Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0191 | 0.035 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.0883 | 0.0841 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.054 | 0.4582 | 0.6801 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.2394 | 0.2359 |
Trichomonas vaginalis | AGC family protein kinase | 0.0166 | 0.0046 | 0.6444 |
Onchocerca volvulus | 0.0189 | 0.033 | 0.0033 | |
Schistosoma mansoni | atypical protein kinase C | 0.029 | 0.1557 | 0.2265 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0716 | 0.6715 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0168 | 0.0072 | 0.0084 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0191 | 0.035 | 0.0456 |
Trichomonas vaginalis | AGC family protein kinase | 0.0166 | 0.0046 | 0.6444 |
Loa Loa (eye worm) | hypothetical protein | 0.0822 | 0.7993 | 0.7984 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0235 | 0.0883 | 0.1256 |
Trichomonas vaginalis | AGC family protein kinase | 0.0166 | 0.0046 | 0.6444 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0417 | 0.3088 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0168 | 0.0072 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.033 | 0.0285 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0235 | 0.0883 | 0.1256 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0254 | 0.1111 | 0.1069 |
Schistosoma mansoni | serine/threonine protein kinase | 0.054 | 0.4582 | 0.6801 |
Trichomonas vaginalis | AGC family protein kinase | 0.0168 | 0.0072 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.054 | 0.4582 | 0.6801 |
Echinococcus granulosus | protein kinase c iota type | 0.029 | 0.1557 | 0.2265 |
Toxoplasma gondii | AGC kinase | 0.0166 | 0.0046 | 0.5 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0235 | 0.0883 | 0.1256 |
Trichomonas vaginalis | AGC family protein kinase | 0.0168 | 0.0072 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0415 | 0.3071 | 0.4536 |
Trichomonas vaginalis | AGC family protein kinase | 0.0168 | 0.0072 | 1 |
Onchocerca volvulus | 0.0822 | 0.7993 | 1 | |
Brugia malayi | Protein kinase c protein 2 | 0.0378 | 0.2621 | 0.3861 |
Brugia malayi | Protein kinase domain containing protein | 0.0168 | 0.0072 | 0.0038 |
Echinococcus granulosus | protein kinase C gamma type | 0.0415 | 0.3071 | 0.4536 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0716 | 0.6715 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0168 | 0.0072 | 0.0084 |
Trichomonas vaginalis | AGC family protein kinase | 0.0168 | 0.0072 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0168 | 0.0072 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0168 | 0.0072 | 1 |
Brugia malayi | protein kinase C II. | 0.0716 | 0.6715 | 1 |
Schistosoma mansoni | protein kinase C mu | 0.0191 | 0.035 | 0.0456 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.054 | 0.4582 | 0.6801 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0304 | 0.0259 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0168 | 0.0072 | 0.0026 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0577 | 0.5023 | 0.7463 |
Trichomonas vaginalis | AGC family protein kinase | 0.0168 | 0.0072 | 1 |
Brugia malayi | C1-like domain containing protein | 0.0191 | 0.035 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0822 | 0.7993 | 0.7984 |
Echinococcus multilocularis | protein kinase c iota type | 0.029 | 0.1557 | 0.2265 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0168 | 0.0072 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0716 | 0.6715 | 0.6699 |
Loa Loa (eye worm) | hypothetical protein | 0.0947 | 0.9504 | 0.9501 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0415 | 0.3062 | 0.4523 |
Loa Loa (eye worm) | hypothetical protein | 0.0822 | 0.7993 | 0.7984 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0716 | 0.6715 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 10'1 ug/ml | Inhibition of p56 lck | ChEMBL. | 1479375 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.