Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0356 | 0.1326 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0912 | 1 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0356 | 0.1326 | 0.1326 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0356 | 0.1326 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0356 | 0.1326 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.0912 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0912 | 1 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0271 | 0 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0912 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0912 | 1 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0912 | 1 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0912 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0356 | 0.1326 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0912 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0356 | 0.1326 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0356 | 0.1326 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0356 | 0.1326 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0356 | 0.1326 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0912 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0356 | 0.1326 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0912 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0356 | 0.1326 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0912 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0912 | 1 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0271 | 0 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0912 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0912 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0356 | 0.1326 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 25 uM | Cytotoxicity against human A498 cells after 48 hrs by SRB binding assay | ChEMBL. | 18508272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.