Detailed information for compound 981168

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 565.533 | Formula: C31H34Cl2N4O2
  • H donors: 1 H acceptors: 2 LogP: 6.97 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(c(c1)Cn1nc(cc1C)C(=O)Nc1ccc(cc1)CN1CCCCC1)OCc1ccccc1.Cl
  • InChi: 1S/C31H33ClN4O2.ClH/c1-23-18-29(31(37)33-28-13-10-24(11-14-28)20-35-16-6-3-7-17-35)34-36(23)21-26-19-27(32)12-15-30(26)38-22-25-8-4-2-5-9-25;/h2,4-5,8-15,18-19H,3,6-7,16-17,20-22H2,1H3,(H,33,37);1H
  • InChiKey: QSEJNNBUVALTRZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin E receptor 1 (subtype EP1), 42kDa Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0739 0.5236
Toxoplasma gondii ABC1 family protein 0.007 0.0623 0.0634
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0341 0.0335
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0018 0.0014 0.0008
Brugia malayi beta-lactamase 0.007 0.0623 0.1112
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0739 0.5236
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.004 0.0265 0.026
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.002 0.0042
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0092 0.0563
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0839 0.9617 0.9617
Leishmania major aldehyde dehydrogenase, putative 0.0046 0.0341 0.0339
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0341 0.0339
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0022 0.0057 0.0604
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0046 0.0341 0.0339
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0206 0.2216 0.2216
Brugia malayi Bromodomain containing protein 0.0258 0.2825 0.5117
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.002 0.0005
Brugia malayi hypothetical protein 0.0084 0.0784 0.1405
Brugia malayi ImpB/MucB/SamB family protein 0.0122 0.1232 0.222
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0025 0.0091 0.0079
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0341 0.0335
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0163 0.1713 0.1768
Brugia malayi beta-lactamase family protein 0.007 0.0623 0.1112
Echinococcus multilocularis PHD finger protein rhinoceros 0.0025 0.0088 0.0088
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0623 0.0633
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0046 0.0341 0.2362
Trichomonas vaginalis glucosylceramidase, putative 0.0142 0.1463 0.285
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0136 0.1398 0.144
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0022 0.0057 0.0312
Echinococcus granulosus transcription factor Dp 1 0.0079 0.0725 0.0725
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0021 0.0044 0.04
Toxoplasma gondii histone lysine methyltransferase SET1 0.0126 0.1273 0.1311
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0022 0.0057 0.0045
Schistosoma mansoni lamin 0.0139 0.143 0.1425
Brugia malayi jmjC domain containing protein 0.008 0.0741 0.1327
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0163 0.1713 0.8883
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0051 0.0399 0.0393
Entamoeba histolytica acyl-CoA synthetase, putative 0.0018 0.0015 0.001
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0644 0.7343 0.7343
Brugia malayi Aldehyde dehydrogenase protein 4 0.0046 0.0341 0.0599
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0007
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0022 0.0057 0.0312
Brugia malayi latrophilin 2 splice variant baaae 0.0209 0.2248 0.4069
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0046 0.0341 0.0339
Loa Loa (eye worm) hypothetical protein 0.0273 0.2996 0.5428
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0027 0.0121 0.0771
Onchocerca volvulus Glucosylceramidase homolog 0.0142 0.1463 0.2712
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.008 0.0739 0.1426
Echinococcus multilocularis dnaJ subfamily B 0.0871 1 1
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0046 0.0341 0.034
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0046 0.0341 0.0335
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0025 0.0091 0.0079
Trypanosoma brucei PAB1-binding protein , putative 0.0039 0.0258 0.1763
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0046 0.0341 0.0599
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0025 0.0091 0.0558
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0022 0.0057 0.0051
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0046 0.0341 0.0339
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0046 0.0341 0.2362
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0067 0.0587 0.0587
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0182 0.1926 0.199
Mycobacterium ulcerans DNA polymerase IV 0.008 0.0739 0.0753
Loa Loa (eye worm) hypothetical protein 0.013 0.1327 0.2393
Echinococcus granulosus survival motor neuron protein 1 0.0488 0.5509 0.5509
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0025 0.0091 0.0079
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0022 0.0057 0.0057
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0548 0.0542
Echinococcus multilocularis thioredoxin glutathione reductase 0.0072 0.0644 0.0644
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0046 0.0341 0.2362
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.001 0.001
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0046 0.0341 0.2362
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0025 0.0091 0.0558
Plasmodium vivax SET domain protein, putative 0.0051 0.0399 0.6121
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0025 0.0091 0.0558
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0046 0.0341 0.0339
Loa Loa (eye worm) hypothetical protein 0.0025 0.0092 0.0146
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0088 0.0139
Schistosoma mansoni bromodomain containing protein 0.0018 0.0012 0.0006
Brugia malayi ImpB/MucB/SamB family protein 0.008 0.0739 0.1323
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0022 0.0057 0.0312
Treponema pallidum NADH oxidase 0.0025 0.0091 0.1462
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0216 0.2334 0.4224
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0046 0.0341 0.0339
Schistosoma mansoni hypothetical protein 0.007 0.0621 0.0616
Leishmania major hypothetical protein, conserved 0.0039 0.0258 0.0253
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0739 0.5236
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0965 0.1735
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0136 0.1398 0.1398
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0025 0.0091 0.0085
Leishmania major DNA polymerase eta, putative 0.0067 0.0585 0.0594
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0046 0.0341 0.0341
Echinococcus multilocularis jumonji domain containing protein 0.0034 0.02 0.02
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0092 0.0563
Trypanosoma brucei ISWI complex protein 0.0052 0.0409 0.2856
Trichomonas vaginalis glucosylceramidase, putative 0.0142 0.1463 0.285
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0182 0.1926 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0025 0.0091 0.0558
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0051 0.0399 0.0401
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0046 0.0341 0.0341
Onchocerca volvulus Alhambra homolog 0.0025 0.0088 0.0136
Onchocerca volvulus 0.0396 0.4438 0.8286
Schistosoma mansoni cpg binding protein 0.0061 0.0517 0.0511
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0447 0.3133
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0046 0.0341 0.0339
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0091 0.0558
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0136 0.1398 0.2522
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0091 0.0558
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0028 0.0128 0.0213
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0044 0.0044
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.006 0.0508 0.0515
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0022 0.0057 0.0044
Trypanosoma cruzi trypanothione reductase, putative 0.0072 0.0639 0.4516
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.008 0.0741 0.0741
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0348 0.3877 0.703
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0046 0.0341 0.0339
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0022 0.0057 0.0085
Leishmania major DNA damage repair protein, putative 0.0025 0.0092 0.008
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0092 0.0563
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0623 0.0633
Mycobacterium ulcerans hypothetical protein 0.007 0.0623 0.0633
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.002 0.0032 0.0133
Trichomonas vaginalis glucosylceramidase, putative 0.0142 0.1463 0.285
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0623 0.1198
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0046 0.0341 0.2362
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.002 0.0011
Onchocerca volvulus 0.0051 0.0399 0.0719
Loa Loa (eye worm) hypothetical protein 0.0065 0.0557 0.0993
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.006 0.0508 0.0515
Loa Loa (eye worm) glutathione reductase 0.0072 0.0639 0.1142
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0623 0.1198
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.002 0.0032 0.0027
Brugia malayi Latrophilin receptor protein 2 0.0097 0.0934 0.1677
Mycobacterium tuberculosis Probable oxidoreductase 0.0182 0.1926 0.199
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0007
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0092 0.1163
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0046 0.0341 0.034
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0022 0.0057 0.0312
Brugia malayi intermediate filament protein 0.0139 0.143 0.258
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.002 0.0042
Entamoeba histolytica hypothetical protein 0.0084 0.0784 0.5562
Echinococcus multilocularis geminin 0.0699 0.7986 0.7986
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0046 0.0341 0.2362
Entamoeba histolytica phosphoinositide kinase, putative 0.0022 0.0057 0.0312
Brugia malayi Calcitonin receptor-like protein seb-1 0.0306 0.3381 0.6129
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0265 0.0265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0109 0.1077 0.1072
Schistosoma mansoni ap endonuclease 0.0019 0.002 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0051 0.0399 0.0399
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0341 0.0335
Schistosoma mansoni aldehyde dehydrogenase 0.0839 0.9617 0.9617
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0092 0.0563
Echinococcus multilocularis amiloride sensitive amine oxidase 0.0544 0.617 0.617
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0739 0.5236
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0088 0.0077
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0623 0.0633
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0022 0.0057 0.0312
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0046 0.0341 0.0341
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0046 0.0341 0.2362
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.006 0.0508 0.258
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.006 0.0508 1
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0046 0.0341 0.2362
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0021 0.0044 0.0153
Trypanosoma cruzi DNA polymerase eta, putative 0.0122 0.1232 0.8802
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.002 0.0032 0.0032
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.008 0.0739 0.0739
Trichomonas vaginalis glucosylceramidase, putative 0.0142 0.1463 0.285
Brugia malayi CXXC zinc finger family protein 0.0061 0.0517 0.0919
Toxoplasma gondii thioredoxin reductase 0.0072 0.0639 0.0651
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.002 0.0032 0.0133
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0046 0.0341 0.2362
Brugia malayi aldehyde dehydrogenase 0.0046 0.0341 0.0599
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0623 0.1198
Schistosoma mansoni lamin 0.0139 0.143 0.1425
Loa Loa (eye worm) hypothetical protein 0.0209 0.2248 0.4069
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0306 0.3381 0.6129
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0046 0.0341 0.0643
Trichomonas vaginalis glucosylceramidase, putative 0.0142 0.1463 0.285
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0623 0.1198
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0739 0.5236
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0097 0.0934 0.0934
Trichomonas vaginalis glucosylceramidase, putative 0.0142 0.1463 0.285
Echinococcus multilocularis musashi 0.0139 0.143 0.143
Loa Loa (eye worm) hypothetical protein 0.0069 0.0614 0.1096
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0094 0.0088
Loa Loa (eye worm) aldehyde dehydrogenase 0.0046 0.0341 0.0599
Plasmodium vivax thioredoxin reductase, putative 0.0072 0.0639 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0025 0.0091 0.1154
Brugia malayi T-complex protein 1, beta subunit 0.002 0.0032 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2334 0.4564
Brugia malayi Probable ClpP-like protease 0.006 0.0508 0.0904
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0025 0.0091 0.0079
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0623 0.4401
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0014 0.0005
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0025 0.0091 0.0091
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0046 0.0341 0.0341
Mycobacterium tuberculosis Probable dehydrogenase 0.0163 0.1713 0.1768
Trichomonas vaginalis esterase, putative 0.007 0.0623 0.1198
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0046 0.0341 0.2362
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0046 0.0341 0.0339
Echinococcus granulosus lamin 0.0139 0.143 0.143
Entamoeba histolytica deoxycytidyl transferase, putative 0.008 0.0739 0.5236
Echinococcus granulosus geminin 0.0699 0.7986 0.7986
Onchocerca volvulus 0.0139 0.143 0.2651
Brugia malayi hypothetical protein 0.0039 0.0258 0.0448
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0111 0.1103 0.1103
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.002 0.0005
Toxoplasma gondii t-complex protein beta subunit 0.002 0.0032 0.0019
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0027 0.0121 0.011
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0046 0.0341 0.0339
Onchocerca volvulus 0.0099 0.0965 0.178
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0273 0.2996 0.2992
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0623 0.4401
Schistosoma mansoni hypothetical protein 0.0097 0.0934 0.0928
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.002 0.0015
Leishmania major DNA polymerase kappa, putative 0.008 0.0739 0.0753
Mycobacterium ulcerans aldehyde dehydrogenase 0.0839 0.9617 1
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0046 0.0341 0.0341
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0623 0.0623
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.002 0.0032 0.0133
Loa Loa (eye worm) T-complex protein 1 0.002 0.0032 0.0038
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0025 0.0091 0.0558
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0739 0.5236
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0163 0.1713 0.1768
Echinococcus granulosus PHD finger protein rhinoceros 0.0025 0.0088 0.0088
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0022 0.0057 0.0057
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0046 0.0341 0.0339
Echinococcus multilocularis dna polymerase kappa 0.008 0.0739 0.0739
Echinococcus multilocularis GPCR, family 2 0.0097 0.0934 0.0934
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0091 0.0558
Trichomonas vaginalis glucosylceramidase, putative 0.0142 0.1463 0.285
Plasmodium falciparum T-complex protein 1 subunit beta 0.002 0.0032 0.0202
Trypanosoma brucei unspecified product 0.0055 0.0447 0.3133
Brugia malayi Pip kinase protein 2 0.0273 0.2996 0.5428
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0136 0.1398 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0623 0.1112
Toxoplasma gondii LsmAD domain-containing protein 0.0039 0.0258 0.0254
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.008 0.0739 0.0753
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0022 0.0057 0.0057
Echinococcus multilocularis transcription factor Dp 1 0.0079 0.0725 0.0725
Brugia malayi hypothetical protein 0.0474 0.5352 0.9714
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0007
Leishmania major hypothetical protein, conserved 0.0052 0.0409 0.041
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0046 0.0341 0.0599
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0182 0.1926 0.199
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0046 0.0341 0.0339
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0111 0.1103 0.1103
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0018 0.0006 0.0006
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0265 0.0461
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0136 0.1398 0.1393
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0022 0.0057 0.0044
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0084 0.0784 0.0784
Echinococcus multilocularis peregrin 0.0033 0.0182 0.0182
Trichomonas vaginalis glutaminase, putative 0.0453 0.5097 1
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0092 0.0563
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0136 0.1398 0.1398
Entamoeba histolytica acyl-coA synthetase, putative 0.0018 0.0015 0.001
Mycobacterium tuberculosis Conserved hypothetical protein 0.008 0.0739 0.0753
Onchocerca volvulus 0.0474 0.5352 1
Mycobacterium ulcerans lipase LipD 0.007 0.0623 0.0633
Leishmania major aldehyde dehydrogenase, putative 0.0046 0.0341 0.0339
Schistosoma mansoni rotamase 0.0028 0.0128 0.0123
Trichomonas vaginalis rotamase, putative 0.0027 0.0121 0.021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0623 0.0618
Plasmodium vivax glutathione reductase, putative 0.0072 0.0639 1
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0022 0.0057 0.0044
Loa Loa (eye worm) hypothetical protein 0.007 0.0623 0.1112
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.006 0.0508 0.0508
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0739 0.5236
Schistosoma mansoni hypothetical protein 0.0871 1 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0136 0.1398 1
Loa Loa (eye worm) bromodomain containing protein 0.006 0.0503 0.0895
Loa Loa (eye worm) PHD-finger family protein 0.007 0.0621 0.111
Trichomonas vaginalis mercuric reductase, putative 0.0025 0.0091 0.0152
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0046 0.0341 0.2362
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0111 0.1103 0.1098
Loa Loa (eye worm) hypothetical protein 0.007 0.0623 0.1112
Mycobacterium leprae conserved hypothetical protein 0.007 0.0623 0.318
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0739 0.5236
Loa Loa (eye worm) hypothetical protein 0.006 0.0508 0.0904
Brugia malayi beta-lactamase family protein 0.007 0.0623 0.1112
Schistosoma mansoni zinc finger protein 0.0052 0.0409 0.0404
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.002 0.0032 0.0202
Echinococcus granulosus cpg binding protein 0.0071 0.0634 0.0634
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0069 0.0614 0.4337
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.002 0.002
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.002 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0137 0.14 0.2526
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.1341 0.1336
Treponema pallidum gamma-glutamyl phosphate reductase 0.0046 0.0341 0.6572
Echinococcus multilocularis expressed protein 0.0028 0.0128 0.0128
Loa Loa (eye worm) glutaminase 2 0.0453 0.5097 0.925
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0265 0.0259
Schistosoma mansoni hypothetical protein 0.0097 0.0934 0.0928
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.002 0.0042
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0341 0.0335
Brugia malayi Intermediate filament tail domain containing protein 0.0139 0.143 0.258
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.002 0.0011
Schistosoma mansoni terminal deoxycytidyl transferase 0.008 0.0739 0.0733
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0163 0.1713 0.1768
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0839 0.9617 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0273 0.2996 0.2992
Schistosoma mansoni hypothetical protein 0.0699 0.7986 0.7985
Echinococcus granulosus fetal alzheimer antigen falz 0.008 0.0738 0.0738
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0163 0.1713 0.1768
Schistosoma mansoni hypothetical protein 0.0097 0.0934 0.0928
Toxoplasma gondii aldehyde dehydrogenase 0.0839 0.9617 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.004 0.0265 0.1305
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0097 0.0934 0.1677
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0092 0.0563
Loa Loa (eye worm) hypothetical protein 0.0488 0.5509 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0027 0.0121 0.0771
Entamoeba histolytica hypothetical protein 0.0084 0.0784 0.5562
Schistosoma mansoni hypothetical protein 0.0025 0.0088 0.0082
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0027 0.0121 0.0771
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0839 0.9617 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0084 0.0784 0.0784
Echinococcus granulosus methyl CpG binding domain protein 2 0.0058 0.0479 0.0479
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0025 0.0091 0.0079
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0046 0.0341 0.0341
Toxoplasma gondii hypothetical protein 0.0021 0.0044 0.0032
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0139 0.143 0.258
Trypanosoma cruzi trypanothione reductase, putative 0.0025 0.0091 0.0558
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.008 0.0739 0.0739
Leishmania major hypothetical protein, conserved 0.007 0.0623 0.0633
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0046 0.0341 0.0339
Echinococcus granulosus dna polymerase eta 0.0122 0.1232 0.1232
Loa Loa (eye worm) hypothetical protein 0.0148 0.1538 0.2776
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2334 0.4564
Mycobacterium tuberculosis Conserved protein 0.007 0.0623 0.0633
Trichomonas vaginalis glucosylceramidase, putative 0.015 0.1552 0.3026
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0022 0.0057 0.052
Brugia malayi hypothetical protein 0.0025 0.0096 0.0154
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0341 0.0335
Brugia malayi cytoplasmic intermediate filament protein 0.0075 0.0673 0.1204
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0109 0.1077 0.1077
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0046 0.0341 0.0599
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0517 0.0919
Echinococcus granulosus dna polymerase kappa 0.008 0.0739 0.0739
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0025 0.0091 0.0558
Echinococcus granulosus peregrin 0.0033 0.0182 0.0182
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.006 0.0508 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.0394 0.0695
Mycobacterium ulcerans aldehyde dehydrogenase 0.0839 0.9617 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0025 0.0091 0.0145
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.002 0.002
Schistosoma mansoni intermediate filament proteins 0.0139 0.143 0.1425
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0058 0.0479 0.0479
Echinococcus granulosus GPCR family 2 0.0097 0.0934 0.0934
Loa Loa (eye worm) latrophilin receptor protein 2 0.0097 0.0934 0.1677
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0273 0.2996 0.2996
Echinococcus granulosus serine protein kinase ATM 0.0018 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.007 0.0623 0.1112
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0623 0.0633
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0623 0.0618
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0072 0.0639 0.065
Mycobacterium tuberculosis Probable reductase 0.0163 0.1713 0.1768
Onchocerca volvulus 0.0139 0.143 0.2651
Loa Loa (eye worm) hypothetical protein 0.0046 0.0341 0.0599
Toxoplasma gondii hypothetical protein 0.0275 0.3018 0.3129
Loa Loa (eye worm) thioredoxin reductase 0.0072 0.0639 0.1142
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0046 0.0341 0.0341
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2334 0.4564
Plasmodium falciparum glutathione reductase 0.0025 0.0091 0.1154
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0025 0.0091 0.0091
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0028 0.0128 0.0213
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0046 0.0341 0.0341
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0022 0.0057 0.0051
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0046 0.0341 0.0339
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0046 0.0341 0.034
Onchocerca volvulus 0.007 0.0623 0.1139
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0111 0.1103 0.1986
Schistosoma mansoni ap endonuclease 0.0019 0.002 0.0014
Echinococcus multilocularis lamin 0.0139 0.143 0.143
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.006 0.0508 0.0508
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0046 0.0341 0.0339
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0022 0.0057 0.0044
Loa Loa (eye worm) hypothetical protein 0.0065 0.0557 0.0993
Schistosoma mansoni cpg binding protein 0.0071 0.0634 0.0628
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0046 0.0341 0.2362
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0025 0.0091 0.0079
Echinococcus granulosus histone lysine methyltransferase setb 0.0109 0.1077 0.1077
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0739 0.5236
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0092 0.0563
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0739 0.5236
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0022 0.0057 0.0315
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0075 0.0673 0.1204
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2334 0.4564
Brugia malayi Bromodomain containing protein 0.0033 0.0182 0.031
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0046 0.0341 0.061
Loa Loa (eye worm) hypothetical protein 0.0067 0.0587 0.1047
Loa Loa (eye worm) pip kinase 1 0.0022 0.0057 0.0083
Brugia malayi Pre-SET motif family protein 0.0348 0.3877 0.703
Echinococcus granulosus jumonji domain containing protein 0.0034 0.02 0.02
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.006 0.0508 0.7891
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0015 0.0007
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0046 0.0341 0.034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0111 0.1103 0.1103
Schistosoma mansoni hypothetical protein 0.0699 0.7986 0.7985
Echinococcus multilocularis serine protein kinase ATM 0.0018 0.0014 0.0014
Mycobacterium leprae Probable lipase LipE 0.007 0.0623 0.318
Brugia malayi Pip kinase protein 1 0.0022 0.0057 0.0083
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0022 0.0057 0.0045
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0265 0.0259
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0027 0.0121 0.0771
Loa Loa (eye worm) intermediate filament protein 0.0139 0.143 0.258
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.008 0.0739 0.1323
Schistosoma mansoni methyl-cpg binding protein mbd 0.0058 0.0479 0.0473
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0097 0.0934 0.0934
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0623 0.0633
Echinococcus granulosus zinc finger protein 0.007 0.062 0.062
Echinococcus granulosus thioredoxin glutathione reductase 0.0072 0.0644 0.0644
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0025 0.0088 0.0082
Brugia malayi hypothetical protein 0.0488 0.5509 1
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0046 0.0341 0.2362
Trypanosoma cruzi ISWI complex protein 0.0052 0.0409 0.2856
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0046 0.0341 0.1704
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0111 0.1103 0.1098
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0111 0.1103 0.1103
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0021 0.0044 0.0507
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0015 0.0007
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.006 0.0508 0.0514
Giardia lamblia Hypothetical protein 0.0022 0.0057 0.052
Brugia malayi glutathione reductase 0.0072 0.0639 0.1142
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0046 0.0341 0.0341
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0046 0.0341 0.2362
Trypanosoma brucei unspecified product 0.0055 0.0447 0.3133
Plasmodium falciparum thioredoxin reductase 0.0072 0.0639 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.143 0.258
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.002 0.0005
Mycobacterium tuberculosis Conserved protein 0.007 0.0623 0.0633
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.006 0.0508 1
Plasmodium falciparum glutathione reductase 0.0072 0.0639 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0122 0.123 0.123
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0046 0.0341 0.0339
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0136 0.1398 0.2522
Leishmania major trypanothione reductase 0.0072 0.0639 0.065
Onchocerca volvulus 0.0273 0.2996 0.5585
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0022 0.0057 0.0312
Giardia lamblia DNA damage repair protein 0.0025 0.0092 0.1002
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0623 0.1198
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0022 0.0057 0.0051
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0022 0.0057 0.0083
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.006 0.0508 0.7891
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0022 0.0057 0.0312
Schistosoma mansoni hypothetical protein 0.0097 0.0934 0.0928
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0022 0.0057 0.0083
Mycobacterium ulcerans glutaminase 0.0453 0.5097 0.5293
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0739 0.5236
Leishmania major T-complex protein 1, beta subunit, putative 0.002 0.0032 0.0018
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0739 0.5236
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0211 0.0363
Entamoeba histolytica hypothetical protein 0.0084 0.0784 0.5562
Loa Loa (eye worm) hypothetical protein 0.007 0.0623 0.1112
Schistosoma mansoni hypothetical protein 0.0052 0.0409 0.0404
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0046 0.0341 0.0599
Loa Loa (eye worm) hypothetical protein 0.024 0.2614 0.4733
Giardia lamblia PHD finger protein 15 0.0025 0.0088 0.0947
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0091 0.0558
Giardia lamblia DINP protein human, muc B family 0.008 0.0739 1
Schistosoma mansoni survival motor neuron protein 0.0099 0.0965 0.096
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.002 0.0042
Echinococcus granulosus intermediate filament protein 0.0139 0.143 0.143
Trichomonas vaginalis glutathione reductase, putative 0.0025 0.0091 0.0152
Loa Loa (eye worm) hypothetical protein 0.0046 0.0341 0.0599
Schistosoma mansoni hypothetical protein 0.0046 0.0341 0.0335
Echinococcus multilocularis survival motor neuron protein 1 0.0488 0.5509 0.5509
Trichomonas vaginalis DNA polymerase eta, putative 0.008 0.0739 0.1426
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0069 0.0614 0.4337
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.002 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2334 0.4564
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0046 0.0341 0.2362
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0623 0.4401
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0092 0.0563
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0022 0.0057 0.0045
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0623 0.0633
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0044 0.0044
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0025 0.0091 0.1462
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0022 0.0057 0.0312
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0025 0.0091 0.1154
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0022 0.0057 0.0051
Leishmania major DNA polymerase eta, putative 0.0122 0.1232 0.1267
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2334 0.4564
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0623 0.0633
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0025 0.0091 0.1462
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0067 0.0587 0.0587
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0739 0.5236
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0046 0.0341 0.0339
Trichomonas vaginalis chaperonin, putative 0.002 0.0032 0.0036
Loa Loa (eye worm) hypothetical protein 0.0097 0.0934 0.1677
Trypanosoma brucei unspecified product 0.008 0.0739 0.5236
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0306 0.3381 0.6129
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0839 0.9617 0.9617
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0092 0.0563
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0092 0.0081
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0018 0.0014 0.0005
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.002 0.0032 0.0036
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0623 0.0633
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0273 0.2996 0.2996
Trypanosoma cruzi PAB1-binding protein , putative 0.0039 0.0258 0.1763
Brugia malayi glutaminase DH11.1 0.0453 0.5097 0.925
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0046 0.0341 0.0339
Mycobacterium ulcerans aldehyde dehydrogenase 0.0839 0.9617 1
Giardia lamblia Alcohol dehydrogenase 0.0046 0.0341 0.4467
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0092 0.0563
Brugia malayi T-complex protein 1, beta subunit 0.002 0.0032 0.0038
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0025 0.0091 0.0079
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0022 0.0057 0.0312
Loa Loa (eye worm) beta-lactamase 0.007 0.0623 0.1112
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0046 0.0341 0.0335
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0092 0.0086
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0046 0.0341 0.2362
Entamoeba histolytica acyl-CoA synthetase, putative 0.0018 0.0015 0.001
Echinococcus granulosus lamin dm0 0.0139 0.143 0.143
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0025 0.0091 0.0079
Schistosoma mansoni methyl-cpg binding protein mbd 0.0058 0.0479 0.0473
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0449 0.5054 0.5248
Onchocerca volvulus 0.007 0.0623 0.1139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0111 0.1103 0.1098
Loa Loa (eye worm) hypothetical protein 0.0306 0.3381 0.6129
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0046 0.0341 0.6572
Schistosoma mansoni hypothetical protein 0.0084 0.0784 0.0778
Echinococcus multilocularis lysine specific demethylase 5A 0.003 0.0148 0.0148
Plasmodium falciparum ataxin-2 like protein, putative 0.0039 0.0258 0.3847
Echinococcus granulosus expressed protein 0.0028 0.0128 0.0128
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0018 0.0006 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0097 0.0934 0.0934
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0018 0.0014 0.0005
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0046 0.0341 0.2362
Echinococcus multilocularis zinc finger protein 0.007 0.062 0.062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0109 0.1077 0.1072
Brugia malayi PHD-finger family protein 0.0025 0.0088 0.0139
Toxoplasma gondii exonuclease III APE 0.0019 0.002 0.0006
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.008 0.0739 0.0733
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0025 0.0091 0.1154
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0091 0.0558
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0022 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.0084 0.0784 0.5562
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0046 0.0341 0.0339
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.008 0.0741 0.0741
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0057 0.0609
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0044 0.0059
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0109 0.1077 0.1938
Echinococcus multilocularis cpg binding protein 0.0071 0.0634 0.0634
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0046 0.0341 0.2362
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0447 0.3133
Toxoplasma gondii peptidylprolyl isomerase 0.0027 0.0121 0.0111
Echinococcus granulosus amiloride sensitive amine oxidase 0.0544 0.617 0.617
Giardia lamblia NADH oxidase lateral transfer candidate 0.0025 0.0091 0.0994
Leishmania major aldehyde dehydrogenase, putative 0.0046 0.0341 0.0339
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0092 0.0563
Trichomonas vaginalis rotamase, putative 0.0028 0.0128 0.0225
Schistosoma mansoni bromodomain containing protein 0.0219 0.2358 0.2354
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0092 0.1163
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0091 0.0558
Schistosoma mansoni aldehyde dehydrogenase 0.0839 0.9617 0.9617
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0216 0.2334 0.4224
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0046 0.0341 0.1704
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0046 0.0341 0.2362
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0025 0.0091 0.008
Mycobacterium ulcerans beta-lactamase 0.007 0.0623 0.0633
Brugia malayi Pre-SET motif family protein 0.0051 0.0399 0.0705
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0022 0.0057 0.0312
Loa Loa (eye worm) pip kinase 2 0.0273 0.2996 0.5428
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0046 0.0341 0.2362
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0022 0.0057 0.0312
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0048 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.007 0.0623 0.1112
Brugia malayi PHD-finger family protein 0.0088 0.0832 0.1493
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0088 0.0077
Toxoplasma gondii NADPH-glutathione reductase 0.0025 0.0091 0.008
Schistosoma mansoni hypothetical protein 0.0209 0.2248 0.2244
Plasmodium vivax hypothetical protein, conserved 0.007 0.0623 0.9742
Plasmodium falciparum thioredoxin reductase 0.0025 0.0091 0.1154
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0092 0.0081
Brugia malayi jmjC domain containing protein 0.004 0.0265 0.0461
Trypanosoma cruzi DNA polymerase eta, putative 0.0067 0.0585 0.4129
Leishmania major DNA polymerase kappa, putative 0.0025 0.0092 0.008
Schistosoma mansoni transcription factor LCR-F1 0.0084 0.0784 0.0778
Echinococcus granulosus peptidase Clp S14 family 0.004 0.0265 0.0265
Onchocerca volvulus 0.007 0.0623 0.1139
Plasmodium falciparum ataxin-2 like protein, putative 0.0039 0.0258 0.3847
Echinococcus multilocularis fetal alzheimer antigen, falz 0.008 0.0738 0.0738
Plasmodium falciparum phd finger protein, putative 0.0025 0.0088 0.11
Onchocerca volvulus 0.0061 0.0517 0.094
Schistosoma mansoni hypothetical protein 0.0544 0.617 0.6168
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.002 0.0032 0.0027
Loa Loa (eye worm) hypothetical protein 0.007 0.0623 0.1112
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0025 0.0091 0.1154
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0046 0.0341 0.0339
Mycobacterium ulcerans hypothetical protein 0.0025 0.0092 0.008
Echinococcus multilocularis peptidase Clp (S14 family) 0.004 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0138 0.1421 0.2564
Trypanosoma brucei DNA polymerase eta, putative 0.0122 0.1232 0.8802
Loa Loa (eye worm) hypothetical protein 0.0039 0.0258 0.0448
Mycobacterium tuberculosis Conserved protein 0.007 0.0623 0.0633
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0739 0.5236
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0128 0.0225
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0046 0.0341 0.0339
Loa Loa (eye worm) FYVE zinc finger family protein 0.0022 0.0057 0.0084
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0046 0.0341 0.0339
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.004 0.0265 0.026
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.008 0.0738 0.0733
Schistosoma mansoni copper/topaquinone oxidase 0.0544 0.617 0.6168
Giardia lamblia TCP-1 chaperonin subunit beta 0.002 0.0032 0.0174
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0015 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0088 0.11
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.0139
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0122 0.123 0.123
Brugia malayi polk-prov protein 0.0025 0.0092 0.0146
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0623 0.0623
Schistosoma mansoni hypothetical protein 0.0099 0.0965 0.096
Trypanosoma cruzi PAB1-binding protein , putative 0.0039 0.0258 0.1763
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0021 0.0044 0.04
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0046 0.0341 0.1704
Schistosoma mansoni zinc finger protein 0.007 0.062 0.0615
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0136 0.1398 1
Echinococcus multilocularis lamin dm0 0.0139 0.143 0.143
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.006 0.0508 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0111 0.1103 0.1986
Brugia malayi Thioredoxin reductase 0.0072 0.0639 0.1142
Mycobacterium ulcerans DNA polymerase IV 0.008 0.0739 0.0753
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0022 0.0057 0.0604
Schistosoma mansoni peptidase Clp (S14 family) 0.006 0.0508 0.0503
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.006 0.0508 0.0514
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0046 0.0341 0.0339
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.008 0.0739 0.0753
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.002 0.0032 0.0027
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0022 0.0057 0.0312
Loa Loa (eye worm) hypothetical protein 0.0474 0.5352 0.9714
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0046 0.0341 0.2362
Trypanosoma brucei trypanothione reductase 0.0072 0.0639 0.4516
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0046 0.0341 0.0339
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0046 0.0341 0.0339
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0739 0.5236
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0206 0.2216 0.2216
Loa Loa (eye worm) hypothetical protein 0.0122 0.1232 0.222
Plasmodium vivax ataxin-2 like protein, putative 0.0039 0.0258 0.3847
Loa Loa (eye worm) hypothetical protein 0.0042 0.0293 0.0512
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0097 0.0934 0.0934
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0739 0.5236
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0739 0.5236
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0067 0.0585 0.0595
Loa Loa (eye worm) glutaminase 0.0453 0.5097 0.925
Trypanosoma cruzi ISWI complex protein 0.0052 0.0409 0.2856
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0022 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0001
Brugia malayi Bromodomain containing protein 0.013 0.1324 0.2388
Echinococcus multilocularis dna polymerase eta 0.0122 0.1232 0.1232
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0623 0.0633
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0447 0.3133
Trichomonas vaginalis glucosylceramidase, putative 0.015 0.1552 0.3026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0399 0.0393
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0623 0.1112
Schistosoma mansoni glutaminase 0.0453 0.5097 0.5094
Schistosoma mansoni DNA polymerase eta 0.0122 0.1232 0.1227
Trichomonas vaginalis set domain proteins, putative 0.0396 0.4438 0.8703
Schistosoma mansoni cpg binding protein 0.0071 0.0634 0.0628
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0136 0.1398 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.9 Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells ChEMBL. 18571922

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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