Detailed information for compound 981656

Basic information

Technical information
  • TDR Targets ID: 981656
  • Name: 2-amino-3-(phenylmethoxy)butanedioic acid
  • MW: 239.225 | Formula: C11H13NO5
  • H donors: 3 H acceptors: 4 LogP: -2.39 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(C(C(=O)O)OCc1ccccc1)C(=O)O
  • InChi: 1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)
  • InChiKey: BYOBCYXURWDEDS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-3-(benzyloxy)succinic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Starlite/ChEMBL References
Homo sapiens solute carrier family 1 (glial high affinity glutamate transporter), member 2 Starlite/ChEMBL References
Homo sapiens solute carrier family 1 (glial high affinity glutamate transporter), member 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum ko:K05614 solute carrier family 1 (glial high affinity glutamate transporter),, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis excitatory amino acid transporter 3 Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum ko:K05613 solute carrier family 1 (glial high affinity glutamate transporter),, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Brugia malayi Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Chlamydia trachomatis glutamate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus sodium:dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum Excitatory amino acid transporter 2, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Theileria parva glutamate transporter, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus excitatory amino acid transporter 3 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Loa Loa (eye worm) excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA Get druggable targets OG5_126739 All targets in OG5_126739
Onchocerca volvulus Excitatory amino acid transporter homolog Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis sodium:dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus neutral amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.001 0.0015 0.0015
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0162 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0023 0.0023
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0121 0.0121
Echinococcus granulosus X box binding protein 1 0.0325 0.3787 0.7064
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.001 0.0015 0.0028
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0121 0.0121
Brugia malayi Melatonin receptor type 1A 0.0019 0.0121 0.0211
Brugia malayi ecdysone receptor 0.0034 0.0303 0.0552
Onchocerca volvulus 0.0019 0.0121 0.0211
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0008 0.0008
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0512 0.0956
Brugia malayi Dopamine receptor protein 1 0.0019 0.0121 0.0211
Brugia malayi photoreceptor-specific nuclear receptor 0.0073 0.0765 0.1414
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0121 0.0211
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0121 0.0226
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0012
Echinococcus granulosus RUN 0.0023 0.0162 0.0301
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0395 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0073 0.0765 0.1414
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0142 0.2628
Mycobacterium ulcerans glutaminase 0.0288 0.3347 1
Brugia malayi Cell death specification protein 2 0.001 0.0015 0.0012
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0008 0.0015
Brugia malayi ecdysteroid receptor 0.0073 0.0765 0.1414
Brugia malayi tailless protein 0.0034 0.0303 0.0552
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0765 0.0765
Schistosoma mansoni hypothetical protein 0.0103 0.1124 0.2097
Brugia malayi hypothetical protein 0.0019 0.0121 0.0211
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0073 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0121 0.0226
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0203 0.232 0.4326
Brugia malayi GnHR receptor homolog 0.0019 0.0121 0.0211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0142 0.218
Schistosoma mansoni hypothetical protein 0.0019 0.0121 0.0226
Echinococcus granulosus g protein coupled receptor 0.0019 0.0121 0.0226
Brugia malayi hypothetical protein 0.0023 0.0162 0.0286
Loa Loa (eye worm) hypothetical protein 0.0023 0.0162 0.0286
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0121 0.0121
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0303 0.0552
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0121 0.0121
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0142 0.0412
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0121 0.0226
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus multilocularis excitatory amino acid transporter 3 0.0457 0.5362 0.5362
Brugia malayi Cell death specification protein 2 0.001 0.0015 0.0012
Onchocerca volvulus 0.0019 0.0121 0.0211
Toxoplasma gondii exonuclease III APE 0.0021 0.0142 0.2185
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0303 0.4809
Echinococcus multilocularis thyroid hormone receptor alpha 0.0073 0.0765 0.0765
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0121 0.0121
Brugia malayi Cytochrome P450 family protein 0.0021 0.0142 0.025
Brugia malayi RNA binding protein 0.0261 0.3016 0.5618
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0512 0.0512
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.0142 0.0411
Schistosoma mansoni nuclear receptor 0.0034 0.0303 0.0566
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0073 0.0765 0.1427
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0262 1
Schistosoma mansoni hypothetical protein 0.0019 0.0121 0.0226
Entamoeba histolytica hypothetical protein 0.0039 0.0364 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0121 0.0226
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.0142 0.0411
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.0303 0.0566
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0121 0.0226
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.001 0.0015 0.0015
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0121 0.0121
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus granulosus lamin 0.0087 0.0935 0.1743
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0303 0.0303
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0552
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0073 0.0765 0.1427
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0121 0.0121
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0121 0.0226
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.045 0.0826
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0121 0.0121
Brugia malayi G-protein coupled receptor 0.0019 0.0121 0.0211
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.0303 0.0303
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0039 0.0353 0.0658
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0121 0.0226
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0121 0.0226
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0121 0.0226
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0039 0.0353 0.0644
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0022 0.0025
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0121 0.0211
Loa Loa (eye worm) hypothetical protein 0.0073 0.0765 0.1414
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0121 0.0211
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0202 0.2316 0.2316
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0765 0.1414
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.0142 0.0411
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0142 0.2628
Echinococcus granulosus cpg binding protein 0.0033 0.0291 0.0542
Schistosoma mansoni hypothetical protein 0.0019 0.0121 0.0226
Echinococcus multilocularis ferritin 0.0009 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0073 0.0765 0.1414
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0073 0.0765 0.1414
Echinococcus granulosus g protein coupled receptor 0.0019 0.0121 0.0226
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0512 0.0942
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0142 0.0257
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0073 0.0765 0.0765
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0121 0.0226
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0121 0.0121
Schistosoma mansoni lamin 0.0087 0.0935 0.1743
Loa Loa (eye worm) RNA binding protein 0.0261 0.3016 0.5618
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0142 0.0257
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0142 0.0257
Schistosoma mansoni myosin xvIII 0.0019 0.0121 0.0226
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0142 0.0257
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0073 0.0765 0.1427
Entamoeba histolytica hypothetical protein 0.0039 0.0364 1
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.001 0.0015 0.0015
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.0303 0.0566
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus multilocularis Excitatory amino acid transporter 0.0457 0.5362 0.5362
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0142 0.0257
Loa Loa (eye worm) hypothetical protein 0.0086 0.0916 0.1695
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0073 0.0765 0.1414
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0121 0.0226
Schistosoma mansoni loxhd1 0.0023 0.0162 0.0301
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0073 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Schistosoma mansoni nuclear hormone receptor 0.0073 0.0765 0.1427
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0303 0.0552
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0073 0.0765 0.1427
Onchocerca volvulus 0.0019 0.0121 0.0211
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0121 0.0121
Onchocerca volvulus 0.0023 0.0162 0.0286
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.0142 0.0411
Brugia malayi mbt repeat family protein 0.0052 0.0512 0.0942
Schistosoma mansoni histamine h1 receptor 0.0019 0.0121 0.0226
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0142 0.0257
Onchocerca volvulus 0.0019 0.0121 0.0211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Plasmodium vivax SET domain protein, putative 0.0034 0.0303 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0121 0.0121
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0008 0.0015
Schistosoma mansoni dishevelled 0.001 0.0008 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0073 0.0765 0.1414
Echinococcus multilocularis sex peptide receptor 0.0019 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0552
Echinococcus granulosus tar DNA binding protein 0.0261 0.3016 0.5624
Schistosoma mansoni tar DNA-binding protein 0.0261 0.3016 0.5624
Echinococcus multilocularis 0.0021 0.0142 0.0142
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0162 0.0301
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0202 0.2316 0.432
Brugia malayi glutaminase DH11.1 0.0288 0.3347 0.6236
Brugia malayi hypothetical protein 0.0039 0.0364 0.0666
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0269 0.0487
Echinococcus multilocularis protocadherin 11 0.001 0.0015 0.0015
Schistosoma mansoni nuclear receptor 0.0034 0.0303 0.0566
Echinococcus granulosus sodium:dicarboxylate symporter 0.0457 0.5362 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0121 0.0211
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0325 0.3789 0.7062
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0551
Echinococcus granulosus expressed protein 0.0009 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0552
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0121 0.0226
Echinococcus granulosus somatostatin receptor 0.0019 0.0121 0.0226
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus granulosus ferritin 0.0009 0.0004 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0073 0.0765 0.1414
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0142 0.2628
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.028 0.0523
Echinococcus granulosus neuropeptide receptor 0.0019 0.0121 0.0226
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0142 0.025
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0121 0.0211
Schistosoma mansoni ap endonuclease 0.0021 0.0142 0.0265
Loa Loa (eye worm) hypothetical protein 0.0039 0.0353 0.0644
Onchocerca volvulus 0.001 0.0015 0.0012
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0121 0.0121
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0099 0.1482
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0261 0.3016 0.5618
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0598 0.1116
Loa Loa (eye worm) latrophilin receptor protein 2 0.0103 0.1124 0.2085
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0073 0.0765 0.0765
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0121 0.0211
Loa Loa (eye worm) steroid hormone receptor 0.0073 0.0765 0.1414
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0135 0.1508 0.1508
Echinococcus multilocularis X box binding protein 1 0.0325 0.3787 0.3787
Loa Loa (eye worm) hypothetical protein 0.0039 0.0353 0.0644
Schistosoma mansoni tar DNA-binding protein 0.0261 0.3016 0.5624
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Onchocerca volvulus 0.0032 0.0269 0.0487
Brugia malayi hypothetical protein 0.0019 0.0121 0.0211
Schistosoma mansoni rab6-interacting 0.0023 0.0162 0.0301
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Brugia malayi Cytochrome P450 family protein 0.0031 0.0262 0.0474
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0099 0.0099
Echinococcus multilocularis serotonin receptor 0.0019 0.0121 0.0121
Brugia malayi G-protein coupled receptor 0.0019 0.0121 0.0211
Onchocerca volvulus 0.0019 0.0121 0.0211
Schistosoma mansoni glutaminase 0.0288 0.3347 0.6242
Brugia malayi G protein-coupled receptor 0.0019 0.0121 0.0211
Schistosoma mansoni dep domain containing protein 0.001 0.0008 0.0015
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0121 0.0226
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0121 0.0226
Onchocerca volvulus 0.0034 0.0303 0.0552
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0121 0.0226
Brugia malayi Calcitonin receptor-like protein seb-1 0.0325 0.3789 0.7062
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0162 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0073 0.0765 0.1414
Brugia malayi AKH receptor 0.0019 0.0121 0.0211
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0457 0.5362 0.5362
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0135 0.1508 0.2812
Brugia malayi Excitatory amino acid transporter 0.0457 0.5362 1
Chlamydia trachomatis glutamate symporter 0.0457 0.5362 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0121 0.0226
Loa Loa (eye worm) hypothetical protein 0.0023 0.0162 0.0286
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.0142 0.0411
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0121 0.0226
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0162 0.3058
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0121 0.0226
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0121 0.0121
Schistosoma mansoni adenoreceptor 0.0019 0.0121 0.0226
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0203 0.232 0.4326
Brugia malayi ORL1-like opioid receptor 0.0019 0.0121 0.0211
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0303 0.0566
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0121 0.0226
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0552
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0121 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0765 0.1414
Schistosoma mansoni opsin-like receptor 0.0019 0.0121 0.0226
Schistosoma mansoni hypothetical protein 0.001 0.0015 0.0028
Onchocerca volvulus Bile acid receptor homolog 0.0073 0.0765 0.1414
Echinococcus multilocularis Excitatory amino acid transporter 0.0457 0.5362 0.5362
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.0142 0.0411
Loa Loa (eye worm) hypothetical protein 0.0073 0.0765 0.1414
Schistosoma mansoni amine GPCR 0.0019 0.0121 0.0226
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0121 0.0226
Schistosoma mansoni lamin 0.0087 0.0935 0.1743
Echinococcus multilocularis ecdysone induced protein 78C 0.0073 0.0765 0.0765
Schistosoma mansoni neuropeptide receptor 0.0019 0.0121 0.0226
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0142 0.0257
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0121 0.0226
Echinococcus granulosus excitatory amino acid transporter 2 0.0457 0.5362 1
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0303 0.0566
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0142 0.2648
Echinococcus granulosus FTZ F1 alpha 0.0073 0.0765 0.1427
Brugia malayi Pre-SET motif family protein 0.0034 0.0303 0.0551
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0121 0.0121
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0121 0.0121
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0099 0.0099
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0142 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0121 0.0211
Echinococcus multilocularis lamin 0.0087 0.0935 0.0935
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0622 1
Schistosoma mansoni dishevelled 0.001 0.0008 0.0015
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0598 0.1116
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0765 0.1427
Echinococcus granulosus Excitatory amino acid transporter 0.0457 0.5362 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0121 0.0211
Onchocerca volvulus 0.0019 0.0121 0.0211
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0142 0.0265
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0008 0.0015
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.0121 0.0211
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0694 0.1281
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0303 0.0566
Loa Loa (eye worm) MBCTL1 0.0059 0.0598 0.1102
Loa Loa (eye worm) hypothetical protein 0.0325 0.3789 0.7062
Echinococcus granulosus serotonin receptor 0.0019 0.0121 0.0226
Schistosoma mansoni tar DNA-binding protein 0.0261 0.3016 0.5624
Brugia malayi hypothetical protein 0.0039 0.0353 0.0644
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0142 0.3645
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0142 0.0257
Echinococcus multilocularis serotonin receptor 0.0019 0.0121 0.0121
Schistosoma mansoni lipoxygenase 0.0135 0.1508 0.2812
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0099 0.017
Brugia malayi neuropeptide F receptor 0.0019 0.0121 0.0211
Brugia malayi hypothetical protein 0.0019 0.0121 0.0211
Onchocerca volvulus 0.0019 0.0121 0.0211
Schistosoma mansoni ferritin light chain 0.0009 0.0004 0.0008
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0162 0.0286
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0099 0.017
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0121 0.0121
Loa Loa (eye worm) TAR-binding protein 0.0261 0.3016 0.5618
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.2714 0.5054
Leishmania major cytochrome p450-like protein 0.0031 0.0262 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.0142 0.0411
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0121 0.0226
Echinococcus multilocularis expressed protein 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus multilocularis RUN 0.0023 0.0162 0.0162
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0202 0.2316 0.432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0073 0.0765 0.1414
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0023 0.0043
Schistosoma mansoni neuropeptide receptor 0.0019 0.0121 0.0226
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0121 0.0121
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0303 0.0566
Echinococcus multilocularis excitatory amino acid transporter 2 0.0457 0.5362 0.5362
Echinococcus multilocularis neutral amino acid transporter A 0.0457 0.5362 0.5362
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0008 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Brugia malayi Dopamine receptor protein 2 0.0019 0.0121 0.0211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.001 0.0015 0.0028
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0121 0.0226
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0142 0.0257
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0457 0.5362 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0121 0.0226
Schistosoma mansoni apoferritin-2 0.0009 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0765 0.1414
Brugia malayi hypothetical protein 0.0019 0.0121 0.0211
Schistosoma mansoni lipoxygenase 0.0094 0.1021 0.1905
Brugia malayi hypothetical protein 0.0034 0.0303 0.0552
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus multilocularis neutral amino acid transporter A 0.0457 0.5362 0.5362
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0765 0.1414
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0121 0.0226
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0142 0.2648
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0121 0.0226
Onchocerca volvulus 0.0019 0.0121 0.0211
Trichomonas vaginalis glutaminase, putative 0.0288 0.3347 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0203 0.232 0.4326
Echinococcus granulosus lamin dm0 0.0087 0.0935 0.1743
Brugia malayi isocitrate dehydrogenase 0.0017 0.0099 0.017
Onchocerca volvulus 0.0019 0.0121 0.0211
Loa Loa (eye worm) cell death specification protein 2 0.001 0.0015 0.0012
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0121 0.0226
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0121 0.0226
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0121 0.0226
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0121 0.0226
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0121 0.0226
Schistosoma mansoni regulator of G protein signaling 0.001 0.0008 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0261 0.3016 0.5624
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0203 0.232 0.4326
Echinococcus multilocularis excitatory amino acid transporter 2 0.0457 0.5362 0.5362
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0121 0.0121
Brugia malayi nuclear receptor NHR-67 0.0034 0.0303 0.0552
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0121 0.0226
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0765 0.0765
Brugia malayi Pre-SET motif family protein 0.0236 0.2714 0.5054
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0262 0.0474
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Brugia malayi hypothetical protein 0.0039 0.0353 0.0644
Loa Loa (eye worm) hypothetical protein 0.004 0.0376 0.0687
Onchocerca volvulus 0.0019 0.0121 0.0211
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0039 0.0353 0.0658
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0142 0.0257
Schistosoma mansoni thyrotroph embryonic factor related 0.001 0.0015 0.0028
Echinococcus multilocularis cpg binding protein 0.0033 0.0291 0.0291
Brugia malayi RE15519p 0.0019 0.0121 0.0211
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0059 0.0598 0.1102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0303 0.0566
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0121 0.0226
Onchocerca volvulus 0.001 0.0015 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0121 0.0226
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0198 0.2266 0.4217
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.0262 0.0771
Schistosoma mansoni biogenic amine receptor 0.0019 0.0121 0.0226
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0012
Schistosoma mansoni RAR-like nuclear receptor 0.0073 0.0765 0.1427
Loa Loa (eye worm) hypothetical protein 0.0039 0.0353 0.0644
Brugia malayi nuclear receptor NHR-88 0.0034 0.0303 0.0552
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0512 0.0512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0121 0.0226
Schistosoma mansoni hypothetical protein 0.0019 0.0121 0.0226
Schistosoma mansoni hypothetical protein 0.0222 0.2556 0.4766
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0121 0.0211
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0121 0.0121
Brugia malayi mbt repeat family protein 0.0052 0.0512 0.0942
Echinococcus granulosus ccaat enhancer binding protein delta 0.001 0.0015 0.0028
Schistosoma mansoni biogenic amine receptor 0.0019 0.0121 0.0226
Echinococcus granulosus neutral amino acid transporter 0.0457 0.5362 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0142 0.0142
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0512 0.0956
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0552
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0262 0.0474
Schistosoma mansoni hypothetical protein 0.0449 0.5271 0.983
Brugia malayi Cell death specification protein 2 0.001 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0203 0.232 0.4326
Echinococcus granulosus neutral amino acid transporter A 0.0457 0.5362 1
Echinococcus granulosus neutral amino acid transporter A 0.0457 0.5362 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0598 0.0598
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0121 0.0121
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0162 0.0301
Schistosoma mansoni ferritin 0.0009 0.0004 0.0008
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0121 0.0226
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0512 0.0942
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.0142 0.0411
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0303 0.0303
Onchocerca volvulus 0.001 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0121 0.0226
Loa Loa (eye worm) hypothetical protein 0.0103 0.1124 0.2085
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0006
Loa Loa (eye worm) intermediate filament protein 0.0087 0.0935 0.1731
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0121 0.0211
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0121 0.0211
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0121 0.0226
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Brugia malayi CXXC zinc finger family protein 0.0032 0.0269 0.0487
Brugia malayi Doublecortin family protein 0.0023 0.0162 0.0286
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0142 0.2648
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0121 0.0121
Brugia malayi Latrophilin receptor protein 2 0.0103 0.1124 0.2085
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0552
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0073 0.0765 0.1414
Brugia malayi putative neuropeptide receptor 0.0019 0.0121 0.0211
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0121 0.0226
Echinococcus granulosus protocadherin 11 0.001 0.0015 0.0028
Schistosoma mansoni amine GPCR 0.0019 0.0121 0.0226
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0142 0.0257
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0103 0.1124 0.2097
Schistosoma mansoni hypothetical protein 0.001 0.0015 0.0028
Onchocerca volvulus 0.0268 0.3103 0.5781
Onchocerca volvulus 0.0034 0.0303 0.0552
Schistosoma mansoni amine GPCR 0.0019 0.0121 0.0226
Onchocerca volvulus 0.0034 0.0303 0.0551
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0303 0.0566
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.001 0.0015 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0303 0.0566
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0121 0.0226
Brugia malayi hypothetical protein 0.001 0.0015 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0073 0.0765 0.1414
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0765 0.1414
Echinococcus granulosus fmrfamide receptor 0.0019 0.0121 0.0226
Echinococcus granulosus protocadherin 11 0.001 0.0015 0.0028
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0598 0.0598
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0121 0.0226
Echinococcus granulosus orexin receptor type 2 0.0019 0.0121 0.0226
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0121 0.0226
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0012
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.0142 0.0411
Schistosoma mansoni opsin-like receptor 0.0019 0.0121 0.0226
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0203 0.232 0.232
Brugia malayi hypothetical protein 0.0019 0.0121 0.0211
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0073 0.0765 0.1427
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0121 0.0226
Loa Loa (eye worm) glutaminase 0.0288 0.3347 0.6236
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.0142 0.0411
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0073 0.0765 0.1427
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0121 0.0226
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0142 0.0257
Brugia malayi hypothetical protein 0.0023 0.0162 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0073 0.0765 0.1414
Loa Loa (eye worm) hypothetical protein 0.004 0.0376 0.0687
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0121 0.0226
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0457 0.5362 1
Schistosoma mansoni amine GPCR 0.0019 0.0121 0.0226
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0142 0.0257
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0099 0.0185
Brugia malayi RNA recognition motif domain containing protein 0.0261 0.3016 0.5618
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0364 0.0364
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0087 0.0935 0.1731
Echinococcus multilocularis neutral amino acid transporter A 0.0457 0.5362 0.5362
Brugia malayi nuclear hormone receptor 0.0073 0.0765 0.1414
Echinococcus multilocularis protocadherin 11 0.001 0.0015 0.0015
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.0303 0.0552
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0203 0.232 0.4318
Brugia malayi N-terminal motif family protein 0.0198 0.2266 0.4217
Brugia malayi conserved hypotetical protein 0.0034 0.0303 0.0552
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0121 0.0211
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0121 0.0226
Loa Loa (eye worm) DR-78 0.0034 0.0303 0.0552
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0121 0.0226
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0325 0.3789 0.7062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Schistosoma mansoni hypothetical protein 0.0103 0.1124 0.2097
Treponema pallidum glutamate/aspartate transporter 0.0202 0.2316 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0142 0.6907
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0121 0.0211
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0142 0.0257
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0552
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0121 0.0121
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0121 0.0211
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0142 0.0412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0121 0.0226
Brugia malayi Dopamine receptor 0.0019 0.0121 0.0211
Brugia malayi Steroid receptor seven-up type 2 0.0073 0.0765 0.1414
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0008 0.0008
Echinococcus granulosus Excitatory amino acid transporter 0.0457 0.5362 1
Brugia malayi hypothetical protein 0.001 0.0015 0.0012
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.0303 0.0566
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0765 0.1427
Echinococcus multilocularis musashi 0.0087 0.0935 0.0935
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0073 0.0765 0.1427
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0073 0.0765 0.1427
Schistosoma mansoni apoferritin-2 0.0009 0.0004 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0073 0.0765 0.1414
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0353 0.0644
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0303 0.0566
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0142 0.0257
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0142 0.0257
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0303 0.0552
Loa Loa (eye worm) glutaminase 2 0.0288 0.3347 0.6236
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Loa Loa (eye worm) hypothetical protein 0.0073 0.0765 0.1414
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0121 0.0121
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0303 0.0303
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0121 0.0121
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0121 0.0226
Onchocerca volvulus 0.0019 0.0121 0.0211
Schistosoma mansoni retinoic acid receptor RXR 0.0073 0.0765 0.1427
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0552
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.0303 0.0552
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.001 0.0015 0.0015
Brugia malayi hypothetical protein 0.0019 0.0121 0.0211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Schistosoma mansoni amine GPCR 0.0019 0.0121 0.0226
Schistosoma mansoni par domain protein 0.001 0.0015 0.0028
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0103 0.1124 0.2097
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0121 0.0211
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0121 0.0211
Brugia malayi latrophilin 2 splice variant baaae 0.0222 0.2556 0.4758
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.045 0.0826
Brugia malayi cytochrome P450 0.0021 0.0142 0.025
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0012
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0121 0.0226
Loa Loa (eye worm) excitatory amino acid transporter 0.0457 0.5362 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.2389 0.2389
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0099 0.1482
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0707 0.1319
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.0142 0.0411
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0142 0.0265
Trichomonas vaginalis set domain proteins, putative 0.0268 0.3103 0.927
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0121 0.0226
Schistosoma mansoni coup transcription factor 0.0073 0.0765 0.1427
Brugia malayi nuclear hormone receptor 0.0034 0.0303 0.0552
Brugia malayi hypothetical protein 0.0019 0.0121 0.0211
Schistosoma mansoni hypothetical protein 0.0021 0.0142 0.0265
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0142 0.2112
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0121 0.0121
Brugia malayi hypothetical protein 0.0019 0.0121 0.0211
Echinococcus granulosus g protein coupled receptor 0.0019 0.0121 0.0226
Echinococcus granulosus hypothetical protein 0.0019 0.0121 0.0226
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.0303 0.0303
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0121 0.0121
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0121 0.0211
Schistosoma mansoni transcriptional factor nfil3/e4bp4 0.001 0.0015 0.0028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Schistosoma mansoni cpg binding protein 0.0033 0.0291 0.0542
Leishmania major cytochrome p450-like protein 0.0021 0.0142 0.2628
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Loa Loa (eye worm) hypothetical protein 0.0042 0.0395 0.0722
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0552
Loa Loa (eye worm) hypothetical protein 0.0198 0.2266 0.4217
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0598 0.1102
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0121 0.0226
Brugia malayi steroid hormone receptor 0.0073 0.0765 0.1414
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.0142 0.0411
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0103 0.1124 0.1124
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0073 0.0765 0.1427
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0008 0.0015
Schistosoma mansoni hypothetical protein 0.0103 0.1124 0.2097
Echinococcus multilocularis GPCR, family 2 0.0103 0.1124 0.1124
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0103 0.1124 0.2085
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.0121 0.0211
Entamoeba histolytica hypothetical protein 0.0039 0.0364 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0303 0.0566
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0039 0.0353 0.0353
Brugia malayi Serotonin receptor 0.0019 0.0121 0.0211
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0073 0.0765 0.1427
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0142 0.2648
Loa Loa (eye worm) hypothetical protein 0.0073 0.0765 0.1414
Loa Loa (eye worm) cytochrome P450 0.0021 0.0142 0.025
Brugia malayi hypothetical protein 0.001 0.0015 0.0012
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0008 0.0015
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0121 0.0121
Onchocerca volvulus 0.0019 0.0121 0.0211
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0552
Onchocerca volvulus 0.0019 0.0121 0.0211
Brugia malayi nuclear receptor RXR 0.0034 0.0303 0.0552
Echinococcus granulosus ecdysone induced protein 78C 0.0073 0.0765 0.1427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0073 0.0765 0.1414
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.0142 0.0411
Schistosoma mansoni cpg binding protein 0.0032 0.0269 0.0502
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0121 0.0226
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.0303 0.0552
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.0303 0.0552
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0121 0.0121
Entamoeba histolytica hypothetical protein 0.0039 0.0364 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.0142 0.0411
Onchocerca volvulus 0.0023 0.0162 0.0286
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Mycobacterium leprae putative cytochrome p450 0.0021 0.0142 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0552
Schistosoma mansoni neuropeptide receptor 0.0019 0.0121 0.0226
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0512 0.0942
Schistosoma mansoni zinc finger protein 0.0034 0.0303 0.0566
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0142 0.025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0121 0.0121
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0512 0.0956
Brugia malayi nuclear receptor NHR-88 0.0073 0.0765 0.1414
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0142 0.0257
Schistosoma mansoni opsin-like receptor 0.0019 0.0121 0.0226
Treponema pallidum glutamate transporter 0.0202 0.2316 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.0303 0.0552
Schistosoma mansoni hypothetical protein 0.0325 0.3787 0.7064
Brugia malayi TAR-binding protein 0.0261 0.3016 0.5618
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0039 0.0353 0.0644
Onchocerca volvulus 0.0019 0.0121 0.0211
Brugia malayi MH2 domain containing protein 0.0131 0.1461 0.2715
Schistosoma mansoni ferritin 0.0009 0.0004 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0103 0.1124 0.1124
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0457 0.5362 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0142 0.0257
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0202 0.2316 0.2316
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0303 0.0566
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0023 0.0028
Leishmania major cytochrome p450-like protein 0.0021 0.0142 0.2628
Schistosoma mansoni steroid hormone receptor ad4bp 0.0073 0.0765 0.1427
Brugia malayi Intermediate filament tail domain containing protein 0.0087 0.0935 0.1731
Onchocerca volvulus 0.0087 0.0935 0.1731
Schistosoma mansoni cpg binding protein 0.0033 0.0291 0.0542
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.1461 0.2715
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.0303 0.0566
Onchocerca volvulus 0.001 0.0015 0.0012
Onchocerca volvulus 0.0019 0.0121 0.0211
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.2389 0.4456
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0142 0.0257
Brugia malayi hypothetical protein 0.0019 0.0121 0.0211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0142 0.0596
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0203 0.232 0.232
Echinococcus multilocularis tar DNA binding protein 0.0261 0.3016 0.3016
Loa Loa (eye worm) hypothetical protein 0.0222 0.2556 0.4758
Brugia malayi Cytochrome P450 family protein 0.0031 0.0262 0.0474
Schistosoma mansoni tar DNA-binding protein 0.0261 0.3016 0.5624
Brugia malayi Hepatic leukemia factor 0.001 0.0015 0.0012
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0765 0.1427
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0364 0.068
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0121 0.0121
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0121 0.0211
Brugia malayi Cytochrome P450 family protein 0.0067 0.0694 0.1281
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.0303 0.0303
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Schistosoma mansoni ap endonuclease 0.0021 0.0142 0.0265
Echinococcus multilocularis dnaJ subfamily B 0.0449 0.5271 0.5271
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0262 0.0474
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0303 0.0552
Schistosoma mansoni biogenic amine receptor 0.0019 0.0121 0.0226
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.0303 0.0552
Brugia malayi intermediate filament protein 0.0087 0.0935 0.1731
Schistosoma mansoni ferritin light chain 0.0009 0.0004 0.0008
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0142 0.2628
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0121 0.0121
Brugia malayi larval opioid receptor 0.0019 0.0121 0.0211
Brugia malayi neuropeptide F receptor 0.0019 0.0121 0.0211
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.0142 0.0411
Brugia malayi nuclear receptor RXR 0.0039 0.0353 0.0644
Onchocerca volvulus Protein ultraspiracle homolog 0.0073 0.0765 0.1414
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0303 0.0303
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0121 0.0211
Onchocerca volvulus 0.0019 0.0121 0.0211
Echinococcus multilocularis somatostatin receptor 0.0019 0.0121 0.0121
Echinococcus granulosus GPCR family 2 0.0103 0.1124 0.2097
Onchocerca volvulus 0.0019 0.0121 0.0211
Echinococcus granulosus dnaJ subfamily B 0.0449 0.5271 0.983
Loa Loa (eye worm) hypothetical protein 0.0039 0.0353 0.0644
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0552
Schistosoma mansoni ferritin 0.0009 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0099 0.0177
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0008 0.0008
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0598 0.1116
Brugia malayi Serotonin receptor 0.0019 0.0121 0.0211
Loa Loa (eye worm) hypothetical protein 0.0073 0.0765 0.1414
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.0142 0.0411
Brugia malayi bZIP transcription factor family protein 0.001 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0073 0.0765 0.1414
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0162 0.0162
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.0303 0.0566
Schistosoma mansoni cytochrome P450 0.0021 0.0142 0.0265
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0457 0.5362 0.5362
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0512 0.0956
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0121 0.0121
Echinococcus granulosus excitatory amino acid transporter 3 0.0457 0.5362 1
Brugia malayi hypothetical protein 0.0019 0.0121 0.0211
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.1461 0.2715
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.0303 0.0566
Loa Loa (eye worm) hypothetical protein 0.0073 0.0765 0.1414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0121 0.0226
Brugia malayi sulfakinin receptor protein 0.0019 0.0121 0.0211
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0121 0.0226
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0353 0.0644
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0364 0.068
Schistosoma mansoni hypothetical protein 0.0023 0.0162 0.0301
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0073 0.0765 0.1414
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0203 0.232 0.4318
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0353 0.0658
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0162 0.0301
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0765 0.1414
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Echinococcus granulosus neuropeptide receptor 0.0019 0.0121 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0073 0.0765 0.1414
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0073 0.0765 0.1414
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0319 0.3717 0.6933
Schistosoma mansoni rab6-interacting 0.0023 0.0162 0.0301
Schistosoma mansoni hypothetical protein 0.0039 0.0364 0.068
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0142 0.0257
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0121 0.0211
Schistosoma mansoni polycystin 1-related 0.0023 0.0162 0.0301
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0008 0.0015
Schistosoma mansoni neuropeptide receptor 0.0019 0.0121 0.0226
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0099 0.0185
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0457 0.5362 1
Echinococcus granulosus allatostatin A receptor 0.0019 0.0121 0.0226
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0512 0.0956
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0121 0.0121
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0765 0.1427
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0121 0.0226
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0303 0.0303
Echinococcus granulosus excitatory amino acid transporter 2 0.0457 0.5362 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0121 0.0226
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0262 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.0142 0.0411
Schistosoma mansoni ferritin 0.0009 0.0004 0.0008
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0142 0.0257
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0142 0.0412
Mycobacterium leprae Conserved hypothetical protein 0.0021 0.0142 1
Onchocerca volvulus 0.0087 0.0935 0.1731
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0552
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Brugia malayi hypothetical protein 0.0034 0.0303 0.0552
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.0142 0.0411
Schistosoma mansoni hypothetical protein 0.0103 0.1124 0.2097
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.0142 0.0411
Echinococcus multilocularis lamin dm0 0.0087 0.0935 0.0935
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0142 0.0257
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0121 0.0226
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0121 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0765 0.1414
Echinococcus granulosus sex peptide receptor 0.0019 0.0121 0.0226
Echinococcus multilocularis FTZ F1 alpha 0.0073 0.0765 0.0765
Schistosoma mansoni intermediate filament proteins 0.0087 0.0935 0.1743
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0121 0.0226
Loa Loa (eye worm) hypothetical protein 0.0087 0.0935 0.1731
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0073 0.0765 0.1427
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.0142 0.0411
Echinococcus granulosus intermediate filament protein 0.0087 0.0935 0.1743
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0211
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0121 0.0226
Loa Loa (eye worm) bZIP transcription factor family protein 0.001 0.0015 0.0012
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0395 0.0736
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0121 0.0226
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0008 0.0008
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0142 0.2628
Onchocerca volvulus 0.0052 0.0512 0.0942
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.0303 0.0552
Onchocerca volvulus 0.0073 0.0765 0.1414

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Activity at human EAAT2 expressed in HEK293 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assay ChEMBL. 19161278
Activity (binding) Activity at human EAAT3 expressed in HEK293 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assay ChEMBL. 19161278
Activity (binding) Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells ChEMBL. 19161278
Activity (binding) Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells ChEMBL. 19161278
Activity (binding) Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells ChEMBL. 19161278
Activity (binding) Activity at human EAAT1 expressed in HEK293 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assay ChEMBL. 19161278
Activity (functional) = 0 % Potency (100 uM) to induce a transport current in the absence of glutamate in oocytes expressing human excitatory amino acid transporter 1 (EAAT1) ChEMBL. 11078189
Activity (functional) = 0 % Potency (100 uM) to induce a transport current in the absence of glutamate in oocytes expressing human excitatory amino acid transporter 2 (EAAT2) ChEMBL. 11078189
Activity (functional) = 0 % Potency (100 uM) to induce a transport current in the presence of glutamate in oocytes expressing human excitatory amino acid transporter 2 (EAAT2) ChEMBL. 11078189
Activity (functional) = 0 % Potency (100 uM) to induce a transport current in the absence of glutamate in oocytes expressing human excitatory amino acid transporter 3 (EAAT3) ChEMBL. 11078189
Activity (functional) = 12.7 % Potency (100 uM) to induce a transport current in the presence of glutamate in oocytes expressing human excitatory amino acid transporter 3 (EAAT3) ChEMBL. 11078189
Activity (functional) = 30.1 % Potency (100 uM) to induce a transport current in the presence of glutamate in oocytes expressing human excitatory amino acid transporter 1 (EAAT1) ChEMBL. 11078189
IC50 (binding) = 5 Inhibition of glutamate-induced depolarization in human EAAT3 expressed in HEK293 cells by FMP assay ChEMBL. 18578477
IC50 (binding) = 5.5 Inhibition of glutamate-induced depolarization in human EAAT1 expressed in HEK293 cells by FMP assay ChEMBL. 18578477
IC50 (binding) = 5.7 Inhibition of glutamate-induced depolarization in human EAAT2 expressed in HEK293 cells by FMP assay ChEMBL. 18578477
IC50 (binding) = 2.2 uM Inhibition of glutamate-induced depolarization in human EAAT2 expressed in HEK293 cells by FMP assay ChEMBL. 18578477
IC50 (binding) = 2.9 uM Inhibition of glutamate-induced depolarization in human EAAT1 expressed in HEK293 cells by FMP assay ChEMBL. 18578477
IC50 (binding) = 7 uM Concentration required for blocking [14C]-glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 2 ChEMBL. 11078189
IC50 (binding) = 8 uM Concentration required for blocking [14C]-glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3 ChEMBL. 11078189
IC50 (binding) = 9.3 uM Inhibition of glutamate-induced depolarization in human EAAT3 expressed in HEK293 cells by FMP assay ChEMBL. 18578477
IC50 (binding) = 48 uM Concentration required for blocking [14C]-glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 1 ChEMBL. 11078189

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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