Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dual specificity | 0.0396 | 0.4291 | 0.4126 |
Loa Loa (eye worm) | chitinase I | 0.0078 | 0.0149 | 0.0149 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0141 | 0.0971 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0396 | 0.4291 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0509 | 0.5756 | 0.5756 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0078 | 0.0149 | 0.0149 |
Echinococcus multilocularis | acetylcholinesterase | 0.0835 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0141 | 0.0971 | 0.0712 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0141 | 0.0971 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0509 | 0.5756 | 0.5634 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0091 | 0.0324 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0971 | 0.0971 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0141 | 0.0971 | 0.0712 |
Loa Loa (eye worm) | haspin protein kinase | 0.0509 | 0.5756 | 0.5756 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0509 | 0.5756 | 0.5634 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0141 | 0.0971 | 0.1631 |
Plasmodium falciparum | conserved protein, unknown function | 0.0124 | 0.0745 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0745 | 0.0745 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0091 | 0.0324 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0745 | 0.0745 |
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0091 | 0.0324 | 0.0046 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0091 | 0.0324 | 0.0423 |
Onchocerca volvulus | 0.0141 | 0.0971 | 1 | |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0091 | 0.0324 | 0.0178 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0091 | 0.0324 | 0.0423 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0396 | 0.4291 | 1 |
Echinococcus multilocularis | dual specificity | 0.0396 | 0.4291 | 0.4126 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0141 | 0.0971 | 0.0712 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0091 | 0.0324 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0971 | 0.0971 |
Echinococcus granulosus | acetylcholinesterase | 0.0835 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0835 | 1 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0087 | 0.0272 | 0.1487 |
Loa Loa (eye worm) | hypothetical protein | 0.0835 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0091 | 0.0324 | 0.0324 |
Brugia malayi | GSG2 | 0.0509 | 0.5756 | 0.5692 |
Echinococcus multilocularis | dual specificity | 0.0396 | 0.4291 | 0.4126 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0141 | 0.0971 | 0.0712 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0091 | 0.0324 | 0.0423 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0124 | 0.0745 | 0.0605 |
Loa Loa (eye worm) | carboxylesterase | 0.0141 | 0.0971 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0971 | 0.0971 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0971 | 0.0971 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0141 | 0.0971 | 0.0712 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0141 | 0.0971 | 0.0712 |
Onchocerca volvulus | 0.0124 | 0.0745 | 0.7246 | |
Schistosoma mansoni | protein kinase | 0.0091 | 0.0324 | 0.0046 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0091 | 0.0324 | 0.0046 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.0971 | 0.0834 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0091 | 0.0324 | 0.0046 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.0745 | 0.0479 |
Plasmodium vivax | hypothetical protein, conserved | 0.0124 | 0.0745 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0396 | 0.4291 | 1 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0091 | 0.0324 | 0.0423 |
Onchocerca volvulus | 0.0141 | 0.0971 | 1 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0396 | 0.4291 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0396 | 0.4291 | 1 |
Onchocerca volvulus | 0.0124 | 0.0745 | 0.7246 | |
Onchocerca volvulus | Putative endochitinase | 0.0087 | 0.0272 | 0.1487 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0509 | 0.5756 | 0.5634 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.0971 | 0.0834 |
Brugia malayi | Protein kinase domain containing protein | 0.0091 | 0.0324 | 0.0178 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0396 | 0.4291 | 1 |
Brugia malayi | endochitinase | 0.0087 | 0.0272 | 0.0124 |
Schistosoma mansoni | gliotactin | 0.0141 | 0.0971 | 0.0712 |
Schistosoma mansoni | acetylcholinesterase | 0.0141 | 0.0971 | 0.0712 |
Loa Loa (eye worm) | carboxylesterase | 0.0141 | 0.0971 | 0.0971 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0141 | 0.0971 | 0.0712 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0141 | 0.0971 | 0.1631 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0509 | 0.5756 | 0.5634 |
Onchocerca volvulus | 0.0141 | 0.0971 | 1 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0141 | 0.0971 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0088 | 0.028 | 0.0315 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0396 | 0.4291 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0396 | 0.4291 | 0.4291 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0971 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0971 | 0.0971 |
Brugia malayi | hypothetical protein | 0.0509 | 0.5756 | 0.5692 |
Loa Loa (eye worm) | haspin protein kinase | 0.0512 | 0.5801 | 0.5801 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0396 | 0.4291 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0396 | 0.4291 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0141 | 0.0971 | 0.0712 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0124 | 0.0745 | 0.0479 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0396 | 0.4291 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0141 | 0.0971 | 0.0712 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0091 | 0.0324 | 0.0046 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.0971 | 0.0834 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0396 | 0.4291 | 0.4126 |
Onchocerca volvulus | 0.0141 | 0.0971 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0835 | 1 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.0091 | 0.0324 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0971 | 0.0971 |
Echinococcus multilocularis | dual specificity | 0.0396 | 0.4291 | 0.4126 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0396 | 0.4291 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0091 | 0.0324 | 0.0324 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.0971 | 0.0834 |
Brugia malayi | Endochitinase | 0.0087 | 0.0272 | 0.0124 |
Echinococcus granulosus | neuroligin | 0.0141 | 0.0971 | 0.0712 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0141 | 0.0971 | 0.0712 |
Echinococcus granulosus | carboxylesterase 5A | 0.0835 | 1 | 1 |
Onchocerca volvulus | 0.0141 | 0.0971 | 1 | |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0396 | 0.4291 | 1 |
Echinococcus granulosus | dual specificity | 0.0396 | 0.4291 | 0.4126 |
Brugia malayi | Cell division protein kinase 2 | 0.0091 | 0.0324 | 0.0178 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0141 | 0.0971 | 0.0712 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0396 | 0.4291 | 0.4204 |
Echinococcus granulosus | dual specificity | 0.0396 | 0.4291 | 0.4126 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0124 | 0.0745 | 0.0479 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0835 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0091 | 0.0324 | 0.0046 |
Onchocerca volvulus | Putative endochitinase | 0.0087 | 0.0272 | 0.1487 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0076 | 0.0122 | 0.0122 |
Brugia malayi | hypothetical protein | 0.0141 | 0.0971 | 0.0834 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0509 | 0.5756 | 0.5634 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0396 | 0.4291 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0835 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0509 | 0.5756 | 0.5634 |
Echinococcus multilocularis | neuroligin | 0.0141 | 0.0971 | 0.0712 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0141 | 0.0971 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.