Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | leukotriene A4 hydrolase | Starlite/ChEMBL | References |
Mus musculus | leukotriene A4 hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | leukotriene A4 hydrolase | 611 aa | 513 aa | 24.0 % |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | leukotriene A4 hydrolase | 611 aa | 508 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aminopeptidase n, putative | 0.003 | 0.0307 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.003 | 0.0307 | 0.0307 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.003 | 0.0307 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.003 | 0.0307 | 0.0307 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0558 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0.0307 | 0.5 | |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.003 | 0.0307 | 0.5 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.003 | 0.0307 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0307 | 0.0307 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.003 | 0.0307 | 0.0307 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.003 | 0.0307 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0307 | 0.0307 |
Trypanosoma cruzi | aminopeptidase, putative | 0.003 | 0.0307 | 0.5 |
Brugia malayi | hypothetical protein | 0.0256 | 0.447 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.0581 | 0.0581 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0307 | 0.0307 |
Brugia malayi | Peptidase family M1 containing protein | 0.003 | 0.0307 | 0.0687 |
Brugia malayi | hypothetical protein | 0.003 | 0.0307 | 0.0687 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.003 | 0.0307 | 0.5 |
Toxoplasma gondii | aminopeptidase N protein | 0.003 | 0.0307 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.003 | 0.0307 | 0.0307 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.003 | 0.0307 | 0.5 |
Toxoplasma gondii | aminopeptidase N, putative | 0.003 | 0.0307 | 0.5 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.003 | 0.0307 | 0.5 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.003 | 0.0307 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0581 | 0.0581 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.003 | 0.0307 | 0.0307 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.003 | 0.0307 | 0.5 |
Trypanosoma brucei | aminopeptidase, putative | 0.003 | 0.0307 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.003 | 0.0307 | 0.0307 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.003 | 0.0307 | 0.5 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.003 | 0.0307 | 0.0307 |
Trypanosoma cruzi | aminopeptidase, putative | 0.003 | 0.0307 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.003 | 0.0307 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.003 | 0.0307 | 0.0307 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0527 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.003 | 0.0307 | 0.0307 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0656 | 0.0656 |
Onchocerca volvulus | 0.003 | 0.0307 | 0.5 | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.003 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.003 | 0.0307 | 0.0307 |
Schistosoma mansoni | Tata binding protein associated factor (M01 family) | 0.003 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.003 | 0.0307 | 0.0307 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.003 | 0.0307 | 0.5 |
Brugia malayi | TATA binding protein associated factor | 0.003 | 0.0307 | 0.0687 |
Brugia malayi | hypothetical protein | 0.003 | 0.0307 | 0.0687 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0558 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.0581 | 0.0581 |
Brugia malayi | Peptidase family M1 containing protein | 0.003 | 0.0307 | 0.0687 |
Onchocerca volvulus | 0.003 | 0.0307 | 0.5 | |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.003 | 0.0307 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0473 | 0.0473 |
Entamoeba histolytica | aminopeptidase, putative | 0.003 | 0.0307 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0558 | 1 | 1 |
Schistosoma mansoni | aminopeptidase A (M01 family) | 0.003 | 0.0307 | 0.0307 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.003 | 0.0307 | 0.0307 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.003 | 0.0307 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0656 | 0.0656 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.003 | 0.0307 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.003 | 0.0307 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.003 | 0.0307 | 0.0307 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.003 | 0.0307 | 0.5 |
Loa Loa (eye worm) | aminopeptidase N | 0.003 | 0.0307 | 0.0307 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.0581 | 0.1299 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.003 | 0.0307 | 0.0307 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0527 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.003 | 0.0307 | 0.0307 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.003 | 0.0307 | 0.0307 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.003 | 0.0307 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.003 | 0.0307 | 0.0687 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.003 | 0.0307 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.003 | 0.0307 | 0.0307 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11 nM | Inhibition of human recombinant leukotriene A4 hydrolase by enzyme immunoassay | ChEMBL. | 18588282 |
IC50 (binding) | = 88 nM | Inhibition of leukotriene A4 hydrolase activity in CD1 mouse whole blood assessed as A-23187-stimulated LTB4 production after 15 mins by enzyme immunoassay | ChEMBL. | 18588282 |
IC50 (binding) | > 10 uM | Inhibition of dofetilide binding to human ERG by patch clamp assay | ChEMBL. | 23127888 |
IC50 (binding) | > 30 uM | Displacement of [3H]astemizole from human ERG potassium channel expressed in HEK293 cell membrane | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human adenosine A1 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human adenosine A3 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human beta 1 adrenergic receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human AT1 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human ETA receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human bradykinin B2 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human dopamine D1 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human GAL2 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human CXCR2 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human MC4 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human substance NK2 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human neuropeptide Y1 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human neuropeptide Y2 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human NTS1 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human kappa opioid receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human mu opioid receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human ORL1 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of 5HT1B receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human 5HT2A receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human 5HT5A receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human 5HT7 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human VIP1 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human NET at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human dopamine D2 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human CCR1 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of histamine H2 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human muscarinic M1 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human muscarinic M2 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human muscarinic M3 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human neuromedin K receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human 5HT1A receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human 5HT3 receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human vasopressin V1a receptor at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | < 10 % | Inhibition of human DAT at 1 uM | ChEMBL. | 18588282 |
Inhibition (binding) | = 20 % | Inhibition of human DAT | ChEMBL. | 18588282 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.