Detailed information for compound 981931

Basic information

Technical information
  • TDR Targets ID: 981931
  • Name: 4-[(5-methyl-1H-pyrazol-3-yl)amino]-7-methyls ulfanyl-2-propan-2-ylphthalazin-1-one
  • MW: 329.42 | Formula: C16H19N5OS
  • H donors: 2 H acceptors: 2 LogP: 2.6 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc2c(c1)c(=O)n(nc2Nc1n[nH]c(c1)C)C(C)C
  • InChi: 1S/C16H19N5OS/c1-9(2)21-16(22)13-8-11(23-4)5-6-12(13)15(20-21)17-14-7-10(3)18-19-14/h5-9H,1-4H3,(H2,17,18,19,20)
  • InChiKey: SFPSMNFXHNJPKC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-isopropyl-4-[(5-methyl-1H-pyrazol-3-yl)amino]-7-methylsulfanyl-phthalazin-1-one
  • 2-isopropyl-4-[(5-methyl-1H-pyrazol-3-yl)amino]-7-(methylthio)-1-phthalazinone
  • 2-isopropyl-4-[(5-methyl-1H-pyrazol-3-yl)amino]-7-(methylthio)phthalazin-1-one
  • 4-[(5-methyl-1H-pyrazol-3-yl)amino]-7-methylsulfanyl-2-propan-2-yl-phthalazin-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens spleen tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum ko:K05855 spleen tyrosine kinase, putative Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Echinococcus multilocularis tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus TRP transient receptor potential channel 0.0014 0.0123 0.0244
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0123 0.0116
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0123 0.0244
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0213 0.3821 1
Echinococcus granulosus transient receptor potential gamma protein 0.0014 0.0123 0.0244
Loa Loa (eye worm) voltage-gated potassium channel 0.0014 0.0123 0.0249
Schistosoma mansoni nicotinate phosphoribosyltransferase 0.0048 0.0755 0.0748
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0213 0.3821 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0014 0.0123 0.0244
Echinococcus multilocularis nicotinamide phosphoribosyltransferase 0.0258 0.4674 0.977
Echinococcus multilocularis potassium large conductance calcium activated 0.0014 0.0123 0.0244
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0014 0.0123 0.0244
Leishmania major hypothetical protein, unknown function 0.0014 0.0123 0.0028
Echinococcus multilocularis two pore calcium channel protein 1 0.0014 0.0123 0.0244
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0014 0.0123 0.0116
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0014 0.0123 0.0244
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0014 0.0123 0.0116
Echinococcus multilocularis transient receptor potential gamma protein 0.0014 0.0123 0.0244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Echinococcus multilocularis ryanodine receptor 44f 0.0014 0.0123 0.0244
Brugia malayi cation channel family protein 0.0014 0.0123 0.0116
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0014 0.0123 0.0116
Trypanosoma cruzi nicotinate phosphoribosyltransferase, putative 0.0048 0.0755 0.0666
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0123 0.0244
Echinococcus granulosus voltage dependent calcium channel 0.0014 0.0123 0.0244
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0123 0.0244
Echinococcus granulosus ryanodine receptor 44f 0.0014 0.0123 0.0244
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0123 0.0244
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0123 0.0244
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0014 0.0123 0.0116
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0126 0.0249
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Schistosoma mansoni ryanodine receptor related 0.0014 0.0123 0.0116
Schistosoma mansoni dehydrodolichyl diphosphate synthase (dedol-pp synthase) 0.0013 0.0095 0.0088
Entamoeba histolytica nicotinate phosphoribosyltransferase, putative 0.0048 0.0755 0.1961
Loa Loa (eye worm) voltage-gated calcium channel 0.0014 0.0123 0.0249
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0014 0.0123 0.0244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Echinococcus multilocularis potassium voltage gated channel protein 0.0014 0.0123 0.0244
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0014 0.0123 0.0244
Brugia malayi Zinc finger, C2H2 type family protein 0.0213 0.3821 0.3817
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0014 0.0123 0.0244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0213 0.3821 0.7984
Schistosoma mansoni dihydroorotate dehydrogenase 0.0544 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Brugia malayi voltage-dependent calcium channel 0.0014 0.0123 0.0116
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0123 0.0244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0014 0.0123 0.0244
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0014 0.0123 0.0116
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0126 0.0249
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0544 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0123 0.0075
Toxoplasma gondii hypothetical protein 0.0014 0.0123 0.0028
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0014 0.0123 0.0116
Leishmania major hypothetical protein, conserved 0.0014 0.0123 0.0028
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0123 0.0244
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB1 0.0048 0.0755 0.0755
Loa Loa (eye worm) ion channel NompC 0.0014 0.0123 0.0249
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0544 1 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0014 0.0123 0.0244
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0014 0.0123 1
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.0258 0.4674 0.467
Schistosoma mansoni dehydrodolichyl diphosphate synthase (dedol-pp synthase) 0.0013 0.0095 0.0088
Schistosoma mansoni vesicular amine transporter 0.0014 0.0123 0.0116
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0123 0.0244
Echinococcus multilocularis calcium activated potassium channel 0.0014 0.0123 0.0244
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0123 0.0244
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0014 0.0123 0.0244
Schistosoma mansoni transient receptor potential channel 0.0014 0.0123 0.0116
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0126 0.0249
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0014 0.0123 0.0244
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0014 0.0123 0.0116
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0014 0.0123 0.0244
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0014 0.0123 0.0116
Brugia malayi Cyclic-nucleotide gated cation channel 0.0014 0.0123 0.0116
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0544 1 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0213 0.3821 0.7984
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0544 1 1
Schistosoma mansoni tyrosine kinase 0.0264 0.4784 0.478
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0123 0.0116
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0014 0.0123 0.0244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Onchocerca volvulus 0.0014 0.0123 1
Echinococcus multilocularis sodium leak channel non selective protein 0.0014 0.0123 0.0244
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0123 0.0249
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0014 0.0123 0.0116
Echinococcus multilocularis short transient receptor potential channel 6 0.0014 0.0123 0.0244
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0544 1 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0014 0.0123 0.0244
Schistosoma mansoni hypothetical protein 0.0014 0.0123 0.0116
Echinococcus granulosus dehydrodolichyl diphosphate synthase 0.0013 0.0095 0.0185
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0014 0.0123 0.0116
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0014 0.0123 0.0244
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0123 0.0116
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0213 0.3821 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0014 0.0123 0.0116
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0014 0.0123 0.0116
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0544 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0123 0.0116
Echinococcus multilocularis conserved hypothetical protein 0.0014 0.0123 0.0244
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0014 0.0123 0.0116
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0123 0.0244
Echinococcus granulosus sodium channel protein 0.0014 0.0123 0.0244
Echinococcus granulosus potassium large conductance calcium activated 0.0014 0.0123 0.0244
Leishmania major nicotinate phosphoribosyltransferase, putative 0.0048 0.0755 0.0666
Schistosoma mansoni dehydrodolichyl diphosphate synthase (dedol-pp synthase) 0.0013 0.0095 0.0088
Echinococcus multilocularis voltage dependent calcium channel 0.0014 0.0123 0.0244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0014 0.0123 0.0028
Toxoplasma gondii hypothetical protein 0.0014 0.0123 0.0028
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0544 1 1
Echinococcus granulosus shaker cognate 0.0014 0.0123 0.0244
Toxoplasma gondii transporter, cation channel family protein 0.0014 0.0123 0.0028
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0014 0.0123 0.0244
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0014 0.0123 0.0028
Echinococcus granulosus hypothetical protein 0.0014 0.0123 0.0244
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0014 0.0123 0.0028
Echinococcus granulosus tyrosine protein kinase shark 0.0264 0.4784 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Toxoplasma gondii transporter, cation channel family protein 0.0014 0.0123 0.0028
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0123 0.0116
Echinococcus granulosus sodium leak channel non selective protein 0.0014 0.0123 0.0244
Echinococcus multilocularis two pore calcium channel protein 2 0.0014 0.0123 0.0244
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0123 0.0244
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0213 0.3821 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0123 0.0244
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0123 0.0116
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0544 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0123 0.0244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0014 0.0123 0.0244
Echinococcus granulosus calcium activated potassium channel 0.0014 0.0123 0.0244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0123 0.0116
Loa Loa (eye worm) voltage-dependent calcium channel 0.0014 0.0123 0.0249
Onchocerca volvulus Dehydrodolichyl diphosphate synthase homolog 0.0013 0.0095 0.7592
Schistosoma mansoni transient receptor potential channel 0.0014 0.0123 0.0116
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0123 0.0116
Echinococcus multilocularis tyrosine protein kinase shark 0.0264 0.4784 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0213 0.3821 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0014 0.0123 0.0244
Echinococcus multilocularis potassium voltage gated channel protein 0.0014 0.0123 0.0244
Trypanosoma brucei nicotinate phosphoribosyltransferase, putative 0.0048 0.0755 0.0666
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.0048 0.0755 0.0748
Echinococcus multilocularis shaker cognate 0.0014 0.0123 0.0244
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0014 0.0123 0.0116
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0544 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0123 0.0244
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0014 0.0123 0.0116
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0123 0.0244
Schistosoma mansoni transient receptor potential channel 0.0014 0.0126 0.0119
Schistosoma mansoni transient receptor potential channel 4 0.0014 0.0123 0.0116
Brugia malayi Undecaprenyl diphosphate synthase family protein 0.0013 0.0095 0.0088
Schistosoma mansoni 60S ribosomal protein L21 0.0014 0.0123 0.0116
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0123 0.0116
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0123 0.0244
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0123 0.0244
Echinococcus multilocularis voltage dependent calcium channel 0.0014 0.0123 0.0244
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0123 0.0244
Loa Loa (eye worm) hypothetical protein 0.0013 0.0095 0.0189
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0544 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0014 0.0123 0.0244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Loa Loa (eye worm) ryanodine receptor 0.0014 0.0123 0.0249
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0213 0.3821 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0123 0.0244
Loa Loa (eye worm) calcium channel 0.0014 0.0123 0.0249
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Echinococcus multilocularis transfer RNA-Gly 0.0014 0.0123 0.0244
Schistosoma mansoni voltage-dependent calcium channel 0.0014 0.0123 0.0116
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0014 0.0123 0.0116
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0123 0.0116
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0123 0.0244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0014 0.0123 0.0244
Schistosoma mansoni calcium-activated potassium channel 0.0014 0.0123 0.0116
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0123 0.0249
Echinococcus granulosus two pore calcium channel protein 1 0.0014 0.0123 0.0244
Plasmodium falciparum nicotinate phosphoribosyltransferase, putative 0.0048 0.0755 0.0666
Schistosoma mansoni two-pore calcium channel 0.0014 0.0123 0.0116
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0014 0.0123 0.0244
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0014 0.0123 0.0028
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0544 1 1
Schistosoma mansoni voltage-gated ion channel 0.0014 0.0123 0.0116
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0014 0.0123 0.0244
Brugia malayi hypothetical protein 0.0014 0.0123 0.0116
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0123 0.0244
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0213 0.3821 1
Loa Loa (eye worm) pre-B cell enhancing factor 0.0258 0.4674 1
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Brugia malayi olfactory channel protein osm-9 0.0014 0.0126 0.0119
Loa Loa (eye worm) voltage-gated potassium channel 0.0014 0.0123 0.0249
Echinococcus multilocularis potassium voltage gated channel protein 0.0014 0.0123 0.0244
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0123 0.0244
Echinococcus granulosus nicotinamide phosphoribosyltransferase 0.0258 0.4674 0.977
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0123 0.0028
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0014 0.0123 0.0244
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0123 0.0028
Schistosoma mansoni voltage-gated cation channel 0.0014 0.0123 0.0116
Echinococcus granulosus voltage dependent calcium channel 0.0014 0.0123 0.0244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0014 0.0123 0.0244
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0014 0.0123 0.0116
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0014 0.0123 1
Treponema pallidum nicotinate phosphoribosyltransferase 0.0048 0.0755 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0123 0.0116
Brugia malayi ion channel NompC 0.0014 0.0123 0.0116
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0213 0.3821 0.3761
Trichomonas vaginalis nicotinate phosphoribosyltransferase, putative 0.0048 0.0755 0.177
Toxoplasma gondii transporter, cation channel family protein 0.0014 0.0123 0.0028
Loa Loa (eye worm) hypothetical protein 0.0014 0.0126 0.0255
Echinococcus granulosus two pore calcium channel protein 2 0.0014 0.0123 0.0244
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0014 0.0123 0.0028
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Echinococcus multilocularis short transient receptor potential channel 6 0.0014 0.0126 0.0249
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0014 0.0123 0.0116
Brugia malayi Transient-receptor-potential like protein 0.0014 0.0123 0.0116
Schistosoma mansoni tyrosine kinase 0.0258 0.4669 0.4665
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0123 0.0244
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0014 0.0123 0.0244
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Giardia lamblia Undecaprenyl pyrophosphate synthase 0.0013 0.0095 0.5
Plasmodium falciparum dihydroorotate dehydrogenase 0.0544 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0123 0.0244
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0123 0.0244
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0014 0.0123 0.0249
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0213 0.3821 0.7984
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Echinococcus multilocularis sodium channel protein 0.0014 0.0123 0.0244
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0123 0.0244
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0014 0.0123 0.0116
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0123 0.0244
Echinococcus granulosus short transient receptor potential channel 6 0.0014 0.0126 0.0249
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0014 0.0123 0.0244
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0123 0.0116
Leishmania major dihydroorotate dehydrogenase 0.0544 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0123 0.0244
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0014 0.0123 0.0244
Echinococcus multilocularis potassium voltage gated channel protein 0.0014 0.0123 0.0244
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0213 0.3821 0.7984
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0014 0.0123 0.0244
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0123 0.0075
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB2 0.0048 0.0755 0.0755
Chlamydia trachomatis isoprenyl transferase 0.0013 0.0095 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0123 0.0116
Echinococcus granulosus short transient receptor potential channel 6 0.0014 0.0123 0.0244
Brugia malayi Pre-B cell enhancing factor precursor 0.0258 0.4674 0.467
Brugia malayi cation channel family protein 0.0014 0.0123 0.0116
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0123 0.0244
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0014 0.0123 0.0116
Echinococcus granulosus voltage gated hydrogen channel 1 0.0014 0.0123 0.0244
Echinococcus multilocularis dehydrodolichyl diphosphate synthase 0.0013 0.0095 0.0185
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0249

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1570 nM Inhibition of recombinant Syk ChEMBL. 19254842

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.