Detailed information for compound 980931

Basic information

Technical information
  • TDR Targets ID: 980931
  • Name: (4S)-4-[[(2S,3S)-2-acetamido-3-methylpentanoy l]amino]-5-[[(2S,3R)-3-hydroxy-1-[[(2S)-4-hyd roxy-1,4-dioxobutan-2-yl]amino]-1-oxobutan-2- yl]amino]-5-oxopentanoic acid
  • MW: 502.515 | Formula: C21H34N4O10
  • H donors: 7 H acceptors: 10 LogP: -1.97 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 3
  • SMILES: O=C[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)C)CCC(=O)O)CC(=O)O
  • InChi: 1S/C21H34N4O10/c1-5-10(2)17(22-12(4)28)20(34)24-14(6-7-15(29)30)19(33)25-18(11(3)27)21(35)23-13(9-26)8-16(31)32/h9-11,13-14,17-18,27H,5-8H2,1-4H3,(H,22,28)(H,23,35)(H,24,34)(H,25,33)(H,29,30)(H,31,32)/t10-,11+,13-,14-,17-,18-/m0/s1
  • InChiKey: AXTKTZHLZLOIIO-PBEPODTISA-N  

Network

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Synonyms

  • (4S)-4-[[(2S,3S)-2-acetamido-3-methyl-pentanoyl]amino]-5-[[(1S,2R)-1-[[(1S)-1-formyl-3-hydroxy-3-oxo-propyl]carbamoyl]-2-hydroxy-propyl]amino]-5-oxo-pentanoic acid
  • (4S)-4-[[(2S,3S)-2-acetamido-3-methyl-1-oxopentyl]amino]-5-[[(1S,2R)-1-[[[(1S)-1-formyl-3-hydroxy-3-oxopropyl]amino]-oxomethyl]-2-hydroxypropyl]amino]-5-oxopentanoic acid
  • (4S)-4-[[(2S,3S)-2-acetamido-3-methyl-pentanoyl]amino]-5-[[(1S,2R)-1-[[(1S)-1-formyl-3-hydroxy-3-keto-propyl]carbamoyl]-2-hydroxy-propyl]amino]-5-keto-valeric acid
  • (4S)-4-[[(2S,3S)-2-acetamido-3-methyl-pentanoyl]amino]-5-[[(2S,3R)-3-hydroxy-1-[[(2S)-4-hydroxy-1,4-dioxo-butan-2-yl]amino]-1-oxo-butan-2-yl]amino]-5-oxo-pentanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens caspase 8, apoptosis-related cysteine peptidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Treponema pallidum sodium- and chloride- dependent transporter 0.0155 0.141 1
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0049 0.0049
Onchocerca volvulus 0.0029 0.0049 0.0127
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0229 0.0171
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0568
Brugia malayi PHD-finger family protein 0.003 0.0054 0.0093
Toxoplasma gondii kringle domain-containing protein 0.023 0.2217 1
Schistosoma mansoni myosin xvIII 0.0029 0.0049 0.0049
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0049 0.003
Onchocerca volvulus 0.004 0.0169 0.0647
Brugia malayi hypothetical protein 0.0029 0.0049 0.0082
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.0882 0.3927
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0049 0.0036
Brugia malayi hypothetical protein 0.0029 0.0049 0.0082
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0019 0.0019
Echinococcus granulosus short transient receptor potential channel 6 0.0126 0.1099 0.1082
Brugia malayi latrophilin 2 splice variant baaae 0.0169 0.156 0.3485
Brugia malayi proteasome subunit beta type 1 0.0069 0.0476 0.1045
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0069 0.0476 0.1395
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0154 0.1395 0.1379
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0048 0.0247 0.1037
Echinococcus granulosus transient receptor potential ion channel A 0.0185 0.1728 0.1712
Onchocerca volvulus 0.0051 0.028 0.1124
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.028 0.04
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0069 0.0476 0.1395
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Loa Loa (eye worm) hypothetical protein 0.0065 0.0433 0.0421
Brugia malayi neuropeptide F receptor 0.0029 0.0049 0.0082
Schistosoma mansoni neuropeptide receptor 0.0029 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0048 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0043 0.0194 0.0176
Schistosoma mansoni hypothetical protein 0.0297 0.2941 0.2941
Echinococcus multilocularis neuropeptide s receptor 0.0029 0.0049 0.003
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0069 0.0476 0.2081
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.058 0.0568
Loa Loa (eye worm) hypothetical protein 0.0048 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.004 0.0169 0.0157
Echinococcus granulosus alpha 1A adrenergic receptor 0.0029 0.0049 0.003
Echinococcus granulosus proteasome prosome macropain 0.0089 0.0689 0.0672
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0049 0.0049
Echinococcus multilocularis Mastin 0.004 0.0169 0.015
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0043 0.0194 0.0797
Schistosoma mansoni adenoreceptor 0.0029 0.0049 0.0049
Brugia malayi hypothetical protein 0.0029 0.0049 0.0082
Brugia malayi Importin beta-1 subunit 0.0028 0.0035 0.0051
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0089 0.0689 1
Echinococcus granulosus allatostatin A receptor 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.003 0.0054 0.0041
Schistosoma mansoni amine GPCR 0.0029 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0155 0.141 0.1399
Loa Loa (eye worm) hypothetical protein 0.0191 0.1797 0.1787
Brugia malayi Glutamate receptor 2 precursor 0.0043 0.0201 0.0424
Echinococcus granulosus serotonin receptor 0.0029 0.0049 0.003
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0049 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0049 0.0049
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.2941 0.2932
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0069 0.0476 0.0476
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0043 0.0194 0.2433
Schistosoma mansoni hypothetical protein 0.0078 0.058 0.058
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.0019 0.0007
Brugia malayi G protein-coupled receptor F59B2.13 0.0029 0.0049 0.0082
Giardia lamblia Proteasome subunit beta type 1 0.0069 0.0476 0.6649
Schistosoma mansoni hypothetical protein 0.0169 0.156 0.156
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus granulosus 7TM GPCR rhodopsin 0.0029 0.0049 0.003
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0169 0.0169
Echinococcus granulosus glycoprotein Antigen 5 0.004 0.0169 0.015
Echinococcus granulosus glutamate receptor subunit protein glur 0.0043 0.0201 0.0182
Loa Loa (eye worm) hypothetical protein 0.023 0.2217 0.2207
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0075 0.0056
Loa Loa (eye worm) hypothetical protein 0.004 0.0169 0.0157
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0007
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0862 0.8342
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Brugia malayi Pre-SET motif family protein 0.0032 0.0075 0.014
Echinococcus granulosus tachykinin peptides receptor 99D 0.0029 0.0049 0.003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.078 0.0762
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0155 0.0155
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0069 0.0476 0.1315
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0029 0.0049 0.0049
Brugia malayi ORL1-like opioid receptor 0.0029 0.0049 0.0082
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0169 0.0169
Chlamydia trachomatis glutamine binding protein 0.0111 0.0929 1
Echinococcus multilocularis geminin 0.0164 0.15 0.1484
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0155 0.0143
Echinococcus multilocularis GPCR, family 2 0.0078 0.058 0.0562
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0049 0.0049
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.004 0.0169 0.0157
Onchocerca volvulus 0.0029 0.0049 0.0127
Brugia malayi hypothetical protein 0.004 0.0169 0.0353
Brugia malayi PAN domain containing protein 0.0048 0.0247 0.0528
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0019 0.0015
Echinococcus granulosus G protein coupled receptor 139 0.0029 0.0049 0.003
Toxoplasma gondii microneme protein, putative 0.0048 0.0247 0.1037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0075 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0049 0.003
Echinococcus granulosus somatostatin receptor 0.0029 0.0049 0.003
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0229 0.0217
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0049 0.003
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0075 0.0056
Loa Loa (eye worm) hypothetical protein 0.007 0.0489 0.0477
Plasmodium vivax proteasome subunit beta type-5, putative 0.0089 0.0689 0.305
Giardia lamblia Proteasome subunit beta type 2 0.0043 0.0194 0.221
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.028 0.0424
Trypanosoma cruzi aminopeptidase, putative 0.0051 0.028 0.0424
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0049 0.0049
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.078 0.0762
Toxoplasma gondii subtilisin SUB12 0.0048 0.0247 0.1037
Brugia malayi hypothetical protein 0.0029 0.0049 0.0082
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.028 0.0261
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0051 0.028 0.0424
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0049 0.003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0049 0.0049
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0054 0.0035
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0029 0.0049 0.0036
Echinococcus multilocularis peregrin 0.003 0.0054 0.0035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0169 0.0169
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0155 0.141 0.141
Onchocerca volvulus 0.0029 0.0049 0.0127
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0054 0.0158
Brugia malayi Trypsin family protein 0.004 0.0169 0.0353
Brugia malayi hypothetical protein 0.0029 0.0049 0.0082
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus granulosus serotonin transporter 0.0155 0.141 0.1394
Brugia malayi Trypsin family protein 0.004 0.0169 0.0353
Onchocerca volvulus 0.0029 0.0049 0.0127
Plasmodium falciparum proteasome subunit beta type-5 0.0089 0.0689 0.305
Schistosoma mansoni histamine h1 receptor 0.0029 0.0049 0.0049
Brugia malayi PAN domain containing protein 0.0048 0.0247 0.0528
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0049 0.003
Loa Loa (eye worm) solute carrier family 6 member 4 0.0155 0.141 0.1399
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0059 0.0369 0.035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus granulosus geminin 0.0164 0.15 0.1484
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0169 0.0169
Echinococcus multilocularis G-protein coupled receptor, putative 0.0029 0.0049 0.003
Schistosoma mansoni neuropeptide receptor 0.0029 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0069 0.0476 0.0458
Plasmodium vivax proteasome subunit beta type-1, putative 0.0069 0.0476 0.2081
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0247 0.1037
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0051 0.028 0.0424
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0049 0.003
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0247 0.0235
Loa Loa (eye worm) trypsin family protein 0.004 0.0169 0.0157
Schistosoma mansoni hypothetical protein 0.0029 0.0049 0.0049
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0089 0.0689 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0019 0.0019
Echinococcus granulosus sex peptide receptor 0.0029 0.0049 0.003
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0089 0.0689 0.6067
Brugia malayi Dopamine receptor 0.0029 0.0049 0.0082
Schistosoma mansoni transient receptor potential channel 0.0126 0.1099 0.1099
Onchocerca volvulus 0.0029 0.0049 0.0127
Schistosoma mansoni opsin-like receptor 0.0029 0.0049 0.0049
Schistosoma mansoni neuropeptide receptor 0.0029 0.0049 0.0049
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0029 0.0049 0.0036
Brugia malayi hypothetical protein 0.0029 0.0049 0.0082
Onchocerca volvulus 0.007 0.0489 0.2022
Onchocerca volvulus 0.0155 0.141 0.5992
Echinococcus granulosus transmembrane protease serine 3 0.004 0.0169 0.015
Loa Loa (eye worm) DOMON domain-containing protein 0.007 0.0489 0.0477
Brugia malayi Trypsin family protein 0.004 0.0169 0.0353
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0049 0.003
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0988 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0029 0.0049 0.0082
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0035 0.0073
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.028 0.0261
Onchocerca volvulus 0.0029 0.0049 0.0127
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0051 0.028 0.0424
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Onchocerca volvulus 0.0048 0.0247 0.0982
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0862 0.8342
Trypanosoma brucei Aminopeptidase M1, putative 0.0051 0.028 0.3745
Brugia malayi Melatonin receptor type 1A 0.0029 0.0049 0.0082
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0155 0.141 0.3146
Loa Loa (eye worm) norepinephrine transporter 0.0155 0.141 0.1399
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0155 0.0155
Entamoeba histolytica aminopeptidase, putative 0.0051 0.028 0.1733
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0862 0.8342
Onchocerca volvulus 0.007 0.0489 0.2022
Toxoplasma gondii microneme protein MIC4 0.0048 0.0247 0.1037
Brugia malayi RE15519p 0.0029 0.0049 0.0082
Leishmania major hypothetical protein, conserved 0.023 0.2217 1
Brugia malayi jmjC domain containing protein 0.0039 0.0155 0.0321
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0059 0.0369 0.035
Loa Loa (eye worm) hypothetical protein 0.0051 0.0282 0.027
Loa Loa (eye worm) peptidase family M1 containing protein 0.0051 0.028 0.0268
Echinococcus granulosus nmda type glutamate receptor 0.0154 0.1395 0.1379
Schistosoma mansoni transient receptor potential channel 0.0191 0.1797 0.1797
Schistosoma mansoni cpg binding protein 0.0056 0.0334 0.0334
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0247 0.1037
Plasmodium vivax cysteine repeat modular protein 1, putative 0.023 0.2217 1
Onchocerca volvulus 0.0048 0.0247 0.0982
Schistosoma mansoni cpg binding protein 0.0059 0.0368 0.0368
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0019 0.0019
Echinococcus granulosus transient receptor potential gamma protein 0.0191 0.1797 0.1781
Onchocerca volvulus 0.0051 0.028 0.1124
Trypanosoma brucei aminopeptidase, putative 0.0051 0.028 0.3745
Loa Loa (eye worm) hypothetical protein 0.0155 0.141 0.1399
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.0155 0.141 0.1399
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Mycobacterium ulcerans proteasome PrcB 0.0089 0.0689 0.6843
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0007
Loa Loa (eye worm) hypothetical protein 0.0051 0.028 0.0268
Plasmodium falciparum cysteine repeat modular protein 1 0.023 0.2217 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Trypanosoma cruzi Aminopeptidase M1, putative 0.0051 0.028 0.0424
Schistosoma mansoni hypothetical protein 0.0078 0.058 0.058
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0051 0.028 0.1187
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0029 0.0049 0.0036
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.028 0.0261
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0049 0.003
Brugia malayi Kringle domain containing protein 0.023 0.2217 0.4963
Loa Loa (eye worm) hypothetical protein 0.0048 0.0247 0.0235
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0075 0.0075
Mycobacterium tuberculosis Probable reductase 0.0105 0.0862 0.8342
Echinococcus multilocularis serotonin receptor 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.004 0.0169 0.0157
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.004 0.0169 0.0353
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.004 0.0169 0.015
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0029 0.0049 0.0036
Onchocerca volvulus 0.0029 0.0049 0.0127
Schistosoma mansoni amine GPCR 0.0029 0.0049 0.0049
Echinococcus multilocularis glutamate receptor 2 0.0059 0.0369 0.035
Brugia malayi PAN domain containing protein 0.0048 0.0247 0.0528
Loa Loa (eye worm) hypothetical protein 0.0048 0.0247 0.0235
Schistosoma mansoni hypothetical protein 0.0164 0.15 0.15
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.058 0.0562
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0049 0.003
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0051 0.028 0.1187
Brugia malayi PAN domain containing protein 0.0048 0.0247 0.0528
Onchocerca volvulus 0.004 0.0169 0.0647
Echinococcus granulosus g protein coupled receptor 0.0029 0.0049 0.003
Schistosoma mansoni glutamate receptor kainate 0.0043 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus multilocularis cpg binding protein 0.0059 0.0368 0.035
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0049 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0049 0.003
Toxoplasma gondii thioredoxin reductase 0.0046 0.0229 0.0955
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.004 0.0169 0.0157
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0019 0.0015
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0069 0.0476 0.0458
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0043 0.0194 0.0194
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0988 1
Brugia malayi hypothetical protein 0.0029 0.0049 0.0082
Brugia malayi sulfakinin receptor protein 0.0029 0.0049 0.0082
Schistosoma mansoni hypothetical protein 0.0043 0.0201 0.0201
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0862 0.8342
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0049 0.003
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0051 0.028 0.1187
Brugia malayi RNA, U transporter 1 0.0079 0.0589 0.1298
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0111 0.0929 1
Brugia malayi Proteasome A-type and B-type family protein 0.0089 0.0689 0.1524
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Brugia malayi Transient-receptor-potential like protein 0.0071 0.0502 0.1101
Echinococcus granulosus 7tm_1 domain containing protein 0.0029 0.0049 0.003
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0029 0.0049 0.0049
Brugia malayi G-protein coupled receptor 0.0029 0.0049 0.0082
Brugia malayi Tachykinin-like peptides receptor 99D 0.0029 0.0049 0.0082
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0049 0.003
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0862 0.8342
Echinococcus granulosus GPCR family 2 0.0078 0.058 0.0562
Brugia malayi Glutamate receptor 1 precursor 0.0043 0.0201 0.0424
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0043 0.0201 0.0182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0049 0.003
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0952 1 1
Brugia malayi Trypsin family protein 0.004 0.0169 0.0353
Echinococcus multilocularis transmembrane protease serine 3 0.004 0.0169 0.015
Echinococcus multilocularis allatostatin A receptor 0.0029 0.0049 0.003
Echinococcus multilocularis NMDA receptor 0.0043 0.0201 0.0182
Echinococcus granulosus peptide allatostatin:somatostatin 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0007
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0054 0.0158
Brugia malayi Muscle positioning protein 4 0.007 0.0489 0.1072
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0029 0.0049 0.0127
Echinococcus multilocularis glycoprotein Antigen 5 0.004 0.0169 0.015
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0988 1
Echinococcus granulosus hypothetical protein 0.0029 0.0049 0.003
Trichomonas vaginalis set domain proteins, putative 0.0242 0.2341 1
Echinococcus granulosus fmrfamide receptor 0.0029 0.0049 0.003
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.004 0.0169 0.015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0049 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0075 0.0075
Brugia malayi Trypsin-like protease protein 5 0.004 0.0169 0.0353
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.1018 0.1018
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Onchocerca volvulus 0.004 0.0169 0.0647
Onchocerca volvulus 0.0048 0.0247 0.0982
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0051 0.028 0.0261
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0988 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0029 0.0049 0.0049
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0049 0.003
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0043 0.0201 0.0182
Plasmodium vivax SET domain protein, putative 0.0032 0.0075 0.0252
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0059 0.0369 0.035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus multilocularis serotonin transporter 0.0155 0.141 0.1394
Brugia malayi G-protein coupled receptor 0.0029 0.0049 0.0082
Echinococcus granulosus importin subunit beta 1 0.0028 0.0035 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0049 0.003
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0043 0.0201 0.0182
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.004 0.0169 0.015
Brugia malayi Serotonin receptor 0.0029 0.0049 0.0082
Echinococcus multilocularis short transient receptor potential channel 6 0.0126 0.1099 0.1082
Echinococcus multilocularis glutamate receptor 2 0.0043 0.0201 0.0182
Schistosoma mansoni hypothetical protein 0.0078 0.058 0.058
Brugia malayi PAN domain containing protein 0.0048 0.0247 0.0528
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.028 0.0424
Echinococcus granulosus short transient receptor potential channel 6 0.0126 0.1099 0.1082
Onchocerca volvulus 0.0048 0.0247 0.0982
Schistosoma mansoni opsin-like receptor 0.0029 0.0049 0.0049
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0029 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Trypanosoma brucei trypanothione reductase 0.0046 0.0229 0.2962
Toxoplasma gondii microneme protein MIC17C 0.0048 0.0247 0.1037
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.023 0.2217 1
Echinococcus granulosus neuropeptide s receptor 0.0029 0.0049 0.003
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0049 0.003
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0051 0.028 0.1187
Brugia malayi hypothetical protein 0.0029 0.0049 0.0082
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Schistosoma mansoni biogenic amine receptor 0.0029 0.0049 0.0049
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0049 0.003
Onchocerca volvulus 0.007 0.0489 0.2022
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0049 0.003
Toxoplasma gondii hypothetical protein 0.0048 0.0247 0.1037
Brugia malayi Pre-SET motif family protein 0.0212 0.2026 0.4533
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0049 0.003
Toxoplasma gondii proteasome subunit beta type, putative 0.0089 0.0689 0.305
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0049 0.003
Echinococcus multilocularis sex peptide receptor 0.0029 0.0049 0.003
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.028 0.0261
Brugia malayi PAN domain containing protein 0.0048 0.0247 0.0528
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0049 0.003
Echinococcus granulosus dro:myosuppressin receptor 0.0029 0.0049 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus multilocularis somatostatin receptor 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.0169 0.156 0.155
Schistosoma mansoni neuropeptide f receptor 76f 0.0029 0.0049 0.0049
Toxoplasma gondii aminopeptidase n, putative 0.0051 0.028 0.1187
Brugia malayi proteasome subunit beta type 2 0.0043 0.0194 0.0409
Brugia malayi GnHR receptor homolog 0.0029 0.0049 0.0082
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0043 0.0201 0.0182
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0054 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0075 0.0075
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0043 0.0201 0.0182
Loa Loa (eye worm) hypothetical protein 0.007 0.0489 0.0477
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0049 0.003
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0169 0.0169
Echinococcus granulosus glutamate receptor 2 0.0059 0.0369 0.035
Echinococcus multilocularis snurportin 1 0.0297 0.2941 0.2928
Loa Loa (eye worm) hypothetical protein 0.0048 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0007
Onchocerca volvulus 0.007 0.0489 0.2022
Echinococcus multilocularis transient receptor potential ion channel A 0.0185 0.1728 0.1712
Schistosoma mansoni hypothetical protein 0.0029 0.0049 0.0049
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.058 0.0562
Echinococcus granulosus Mastin 0.004 0.0169 0.015
Schistosoma mansoni amine GPCR 0.0029 0.0049 0.0049
Brugia malayi neuropeptide F receptor 0.0029 0.0049 0.0082
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0059 0.0369 0.035
Echinococcus multilocularis nmda type glutamate receptor 0.0154 0.1395 0.1379
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0007
Onchocerca volvulus Neuropeptide F receptor homolog 0.0029 0.0049 0.0127
Echinococcus multilocularis aminopeptidase N 0.0051 0.028 0.0261
Loa Loa (eye worm) glutathione reductase 0.0046 0.0229 0.0217
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0862 0.5785
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0029 0.0049 0.0082
Echinococcus granulosus glutamate NMDA receptor subunit 0.0043 0.0201 0.0182
Toxoplasma gondii aminopeptidase N protein 0.0051 0.028 0.1187
Loa Loa (eye worm) TK/ROR protein kinase 0.023 0.2217 0.2207
Plasmodium vivax hypothetical protein, conserved 0.003 0.0054 0.0158
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0026 0.0019 0.0015
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0565 0.0565
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.028 0.0424
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.005 0.003
Mycobacterium ulcerans aminopeptidase N PepN 0.0051 0.028 0.1458
Brugia malayi hypothetical protein 0.0051 0.028 0.0603
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.004 0.0169 0.015
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0169 0.0169
Plasmodium vivax glutathione reductase, putative 0.0046 0.0229 0.0955
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0049 0.0049
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.028 0.0261
Onchocerca volvulus 0.004 0.0169 0.0647
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.0248 0.2405 0.2396
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.2026 0.2016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0169 0.0169
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.058 0.0562
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0051 0.028 0.028
Plasmodium vivax proteasome subunit beta type-2, putative 0.0043 0.0194 0.0797
Onchocerca volvulus 0.004 0.0169 0.0647
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0247 0.1037
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus granulosus g-protein coupled receptor 0.0029 0.0049 0.003
Brugia malayi Protein kinase domain containing protein 0.023 0.2217 0.4963
Onchocerca volvulus 0.0048 0.0247 0.0982
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0019 0.0019
Echinococcus multilocularis neuropeptide receptor A26 0.0029 0.0049 0.003
Schistosoma mansoni alpha-1 adrenergic receptor 0.0029 0.0049 0.0049
Echinococcus granulosus cpg binding protein 0.0059 0.0368 0.035
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0049 0.003
Brugia malayi G protein-coupled receptor 0.0029 0.0049 0.0082
Schistosoma mansoni hypothetical protein 0.0078 0.058 0.058
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0169 0.0169
Echinococcus granulosus peregrin 0.003 0.0054 0.0035
Trypanosoma cruzi aminopeptidase, putative 0.0051 0.028 0.0424
Brugia malayi hypothetical protein 0.0029 0.0049 0.0082
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0049 0.0036
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0029 0.0049 0.003
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0089 0.0689 0.2448
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0049 0.0049
Schistosoma mansoni cpg binding protein 0.0059 0.0368 0.0368
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0029 0.0049 0.0082
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0043 0.0194 0.0194
Brugia malayi larval opioid receptor 0.0029 0.0049 0.0082
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0043 0.0194 0.0797
Echinococcus granulosus TRP transient receptor potential channel 0.0071 0.0502 0.0483
Schistosoma mansoni growth hormone secretagogue receptor 0.0029 0.0049 0.0049
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0035 0.0016
Brugia malayi Dopamine receptor protein 1 0.0029 0.0049 0.0082
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0247 0.1037
Loa Loa (eye worm) hypothetical protein 0.0051 0.028 0.0268
Toxoplasma gondii PAN/Apple domain-containing protein 0.0048 0.0247 0.1037
Onchocerca volvulus 0.0029 0.0049 0.0127
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0075 0.0252
Loa Loa (eye worm) serotonin transporter b 0.0155 0.141 0.1399
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.028 0.0261
Onchocerca volvulus 0.007 0.0489 0.2022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0049 0.0049
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0179 0.016
Loa Loa (eye worm) glutamate receptor 2 0.0043 0.0201 0.0189
Schistosoma mansoni amine GPCR 0.0029 0.0049 0.0049
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0111 0.0929 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0059 0.0369 0.035
Loa Loa (eye worm) hypothetical protein 0.0071 0.0502 0.049
Echinococcus multilocularis proteasome (prosome, macropain) 0.0089 0.0689 0.0672
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0049 0.003
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.0019 0.0007
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0034 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0049 0.0049
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0049 0.003
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0247 0.1037
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0071 0.0502 0.0483
Brugia malayi hypothetical protein 0.0438 0.4454 1
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0049 0.003
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0054 0.0035
Brugia malayi SEA domain containing protein 0.007 0.0489 0.1072
Brugia malayi Serotonin receptor 0.0029 0.0049 0.0082
Brugia malayi PAN domain containing protein 0.0048 0.0247 0.0528
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0029 0.0049 0.0049
Schistosoma mansoni glutamate receptor AMPA 0.0043 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.058 0.0562
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0051 0.028 0.028
Schistosoma mansoni glutamate receptor NMDA 0.0059 0.0369 0.0369
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0019 0.0019
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0029 0.0049 0.003
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0043 0.0201 0.0182
Onchocerca volvulus 0.0029 0.0049 0.0127
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0062
Toxoplasma gondii microneme protein MIC17A 0.0048 0.0247 0.1037
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0049 0.003
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0169 0.0169
Onchocerca volvulus 0.0029 0.0049 0.0127
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0247 0.0235
Onchocerca volvulus 0.0048 0.0247 0.0982
Schistosoma mansoni biogenic amine receptor 0.0029 0.0049 0.0049
Plasmodium falciparum glutathione reductase 0.0046 0.0229 0.0955
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Leishmania major proteasome beta 5 subunit, putative 0.0089 0.0689 0.2448
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0952 1 1
Schistosoma mansoni transient receptor potential channel 0.0126 0.1099 0.1099
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0029 0.0049 0.0049
Onchocerca volvulus 0.0056 0.0334 0.1357
Onchocerca volvulus 0.0048 0.0247 0.0982
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0029 0.0049 0.003
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0069 0.0476 0.2081
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0247 0.0235
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0334 0.0322
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus multilocularis transient receptor potential gamma protein 0.0191 0.1797 0.1781
Schistosoma mansoni hypothetical protein 0.003 0.0054 0.0054
Onchocerca volvulus Alhambra homolog 0.003 0.0054 0.015
Toxoplasma gondii hypothetical protein 0.0048 0.0247 0.1037
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0089 0.0689 0.2307
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0019 0.0019
Onchocerca volvulus 0.004 0.0169 0.0647
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0169 0.0169
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0049 0.003
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0059 0.0369 0.035
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0952 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Onchocerca volvulus 0.0029 0.0049 0.0127
Echinococcus granulosus tissue type plasminogen activator 0.023 0.2217 0.2202
Schistosoma mansoni opsin-like receptor 0.0029 0.0049 0.0049
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.028 0.0261
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0049 0.0049
Echinococcus multilocularis dro:myosuppressin receptor 0.0029 0.0049 0.003
Schistosoma mansoni hypothetical protein 0.004 0.0169 0.0169
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0169 0.0169
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0049 0.003
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0029 0.0049 0.003
Echinococcus multilocularis G protein coupled receptor 139 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.004 0.0169 0.0157
Schistosoma mansoni glutamate receptor NMDA 0.0043 0.0201 0.0201
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0029 0.0049 0.0049
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0229 0.021
Onchocerca volvulus 0.0048 0.0247 0.0982
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0075 0.0056
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0169 0.0169
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0049 0.003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0248 0.2405 0.5387
Brugia malayi jmjC domain containing protein 0.0097 0.078 0.1728
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0019 0.0019
Brugia malayi PAN domain containing protein 0.0048 0.0247 0.0528
Schistosoma mansoni hypothetical protein 0.023 0.2217 0.2217
Echinococcus granulosus neuropeptide receptor A26 0.0029 0.0049 0.003
Loa Loa (eye worm) melatonin receptor type 1A 0.0029 0.0049 0.0036
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.028 0.0261
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0394 0.0382
Echinococcus multilocularis serotonin receptor 0.0029 0.0049 0.003
Schistosoma mansoni hypothetical protein 0.0029 0.0049 0.0049
Loa Loa (eye worm) proteasome subunit beta type 2 0.0043 0.0194 0.0182
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Echinococcus granulosus enteropeptidase 0.004 0.0169 0.015
Toxoplasma gondii aminopeptidase N, putative 0.0051 0.028 0.1187
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0229 0.0955
Brugia malayi hypothetical protein 0.0029 0.0049 0.0082
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0053 0.031 0.031
Echinococcus granulosus neuropeptide receptor 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0035 0.0023
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0043 0.0194 0.0176
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.028 0.04
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0059 0.0369 0.035
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0049 0.0036
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.058 0.1277
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0029 0.0049 0.0082
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0029 0.0049 0.003
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.028 0.0424
Schistosoma mansoni neuropeptide receptor 0.0029 0.0049 0.0049
Schistosoma mansoni sodium/chloride dependent transporter 0.0155 0.141 0.141
Onchocerca volvulus 0.0242 0.2341 1
Schistosoma mansoni hypothetical protein 0.0164 0.15 0.15
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0049 0.0036
Echinococcus granulosus orexin receptor type 2 0.0029 0.0049 0.003
Brugia malayi TATA binding protein associated factor 0.0051 0.028 0.0603
Brugia malayi PAN domain containing protein 0.0048 0.0247 0.0528
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0029 0.0049 0.0082
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.0019 0.0019
Loa Loa (eye worm) TYRA-2 protein 0.0029 0.0049 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.0247 0.0235
Echinococcus multilocularis short transient receptor potential channel 6 0.0126 0.1099 0.1082
Onchocerca volvulus 0.0048 0.0247 0.0982
Loa Loa (eye worm) TATA binding protein associated factor 0.0051 0.028 0.0268
Brugia malayi Peptidase family M1 containing protein 0.0051 0.028 0.0603
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0019 0.0019
Brugia malayi putative neuropeptide receptor NPR1 0.0029 0.0049 0.0082
Echinococcus granulosus g protein coupled receptor 0.0029 0.0049 0.003
Plasmodium vivax importin-beta 2, putative 0.0028 0.0035 0.0073
Brugia malayi PAN domain containing protein 0.0048 0.0247 0.0528
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Brugia malayi follicle stimulating hormone receptor 0.0029 0.0049 0.0082
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0247 0.1037
Loa Loa (eye worm) proteasome subunit beta type 1 0.0069 0.0476 0.0465
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Loa Loa (eye worm) hypothetical protein 0.004 0.0169 0.0157
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0121 0.0102
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0169 0.0169
Schistosoma mansoni biogenic amine receptor 0.0029 0.0049 0.0049
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0029 0.0049 0.003
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0029 0.0049 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0049 0.003
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0091 0.0715 0.0715
Brugia malayi AKH receptor 0.0029 0.0049 0.0082
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.028 0.0261
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0247 0.0235
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0169 0.0169
Plasmodium falciparum phd finger protein, putative 0.003 0.0054 0.0158
Loa Loa (eye worm) aminopeptidase N 0.0051 0.028 0.0268
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0029 0.0049 0.003
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0051 0.028 0.3745
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0169 0.0169
Brugia malayi Peptidase family M1 containing protein 0.0051 0.028 0.0603
Trypanosoma brucei Aminopeptidase M1, putative 0.0051 0.028 0.3745
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0111 0.0929 0.9229
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0049 0.003
Brugia malayi Peptidase family M1 containing protein 0.0051 0.028 0.0603
Schistosoma mansoni hypothetical protein 0.007 0.0489 0.0489
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.004 0.0169 0.0169
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0229 0.021
Echinococcus multilocularis orexin receptor type 2 0.0029 0.0049 0.003
Echinococcus granulosus dnaJ subfamily B 0.0792 0.827 0.8267
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.028 0.04
Schistosoma mansoni ATP-binding cassette transporter 0.0043 0.0201 0.0201
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0043 0.0201 0.0182
Schistosoma mansoni transient receptor potential channel 4 0.0191 0.1797 0.1797
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0447 0.0447
Brugia malayi glutathione reductase 0.0046 0.0229 0.0487
Brugia malayi Bromodomain containing protein 0.003 0.0054 0.0093
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.028 0.0261
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0248 0.2405 0.5387
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0051 0.028 0.0424
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0049 0.0049
Echinococcus granulosus snurportin 1 0.0297 0.2941 0.2928
Plasmodium falciparum thioredoxin reductase 0.0046 0.0229 0.0955
Plasmodium falciparum importin beta, putative 0.0028 0.0035 0.0073
Echinococcus granulosus aminopeptidase N 0.0051 0.028 0.0261
Brugia malayi hypothetical protein 0.0051 0.028 0.0603
Echinococcus granulosus g protein coupled receptor 0.0029 0.0049 0.003
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0089 0.0689 0.2448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0049 0.0049
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0069 0.0476 0.1395
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0029 0.0049 0.0049
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0051 0.028 0.0424
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0049 0.003
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0089 0.0689 0.0689
Schistosoma mansoni sodium-dependent amino acid transporter 0.0026 0.0019 0.0019
Echinococcus multilocularis neuropeptide FF receptor 2 0.0029 0.0049 0.003
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0029 0.0049 0.0049
Onchocerca volvulus 0.023 0.2217 0.9468
Schistosoma mansoni amine GPCR 0.0029 0.0049 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0248 0.2405 0.2396
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0089 0.0689 1
Onchocerca volvulus 0.0048 0.0247 0.0982
Loa Loa (eye worm) hypothetical protein 0.0048 0.0247 0.0235
Onchocerca volvulus 0.0029 0.0049 0.0127
Schistosoma mansoni glutamate receptor AMPA 0.0043 0.0201 0.0201
Echinococcus multilocularis dnaJ subfamily B 0.0792 0.827 0.8267
Schistosoma mansoni glutamate receptor kainate 0.0043 0.0201 0.0201
Schistosoma mansoni glutamate receptor kainate 0.0043 0.0201 0.0201
Mycobacterium ulcerans aminopeptidase N PepN 0.0051 0.028 0.1458
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0029 0.0049 0.003
Onchocerca volvulus 0.0029 0.0049 0.0127
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0029 0.0049 0.003
Brugia malayi Thioredoxin reductase 0.0046 0.0229 0.0487
Schistosoma mansoni hypothetical protein 0.0792 0.827 0.827
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0059 0.0369 0.035
Onchocerca volvulus 0.0048 0.0247 0.0982
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.012 0.103 0.1019
Echinococcus granulosus neuropeptide receptor 0.0029 0.0049 0.003
Echinococcus granulosus neuropeptide FF receptor 2 0.0029 0.0049 0.003
Trypanosoma brucei proteasome beta 6 subunit 0.0069 0.0476 0.6745
Onchocerca volvulus 0.0032 0.0075 0.0239
Leishmania major trypanothione reductase 0.0046 0.0229 0.0171
Brugia malayi hypothetical protein 0.0026 0.0019 0.0015
Toxoplasma gondii microneme protein MIC17B 0.0048 0.0247 0.1037
Onchocerca volvulus 0.0029 0.0049 0.0127
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0069 0.0476 0.5699
Brugia malayi Latrophilin receptor protein 2 0.0078 0.058 0.1277
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0179 0.016
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0054 0.0041
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0169 0.0169
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0089 0.0689 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0049 0.0049
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0029 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.0051 0.028 0.0268
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0036
Brugia malayi Dopamine receptor protein 2 0.0029 0.0049 0.0082
Echinococcus multilocularis enteropeptidase 0.004 0.0169 0.015
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0049 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0049 0.003
Onchocerca volvulus 0.0029 0.0049 0.0127
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0155 0.0136
Brugia malayi CXXC zinc finger family protein 0.0056 0.0334 0.0724
Loa Loa (eye worm) glutamate receptor 1 0.0043 0.0201 0.0189
Echinococcus multilocularis g-protein coupled receptor 0.0029 0.0049 0.003
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0019 0.0015
Brugia malayi putative neuropeptide receptor 0.0029 0.0049 0.0082
Onchocerca volvulus 0.0029 0.0049 0.0127
Onchocerca volvulus 0.0029 0.0049 0.0127
Echinococcus multilocularis tissue type plasminogen activator 0.023 0.2217 0.2202
Schistosoma mansoni importin beta-1 0.0028 0.0035 0.0035
Onchocerca volvulus 0.0051 0.028 0.1124
Schistosoma mansoni aminopeptidase A (M01 family) 0.0051 0.028 0.028

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.2 nM Inhibition of human recombinant caspase 8 assessed as accumulation of fluorogenic product by fluorometric assay ChEMBL. 19326941
IC50 (binding) = 4.2 nM Inhibition of caspase 8 by fluorometric assay ChEMBL. 21441025

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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