Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0462 | 0.1496 | 0.1496 |
Toxoplasma gondii | phosphorylase family protein | 0.0462 | 0.1496 | 0.5 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0462 | 0.1496 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0462 | 0.1496 | 0.1496 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0462 | 0.1496 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0462 | 0.1496 | 0.5 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Trypanosoma brucei | uridine phosphorylase | 0.0462 | 0.1496 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Schistosoma mansoni | uridine phosphorylase | 0.0462 | 0.1496 | 0.1496 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.223 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1768 | 0.7779 | 0.7389 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0462 | 0.1496 | 0.5 |
Toxoplasma gondii | phosphorylase family protein | 0.0462 | 0.1496 | 0.5 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Treponema pallidum | pfs protein (pfs) | 0.0462 | 0.1496 | 0.5 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.223 | 1 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.223 | 1 | 0.5 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0462 | 0.1496 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1768 | 0.7779 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.223 | 1 | 1 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0462 | 0.1496 | 0.5 |
Schistosoma mansoni | uridine phosphorylase | 0.0462 | 0.1496 | 0.1496 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0462 | 0.1496 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1768 | 0.7779 | 0.7389 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Chlamydia trachomatis | AMP nucleosidase | 0.0462 | 0.1496 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.223 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.1768 | 0.7779 | 0.7389 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0462 | 0.1496 | 0.1496 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 1.05 10'-5M | Growth inhibition of human HT-29 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
GI50 (functional) | = 8.19 10'-6M | Growth inhibition of human A549 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
GI50 (functional) | > 100 mM | Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
LC50 (functional) | > 100 mM | Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
LC50 (functional) | > 100 mM | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
LC50 (functional) | > 100 mM | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
TGI (functional) | = 1.68 10'-5M | Growth inhibition of human A549 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
TGI (functional) | > 100 mM | Growth inhibition of human HT-29 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
TGI (functional) | > 100 mM | Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.