Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | reductase, putative | 0.0029 | 0.0114 | 0.034 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0029 | 0.0114 | 0.034 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0029 | 0.0114 | 0.0114 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.0149 | 0.0149 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0032 | 0.0149 | 0.0445 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0032 | 0.0149 | 0.0445 |
Mycobacterium ulcerans | oxidoreductase | 0.0029 | 0.0114 | 0.034 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0326 | 0.0326 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0029 | 0.0114 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0259 | 0.3348 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0099 | 0.1095 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0259 | 0.3348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0727 | 0.0727 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0732 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0067 | 0.0649 | 0.0649 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0073 | 0.0727 | 0.0727 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0029 | 0.0114 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.023 | 0.2933 | 1 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0029 | 0.0114 | 0.0114 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0129 | 0.151 | 0.151 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0259 | 0.3348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0244 | 0.0244 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0029 | 0.0114 | 0.034 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0029 | 0.0114 | 1 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0029 | 0.0114 | 0.0279 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.0326 | 0.0326 |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.0149 | 0.0149 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0099 | 0.1095 | 0.327 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0129 | 0.151 | 1 |
Leishmania major | NADH-dependent fumarate reductase, putative | 0.0029 | 0.0114 | 0.034 |
Leishmania major | cytochrome P450 reductase, putative | 0.023 | 0.2933 | 0.8761 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0029 | 0.0114 | 0.034 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0029 | 0.0114 | 1 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0029 | 0.0114 | 0.034 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0311 | 0.4083 | 1 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0099 | 0.1095 | 0.3033 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0099 | 0.1095 | 0.3033 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.023 | 0.2933 | 0.8646 |
Brugia malayi | diaphorase | 0.0029 | 0.0114 | 0.0114 |
Trypanosoma cruzi | p450 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0259 | 0.3348 | 1 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Mycobacterium ulcerans | flavodoxin oxidoreductase | 0.0029 | 0.0114 | 0.034 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0259 | 0.3348 | 1 |
Schistosoma mansoni | cytochrome B5 | 0.0029 | 0.0114 | 0.0114 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0099 | 0.1095 | 0.327 |
Plasmodium vivax | flavodoxin domain containing protein | 0.023 | 0.2933 | 0.8717 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0099 | 0.1095 | 0.327 |
Brugia malayi | FAD binding domain containing protein | 0.0259 | 0.3348 | 0.3348 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Trypanosoma brucei | cytochrome P450, putative | 0.0032 | 0.0149 | 0.0445 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0259 | 0.3348 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0099 | 0.1095 | 0.2644 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0029 | 0.0114 | 0.034 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0029 | 0.0114 | 0.034 |
Leishmania major | NADH-dependent fumarate reductase-like protein | 0.0029 | 0.0114 | 0.034 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0029 | 0.0114 | 0.0279 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.0326 | 0.0799 |
Loa Loa (eye worm) | diaphorase | 0.0029 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0073 | 0.0727 | 0.0727 |
Brugia malayi | flavodoxin family protein | 0.0259 | 0.3348 | 0.3348 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0727 | 0.0727 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0029 | 0.0114 | 0.0279 |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.0149 | 0.0149 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Echinococcus multilocularis | methionine synthase reductase | 0.016 | 0.1952 | 0.4781 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.016 | 0.1952 | 0.1952 |
Brugia malayi | Cytochrome P450 family protein | 0.0067 | 0.0649 | 0.0649 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0099 | 0.1095 | 0.5 |
Trypanosoma brucei | oxidoreductase-protein, putative | 0.0029 | 0.0114 | 0.034 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0099 | 0.1095 | 0.2644 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0131 | 0.1537 | 0.1537 |
Mycobacterium ulcerans | oxygenase | 0.0029 | 0.0114 | 0.034 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Leishmania major | cytochrome p450-like protein | 0.0032 | 0.0149 | 0.0445 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0732 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0099 | 0.1095 | 1 |
Toxoplasma gondii | ferredoxin NADP+ oxidoreductase FNR | 0.0029 | 0.0114 | 0.0755 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0029 | 0.0114 | 0.034 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0259 | 0.3348 | 0.8199 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0029 | 0.0114 | 0.034 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0259 | 0.3348 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0073 | 0.0727 | 0.0727 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Trypanosoma cruzi | oxidoreductase-protein, putative | 0.0029 | 0.0114 | 0.034 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0259 | 0.3348 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0099 | 0.1095 | 0.5 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0029 | 0.0114 | 0.034 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0029 | 0.0114 | 0.034 |
Leishmania major | oxidoreductase-like protein | 0.0029 | 0.0114 | 0.034 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0029 | 0.0114 | 0.0279 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0259 | 0.3348 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.016 | 0.1952 | 0.1952 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.0149 | 0.0149 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Echinococcus granulosus | serotonin transporter | 0.0073 | 0.0727 | 0.1781 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0073 | 0.0727 | 0.0727 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0073 | 0.0727 | 0.625 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0029 | 0.0114 | 0.0114 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0099 | 0.1095 | 0.2644 |
Trypanosoma cruzi | nitrate reductase, putative | 0.0029 | 0.0114 | 0.034 |
Leishmania major | p450 reductase, putative | 0.0259 | 0.3348 | 1 |
Trypanosoma brucei | NADH-cytochrome b5 reductase-like protein | 0.0029 | 0.0114 | 0.034 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0073 | 0.0727 | 0.0727 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0032 | 0.0149 | 0.0149 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0259 | 0.3348 | 0.8199 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Echinococcus multilocularis | serotonin receptor | 0.0311 | 0.4083 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.4342 | 0.4342 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0311 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.4083 | 0.4083 |
Chlamydia trachomatis | sulfite reductase | 0.016 | 0.1952 | 1 |
Trypanosoma cruzi | reductase, putative | 0.0029 | 0.0114 | 0.034 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0032 | 0.0149 | 0.0445 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Echinococcus multilocularis | serotonin transporter | 0.0073 | 0.0727 | 0.1781 |
Leishmania major | nitrate reductase, putative | 0.0029 | 0.0114 | 0.034 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0259 | 0.3348 | 0.3348 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0099 | 0.1095 | 0.1095 |
Mycobacterium leprae | putative cytochrome p450 | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0259 | 0.3348 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0099 | 0.1095 | 0.327 |
Loa Loa (eye worm) | serotonin transporter b | 0.0073 | 0.0727 | 0.0727 |
Trypanosoma brucei | nitrate reductase, putative | 0.0029 | 0.0114 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.3348 | 0.3348 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0384 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0727 | 0.0727 |
Onchocerca volvulus | 0.0073 | 0.0727 | 1 | |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0129 | 0.151 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0099 | 0.1095 | 0.5 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0029 | 0.0114 | 0.034 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.016 | 0.1952 | 0.1952 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0259 | 0.3348 | 0.8199 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0259 | 0.3348 | 1 |
Toxoplasma gondii | NADH-cytochrome b5 reductase 1, putative | 0.0029 | 0.0114 | 0.0755 |
Mycobacterium ulcerans | flavodoxin reductase Hmp | 0.0029 | 0.0114 | 0.034 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0099 | 0.1095 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0259 | 0.3348 | 0.8199 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0029 | 0.0114 | 1 |
Mycobacterium ulcerans | monooxygenase | 0.0029 | 0.0114 | 0.034 |
Trypanosoma cruzi | p450 reductase, putative | 0.0259 | 0.3348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0732 | 1 | 1 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0029 | 0.0114 | 0.034 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0259 | 0.3348 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.0326 | 0.0799 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.4083 | 0.4083 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0259 | 0.3348 | 0.3348 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0099 | 0.1095 | 0.2644 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0384 | 0.0384 |
Echinococcus multilocularis | serotonin receptor | 0.0311 | 0.4083 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.016 | 0.1952 | 0.4781 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0029 | 0.0114 | 0.0279 |
Brugia malayi | flavodoxin family protein | 0.0099 | 0.1095 | 0.1095 |
Plasmodium vivax | hypothetical protein, conserved | 0.0099 | 0.1095 | 0.3033 |
Giardia lamblia | Hypothetical protein | 0.023 | 0.2933 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0099 | 0.1095 | 0.327 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0029 | 0.0114 | 0.034 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 5 | Inhibition of human ERG tail current by patch clamp electrophysiology assay | ChEMBL. | 20590088 |
IC50 (ADMET) | > 9 uM | Inhibition of human recombinant CYP2C9 preincubated for 10 mins | ChEMBL. | 20590088 |
IC50 (ADMET) | > 9 uM | Inhibition of human recombinant CYP2C19 preincubated for 10 mins | ChEMBL. | 20590088 |
IC50 (ADMET) | > 9 uM | Inhibition of CYP3A4 in human liver microsomes using diethoxyfluorescein as substrate | ChEMBL. | 20590088 |
IC50 (ADMET) | > 9 uM | Inhibition of human recombinant CYP1A2 preincubated for 10 mins | ChEMBL. | 20590088 |
IC50 (ADMET) | > 9 uM | Inhibition of human recombinant CYPD6 preincubated for 10 mins | ChEMBL. | 20590088 |
IC50 (ADMET) | > 9 uM | Inhibition of CYP3A4 in human liver microsomes using diethoxyfluorescein/7-benzyloxyquinoline as substrate | ChEMBL. | 20590088 |
IC50 (ADMET) | = 61 uM | Inhibition of CYP3A4 in human liver microsomes measured after incubation | ChEMBL. | 20590088 |
IC50 (ADMET) | = 88 uM | Inhibition of CYP3A4 in human liver microsomes measured immediately | ChEMBL. | 20590088 |
IC50 (ADMET) | = 100 uM | Inhibition of CYP3A4 in human liver microsomes measured immediately | ChEMBL. | 20590088 |
IC50 (ADMET) | = 100 uM | Inhibition of CYP3A4 in human liver microsomes measured after incubation | ChEMBL. | 20590088 |
Intrinsic activity (functional) | = 0 | Intrinsic activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay | ChEMBL. | 20590088 |
Intrinsic activity (functional) | = 0 | Intrinsic activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay | ChEMBL. | 20590088 |
Intrinsic activity (functional) | = 0 | Intrinsic activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay | ChEMBL. | 20590088 |
Kd (functional) | = 8.93 | Antagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay | ChEMBL. | 20590088 |
Kd (functional) | = 9.69 | Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay | ChEMBL. | 20590088 |
Kd (functional) | = 9.77 | Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay | ChEMBL. | 20590088 |
Ki (binding) | = 4.5 | Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay | ChEMBL. | 20590088 |
Ki (binding) | = 7.5 | Displacement of [3H]citalopram from human recombinant SERT expressed in LLCPK cells after 2 hrs by liquid scintillation counting | ChEMBL. | 20590088 |
Ki (binding) | = 7.54 | Displacement of [3H]citalopram from human recombinant SERT expressed in LLCPK cells after 2 hrs by filtration binding assay | ChEMBL. | 20590088 |
Ki (binding) | = 8.49 | Displacement of [3H]-GR125743 from 5HT1B receptor in rat brain cortex after 45 mins by liquid scintillation spectrometry | ChEMBL. | 20590088 |
Ki (binding) | = 8.56 | Displacement of [3H]prazosin from human adrenergic alpha1A receptor by filtration binding assay | ChEMBL. | 20590088 |
Ki (functional) | = 8.8 | Antagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay | ChEMBL. | 20590088 |
Ki (binding) | = 9.1 | Displacement of [3H]-5-HT from human recombinant 5HT1B receptor expressed in CHO cells after 45 mins by scintillation counting | ChEMBL. | 20590088 |
Ki (functional) | = 9.5 | Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay | ChEMBL. | 20590088 |
Ki (functional) | = 9.8 | Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay | ChEMBL. | 20590088 |
Ki (binding) | = 9.94 | Displacement of [3H]-WAY100635 from human recombinant 5HT1A receptor expressed in CHO cells after 45 mins by scintillation counting | ChEMBL. | 20590088 |
Ki (binding) | = 10 | Displacement of [3H]-5-HT from human recombinant 5HT1D receptor expressed in CHO cells after 45 mins by scintillation counting | ChEMBL. | 20590088 |
Ki (binding) | = 10.16 | Displacement of [3H]-WAY100635 from 5HT1A receptor in rat brain cortex after 45 mins by liquid scintillation spectrometry | ChEMBL. | 20590088 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.