worm) acetyltransferase 0.0144 0.3945 0.5239
Brugia malayi hypothetical protein 0.0086 0.2055 0.2687
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0182 0.518 0.6907
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1278 0.1637
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0781 0.0921
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0086 0.2055 0.2055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0182 0.518 0.518
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0718 0.0881
Brugia malayi TAR-binding protein 0.0062 0.1278 0.1637
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0182 0.518 0.6907
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0086 0.2055 0.2055
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0182 0.518 0.518
Brugia malayi nuclear hormone receptor 0.0086 0.2055 0.2687
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0182 0.518 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0086 0.2055 0.2055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0182 0.518 0.518
Loa Loa (eye worm) hypothetical protein 0.0086 0.2055 0.2687
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1278 0.1507
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.5237 0.5237
Brugia malayi tailless protein 0.0086 0.2055 0.2687
Schistosoma mansoni coup transcription factor 0.0182 0.518 0.611
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.1889 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0718 0.0847
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.1275 0.1275
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0086 0.2055 0.2687
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.747 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0182 0.518 0.6907
Loa Loa (eye worm) hypothetical protein 0.0086 0.2055 0.2687
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0507 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1278 0.1637
Brugia malayi Nuclear hormone receptor E75 0.0086 0.2055 0.2687
Echinococcus multilocularis thyroid hormone receptor alpha 0.0182 0.518 0.518
Schistosoma mansoni nuclear hormone receptor 0.0182 0.518 0.611
Loa Loa (eye worm) hypothetical protein 0.0086 0.2055 0.2687
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.3945 0.5239
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0182 0.518 0.611
Schistosoma mansoni RAR-like nuclear receptor 0.0182 0.518 0.611
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0096 0.239 0.2819
Echinococcus multilocularis ecdysone induced protein 78C 0.0182 0.518 0.518
Schistosoma mansoni hypothetical protein 0.0166 0.4649 0.5483
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0781 0.0921
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0781 0.0921
Brugia malayi Bromodomain containing protein 0.0077 0.1761 0.2289
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0507 0.5
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0086 0.2055 0.2424
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0182 0.518 0.611
Brugia malayi ecdysone receptor 0.0086 0.2055 0.2687
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0096 0.239 0.239
Loa Loa (eye worm) hypothetical protein 0.0096 0.239 0.3139
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.4649 0.8793
Brugia malayi mbt repeat family protein 0.0047 0.0781 0.0965
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0781 0.0781
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0407 0.0407
Loa Loa (eye worm) hypothetical protein 0.0032 0.0292 0.0305
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0182 0.518 0.6907
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0182 0.518 0.6907
Schistosoma mansoni thyroid hormone receptor 0.0182 0.518 0.611
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.2055 0.2055
Echinococcus multilocularis FTZ F1 alpha 0.0182 0.518 0.518
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0096 0.239 0.239
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0086 0.2055 0.2424
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0182 0.518 0.6907
Brugia malayi hypothetical protein 0.0096 0.239 0.3139
Brugia malayi nuclear hormone receptor family member odr-7 0.0086 0.2055 0.2687
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0086 0.2055 0.2687
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0066 0.5
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0086 0.2055 0.2687
Loa Loa (eye worm) hypothetical protein 0.0182 0.518 0.6907
Loa Loa (eye worm) hypothetical protein 0.0146 0.4011 0.5328
Loa Loa (eye worm) hypothetical protein 0.0182 0.518 0.6907
Echinococcus granulosus tar DNA binding protein 0.0062 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0053 0.099 0.1248
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0182 0.518 0.518
Schistosoma mansoni steroid hormone receptor ad4bp 0.0182 0.518 0.611
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.747 1
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0781 0.0965
Brugia malayi PHD-finger family protein 0.0028 0.0169 0.014
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0781 0.0781
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1278 0.1507
Schistosoma mansoni nuclear receptor nhr-48 0.0086 0.2055 0.2424
Schistosoma mansoni nuclear receptor 0.0086 0.2055 0.2424
Loa Loa (eye worm) hypothetical protein 0.0096 0.239 0.3139
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0096 0.239 0.3139
Loa Loa (eye worm) hypothetical protein 0.0096 0.239 0.3139
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0695 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0182 0.518 0.6907
Echinococcus granulosus thyroid hormone receptor alpha 0.0086 0.2055 0.2055
Loa Loa (eye worm) hypothetical protein 0.0086 0.2055 0.2687
Brugia malayi RNA binding protein 0.0062 0.1278 0.1637
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.0086 0.2055 0.2687
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.4649 0.6026
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0182 0.518 0.611
Brugia malayi Bromodomain containing protein 0.0041 0.0595 0.0714
Echinococcus multilocularis nuclear receptor nhr 48 0.0086 0.2055 0.2055
Loa Loa (eye worm) hypothetical protein 0.0081 0.1889 0.2462
Schistosoma mansoni thyroid hormone receptor 0.0182 0.518 0.611
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0718 0.0718
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0718 0.0718
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.4938 0.6434
Loa Loa (eye worm) hypothetical protein 0.0096 0.239 0.3139
Brugia malayi Nuclear hormone receptor E75 0.0086 0.2055 0.2687
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.099 0.1168
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.747 1
Echinococcus granulosus nuclear receptor nhr 48 0.0086 0.2055 0.2055
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.3741 0.3741
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0182 0.518 0.6907
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0182 0.518 0.518
Brugia malayi hypothetical protein 0.0086 0.2055 0.2687
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.747 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0182 0.518 0.6907
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.4649 0.6026
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.1275 0.1275
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.4649 0.6026
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.747 1
Brugia malayi Nuclear hormone receptor-like 1 0.0096 0.239 0.3139
Loa Loa (eye worm) hypothetical protein 0.0086 0.2055 0.2687
Echinococcus granulosus Nuclear hormone receptor HR96 0.0086 0.2055 0.2055
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.4649 0.6026
Brugia malayi Muscleblind-like protein 0.0146 0.4011 0.5328
Brugia malayi nuclear receptor RXR 0.0086 0.2055 0.2687
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0718 0.0847
Onchocerca volvulus 0.0048 0.0836 0.0127
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0836 0.0987
Loa Loa (eye worm) hypothetical protein 0.0086 0.2055 0.2687
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0182 0.518 0.6907
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0086 0.2055 0.2897
Schistosoma mansoni hypothetical protein 0.0284 0.8477 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.3945 0.3945
Echinococcus multilocularis geminin 0.0166 0.4649 0.4649
Loa Loa (eye worm) hypothetical protein 0.0182 0.518 0.6907
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.5237 0.5237
Loa Loa (eye worm) MBCTL1 0.0053 0.099 0.1248
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.099 0.099
Brugia malayi mbt repeat family protein 0.0047 0.0781 0.0965
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0086 0.2055 0.2687

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 6 % Antitubercular activity against Mycobacterium tuberculosis H37Rv at 12.5 ug/mL after 5 to 8 days ChEMBL. 18328603

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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