Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.1001 | 0.1001 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.2347 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1001 | 0.5 |
Brugia malayi | hypothetical protein | 0.0041 | 0.1001 | 0.4264 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.2347 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1001 | 0.1001 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2347 | 0.2347 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.2347 | 0.2347 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.2347 | 1 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.2347 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2347 | 0.2347 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0242 | 0.9594 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2347 | 0.2347 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1001 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0251 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1001 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.2347 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.1001 | 0.1001 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.2347 | 0.2447 |
Brugia malayi | RNA binding protein | 0.0073 | 0.2347 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2347 | 0.2347 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1001 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.1001 | 0.1043 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2347 | 0.2347 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 8.5 ug ml-1 | Cytotoxicity against human KB cells by sulforhodamine B assay | ChEMBL. | 18473435 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.