Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1322 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0478 | 0.1313 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0478 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1322 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0478 | 0.5 |
Echinococcus multilocularis | geminin | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.3203 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.1322 | 0.3095 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.2129 | 0.6577 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0478 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.2129 | 0.606 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0067 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1322 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2129 | 0.6577 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1091 | 0.225 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0067 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1322 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.3203 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.1322 | 0.0258 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0478 | 1 |
Onchocerca volvulus | 0.0027 | 0.0478 | 0.5 | |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0478 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0067 | 0.139 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0478 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0478 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.3203 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3203 | 0.237 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3203 | 0.237 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.3203 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3203 | 0.237 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0478 | 0.1313 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0067 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.2129 | 0.606 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0478 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3203 | 0.237 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0478 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0478 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.3203 | 0.2168 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0478 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0478 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1091 | 0.3268 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0073 | 0.3203 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.3203 | 0.2168 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.1322 | 0.0258 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.3203 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0478 | 0.1313 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3203 | 0.237 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 100 uM | Antiproliferative activity against human HT1080 cells by MTT assay | ChEMBL. | 11325233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.