Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0376 | 0.2605 | 0.2605 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0376 | 0.2605 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0376 | 0.2605 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0046 | 0.0224 | 0.0605 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0214 | 0.0313 |
Schistosoma mansoni | hypothetical protein | 0.0528 | 0.3707 | 0.5423 |
Schistosoma mansoni | hypothetical protein | 0.0155 | 0.1012 | 0.148 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0376 | 0.2605 | 0.3812 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0962 | 0.6835 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0044 | 0.0214 | 0.0313 |
Leishmania major | dihydroorotate dehydrogenase | 0.0962 | 0.6835 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0376 | 0.2605 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0133 | 0.0195 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0962 | 0.6835 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0224 | 0.0605 |
Schistosoma mansoni | hypothetical protein | 0.0155 | 0.1012 | 0.148 |
Brugia malayi | indoleamine 2,3-dioxygenase | 0.0528 | 0.3707 | 0.5423 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0033 | 0.0133 | 0.0195 |
Echinococcus multilocularis | indoleamine 2,3 dioxygenase 2 | 0.0528 | 0.3707 | 0.3707 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0376 | 0.2605 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0376 | 0.2605 | 0.7029 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0962 | 0.6835 | 1 |
Onchocerca volvulus | 0.0044 | 0.0214 | 0.5 | |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0376 | 0.2605 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0216 | 0.1453 | 0.1453 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0962 | 0.6835 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0031 | 0.012 | 0.0176 |
Echinococcus multilocularis | geminin | 0.0155 | 0.1012 | 0.1012 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.012 | 0.0176 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0962 | 0.6835 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0376 | 0.2605 | 0.7029 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0376 | 0.2605 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0044 | 0.0214 | 0.0313 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0962 | 0.6835 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0376 | 0.2605 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0033 | 0.0133 | 0.0359 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0376 | 0.2605 | 0.2605 |
Brugia malayi | hypothetical protein | 0.0216 | 0.1453 | 0.2126 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0962 | 0.6835 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0962 | 0.6835 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0962 | 0.6835 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.012 | 0.0325 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0962 | 0.6835 | 1 |
Echinococcus granulosus | indoleamine 23 dioxygenase 2 | 0.0528 | 0.3707 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0109 | 0.0682 | 0.184 |
Schistosoma mansoni | hypothetical protein | 0.0528 | 0.3707 | 0.5423 |
Loa Loa (eye worm) | indoleamine 2,3-dioxygenase | 0.0528 | 0.3707 | 1 |
Echinococcus granulosus | geminin | 0.0155 | 0.1012 | 0.2729 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0109 | 0.0682 | 0.184 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0046 | 0.0224 | 0.0328 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0133 | 0.0195 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0962 | 0.6835 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0033 | 0.0133 | 0.0133 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0046 | 0.0224 | 0.0328 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0216 | 0.1453 | 0.3919 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.1453 | 0.3919 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0962 | 0.6835 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0109 | 0.0682 | 0.0998 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0962 | 0.6835 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0962 | 0.6835 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0376 | 0.2605 | 0.3812 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 97.6 uM | Antitrypanosomal activity against bloodstream trypomastigote form of Trypanosoma cruzi Y isolated from albino mouse blood after 24 hrs | ChEMBL. | 21450374 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.