TDR Targets

Basic information

Technical information

TDR Targets ID: 984106
Name: 3-chloro-1-[2,6-difluoro-4-(4-methylpiperazin -1-yl)phenyl]-4-[(2,4-difluorophenyl)methoxy] -6-methylpyridin-2-one
MW: 495.897 | Formula: C24H22ClF4N3O2
H donors: 0 H acceptors: 1 LogP: 4.68 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)c1cc(F)c(c(c1)F)n1c(C)cc(c(c1=O)Cl)OCc1ccc(cc1F)F
InChi: 1S/C24H22ClF4N3O2/c1-14-9-21(34-13-15-3-4-16(26)10-18(15)27)22(25)24(33)32(14)23-19(28)11-17(12-20(23)29)31-7-5-30(2)6-8-31/h3-4,9-12H,5-8,13H2,1-2H3
InChiKey: GQNDLBHAIXJGDR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-chloro-1-[2,6-difluoro-4-(4-methylpiperazin-1-yl)phenyl]-4-[(2,4-difluorophenyl)methoxy]-6-methyl-pyridin-2-one
3-chloro-1-[2,6-difluoro-4-(4-methyl-1-piperazinyl)phenyl]-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-pyridinone
3-chloro-4-(2,4-difluorobenzyl)oxy-1-[2,6-difluoro-4-(4-methylpiperazin-1-yl)phenyl]-6-methyl-2-pyridone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	smdr2	0.001	0.0056	0.0017
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0123	0.0129
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0056	0.02
Loa Loa (eye worm)	hypothetical protein	0.0438	0.5469	1
Brugia malayi	jmjC domain containing protein	0.0016	0.0123	0.0129
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.001	0.0056	0.2255
Schistosoma mansoni	hypothetical protein	0.0077	0.0901	0.442
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0053	0.0184
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0053	0.0184
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.0662	0.1125
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0056	0.02
Schistosoma mansoni	protein phosphatase 2C	0.0016	0.0128	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0123	0.0129
Loa Loa (eye worm)	hypothetical protein	0.001	0.0056	0.0006
Echinococcus multilocularis	jumonji domain containing 1A	0.0016	0.0123	0.0541
Brugia malayi	jmjC domain containing protein	0.0058	0.0662	0.1125
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.001	0.0056	0.0006
Brugia malayi	P38 map kinase family protein 2	0.0152	0.1849	0.3317
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0053	0.0184
Leishmania major	hypothetical protein, conserved	0.0077	0.0901	0.2819
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0053	0.0184
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0056	0.2255
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0056	0.02
Trichomonas vaginalis	abcb9, putative	0.001	0.0056	0.2255
Trypanosoma brucei	protein phosphatase 2C, putative	0.0021	0.0191	0.0232
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0056	0.2255
Brugia malayi	hypothetical protein	0.0035	0.0368	0.0581
Toxoplasma gondii	protein phosphatase 2C domain-containing protein	0.0021	0.0191	1
Echinococcus granulosus	mitogen activated protein kinase 14	0.0152	0.1849	0.9373
Echinococcus granulosus	phd:f box containing protein	0.0016	0.0123	0.0541
Trichomonas vaginalis	protein phosphatase type 2C, putative	0.0021	0.0191	1
Schistosoma mansoni	phd/f-box containing protein	0.0016	0.0123	0.0364
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0152	0.1849	0.5891
Loa Loa (eye worm)	runx1	0.0055	0.0622	0.105
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0056	0.02
Leishmania major	hypothetical protein, conserved	0.0016	0.0123	0.0222
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.0662	0.3176
Trypanosoma brucei	squalene synthase, putative	0.0247	0.3054	1
Echinococcus multilocularis	protein phosphatase 1b	0.0141	0.1713	0.8676
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0053	0.0184
Echinococcus multilocularis	protein phosphatase 2C	0.0021	0.0191	0.0889
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0056	0.02
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0152	0.1849	0.3317
Brugia malayi	Protein phosphatase 2C containing protein	0.0021	0.0191	0.0254
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0056	0.2255
Echinococcus multilocularis	Squalene phytoene synthase	0.0077	0.0901	0.4522
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0152	0.1849	0.5983
Echinococcus multilocularis	multidrug resistance protein 1	0.001	0.0056	0.02
Mycobacterium tuberculosis	Probable phytoene synthase PhyA	0.0077	0.0901	0.085
Plasmodium vivax	protein phosphatase PPM2, putative	0.0021	0.0191	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0056	0.2255
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0056	0.2255
Trypanosoma cruzi	squalene synthase, putative	0.0247	0.3054	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0056	0.2255
Entamoeba histolytica	P-glycoprotein-2	0.001	0.0056	0.1532
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0053	0.0184
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0056	0.2255
Loa Loa (eye worm)	hypothetical protein	0.0438	0.5469	1
Schistosoma mansoni	protein phosphatase 2c gamma	0.0021	0.0191	0.0718
Brugia malayi	probable protein phosphatase 2C	0.0021	0.0191	0.0254
Schistosoma mansoni	multidrug resistance protein	0.001	0.0056	0.0017
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0056	0.2255
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0053	0.0184
Giardia lamblia	Ser/Thr phosphatase 2C, putative	0.0021	0.0191	0.5
Echinococcus multilocularis	lysine specific demethylase 5A	0.0058	0.0662	0.3301
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0058	0.0662	0.3301
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0053	0.0184
Giardia lamblia	Phosphatase	0.0021	0.0191	0.5
Entamoeba histolytica	hypothetical protein	0.0035	0.0368	1
Onchocerca volvulus		0.001	0.0056	0.0006
Brugia malayi	jmjC domain containing protein	0.0016	0.0123	0.0129
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0053	0.0184
Onchocerca volvulus	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog	0.0077	0.0901	0.1566
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0056	0.2255
Entamoeba histolytica	P-glycoprotein 5, putative	0.001	0.0056	0.1532
Loa Loa (eye worm)	protein phosphatase 2C containing protein	0.0162	0.1972	0.3544
Schistosoma mansoni	hypothetical protein	0.0035	0.0368	0.1639
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0056	0.2255
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0123	0.0129
Echinococcus granulosus	protein phosphatase 2c	0.0021	0.0191	0.0889
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0016	0.0123	0.0541
Trichomonas vaginalis	abcb9, putative	0.001	0.0056	0.2255
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.1849	0.5891
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0016	0.0123	0.4946
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0016	0.0123	0.4946
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.0055	0.0193
Echinococcus granulosus	protein phosphatase 1b	0.0141	0.1713	0.8676
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0191	0.0254
Entamoeba histolytica	P-glycoprotein-1	0.001	0.0056	0.1532
Trypanosoma brucei	protein phosphatase 2C, putative	0.0021	0.0191	0.0232
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0053	0.0184
Leishmania major	protein phosphatase 2C-like protein	0.0021	0.0191	0.0449
Brugia malayi	jmjC domain containing protein	0.0058	0.0662	0.1125
Echinococcus granulosus	lysine specific demethylase 5A	0.0058	0.0662	0.3301
Loa Loa (eye worm)	hypothetical protein	0.001	0.0056	0.0006
Brugia malayi	Protein phosphatase 2C containing protein	0.0162	0.1972	0.3544
Brugia malayi	multidrug resistance protein 3	0.001	0.0056	0.0006
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0056	0.2255
Echinococcus multilocularis	phd:f box containing protein	0.0016	0.0123	0.0541
Echinococcus multilocularis	Protein lozenge	0.0055	0.0622	0.3093
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0056	0.02
Brugia malayi	jmjC domain containing protein	0.0016	0.0123	0.0129
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.001	0.0056	0.2255
Brugia malayi	hypothetical protein	0.0438	0.5469	1
Loa Loa (eye worm)	multidrug resistance protein 3	0.001	0.0056	0.0006
Entamoeba histolytica	hypothetical protein	0.0035	0.0368	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0053	0.0184
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0053	0.0184
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0056	0.2255
Mycobacterium ulcerans	proteasome PrcA	0.0797	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0053	0.0184
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0123	0.0129
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.1849	0.9373
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0016	0.0123	0.0541
Entamoeba histolytica	hypothetical protein	0.0035	0.0368	1
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0056	0.02
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0056	0.2255
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0053	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0191	0.0254
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.001	0.0055	0.0193
Trypanosoma cruzi	protein phosphatase 2C-like, putative	0.0021	0.0191	0.0232
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0053	0.0184
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0056	0.2255
Trypanosoma cruzi	squalene synthase, putative	0.0247	0.3054	1
Echinococcus multilocularis	protein phosphatase 1b	0.0162	0.1972	1
Trypanosoma cruzi	phytoene synthase, putative	0.0077	0.0901	0.2656
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0123	0.0129
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.1849	0.5891
Schistosoma mansoni	protein phosphatase 2C	0.0141	0.1713	0.8651
Echinococcus granulosus	jumonji domain containing 1A	0.0016	0.0123	0.0541
Schistosoma mansoni	protein phosphatase 2C	0.0162	0.1972	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.0662	0.3176
Entamoeba histolytica	P-glycoprotein-5	0.001	0.0056	0.1532
Trichomonas vaginalis	abcb9, putative	0.001	0.0056	0.2255
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0368	0.1793
Entamoeba histolytica	P-glyco protein 6, putative	0.001	0.0056	0.1532
Entamoeba histolytica	P-glycoprotein-2, putative	0.001	0.0056	0.1532
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0053	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0123	0.0129
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0056	0.2255
Echinococcus multilocularis	lysine specific demethylase 6a	0.0016	0.0123	0.0541
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0056	0.02
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0056	0.02
Echinococcus granulosus	mitogen activated protein kinase 11	0.0152	0.1849	0.9373
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.1849	0.9373
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0056	0.2255
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0056	0.02
Leishmania major	protein phosphatase 2C, putative	0.0021	0.0191	0.0449
Entamoeba histolytica	hypothetical protein	0.0035	0.0368	1
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0797	1	1
Schistosoma mansoni	jumonji domain containing protein	0.0016	0.0123	0.0364
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0016	0.0123	0.4946
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0056	0.2255
Schistosoma mansoni	phosphatidylserine receptor	0.0016	0.0123	0.0364
Trypanosoma cruzi	protein phosphatase 2C, putative	0.0021	0.0191	0.0232
Toxoplasma gondii	protein phosphatase 2C domain-containing protein	0.0021	0.0191	1
Plasmodium vivax	JmjC domain containing protein	0.0016	0.0123	0.4946
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0056	0.2255
Schistosoma mansoni	protein phosphatase 2C	0.0021	0.0191	0.0718
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0368	0.1793
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.1849	0.9373
Schistosoma mansoni	multidrug resistance protein	0.001	0.0056	0.0017
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0056	0.2255
Entamoeba histolytica	P-glycoprotein-2	0.001	0.0056	0.1532
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0053	0.0184
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0056	0.2255
Echinococcus granulosus	protein phosphatase 2c	0.0021	0.0191	0.0889
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.1849	0.9373
Leishmania major	squalene synthase, putative	0.0247	0.3054	1
Echinococcus multilocularis	protein phosphatase 2C	0.0021	0.0191	0.0889
Schistosoma mansoni	jumonji domain containing protein	0.0058	0.0662	0.3176
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0056	0.2255
Echinococcus multilocularis	multidrug resistance protein 1	0.001	0.0056	0.02
Schistosoma mansoni	multidrug resistance protein	0.001	0.0056	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0901	0.1566
Echinococcus multilocularis	JmjC domain containing protein 4	0.0016	0.0123	0.0541
Entamoeba histolytica	protein phosphatase, putative	0.0021	0.0191	0.5191
Echinococcus granulosus	lysine specific demethylase 6a	0.0016	0.0123	0.0541
Loa Loa (eye worm)	hypothetical protein	0.001	0.0055	0.0003
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0058	0.0662	0.3301
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0016	0.0123	0.0364
Echinococcus granulosus	protein phosphatase 1b	0.0162	0.1972	1
Plasmodium falciparum	protein phosphatase PPM2	0.0021	0.0191	1
Schistosoma mansoni	lozenge	0.0055	0.0622	0.2964
Echinococcus granulosus	JmjC domain containing protein 4	0.0016	0.0123	0.0541
Trichomonas vaginalis	taga, putative	0.001	0.0056	0.2255
Onchocerca volvulus		0.0438	0.5469	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0056	0.2255
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.001	0.0056	0.5
Schistosoma mansoni	protein phosphatase 2C	0.0141	0.1713	0.8651
Brugia malayi	ABC transporter family protein	0.001	0.0056	0.0006
Brugia malayi	jmjC domain containing protein	0.0016	0.0123	0.0129
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0056	0.2255
Echinococcus granulosus	Squalene phytoene synthase	0.0077	0.0901	0.4522
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0368	0.1639
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0056	0.02
Onchocerca volvulus	Putative protein phosphatase 2C	0.0021	0.0191	0.0254
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0053	0.0184
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0056	0.02
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0056	0.2255

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.023 uM	Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay	ChEMBL.	21640588

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1797205

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 984106