TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 396.526 | Formula: C23H32N4O2
H donors: 2 H acceptors: 2 LogP: 2.87 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)C(=O)c1cccc(c1)NC(=O)NC12CC3CC(C2)CC(C1)C3
InChi: 1S/C23H32N4O2/c1-26-5-7-27(8-6-26)21(28)19-3-2-4-20(12-19)24-22(29)25-23-13-16-9-17(14-23)11-18(10-16)15-23/h2-4,12,16-18H,5-11,13-15H2,1H3,(H2,24,25,29)
InChiKey: SPKPTNYZXOLVRR-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epoxide hydrolase 2, cytoplasmic	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	Get druggable targets OG5_129061	All targets in OG5_129061
Mycobacterium ulcerans	epoxide hydrolase EphA	Get druggable targets OG5_129061	All targets in OG5_129061

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0482	0.2976	0.2734
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0113	0.0373	0.0041
Schistosoma mansoni	RAR-like nuclear receptor	0.0482	0.2976	0.2948
Brugia malayi	nuclear hormone receptor	0.0228	0.118	0.1053
Brugia malayi	nuclear receptor RXR	0.0228	0.118	0.1053
Loa Loa (eye worm)	hypothetical protein	0.0228	0.118	0.118
Schistosoma mansoni	metabotropic glutamate receptor	0.1006	0.6669	0.713
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0308	0.1747	0.1747
Echinococcus multilocularis	Niemann Pick C1 protein	0.0163	0.0727	0.0408
Schistosoma mansoni	zinc finger protein	0.0228	0.118	0.0914
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0188	0.0901	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0482	0.2976	0.3394
Loa Loa (eye worm)	steroid hormone receptor	0.0482	0.2976	0.2976
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0113	0.0373	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0255	0.1373	0.1373
Loa Loa (eye worm)	hypothetical protein	0.0482	0.2976	0.2976
Onchocerca volvulus		0.0482	0.2976	0.8287
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0373	0.0373
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0482	0.2976	0.3394
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0482	0.2976	0.3394
Brugia malayi	Nuclear hormone receptor-like 1	0.0255	0.1373	0.1303
Loa Loa (eye worm)	glutamate receptor	0.0473	0.2908	0.2908
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0482	0.2976	0.2734
Loa Loa (eye worm)	glutamate receptor	0.1201	0.8043	0.8043
Schistosoma mansoni	metabotropic glutamate receptor	0.0586	0.3704	0.3772
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0113	0.0373	0.0041
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0113	0.0373	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0482	0.2976	0.2976
Loa Loa (eye worm)	hypothetical protein	0.0255	0.1373	0.1373
Brugia malayi	ecdysteroid receptor	0.0482	0.2976	0.3394
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0482	0.2976	0.2976
Schistosoma mansoni	nuclear hormone receptor	0.0228	0.118	0.0914
Loa Loa (eye worm)	hypothetical protein	0.0228	0.118	0.118
Onchocerca volvulus	Metabotropic glutamate receptor homolog	0.0195	0.0951	0.184
Loa Loa (eye worm)	hypothetical protein	0.0482	0.2976	0.2976
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0482	0.2976	0.2734
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0373	0.0373
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0482	0.2976	0.8287
Loa Loa (eye worm)	hypothetical protein	0.0255	0.1373	0.1373
Brugia malayi	conserved hypotetical protein	0.0228	0.118	0.1053
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0113	0.0373	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0255	0.1373	0.1373
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0482	0.2976	0.2734
Schistosoma mansoni	nuclear receptor	0.0228	0.118	0.0914
Brugia malayi	nuclear receptor NHR-67	0.0228	0.118	0.1053
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0255	0.1373	0.1075
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0113	0.0373	0.0041
Onchocerca volvulus	Poor gastrulation protein homolog	0.0195	0.0951	0.184
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0228	0.118	0.257
Echinococcus granulosus	GPCR family 3 C terminal	0.0195	0.0951	0.0639
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0482	0.2976	0.3394
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0482	0.2976	0.2734
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0228	0.118	0.118
Loa Loa (eye worm)	DR-78	0.0228	0.118	0.118
Schistosoma mansoni	nuclear receptor nhr-48	0.0228	0.118	0.0914
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0188	0.0901	0.0587
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0559	0.3514	1
Loa Loa (eye worm)	hypothetical protein	0.0255	0.1373	0.1373
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0228	0.118	0.0914
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0373	0.0373
Brugia malayi	prolyl oligopeptidase family protein	0.0188	0.0901	0.0688
Brugia malayi	orphan nuclear receptor NR2E1	0.0228	0.118	0.1053
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0482	0.2976	0.2734
Schistosoma mansoni	coup transcription factor	0.0482	0.2976	0.2948
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0482	0.2976	0.3394
Loa Loa (eye worm)	hypothetical protein	0.0308	0.1747	0.1747
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0113	0.0373	0.0373
Echinococcus multilocularis	geminin	0.0197	0.0962	0.0651
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0559	0.3514	0.3557
Echinococcus granulosus	metabotropic glutamate receptor 2	0.1006	0.6669	0.6555
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0482	0.2976	0.2734
Loa Loa (eye worm)	hypothetical protein	0.0482	0.2976	0.2976
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0228	0.118	0.0876
Brugia malayi	nuclear receptor NHR-88	0.0228	0.118	0.1053
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0113	0.0373	0.0041
Brugia malayi	Receptor family ligand binding region containing protein	0.0308	0.1747	0.1792
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0482	0.2976	0.2734
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0373	0.0373
Brugia malayi	nuclear receptor NHR-88	0.0482	0.2976	0.3394
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.1479	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0113	0.0373	0.0373
Brugia malayi	Nuclear hormone receptor E75	0.0228	0.118	0.1053
Brugia malayi	tailless protein	0.0228	0.118	0.1053
Loa Loa (eye worm)	prolyl oligopeptidase	0.0559	0.3514	0.3514
Echinococcus multilocularis	tyrosine kinase	0.0113	0.0373	0.0041
Brugia malayi	nuclear receptor RXR	0.0255	0.1373	0.1303
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0482	0.2976	0.3394
Loa Loa (eye worm)	hypothetical protein	0.0228	0.118	0.118
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0482	0.2976	0.2948
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.1006	0.6669	0.6555
Brugia malayi	Nuclear hormone receptor-like 1	0.0482	0.2976	0.3394
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0188	0.0901	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0113	0.0373	0.0373
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0482	0.2976	0.2734
Brugia malayi	steroid hormone receptor	0.0482	0.2976	0.3394
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0482	0.2976	0.2976
Loa Loa (eye worm)	hypothetical protein	0.0482	0.2976	0.2976
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0482	0.2976	0.2734
Echinococcus granulosus	thyroid hormone receptor alpha	0.0228	0.118	0.0876
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0113	0.0373	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0228	0.118	0.118
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0482	0.2976	0.2734
Echinococcus multilocularis	glutamate receptor 2	0.0113	0.0373	0.0041
Echinococcus granulosus	FTZ F1 alpha	0.0482	0.2976	0.2734
Echinococcus granulosus	glutamate receptor 2	0.0113	0.0373	0.0041
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0113	0.0373	0.0041
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0228	0.118	0.1053
Brugia malayi	nuclear hormone receptor family member odr-7	0.0228	0.118	0.1053
Echinococcus granulosus	geminin	0.0197	0.0962	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0228	0.118	0.118
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0114	0.0382	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0228	0.118	0.0876
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0482	0.2976	0.3394
Brugia malayi	nuclear hormone receptor	0.0482	0.2976	0.3394
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0482	0.2976	0.2734
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0373	0.0373
Brugia malayi	Nuclear hormone receptor E75	0.0228	0.118	0.1053
Loa Loa (eye worm)	hypothetical protein	0.0228	0.118	0.118
Brugia malayi	hypothetical protein	0.0228	0.118	0.1053
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0188	0.0901	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0482	0.2976	0.2948
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0188	0.0901	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0255	0.1373	0.1373
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0482	0.2976	0.3394
Echinococcus granulosus	tyrosine kinase	0.0113	0.0373	0.0041
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0482	0.2976	0.3394
Schistosoma mansoni	hypothetical protein	0.0195	0.0951	0.0655
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0482	0.2976	0.2948
Echinococcus multilocularis	nuclear receptor nhr 48	0.0228	0.118	0.0876
Loa Loa (eye worm)	hypothetical protein	0.0228	0.118	0.118
Schistosoma mansoni	nuclear receptor	0.0228	0.118	0.0914
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0228	0.118	0.118
Onchocerca volvulus		0.0228	0.118	0.257
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0188	0.0901	0.0598
Brugia malayi	hypothetical protein	0.0255	0.1373	0.1303
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0482	0.2976	0.2976
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0482	0.2976	0.2734
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0482	0.2976	0.2976
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0228	0.118	0.0876
Loa Loa (eye worm)	hypothetical protein	0.1479	1	1
Echinococcus granulosus	nmda type glutamate receptor	0.0113	0.0373	0.0041
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0228	0.118	0.0876
Schistosoma mansoni	retinoic acid receptor RXR	0.0482	0.2976	0.2948
Echinococcus multilocularis	Niemann Pick C1 protein	0.0114	0.0382	0.0051
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0482	0.2976	0.2976
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0188	0.0901	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0228	0.118	0.0876
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0482	0.2976	0.2948
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0228	0.118	0.0876
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0255	0.1373	0.1075
Loa Loa (eye worm)	hypothetical protein	0.0228	0.118	0.118
Echinococcus granulosus	receptor type guanylyl cyclase	0.0113	0.0373	0.0041
Echinococcus multilocularis	glutamate receptor 2	0.0113	0.0373	0.0041
Schistosoma mansoni	hypothetical protein	0.0197	0.0962	0.0668
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0228	0.118	0.257
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0308	0.1747	0.1747
Brugia malayi	hypothetical protein	0.0255	0.1373	0.1303
Schistosoma mansoni	thyroid hormone receptor	0.0482	0.2976	0.2948
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0589	0.0589
Brugia malayi	hypothetical protein	0.0144	0.0589	0.0281
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0228	0.118	0.0876
Brugia malayi	ecdysone receptor	0.0228	0.118	0.1053
Brugia malayi	metabotropic glutamate receptor type 2	0.0586	0.3704	0.4342
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0482	0.2976	0.2948
Echinococcus granulosus	Niemann Pick C1 protein	0.0114	0.0382	0.0051
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0482	0.2976	0.3394
Loa Loa (eye worm)	hypothetical protein	0.0228	0.118	0.118
Brugia malayi	Nuclear hormone receptor-like 1	0.0255	0.1373	0.1303
Brugia malayi	Niemann-Pick C1 protein precursor	0.0114	0.0382	0.0012
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0482	0.2976	0.2948
Schistosoma mansoni	nuclear hormone receptor	0.0482	0.2976	0.2948
Echinococcus multilocularis	nmda type glutamate receptor	0.0113	0.0373	0.0041
Echinococcus granulosus	nuclear receptor nhr 48	0.0228	0.118	0.0876
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0113	0.0373	0.0041
Echinococcus granulosus	ecdysone induced protein 78C	0.0482	0.2976	0.2734
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0482	0.2976	0.2734
Echinococcus granulosus	glutamate receptor 2	0.0113	0.0373	0.0041
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0116	0.0394	0.0024
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0228	0.118	0.0914
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0482	0.2976	0.3394
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0482	0.2976	0.3394
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0113	0.0373	0.0041
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.1088	0.7247	0.8962
Echinococcus granulosus	Niemann Pick C1 protein	0.0163	0.0727	0.0408
Schistosoma mansoni	nuclear hormone receptor	0.0228	0.118	0.0914
Brugia malayi	prolyl oligopeptidase family protein	0.0559	0.3514	0.4095
Schistosoma mansoni	hypothetical protein	0.0197	0.0962	0.0668
Echinococcus multilocularis	GPCR, family 3, C terminal	0.0195	0.0951	0.0639
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0559	0.3514	0.3291
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0188	0.0901	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0228	0.118	0.0876
Loa Loa (eye worm)	hypothetical protein	0.0482	0.2976	0.2976
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0188	0.0901	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0951	0.0951
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.1366	0.9204	1
Onchocerca volvulus		0.0228	0.118	0.257
Brugia malayi	photoreceptor-specific nuclear receptor	0.0482	0.2976	0.3394
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0197	0.0968	0.5
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0195	0.0951	0.0754
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0228	0.118	0.1053
Echinococcus multilocularis	FTZ F1 alpha	0.0482	0.2976	0.2734
Loa Loa (eye worm)	hypothetical protein	0.0482	0.2976	0.2976
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0267	0.1458	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0255	0.1373	0.1132
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0113	0.0373	0.0041
Brugia malayi	Steroid receptor seven-up type 2	0.0482	0.2976	0.3394
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0373	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0373	0.0373
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0255	0.1373	0.1132
Loa Loa (eye worm)	hypothetical protein	0.0228	0.118	0.118
Schistosoma mansoni	thyroid hormone receptor	0.0482	0.2976	0.2948
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0559	0.3514	0.3291
Loa Loa (eye worm)	hypothetical protein	0.0228	0.118	0.118
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0382	0.0382
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0482	0.2976	0.2976
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0482	0.2976	0.2976
Brugia malayi	Metabotropic glutamate receptor precursor.	0.1201	0.8043	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0482	0.2976	0.2948
Loa Loa (eye worm)	nuclear hormone receptor	0.0228	0.118	0.118
Loa Loa (eye worm)	hypothetical protein	0.0228	0.118	0.118
Brugia malayi	hypothetical protein	0.0228	0.118	0.1053
Loa Loa (eye worm)	hypothetical protein	0.0228	0.118	0.118
Loa Loa (eye worm)	hypothetical protein	0.0482	0.2976	0.2976
Onchocerca volvulus	Bile acid receptor homolog	0.0482	0.2976	0.8287
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0482	0.2976	0.3394
Echinococcus multilocularis	ecdysone induced protein 78C	0.0482	0.2976	0.2734
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0228	0.118	0.0876
Onchocerca volvulus	Protein ultraspiracle homolog	0.0482	0.2976	0.8287

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 35 nM	Inhibition of human soluble epoxide hydrolase by fluorescence assay	ChEMBL.	19216074
IC50 (binding)	= 36 nM	Inhibition of soluble epoxide hydrolase by fluorescence assay	ChEMBL.	20363133

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL478146

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 981392