Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Leishmania major | squalene synthase, putative | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Methionine aminopeptidase protein type I | 0.144354 | 1 | 0.5 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.144354 | 1 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.144354 | 1 | 1 |
Toxoplasma gondii | methionine aminopeptidase | 0.144354 | 1 | 1 |
Treponema pallidum | methionine aminopeptidase (map) | 0.117043 | 0.766654 | 0.5 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.144354 | 1 | 1 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.117043 | 0.766654 | 0.766654 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.144354 | 1 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.117043 | 0.766654 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase | 0.117043 | 0.766654 | 0.766654 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.117043 | 0.766654 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.117043 | 0.766654 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.0295602 | 0.0192128 | 0.0192128 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.117043 | 0.766654 | 0.5 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.117043 | 0.766654 | 0.5 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.144354 | 1 | 1 |
Leishmania major | squalene synthase, putative | 0.0295602 | 0.0192128 | 0.0192128 |
Trypanosoma cruzi | squalene synthase, putative | 0.0295602 | 0.0192128 | 0.0192128 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.117043 | 0.766654 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.117043 | 0.766654 | 0.766654 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.117043 | 0.766654 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.144354 | 1 | 1 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.144354 | 1 | 0.5 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.117043 | 0.766654 | 0.5 |
Trypanosoma brucei | squalene synthase, putative | 0.0295602 | 0.0192128 | 0.0192128 |
Chlamydia trachomatis | methionine aminopeptidase | 0.117043 | 0.766654 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.144354 | 1 | 1 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.144354 | 1 | 1 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.144354 | 1 | 1 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.144354 | 1 | 0.5 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.117043 | 0.766654 | 0.5 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.117043 | 0.766654 | 0.766654 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21(DE3 pLysS) by liquid scintillation counter | ChEMBL. | 17709461 | |
IC50 (binding) | > 1 uM | Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter | ChEMBL. | 17709461 |
IC50 (functional) | = 15 uM | Antiplasmodial activity after 48 hrs against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 in human erythrocytes by [3H]hypoxanthine uptake | ChEMBL. | 17709461 |
IC50 (functional) | = 22.4 uM | Trypanocidal activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream form after 72 hrs by resazurin assay | ChEMBL. | 17709461 |
IC50 (functional) | = 51.1 uM | Antitrypanosomal activity against trypomastigotes of Trypanosoma cruzi Tulahuen C2C4 containing lacZ gene in rat L6 cells after 4 days by chlorophenol red-beta-D-galactopyranoside/Nonidet assay | ChEMBL. | 17709461 |
IC50 (functional) | = 72.4 uM | Antileishmanial activity against Leishmania donovani MHOM/ET/67/L82 axenic amastigotes after 72 hrs by resazurin assay | ChEMBL. | 17709461 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 17709461 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.