Detailed information for compound 982735

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.635 | Formula: C27H44O5
  • H donors: 0 H acceptors: 2 LogP: 6.8 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOC(=O)CC(=O)O[C@H]1C[C@@]2(C)O[C@@](C)(C=C)CC[C@@H]2[C@@]2([C@@H]1C(C)(C)CCC2)C
  • InChi: 1S/C27H44O5/c1-8-10-16-30-21(28)17-22(29)31-19-18-27(7)20(12-15-25(5,9-2)32-27)26(6)14-11-13-24(3,4)23(19)26/h9,19-20,23H,2,8,10-18H2,1,3-7H3/t19-,20+,23-,25-,26+,27+/m0/s1
  • InChiKey: FLQJTWRILTVLCE-ZSTIODBZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0007 0.0111 0.022
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.1416 0.132
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0088 0.0175
Mycobacterium tuberculosis Conserved protein 0.0037 0.1416 0.132
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.1416 0.3393
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0007 0.0111 0.0151
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0414 0.0766
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.1331 0.1806
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0007 0.0111 0.0058
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0007 0.0111 0.022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.1534 0.2836
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0007 0.0111 0.5
Echinococcus granulosus GPCR family 2 0.0016 0.0521 0.0964
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0521 0.0707
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0007 0.0111 0.0058
Brugia malayi DIX domain containing protein 0.0009 0.0195 0.0264
Schistosoma mansoni hypothetical protein 0.0072 0.2906 0.5757
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0414 0.0833
Echinococcus granulosus ras GTP exchange factor 0.0006 0.0088 0.0163
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.1416 0.2644
Leishmania major aldehyde dehydrogenase, putative 0.0007 0.0111 0.022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.237 0.4695
Schistosoma mansoni cpg binding protein 0.003 0.1093 0.2164
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0007 0.0111 0.0031
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.4002 1
Schistosoma mansoni cpg binding protein 0.0028 0.1024 0.2029
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0007 0.0111 0.0058
Mycobacterium leprae conserved hypothetical protein 0.0037 0.1416 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.4002 0.543
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0111 0.022
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.1416 0.1922
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0122 0.0225
Schistosoma mansoni kinase 0.005 0.1947 0.3858
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0007 0.0111 0.0205
Brugia malayi isocitrate dehydrogenase 0.0014 0.0414 0.0562
Loa Loa (eye worm) hypothetical protein 0.0009 0.0195 0.0264
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0096 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0096 0.0018
Echinococcus multilocularis son of sevenless 1 0.0006 0.0088 0.0163
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.4002 1
Schistosoma mansoni dep domain containing protein 0.0009 0.0195 0.0386
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0195 0.0386
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0111 0.022
Entamoeba histolytica hypothetical protein 0.0072 0.2906 0.7199
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0007 0.0111 0.022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0195 0.0264
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.5048 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.5048 0.9332
Loa Loa (eye worm) hypothetical protein 0.0131 0.541 0.734
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0007 0.0111 0.0151
Schistosoma mansoni hypothetical protein 0.0016 0.0521 0.1033
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0014 0.0414 0.0833
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0096 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.1534 0.3039
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.0088 0.0163
Loa Loa (eye worm) hypothetical protein 0.0009 0.0195 0.0264
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0096 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.5048 1
Brugia malayi hypothetical protein 0.0072 0.2906 0.3943
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0007 0.0111 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0096 0.0018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0414 0.0766
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1416 0.3393
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1892 0.4609
Toxoplasma gondii ABC1 family protein 0.0037 0.1416 0.2806
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0007 0.0111 0.0205
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0007 0.0111 0.0058
Trichomonas vaginalis esterase, putative 0.0037 0.1416 0.3393
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.1416 0.132
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0007 0.0111 0.0205
Entamoeba histolytica hypothetical protein 0.0072 0.2906 0.7199
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1416 0.3393
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.2906 0.5757
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.5048 0.9332
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0096 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0096 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0111 0.022
Loa Loa (eye worm) hypothetical protein 0.0131 0.541 0.734
Leishmania major hypothetical protein, conserved 0.0037 0.1416 0.2806
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0014 0.0414 0.0766
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0014 0.0414 1
Brugia malayi N-terminal motif family protein 0.0006 0.0088 0.012
Toxoplasma gondii hypothetical protein 0.0009 0.0195 0.0386
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0414 0.0821
Brugia malayi hypothetical protein 0.0009 0.0195 0.0264
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0088 0.0175
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0521 0.0707
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.1416 0.2618
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0007 0.0111 0.0058
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.1024 0.1389
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.1416 0.132
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0122 0.0241
Trichomonas vaginalis helicase, putative 0.0006 0.0096 0.0018
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.1416 0.132
Brugia malayi beta-lactamase family protein 0.0037 0.1416 0.1922
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0007 0.0111 0.0205
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0521 0.0964
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0075 0.0149
Loa Loa (eye worm) hypothetical protein 0.0037 0.1416 0.1922
Loa Loa (eye worm) hypothetical protein 0.0052 0.2029 0.2753
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0195 0.0264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.1534 0.3039
Mycobacterium tuberculosis Conserved protein 0.0037 0.1416 0.132
Brugia malayi aldehyde dehydrogenase 0.0007 0.0111 0.0151
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0007 0.0111 0.0058
Brugia malayi N-terminal motif family protein 0.0177 0.737 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.004 0.1534 0.2081
Loa Loa (eye worm) hypothetical protein 0.0037 0.1416 0.1922
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.2906 0.5372
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0122 0.0225
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0414 0.0779
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0195 0.0264
Loa Loa (eye worm) hypothetical protein 0.0037 0.1416 0.1922
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0007 0.0111 0.0205
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.5048 1
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0007 0.0111 0.0058
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.4002 0.7399
Brugia malayi Aldehyde dehydrogenase protein 4 0.0007 0.0111 0.0151
Leishmania major aldehyde dehydrogenase, putative 0.0007 0.0111 0.022
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.0088 0.0163
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0414 0.0821
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0096 0.0018
Schistosoma mansoni hypothetical protein 0.0016 0.0521 0.1033
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0007 0.0111 0.0205
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.5048 1
Schistosoma mansoni cpg binding protein 0.003 0.1093 0.2164
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.0088 0.0163
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.4002 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.1416 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.4002 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1416 0.3393
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0195 0.036
Brugia malayi RasGEF domain containing protein 0.0006 0.0088 0.012
Schistosoma mansoni dishevelled 0.0009 0.0195 0.0386
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.4002 0.7929
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0096 0.0018
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0007 0.0111 0.0205
Brugia malayi hypothetical protein 0.0009 0.0195 0.0264
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.4002 0.7929
Loa Loa (eye worm) hypothetical protein 0.0035 0.1331 0.1806
Onchocerca volvulus 0.0009 0.0195 0.0146
Mycobacterium ulcerans beta-lactamase 0.0037 0.1416 0.2644
Echinococcus multilocularis Protein son of sevenless 0.0006 0.0088 0.0163
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.004 0.1534 0.2081
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0088 0.012
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.1416 0.2644
Schistosoma mansoni hypothetical protein 0.0016 0.0521 0.1033
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0088 0.012
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.4002 0.543
Loa Loa (eye worm) aldehyde dehydrogenase 0.0007 0.0111 0.0151
Mycobacterium ulcerans hypothetical protein 0.0037 0.1416 0.2644
Echinococcus granulosus cpg binding protein 0.003 0.1093 0.202
Trypanosoma brucei polo-like protein kinase 0.0098 0.4002 1
Schistosoma mansoni hypothetical protein 0.0016 0.0521 0.1033
Brugia malayi RasGEF domain containing protein 0.0006 0.0088 0.012
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0007 0.0111 0.0058
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0007 0.0111 0.0151
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0014 0.0414 0.0307
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0007 0.0111 0.0058
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.0088 0.0163
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0195 0.036
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.1416 0.132
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0088 0.0175
Echinococcus multilocularis GPCR, family 2 0.0016 0.0521 0.0964
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.5048 0.4993
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0007 0.0111 0.0205
Schistosoma mansoni hypothetical protein 0.0035 0.1331 0.2637
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0111 0.022
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.737 1
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0007 0.0111 0.0058
Loa Loa (eye worm) hypothetical protein 0.0007 0.0111 0.0151
Loa Loa (eye worm) hypothetical protein 0.0037 0.1416 0.1922
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0007 0.0111 0.022
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0195 0.036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.5048 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.4002 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.4002 0.7399
Treponema pallidum gamma-glutamyl phosphate reductase 0.0007 0.0111 0.5
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0195 0.0264
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0414 0.0821
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0111 0.022
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0007 0.0111 0.0058
Mycobacterium ulcerans lipase LipD 0.0037 0.1416 0.2644
Echinococcus granulosus muscleblind protein 0.0131 0.541 1
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0007 0.0111 0.0205
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.2029 0.2753
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.5048 1
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0195 0.0386
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0088 0.012
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.1416 0.132
Brugia malayi beta-lactamase family protein 0.0037 0.1416 0.1922
Onchocerca volvulus 0.0037 0.1416 0.1824
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0096 0.0018
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0195 0.036
Loa Loa (eye worm) isocitrate dehydrogenase 0.0014 0.0414 0.0562
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.1416 0.2806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0096 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.4002 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0521 0.0707
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.4002 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0122 0.0225
Onchocerca volvulus 0.0037 0.1416 0.1824
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0007 0.0111 0.0058
Giardia lamblia Kinase, PLK 0.0098 0.4002 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.1024 0.1389
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0521 0.0964
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0096 0.0018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0521 0.0964
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.1416 0.2618
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0096 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.1534 0.3039
Loa Loa (eye worm) hypothetical protein 0.0037 0.1416 0.1922
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0195 0.036
Schistosoma mansoni dishevelled 0.0009 0.0195 0.0386
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0088 0.0175
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.019 0.0258
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0195 0.0264
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0195 0.036
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0195 0.036
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.1416 0.3393
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0195 0.0386
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0521 0.0964
Loa Loa (eye worm) hypothetical protein 0.0177 0.737 1
Brugia malayi beta-lactamase 0.0037 0.1416 0.1922
Echinococcus granulosus Protein son of sevenless 0.0006 0.0088 0.0163
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.1416 0.3393
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.1534 0.2836
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.2906 0.5372
Loa Loa (eye worm) beta-lactamase 0.0037 0.1416 0.1922
Brugia malayi RasGEF domain containing protein 0.0006 0.0088 0.012
Echinococcus multilocularis muscleblind protein 0.0131 0.541 1
Schistosoma mansoni hypothetical protein 0.0007 0.0111 0.022
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.1416 0.132
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0007 0.0111 0.0058
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0088 0.0175
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.2029 0.2753
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.4002 0.5375
Onchocerca volvulus 0.0028 0.1024 0.1285
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.012
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0014 0.0414 0.0766
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.1416 0.2806
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0195 0.036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.1534 0.2836
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0195 0.036
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0195 0.036
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.0088 0.0163
Brugia malayi N-terminal motif family protein 0.0006 0.0088 0.012
Echinococcus granulosus son of sevenless 1 0.0006 0.0088 0.0163
Onchocerca volvulus 0.0037 0.1416 0.1824
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0007 0.0111 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.4002 1
Entamoeba histolytica hypothetical protein 0.0072 0.2906 0.7199
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0014 0.0414 0.0779
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0007 0.0111 0.022
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0007 0.0111 0.0058
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0122 0.0225
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0014 0.0414 0.0821
Plasmodium vivax hypothetical protein, conserved 0.0037 0.1416 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.1416 0.3393
Echinococcus multilocularis muscleblind protein 1 0.0131 0.541 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.4002 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0096 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1892 0.4609
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0414 0.0766
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.2098 0.4156
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.012
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0195 0.0264
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0007 0.0111 0.0058
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0195 0.0146
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.5048 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.1416 0.132
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0521 0.0707
Brugia malayi Isocitrate dehydrogenase 0.0014 0.0414 0.0562
Loa Loa (eye worm) hypothetical protein 0.0007 0.0111 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0096 0.0018
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.1416 0.3354
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0007 0.0111 0.022
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0195 0.036
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.4002 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0096 0.0018
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0195 0.0264
Entamoeba histolytica hypothetical protein 0.0072 0.2906 0.7199
Echinococcus multilocularis cpg binding protein 0.003 0.1093 0.202
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0096 0.0018
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0007 0.0111 0.022
Leishmania major aldehyde dehydrogenase, putative 0.0007 0.0111 0.022
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.2029 0.2753
Echinococcus multilocularis isocitrate dehydrogenase 0.0014 0.0414 0.0766
Loa Loa (eye worm) hypothetical protein 0.0037 0.1416 0.1922
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0007 0.0111 0.0058
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0195 0.036
Brugia malayi Muscleblind-like protein 0.0131 0.541 0.734
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.1416 0.1922
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.1534 0.2836
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0007 0.0111 0.022

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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