Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0106 | 0.5019 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0114 | 0.5467 | 0.5467 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0124 | 0.6094 | 0.6094 |
Schistosoma mansoni | neuropeptide receptor | 0.0115 | 0.5568 | 0.5568 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0033 | 0.0626 | 0.0626 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0026 | 0.0213 | 0.0213 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0124 | 0.6094 | 0.6094 |
Echinococcus granulosus | voltage gated potassium channel | 0.0033 | 0.0626 | 0.0626 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0189 | 1 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0062 | 0.2347 | 0.2347 |
Leishmania major | 0.0189 | 1 | 0.5 | |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0189 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0189 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0114 | 0.5467 | 0.5467 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0189 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0033 | 0.0626 | 0.0626 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0033 | 0.0626 | 0.0626 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0115 | 0.5568 | 0.5568 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0106 | 0.5019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.4567 | 0.4567 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0026 | 0.0213 | 0.0213 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0626 | 0.0626 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0189 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0033 | 0.0626 | 0.0626 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0114 | 0.5467 | 0.5467 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0026 | 0.0213 | 0.0213 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0033 | 0.0626 | 0.0626 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0062 | 0.2347 | 0.2347 |
Echinococcus granulosus | neuropeptide receptor | 0.0115 | 0.5568 | 0.5568 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0062 | 0.2347 | 0.2347 |
Echinococcus multilocularis | neuropeptide receptor | 0.0115 | 0.5568 | 0.5568 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0033 | 0.0626 | 0.0626 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0114 | 0.5467 | 0.5467 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0189 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 uM | Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry | ChEMBL. | 19348494 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.