Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0067 | 0.2803 | 0.2803 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0067 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.0255 | 0.0908 |
Loa Loa (eye worm) | glutathione reductase | 0.0194 | 1 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0255 | 0.0255 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0255 | 0.0255 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0067 | 0.2803 | 1 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0067 | 0.2803 | 0.2803 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0.0255 | 1 |
Schistosoma mansoni | cytochrome c | 0.0033 | 0.0881 | 0.0881 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0.0255 | 0.0255 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0067 | 0.2803 | 0.2803 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0067 | 0.2803 | 0.2803 |
Echinococcus multilocularis | cytochrome c | 0.0033 | 0.0881 | 0.0881 |
Loa Loa (eye worm) | cytochrome c type-1 | 0.0033 | 0.0881 | 0.0881 |
Brugia malayi | Cytochrome c type-1 | 0.0033 | 0.0881 | 0.0881 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Plasmodium falciparum | glutathione reductase | 0.0067 | 0.2803 | 0.2803 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0255 | 0.0255 |
Trypanosoma brucei | trypanothione reductase | 0.0194 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0067 | 0.2803 | 0.2803 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0255 | 0.0908 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0194 | 1 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0067 | 0.2803 | 0.2803 |
Brugia malayi | Thioredoxin reductase | 0.0194 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0067 | 0.2803 | 0.2803 |
Wolbachia endosymbiont of Brugia malayi | cytochrome c2 | 0.0033 | 0.0881 | 0.3143 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0067 | 0.2803 | 1 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Trypanosoma cruzi | cytochrome c, putative | 0.0033 | 0.0881 | 0.0881 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0067 | 0.2803 | 0.2803 |
Plasmodium falciparum | cytochrome c, putative | 0.0033 | 0.0881 | 0.0881 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0255 | 0.0908 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0255 | 0.0255 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0255 | 0.0255 |
Plasmodium vivax | cytochrome c, putative | 0.0033 | 0.0881 | 0.0881 |
Trypanosoma brucei | cytochrome c | 0.0033 | 0.0881 | 0.0881 |
Plasmodium vivax | glutathione reductase, putative | 0.0194 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0194 | 1 | 1 |
Leishmania major | cytochrome c, putative | 0.0033 | 0.0881 | 0.0881 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.0255 | 0.0255 |
Leishmania major | cytochrome c, putative | 0.0033 | 0.0881 | 0.0881 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0067 | 0.2803 | 0.2803 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0049 | 0.179 | 0.179 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0067 | 0.2803 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0194 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0067 | 0.2803 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0067 | 0.2803 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0255 | 0.0255 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0067 | 0.2803 | 0.2803 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0067 | 0.2803 | 0.2803 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.0255 | 0.0255 |
Echinococcus granulosus | cytochrome c | 0.0033 | 0.0881 | 0.0881 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.0255 | 0.0255 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0049 | 0.179 | 0.179 |
Plasmodium falciparum | thioredoxin reductase | 0.0067 | 0.2803 | 0.2803 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0067 | 0.2803 | 0.2803 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.0255 | 0.0255 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0067 | 0.2803 | 0.2803 |
Leishmania major | trypanothione reductase | 0.0194 | 1 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0067 | 0.2803 | 0.2803 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0067 | 0.2803 | 0.2803 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0194 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0067 | 0.2803 | 0.2803 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0255 | 0.0255 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0255 | 0.0908 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0067 | 0.2803 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0067 | 0.2803 | 0.2803 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0067 | 0.2803 | 0.2803 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.0255 | 0.0255 |
Trypanosoma cruzi | cytochrome c, putative | 0.0033 | 0.0881 | 0.0881 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0067 | 0.2803 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0067 | 0.2803 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0255 | 0.0255 |
Toxoplasma gondii | thioredoxin reductase | 0.0194 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0255 | 0.0908 |
Toxoplasma gondii | cytochrome c, putative | 0.0033 | 0.0881 | 0.0881 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Plasmodium falciparum | thioredoxin reductase | 0.0194 | 1 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0067 | 0.2803 | 0.2803 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0194 | 1 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0067 | 0.2803 | 0.2803 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0194 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0067 | 0.2803 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0255 | 0.0908 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0194 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0067 | 0.2803 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0067 | 0.2803 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.