Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | leukotriene A4 hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma japonicum | ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus granulosus | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | leukotriene A4 hydrolase | 611 aa | 508 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.0093 | 0.2371 | 0.5 | |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0279 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0391 | 0.0391 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0391 | 0.0391 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0391 | 0.0391 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0391 | 0.0391 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0391 | 0.0391 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0391 | 0.0756 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0279 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.4249 | 0.4249 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.4249 | 0.4249 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0391 | 0.0391 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0391 | 0.0391 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0128 | 0.38 | 0.7343 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0162 | 0.5175 | 0.5175 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0162 | 0.5175 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0162 | 0.5175 | 0.5175 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0162 | 0.5175 | 0.5175 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0222 | 0.7669 | 0.5 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0279 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0162 | 0.5175 | 0.5175 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0391 | 0.0391 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.