Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear hormone receptor | 0.2298 | 0.7815 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.202 | 0.601 | 0.7691 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.2298 | 0.7815 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1102 | 0.0055 | 0.007 |
Brugia malayi | ecdysteroid receptor | 0.1102 | 0.0055 | 0.007 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1371 | 0.1804 | 0.2309 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 34 % | Antibacterial activity against Escherichia coli at 50 ug/mL after 48 hrs by cup-plate method | ChEMBL. | 17959273 |
Inhibition (functional) | = 57 % | Antibacterial activity against Escherichia coli at 100 ug/mL after 48 hrs by cup-plate method | ChEMBL. | 17959273 |
IZ (functional) | = 92 mm | Antibacterial activity against Escherichia coli at 50 ug/mL after 48 hrs by cup-plate method | ChEMBL. | 17959273 |
IZ (functional) | = 158 mm | Antibacterial activity against Escherichia coli at 100 ug/mL after 48 hrs by cup-plate method | ChEMBL. | 17959273 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.