Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.3224 | 0.3224 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.168 | 0.2412 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0227 | 0.0049 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.0664 | 0.0771 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0049 | 0.0816 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.4143 | 0.6503 |
Brugia malayi | hypothetical protein | 0.0151 | 0.4143 | 0.6521 |
Schistosoma mansoni | ets-related | 0.0215 | 0.6249 | 0.6249 |
Loa Loa (eye worm) | fli-1 protein | 0.0215 | 0.6249 | 1 |
Onchocerca volvulus | 0.0151 | 0.4143 | 0.5 | |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.0467 | 0.0467 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0227 | 0.0227 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0227 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.2241 | 0.3345 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0067 | 0.141 | 0.141 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0145 | 0.3962 | 0.6221 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0049 | 0.0816 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0747 | 0.0747 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0011 | 0.0011 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.0669 | 0.0669 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0472 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0227 | 0.0049 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0227 | 0.0227 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0747 | 0.0747 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.3224 | 0.3224 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0749 | 0.0867 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0747 | 0.0909 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.3224 | 0.3224 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.3224 | 0.3224 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.3224 | 0.3224 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.1401 | 0.199 |
Schistosoma mansoni | bromodomain containing protein | 0.0071 | 0.1534 | 0.1534 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.1943 | 0.2885 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.0669 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0372 | 0.0372 |
Schistosoma mansoni | hypothetical protein | 0.033 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.2414 | 0.3663 |
Brugia malayi | TAR-binding protein | 0.0123 | 0.3224 | 0.5002 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0747 | 0.0747 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0227 | 0.0227 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0227 | 0.0227 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0227 | 0.0227 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0011 | 0.0011 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0372 | 0.0372 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0049 | 0.0816 | 1 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0071 | 0.1531 | 0.1531 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0747 | 0.0864 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0372 | 0.0372 |
Brugia malayi | Fli-1 protein | 0.0215 | 0.6249 | 1 |
Echinococcus multilocularis | geminin | 0.033 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0227 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0816 | 0.0979 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0067 | 0.141 | 0.141 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0049 | 0.0816 | 0.5 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0071 | 0.1531 | 0.2166 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0049 | 0.0816 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0145 | 0.3962 | 0.3962 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0552 | 0.054 |
Echinococcus multilocularis | tar DNA binding protein | 0.0123 | 0.3224 | 0.3224 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0139 | 0.3749 | 0.3749 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0747 | 0.0747 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0123 | 0.3224 | 0.4977 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0372 | 0.0372 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.1531 | 0.2205 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.1531 | 0.2205 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0049 | 0.0816 | 0.5 |
Brugia malayi | hypothetical protein | 0.0093 | 0.2241 | 0.3378 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0011 | 0.0011 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0145 | 0.3962 | 0.3962 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0248 | 0.0085 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.2414 | 0.3632 |
Schistosoma mansoni | hypothetical protein | 0.033 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1401 | 0.1401 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0747 | 0.0747 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0747 | 0.0747 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0227 | 0.0227 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0123 | 0.3224 | 0.5002 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0372 | 0.029 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0816 | 0.1023 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.2414 | 0.3663 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.0472 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0123 | 0.3224 | 0.4977 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0049 | 0.0816 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.2241 | 0.3345 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0815 | 0.0977 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0227 | 0.0227 |
Leishmania major | hypothetical protein, conserved | 0.0049 | 0.0816 | 0.5 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0071 | 0.1531 | 0.1531 |
Brugia malayi | RNA binding protein | 0.0123 | 0.3224 | 0.5002 |
Echinococcus granulosus | tar DNA binding protein | 0.0123 | 0.3224 | 0.3224 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0747 | 0.0747 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2414 | 0.3632 |
Loa Loa (eye worm) | acetyltransferase | 0.0145 | 0.3962 | 0.6202 |
Schistosoma mansoni | eyes absent homolog | 0.0093 | 0.2241 | 0.2241 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.0669 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1195 | 0.1608 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0227 | 0.0227 |
Schistosoma mansoni | gabp alpha | 0.0071 | 0.1531 | 0.1531 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1401 | 0.1951 |
Loa Loa (eye worm) | RNA binding protein | 0.0123 | 0.3224 | 0.4977 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.