Detailed information for compound 980695

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 506.678 | Formula: C25H34N2O5S2
  • H donors: 1 H acceptors: 4 LogP: 5.9 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)C(=O)N1CCCCC1)CC(C)C
  • InChi: 1S/C25H34N2O5S2/c1-4-5-15-32-25(29)26-34(30,31)24-22(17-21(33-24)16-18(2)3)19-9-11-20(12-10-19)23(28)27-13-7-6-8-14-27/h9-12,17-18H,4-8,13-16H2,1-3H3,(H,26,29)
  • InChiKey: PQLJODPWSGTUJB-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Type-1A angiotensin II receptor Starlite/ChEMBL References
Sus scrofa Type-1 angiotensin II receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis growth hormone secretagogue receptor type 1 Type-1A angiotensin II receptor   359 aa 351 aa 21.9 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Type-1A angiotensin II receptor   359 aa 336 aa 22.3 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Type-1A angiotensin II receptor   359 aa 407 aa 19.4 %
Onchocerca volvulus Type-1A angiotensin II receptor   359 aa 303 aa 25.1 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Type-1A angiotensin II receptor   359 aa 311 aa 23.5 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Type-1 angiotensin II receptor   359 aa 346 aa 23.4 %
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Type-1A angiotensin II receptor   359 aa 303 aa 22.4 %
Onchocerca volvulus Type-1A angiotensin II receptor   359 aa 312 aa 19.2 %
Echinococcus multilocularis G-protein coupled receptor, putative Type-1A angiotensin II receptor   359 aa 308 aa 22.4 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Type-1A angiotensin II receptor   359 aa 334 aa 23.7 %
Loa Loa (eye worm) neuropeptide F receptor Type-1A angiotensin II receptor   359 aa 356 aa 24.2 %
Brugia malayi GnHR receptor homolog Type-1A angiotensin II receptor   359 aa 364 aa 20.9 %
Loa Loa (eye worm) hypothetical protein Type-1A angiotensin II receptor   359 aa 335 aa 23.3 %
Onchocerca volvulus Type-1 angiotensin II receptor   359 aa 321 aa 20.2 %
Onchocerca volvulus Type-1 angiotensin II receptor   359 aa 349 aa 24.4 %
Echinococcus granulosus tm gpcr rhodopsin Type-1A angiotensin II receptor   359 aa 303 aa 22.4 %
Schistosoma mansoni opsin-like receptor Type-1A angiotensin II receptor   359 aa 299 aa 25.1 %
Echinococcus multilocularis neuropeptide receptor Type-1A angiotensin II receptor   359 aa 316 aa 25.3 %
Loa Loa (eye worm) hypothetical protein Type-1A angiotensin II receptor   359 aa 330 aa 26.7 %
Onchocerca volvulus Type-1A angiotensin II receptor   359 aa 314 aa 25.8 %
Echinococcus multilocularis allatostatin A receptor Type-1A angiotensin II receptor   359 aa 348 aa 25.9 %
Onchocerca volvulus Type-1A angiotensin II receptor   359 aa 386 aa 24.9 %
Brugia malayi putative neuropeptide receptor NPR1 Type-1A angiotensin II receptor   359 aa 295 aa 27.5 %
Schistosoma mansoni peptide (allatostatin)-like receptor Type-1A angiotensin II receptor   359 aa 314 aa 26.1 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Type-1A angiotensin II receptor   359 aa 352 aa 20.5 %
Onchocerca volvulus Type-1A angiotensin II receptor   359 aa 294 aa 23.8 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Type-1A angiotensin II receptor   359 aa 346 aa 18.2 %
Schistosoma japonicum Rhodopsin, putative Type-1A angiotensin II receptor   359 aa 327 aa 24.2 %
Onchocerca volvulus Type-1A angiotensin II receptor   359 aa 395 aa 23.0 %
Echinococcus granulosus allatostatin A receptor Type-1A angiotensin II receptor   359 aa 348 aa 25.9 %
Brugia malayi ORL1-like opioid receptor Type-1A angiotensin II receptor   359 aa 314 aa 20.1 %
Echinococcus granulosus growth hormone secretagogue receptor type 1 Type-1A angiotensin II receptor   359 aa 351 aa 21.9 %
Echinococcus granulosus neuropeptide receptor Type-1A angiotensin II receptor   359 aa 316 aa 25.0 %
Echinococcus granulosus thyrotropin releasing hormone receptor Type-1A angiotensin II receptor   359 aa 337 aa 24.0 %
Schistosoma mansoni adenoreceptor Type-1A angiotensin II receptor   359 aa 329 aa 24.0 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Type-1A angiotensin II receptor   359 aa 406 aa 20.0 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.1083
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Echinococcus granulosus neurogenic locus notch protein 0.0009 0.0000000090804 0.000000018869
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0042 0.0074
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0011 0.0022
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0034 0.0154
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0034 0.0042
Echinococcus granulosus X box binding protein 1 0.0281 0.1973 0.41
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.016 0.0282
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0008 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0158 0.1083
Schistosoma mansoni par domain protein 0.0009 0.0003 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0299 1
Schistosoma mansoni brg-1 associated factor 0.001 0.0014 0.0029
Onchocerca volvulus 0.0009 0.0003 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0158 0.1083
Schistosoma mansoni hypothetical protein 0.0281 0.1973 0.41
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.016 0.0332
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0032 0.0117
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0034 0.0042
Echinococcus multilocularis geminin 0.0338 0.2383 0.4206
Schistosoma mansoni hypothetical protein 0.004 0.0226 0.047
Echinococcus granulosus protocadherin 11 0.0009 0.0003 0.0006
Echinococcus multilocularis SWI:SNF matrix associated 0.001 0.0014 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0299 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0147 0.101
Brugia malayi heat shock protein 90 0.0032 0.0168 0.1154
Echinococcus granulosus geminin 0.0338 0.2383 0.4952
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0179 0.1231
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0158 0.1083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0158 0.1083
Loa Loa (eye worm) DR-78 0.0014 0.0042 0.0287
Echinococcus multilocularis endoplasmin 0.0025 0.0121 0.0214
Schistosoma mansoni patched 1 0.0041 0.0237 0.0492
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0644 0.1339
Loa Loa (eye worm) histone methyltransferase 0.001 0.0011 0.0074
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.005 0.0343
Mycobacterium tuberculosis Probable reductase 0.0087 0.0565 0.0745
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0158 0.0327
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.5076
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1584
Echinococcus multilocularis protocadherin 11 0.0009 0.0003 0.0005
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0042 0.0287
Loa Loa (eye worm) hypothetical protein 0.012 0.0804 0.5526
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0168 0.5075
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.005 0.1261
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0287
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0042 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0158 0.1083
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0129 0.0889
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0129 0.0889
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0634 0.4357
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0032 0.0002
Brugia malayi Pre-SET motif family protein 0.0209 0.1454 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0372
Brugia malayi hypothetical protein 0.0016 0.0054 0.0372
Schistosoma mansoni transcriptional factor nfil3/e4bp4 0.0009 0.0003 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0034 0.0042
Brugia malayi Isocitrate dehydrogenase 0.0015 0.005 0.0343
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0042 0.0074
Echinococcus multilocularis heat shock protein 90 0.0032 0.0168 0.0296
Onchocerca volvulus 0.003 0.0158 0.0947
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0168 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0392 0.2775 0.2765
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0121 0.3324
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0237 0.0492
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.1083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0158 0.1083
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0158 0.0327
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0213 0.6974
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0158 0.1083
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0121 0.0683
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0032 0.0647
Plasmodium falciparum heat shock protein 90 0.0032 0.0168 0.5393
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0129 0.0777
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0287
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.005 0.0088
Brugia malayi brahma associated protein 60 kDa 0.001 0.0014 0.0096
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0158 0.0278
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0008 0.0083
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0372
Brugia malayi hypothetical protein 0.0009 0.0003 0.0019
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.005 0.0656
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0008 0.0002
Echinococcus granulosus dna polymerase kappa 0.0019 0.0075 0.0155
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0299 1
Brugia malayi hypothetical protein 0.012 0.0804 0.5526
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0042 0.0074
Brugia malayi Endoplasmin precursor 0.0032 0.0168 0.1154
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.005 0.0088
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0054 0.0372
Echinococcus multilocularis expressed conserved protein 0.009 0.0592 0.1044
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0075 0.0155
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.5076
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0042 0.0087
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0042 0.0251
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0392 0.2775 1
Leishmania major hypothetical protein, conserved 0.005 0.0299 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1584
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0889
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0168 0.2617
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.001 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0158 0.0278
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0998 0.7163 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0075 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0158 0.1083
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0075 0.0058
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.005 0.0088
Loa Loa (eye worm) hypothetical protein 0.005 0.0299 0.2059
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0042 0.0074
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.5076
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0372
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.005 0.018
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0158 0.0327
Schistosoma mansoni cpg binding protein 0.003 0.0159 0.033
Brugia malayi Peroxidasin 0.0026 0.0129 0.0889
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Plasmodium falciparum thioredoxin reductase 0.0038 0.0213 0.6974
Brugia malayi Blistered cuticle protein 3 0.0026 0.0129 0.0889
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0075 0.1582
Brugia malayi Hsp90 protein 0.0013 0.0032 0.0223
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0079 0.043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.016 0.0332
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0889
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0168 0.5075
Trypanosoma brucei unspecified product 0.0019 0.0075 0.1584
Echinococcus multilocularis protein dispatched 1 0.0047 0.0279 0.0492
Echinococcus multilocularis dna polymerase eta 0.0019 0.0075 0.0132
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0237 0.0492
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0034 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1584
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.005 0.1261
Brugia malayi hypothetical protein 0.0014 0.0042 0.0287
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0158 0.1083
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0054 0.0372
Brugia malayi nuclear receptor RXR 0.0016 0.0054 0.0372
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.5076
Giardia lamblia Grp94/Hsp90 0.0025 0.0121 0.7215
Schistosoma mansoni endoplasmin 0.0032 0.0168 0.0349
Echinococcus multilocularis SWI:SNF matrix associated 0.001 0.0014 0.0025
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0009 0.0000000090804 0.000000054599
Giardia lamblia Myb 1-like protein 0.001 0.0008 0.0498
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0158 0.0327
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0009 0.0003 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0034 0.0042
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.4812 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0179 0.1231
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0168 0.5076
Schistosoma mansoni heat shock protein 0.0013 0.0032 0.0067
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.5076
Schistosoma mansoni hypothetical protein 0.0022 0.01 0.0208
Echinococcus granulosus heat shock protein 90 0.0032 0.0168 0.0349
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.029 0.1997
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0889
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0158 0.1083
Schistosoma mansoni thyroid hormone receptor 0.003 0.0158 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0014 0.0035
Plasmodium vivax glutathione reductase, putative 0.0038 0.0213 0.6974
Onchocerca volvulus 0.0009 0.0003 0.0017
Brugia malayi MH2 domain containing protein 0.0117 0.0782 0.5374
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0121 0.0088
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0158 0.0947
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0034 0.007
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0054 0.0112
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0075 0.0402
Onchocerca volvulus Huntingtin homolog 0.012 0.0804 0.4832
Onchocerca volvulus Peroxidase homolog 0.0026 0.0129 0.0777
Echinococcus multilocularis cpg binding protein 0.003 0.0159 0.028
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0168 0.5076
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0075 0.0513
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0287
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.005 0.018
Schistosoma mansoni peroxidasin 0.0026 0.0129 0.0269
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0032 0.0647
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0034 0.002
Brugia malayi steroid hormone receptor 0.003 0.0158 0.1083
Brugia malayi Latrophilin receptor protein 2 0.0015 0.005 0.0342
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0121 0.0123
Onchocerca volvulus 0.0009 0.0003 0.0017
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.0635 0.0843
Brugia malayi nuclear receptor NHR-88 0.003 0.0158 0.1083
Schistosoma mansoni hypothetical protein 0.001 0.0014 0.0029
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0034 0.0059
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0168 0.5075
Echinococcus granulosus FTZ F1 alpha 0.003 0.0158 0.0327
Echinococcus granulosus dna polymerase eta 0.0019 0.0075 0.0155
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0287
Plasmodium falciparum thioredoxin reductase 0.0013 0.0034 0.0686
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0158 0.0327
Onchocerca volvulus Neurogenic locus notch homolog 0.0009 0.0000000090804 0.000000054599
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0042 0.0287
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0009 0.0003 0.0006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0054 0.0112
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0042 0.0087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0042 0.0087
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0042 0.0287
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0158 0.1083
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0158 0.0327
Loa Loa (eye worm) glutathione reductase 0.0038 0.0213 0.1465
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0889
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0287
Schistosoma mansoni heat shock protein 0.0032 0.0168 0.0349
Loa Loa (eye worm) hypothetical protein 0.0154 0.1051 0.7229
Giardia lamblia DINP protein human, muc B family 0.0019 0.0075 0.4445
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1454 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0075 0.1584
Echinococcus granulosus SWI:SNF matrix associated 0.001 0.0014 0.0029
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Schistosoma mansoni zinc finger protein 0.0014 0.0042 0.0087
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0121 0.0683
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0054 0.0112
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0287
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0129 0.0889
Brugia malayi ecdysone receptor 0.0014 0.0042 0.0287
Brugia malayi conserved hypotetical protein 0.0014 0.0042 0.0287
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0075 0.0132
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.001 0.0014 0.0096
Echinococcus multilocularis SWI:SNF matrix associated 0.001 0.0014 0.0025
Brugia malayi hypothetical protein 0.005 0.0299 0.2059
Brugia malayi notch-like transmembrane receptor 0.0009 0.0000000090804 0.000000062439
Brugia malayi nuclear hormone receptor 0.003 0.0158 0.1083
Schistosoma mansoni hypothetical protein 0.001 0.0014 0.0029
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0565 0.0745
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.01 0.0208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0158 0.1083
Echinococcus granulosus Upstream activation factor subunit UAF30 0.001 0.0014 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.1582
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0042 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1584
Schistosoma mansoni hypothetical protein 0.001 0.0014 0.0029
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0042 0.0087
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.005 0.0023
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0075 0.1584
Schistosoma mansoni coup transcription factor 0.003 0.0158 0.0327
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0287
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0034 0.0686
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0158 0.0327
Brugia malayi nuclear receptor NHR-88 0.0014 0.0042 0.0287
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0042 0.0087
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0075 0.0155
Onchocerca volvulus 0.0026 0.0129 0.0777
Brugia malayi hypothetical protein 0.0026 0.0129 0.0889
Echinococcus granulosus peroxidasin 0.0026 0.0129 0.0269
Onchocerca volvulus 0.0029 0.0147 0.0883
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.0635 0.0843
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0034 0.0042
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0158 0.0278
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0565 0.0745
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.1582
Brugia malayi Cell death specification protein 2 0.0009 0.0003 0.0019
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0034 0.0154
Schistosoma mansoni hypothetical protein 0.004 0.0226 0.047
Schistosoma mansoni hypothetical protein 0.0338 0.2383 0.4952
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1663 1
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.0009 0.0003 0.0006
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0299 0.1079
Plasmodium falciparum endoplasmin, putative 0.0019 0.0079 0.2285
Echinococcus multilocularis heat shock protein 90 0.0025 0.0121 0.0214
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.001 0.0008 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.016 0.0332
Brugia malayi bZIP transcription factor family protein 0.0009 0.0003 0.0019
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0287
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.016 0.0282
Echinococcus granulosus microtubule associated protein 2 0.0674 0.4812 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.1582
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0158 0.0278
Brugia malayi Pre-SET motif family protein 0.0031 0.016 0.1098
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0075 0.0132
Loa Loa (eye worm) hypothetical protein 0.0009 0.0000000090804 0.000000062439
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0034 0.0686
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.005 0.0656
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.005 0.0659
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.0009 0.0003 0.0005
Echinococcus granulosus endoplasmin 0.0025 0.0121 0.0252
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.005 0.0088
Echinococcus multilocularis heat shock protein 0.0032 0.0168 0.0296
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0054 0.0096
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0034 0.0045
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0287
Loa Loa (eye worm) hypothetical protein 0.0041 0.0237 0.1628
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.0635 0.073
Leishmania major trypanothione reductase 0.0038 0.0213 0.6765
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0565 0.063
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.0009 0.0003 0.0005
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0213 0.1465
Plasmodium vivax SET domain protein, putative 0.0031 0.016 0.5105
Loa Loa (eye worm) endoplasmin 0.0032 0.0168 0.1154
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0032 0.0067
Schistosoma mansoni nuclear receptor 0.0014 0.0042 0.0087
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0075 0.0513
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0158 0.0278
Schistosoma mansoni peroxidasin 0.0026 0.0129 0.0269
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0042 0.0087
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0121 0.3324
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0129 0.0889
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0782 0.5374
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0217 0.045
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0034 0.0045
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0034 0.007
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0121 0.0252
Schistosoma mansoni nuclear receptor 0.0014 0.0042 0.0087
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.139 1 1
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0042 0.0087
Onchocerca volvulus 0.0014 0.0042 0.0251
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0042 0.0087
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0075 0.0041
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0889
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0287
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0008 0.0057
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.1083
Loa Loa (eye worm) hypothetical protein 0.012 0.0804 0.5526
Echinococcus granulosus heat shock protein 0.0032 0.0168 0.0349
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0158 0.0327
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.0103
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0034 0.0121
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.005 0.0088
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.5076
Brugia malayi brahma associated protein 60 kDa 0.001 0.0014 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0237 0.1382
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1584
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0129 0.0889
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0075 0.0402
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0237 0.0418
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.005 0.0342
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0791 0.5666 1
Onchocerca volvulus 0.0009 0.0003 0.0017
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0042 0.0287
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0032 0.0223
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0129 0.0777
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0168 0.0605
Plasmodium vivax heat shock protein, putative 0.0013 0.0032 0.0647
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.016 0.0575
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0034 0.0042
Plasmodium vivax endoplasmin, putative 0.0032 0.0168 0.5393
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0075 0.0155
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0158 0.0327
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0158 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0158 0.1083
Onchocerca volvulus 0.0031 0.016 0.096
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0032 0.0147
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Brugia malayi hypothetical protein 0.0154 0.1051 0.7229
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0158 0.1083
Trypanosoma brucei trypanothione reductase 0.0038 0.0213 0.6766
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1584
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0147 0.101
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0565 0.0745
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0009 0.0003 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0158 0.1083
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0889
Schistosoma mansoni hypothetical protein 0.004 0.0226 0.047
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.01 0.0177
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.005 0.0088
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.5076
Brugia malayi SWIB/MDM2 domain containing protein 0.001 0.0014 0.0096
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0565 0.0745
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0034 0.023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0158 0.1083
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.1083
Schistosoma mansoni thyroid hormone receptor 0.003 0.0158 0.0327
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0042 0.0074
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0075 0.0513
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0158 0.1083
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0158 0.0278
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0032 0.0117
Brugia malayi CHE-14 protein 0.0041 0.0237 0.1628
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0008 0.0083
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0634 0.1118
Echinococcus multilocularis protocadherin 11 0.0009 0.0003 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0158 0.1083
Echinococcus multilocularis protein patched 0.0041 0.0237 0.0418
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0034 0.0042
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.005 0.0656
Brugia malayi hypothetical protein 0.0016 0.0054 0.0372
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.139 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0889
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1584
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0042 0.0251
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0158 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0158 0.1083
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0019
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0168 0.5075
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0034 0.0121
Schistosoma mansoni nuclear hormone receptor 0.003 0.0158 0.0327
Brugia malayi hypothetical protein 0.0032 0.0171 0.1179
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.001 0.0014 0.0025
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.0103
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0932 0.1645
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.0103
Loa Loa (eye worm) hypothetical protein 0.0096 0.0634 0.4357
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0074 0.1552
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.0103
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0168 0.5076
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0158 0.0327
Brugia malayi isocitrate dehydrogenase 0.0015 0.005 0.0343
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.029 0.1997
Brugia malayi Thioredoxin reductase 0.0038 0.0213 0.1465
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.1083
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0034 0.1996
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.005 0.0104
Loa Loa (eye worm) bZIP transcription factor family protein 0.0009 0.0003 0.0019
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0158 0.1083
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0389 0.0808
Onchocerca volvulus Huntingtin homolog 0.012 0.0804 0.4832
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.1083
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0121 0.7215
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0034 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.1083
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0034 0.0042
Plasmodium falciparum glutathione reductase 0.0013 0.0034 0.0686
Brugia malayi EGF-like domain containing protein 0.0009 0.0000000090804 0.000000062439
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0129 0.0777
Toxoplasma gondii thioredoxin reductase 0.0038 0.0213 0.0768
Echinococcus granulosus protocadherin 11 0.0009 0.0003 0.0006
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0008 0.0083
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.4812 0.8494
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0009 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0889
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0032 0.0647
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0121 0.3324
Plasmodium falciparum glutathione reductase 0.0038 0.0213 0.6974
Brugia malayi tailless protein 0.0014 0.0042 0.0287
Onchocerca volvulus 0.0026 0.0129 0.0777
Brugia malayi nuclear hormone receptor 0.0014 0.0042 0.0287
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Brugia malayi Cell death specification protein 2 0.0009 0.0003 0.0019
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.001 0.0014 0.005
Loa Loa (eye worm) brahma associated protein 0.001 0.0014 0.0096
Onchocerca volvulus 0.0026 0.0129 0.0777
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0034 0.0045
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0019
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0042 0.0287
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0168 0.0605
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.0635 0.0843
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0158 0.0327
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0129 0.0889
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0009 0.0003 0.0005
Onchocerca volvulus 0.001 0.0014 0.0084
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0372
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.016 0.0332
Schistosoma mansoni hypothetical protein 0.0033 0.0179 0.0372
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0287
Brugia malayi ecdysteroid receptor 0.003 0.0158 0.1083
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.005 0.0342
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0034 0.0042
Echinococcus granulosus GPCR family 2 0.0015 0.005 0.0103
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0392 0.2775 0.3768
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0932 0.1937
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0075 0.1584
Brugia malayi hypothetical protein 0.0009 0.0003 0.0019
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0006
Echinococcus granulosus expressed conserved protein 0.009 0.0592 0.1229
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0042 0.0287
Brugia malayi hypothetical protein 0.0009 0.0003 0.0019
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0158 0.0278
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0013 0.0032 0.0469
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0042 0.0074
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0168 0.5075
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0034 0.0042
Echinococcus granulosus ccaat enhancer binding protein delta 0.0009 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0889
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0054 0.0372
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.005 0.0088
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0032 0.0057
Giardia lamblia Hypothetical protein 0.0009 0.0003 0.0166
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0158 0.0327
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0129 0.0889
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0213 0.0252
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0889
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0565 0.0745
Onchocerca volvulus 0.0238 0.1663 1
Schistosoma mansoni hypothetical protein 0.004 0.0226 0.047
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0129 0.0889
Brugia malayi Cell death specification protein 2 0.0009 0.0003 0.0019
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.029 0.1997
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1584
Echinococcus multilocularis peroxidasin 0.0026 0.0129 0.0228
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1584
Schistosoma mansoni endoplasmin 0.0032 0.0168 0.0349
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.016 0.0332
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0019
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0782 0.5374
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0158 0.0278
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0213 0.6765
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0158 0.1083
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0011 0.0019
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0034 0.0042
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.5076
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0158 0.0947
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0158 0.1083
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.1098
Onchocerca volvulus Peroxidase homolog 0.0026 0.0129 0.0777
Loa Loa (eye worm) hypothetical protein 0.0019 0.0075 0.0513
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0392 0.2775 0.2751
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0168 0.1154
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.1582
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0168 0.0966
Schistosoma mansoni thyrotroph embryonic factor related 0.0009 0.0003 0.0006
Echinococcus multilocularis X box binding protein 1 0.0281 0.1973 0.3483
Leishmania major DNA polymerase kappa, putative 0.0019 0.0075 0.1582
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0158 0.0327
Schistosoma mansoni cpg binding protein 0.0029 0.0147 0.0305
Echinococcus granulosus cpg binding protein 0.003 0.0159 0.033
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0079 0.043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0034 0.0042
Echinococcus multilocularis neurogenic locus notch protein 0.0009 0.0000000090804 0.000000016027
Echinococcus granulosus heat shock protein 90 0.0025 0.0121 0.0252
Schistosoma mansoni cpg binding protein 0.003 0.0159 0.033
Trichomonas vaginalis MYB, putative 0.001 0.0008 0.0002
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0006
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0075 0.0058
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0299 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0634 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0889
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.005 0.0104
Schistosoma mansoni DNA polymerase eta 0.0019 0.0075 0.0155
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0121 0.0683
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0129 0.0889
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0075 0.1139
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0889
Leishmania major DNA polymerase eta, putative 0.0019 0.0075 0.1582
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0158 0.1083
Loa Loa (eye worm) hypothetical protein 0.0051 0.0304 0.209
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0034 0.0686
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0299 1
Onchocerca volvulus 0.0154 0.1051 0.6322
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0158 0.0327
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.0121 0.0088
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0032 0.0195
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0217 0.0382
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0158 0.0278
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.005 0.0103
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0158 0.0947
Treponema pallidum heat shock protein 90 0.0025 0.0121 0.0088
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0158 0.1083
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.1083
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0042 0.0287
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0168 0.2617
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0889
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0998 0.7163 1
Brugia malayi nuclear receptor NHR-67 0.0014 0.0042 0.0287
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0008 0.0002
Loa Loa (eye worm) hypothetical protein 0.0049 0.029 0.1997
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0168 0.5393
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0008 0.0057
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0008 0.0083
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0129 0.0889
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0372
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0889
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.005 0.0659
Brugia malayi glutathione reductase 0.0038 0.0213 0.1465
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.5075
Brugia malayi Hepatic leukemia factor 0.0009 0.0003 0.0019
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0299 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.005 0.0342
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0129 0.0777
Schistosoma mansoni heat shock protein 0.0032 0.0168 0.0349
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0075 0.1584
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.005 0.0103
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0158 0.0327
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0341 0.123
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0075 0.1582
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0042 0.0087
Loa Loa (eye worm) cell death specification protein 2 0.0009 0.0003 0.0019
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0042 0.0287
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0634 0.1317
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0019
Brugia malayi hypothetical protein 0.0014 0.0042 0.0287
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0034 0.0686
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0287
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0042 0.0287
Onchocerca volvulus 0.0014 0.0042 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1584
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0237 0.1628
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0287
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.139 1 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.001 0.0014 0.005
Brugia malayi nuclear receptor RXR 0.0014 0.0042 0.0287
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0147 0.0306
Echinococcus multilocularis GPCR, family 2 0.0015 0.005 0.0088
Schistosoma mansoni hypothetical protein 0.0338 0.2383 0.4952

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 3.2 nM Displacement of [125]Ang2 from AT2 receptor in pig uterus membrane ChEMBL. 18599297
Ki (binding) > 10000 nM Displacement of [125]Ang2 from AT1 receptor in rat liver membrane ChEMBL. 18599297

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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