Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | urotensin 2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.2299 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0112 | 0.6806 | 0.8837 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0063 | 0.3345 | 1 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0063 | 0.3345 | 1 |
Brugia malayi | glutathione reductase | 0.0049 | 0.2299 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0049 | 0.2299 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0.2299 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0017 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0049 | 0.2299 | 0.2985 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0112 | 0.6806 | 0.8837 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.2299 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.0063 | 0.3345 | 0.4343 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0112 | 0.6806 | 0.7945 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0063 | 0.3345 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0124 | 0.7701 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.2299 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0112 | 0.6806 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0112 | 0.6806 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0124 | 0.7701 | 1 |
Treponema pallidum | NADH oxidase | 0.0017 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (LuxR-family) | 0.0063 | 0.3345 | 0.4343 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0017 | 0 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0.2299 | 1 |
Mycobacterium tuberculosis | Possible transcriptional regulatory protein | 0.0063 | 0.3345 | 0.4343 |
Mycobacterium ulcerans | putative regulatory protein | 0.0063 | 0.3345 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0124 | 0.7701 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.2299 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0124 | 0.7701 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0112 | 0.6806 | 0.8837 |
Mycobacterium tuberculosis | Possible two component transcriptional regulatory protein (probably LuxR-family) | 0.0063 | 0.3345 | 0.4343 |
Leishmania major | trypanothione reductase | 0.0049 | 0.2299 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0112 | 0.6806 | 0.8837 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0.2299 | 1 |
Mycobacterium tuberculosis | Possible nitrate/nitrite response transcriptional regulatory protein NarL | 0.0063 | 0.3345 | 0.4343 |
Mycobacterium ulcerans | hypothetical protein | 0.0063 | 0.3345 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.2299 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0049 | 0.2299 | 0.5 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (probably LuxR/UhpA-family) | 0.0063 | 0.3345 | 0.4343 |
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0.2299 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.2299 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 10 nM | Displacement of [I125]hU2 from human recombinant urotensin 2 receptor expressed in HEK293 cells | ChEMBL. | 18573659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.