Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin | 0.0028 | 0.2706 | 0.1768 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.2706 | 0.1768 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.2599 | 0.9606 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0021 | 0.1139 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.2706 | 0.1768 |
Schistosoma mansoni | lamin | 0.0028 | 0.2706 | 0.1768 |
Onchocerca volvulus | 0.0028 | 0.2706 | 1 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0028 | 0.2531 | 0.9354 |
Loa Loa (eye worm) | doublecortin family protein | 0.0021 | 0.1139 | 0.4209 |
Echinococcus granulosus | lamin | 0.0028 | 0.2706 | 0.1768 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0021 | 0.1139 | 0.5 |
Onchocerca volvulus | 0.0028 | 0.2706 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.2706 | 1 |
Brugia malayi | hypothetical protein | 0.0021 | 0.1139 | 0.4209 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.2706 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.2706 | 0.1768 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.2706 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.2706 | 0.1768 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0028 | 0.2706 | 0.1768 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1139 | 0.4209 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1139 | 0.4209 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 1 | 0.5 |
Brugia malayi | Doublecortin family protein | 0.0021 | 0.1139 | 0.4209 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.2706 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.2706 | 1 |
Schistosoma mansoni | lamin | 0.0028 | 0.2706 | 0.1768 |
Schistosoma mansoni | lipoxygenase | 0.0058 | 0.8808 | 0.8655 |
Brugia malayi | Cytochrome P450 family protein | 0.0028 | 0.2531 | 0.9354 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 1 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0058 | 0.8808 | 0.8655 |
Brugia malayi | hypothetical protein | 0.0021 | 0.1139 | 0.4209 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0058 | 0.8808 | 0.8655 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 100 mg Kg-1 | Anticonvulsant activity in ip dosed CF1 albino mouse assessed as inhibition of maximal electroshock-induced seizures after 0.5 hrs | ChEMBL. | 18603334 |
Activity (functional) | = 100 mg Kg-1 | Anticonvulsant activity in ip dosed CF1 albino mouse assessed as inhibition of maximal electroshock-induced seizures after 4 hrs | ChEMBL. | 18603334 |
Activity (ADMET) | = 300 mg Kg-1 | Neurotoxicity in ip dosed CF1 albino mouse assessed as ability to maintain equilibrium for 1 min on maze after 0.5 hrs by rotarod test | ChEMBL. | 18603334 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.