Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.2595 | 0.3233 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.2595 | 0.3233 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 1 | 1 |
Trypanosoma brucei | ABC transporter, putative | 0.0023 | 0.8027 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.6737 | 0.8194 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.2595 | 0.2595 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.2595 | 0.3233 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.2595 | 0.3233 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0008 | 0.0883 | 0.0546 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.2595 | 0.2595 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.2595 | 0.2595 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.2595 | 0.3233 |
Leishmania major | ATP-binding cassette protein subfamily G, member 4, putative | 0.0023 | 0.8027 | 0.7836 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0008 | 0.0883 | 0.11 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.2595 | 0.3233 |
Giardia lamblia | ABC transporter | 0.0023 | 0.79 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.2595 | 0.3233 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0883 | 0.0546 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.2595 | 0.3233 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.6211 | 0.6071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.2595 | 0.2595 |
Schistosoma mansoni | ABC transporter | 0.0019 | 0.6365 | 0.793 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.2595 | 0.2595 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0883 | 0.0546 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.2595 | 0.2595 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.2595 | 0.2595 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0023 | 0.8027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.2595 | 0.2595 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.2595 | 0.1878 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.2595 | 0.3233 |
Entamoeba histolytica | ABC transporter, putative | 0.0023 | 0.8027 | 0.7836 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.6238 | 0.7771 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.2595 | 0.2595 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.2595 | 0.2595 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0008 | 0.0883 | 0.11 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.2595 | 0.2595 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.2595 | 0.3233 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.2595 | 0.2595 |
Trypanosoma brucei | ATP-binding cassette protein, putative | 0.0023 | 0.8027 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.6211 | 0.6071 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.2595 | 0.3233 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.2595 | 0.3233 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.2595 | 0.3233 |
Brugia malayi | ABC transporter family protein | 0.0019 | 0.6365 | 0.6365 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0023 | 0.8027 | 0.7836 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0008 | 0.0883 | 0.0546 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.2595 | 0.3233 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.2595 | 0.3233 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.2595 | 0.3233 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0023 | 0.8027 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.2595 | 0.3233 |
Loa Loa (eye worm) | oxidoreductase | 0.0008 | 0.0883 | 0.0883 |
Trypanosoma cruzi | ATP-binding cassette protein, putative | 0.0023 | 0.8027 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 1 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0023 | 0.8027 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.2595 | 0.2595 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.2595 | 0.3233 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0008 | 0.0883 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0883 | 0.0883 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0023 | 0.8027 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.2595 | 0.2595 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.2595 | 0.2595 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0008 | 0.0883 | 0.0883 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0008 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.2595 | 0.2595 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.2595 | 0.2595 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.6737 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.6737 | 0.6737 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 1 | 1 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0008 | 0.0883 | 0.11 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0023 | 0.8027 | 0.7836 |
Onchocerca volvulus | 0.0012 | 0.2595 | 0.1878 | |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.2595 | 0.2595 |
Brugia malayi | AMP-binding enzyme family protein | 0.0008 | 0.0883 | 0.0883 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 1 | 1 |
Schistosoma mansoni | ATP-binding cassette sub-family g2 (white protein) (abcg2) | 0.0023 | 0.8027 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0008 | 0.0883 | 0.0883 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.2595 | 0.3233 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.2595 | 0.3233 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.002 | 0.6737 | 0.6421 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.6211 | 0.6071 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0883 | 0.0546 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.2595 | 0.3233 |
Leishmania major | ATP-binding cassette protein subfamily G, member 6, putative | 0.0023 | 0.8027 | 0.7836 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.2595 | 0.3233 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.2595 | 0.2595 |
Toxoplasma gondii | ATP-binding cassette G family transporter ABCG84 | 0.0023 | 0.8027 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.2595 | 0.2595 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.6211 | 0.6071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.2595 | 0.2595 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.2595 | 0.3233 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.2595 | 0.2595 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0008 | 0.0883 | 0.0546 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0008 | 0.0883 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.2595 | 0.2595 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0008 | 0.0883 | 0.0546 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.2595 | 0.2595 |
Plasmodium vivax | ABC transporter G family member 2, putative | 0.0023 | 0.8027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0883 | 0.0883 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0008 | 0.0883 | 0.0883 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.2595 | 0.3233 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.6737 | 0.6737 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0023 | 0.8027 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.2595 | 0.2595 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.2595 | 0.2595 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0023 | 0.8027 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.2595 | 0.2595 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.2595 | 0.1878 |
Trypanosoma cruzi | ABC transporter, putative | 0.0023 | 0.8027 | 1 |
Loa Loa (eye worm) | ABC transporter | 0.0019 | 0.6365 | 0.6365 |
Plasmodium falciparum | ABC transporter G family member 2 | 0.0023 | 0.8027 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.2595 | 0.2595 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.2595 | 0.2595 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.2595 | 0.3233 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.2595 | 0.3233 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.2595 | 0.2595 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.2595 | 0.3233 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 1 | 1 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0008 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.6737 | 0.6737 |
Brugia malayi | AMP-binding enzyme family protein | 0.0008 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.6737 | 0.6737 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.2595 | 0.3233 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0023 | 0.8027 | 0.7836 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 1 | 1 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.2595 | 0.3233 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.2595 | 0.3233 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.2595 | 0.1878 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0008 | 0.0883 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.6737 | 0.6737 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0008 | 0.0883 | 0.0546 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.2595 | 0.3233 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 1 | 1 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0883 | 0.0546 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane ATP-binding protein ABC transporter | 0.0019 | 0.6238 | 0.6099 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0008 | 0.0883 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.2595 | 0.2595 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.6737 | 0.6617 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0008 | 0.0883 | 0.0883 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.6737 | 0.8194 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0027 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 100 uM | Cytotoxicity against mock-infected human MT4 cells by MTT assay | ChEMBL. | 18954921 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.