Detailed information for compound 985427

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 423.458 | Formula: C24H25NO6
  • H donors: 1 H acceptors: 2 LogP: 3.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cc(OCCN2CCCCC2)cc2c1c(=O)cc(o2)c1ccc2c(c1)OCCO2
  • InChi: 1S/C24H25NO6/c26-18-13-17(28-9-8-25-6-2-1-3-7-25)14-23-24(18)19(27)15-21(31-23)16-4-5-20-22(12-16)30-11-10-29-20/h4-5,12-15,26H,1-3,6-11H2
  • InChiKey: AURSPSAEXNSNJN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans Type I modular polyketide synthase 0.008 0.0071 0.1674
Loa Loa (eye worm) endoprotease bli-4 0.774 1 1
Schistosoma mansoni glutamate receptor AMPA 0.0034 0.0011 0.0005
Brugia malayi hypothetical protein 0.0047 0.0028 0.0028
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.067 0.0836 0.1362
Loa Loa (eye worm) WD40 repeat protein 0.0071 0.0059 0.0052
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1531 0.1951 0.3192
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0087 0.0079 0.5
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0006
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0031 0.0008 0.0003
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0128 0.0133 0.0159
Echinococcus multilocularis protoporphyrinogen oxidase 0.0103 0.0101 0.0118
Schistosoma mansoni integrin alpha-ps 0.0367 0.0443 0.0437
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0009 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1882 0.2406 0.3939
Loa Loa (eye worm) hypothetical protein 0.0044 0.0023 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0072 0.0067
Echinococcus multilocularis protein jagged 2 0.014 0.0149 0.0178
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0081 0.0072 0.0551
Brugia malayi transcriptional regulator, Sir2 family protein 0.0099 0.0095 0.0095
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0059 0.0044 0.1045
Plasmodium vivax subtilisin-like protease 2, putative 0.0351 0.0422 0.656
Onchocerca volvulus 0.0144 0.0154 0.2169
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0034 0.0011 0.0005
Mycobacterium ulcerans oxidoreductase 0.0103 0.0101 0.2388
Brugia malayi EGF-like domain containing protein 0.014 0.0149 0.0149
Schistosoma mansoni SWI/SNF complex-related 0.0043 0.0023 0.0017
Schistosoma mansoni hypothetical protein 0.0281 0.0332 0.0326
Brugia malayi Integrin beta pat-3 precursor 0.6164 0.7957 0.7957
Loa Loa (eye worm) hypothetical protein 0.014 0.0149 0.0142
Loa Loa (eye worm) transcription factor SMAD2 0.0107 0.0106 0.01
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0035 0.0012 0.001
Echinococcus granulosus discoidin domain containing receptor 2 0.0031 0.0008 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1882 0.2406 0.3939
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Onchocerca volvulus 0.0035 0.0012 0.006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Toxoplasma gondii hypothetical protein 0.014 0.0149 0.2251
Echinococcus granulosus protein kinase c epsilon type 0.0087 0.008 0.0074
Schistosoma mansoni glutamate receptor NMDA 0.0051 0.0033 0.0027
Loa Loa (eye worm) hypothetical protein 0.0367 0.0443 0.0436
Plasmodium falciparum plasmepsin VII 0.0035 0.0012 0.0092
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0351 0.0422 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.1531 0.1951 0.3192
Brugia malayi transcriptional regulator, Sir2 family protein 0.067 0.0836 0.0836
Toxoplasma gondii subtilisin SUB10 0.0351 0.0422 0.656
Giardia lamblia Transcriptional regulator, Sir2 family 0.0099 0.0095 0.0199
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0739 0.0925 0.092
Schistosoma mansoni hypothetical protein 0.0152 0.0165 0.0159
Loa Loa (eye worm) hypothetical protein 0.0135 0.0143 0.0136
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0059 0.0044 0.0038
Plasmodium falciparum subtilisin-like protease 1 0.0519 0.064 1
Schistosoma mansoni integrin alpha-ps 0.0587 0.0728 0.0722
Brugia malayi proprotein convertase 2 0.489 0.6306 0.6306
Echinococcus multilocularis integrin beta 2 0.4551 0.5866 0.7316
Echinococcus granulosus chromatin regulatory protein sir2 0.067 0.0836 0.0831
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0033 0.001 0.0246
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0351 0.0422 0.0416
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0351 0.0422 1
Brugia malayi Glutamate receptor 1 precursor 0.0034 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.1531 0.1951 0.3192
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0103 0.0101 0.1495
Onchocerca volvulus Fatty acid synthase homolog 0.0149 0.016 0.2268
Echinococcus multilocularis fibrillin 2 0.014 0.0149 0.0178
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0103 0.0101 0.2375
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0027
Toxoplasma gondii subtilisin SUB6 0.0351 0.0422 0.656
Schistosoma mansoni hypothetical protein 0.1531 0.1951 0.1947
Plasmodium falciparum plasmepsin V 0.0388 0.0471 0.7327
Entamoeba histolytica protein kinase, putative 0.0081 0.0072 0.0767
Mycobacterium leprae Possible secreted protease 0.0351 0.0422 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0099 0.0095 0.0111
Mycobacterium ulcerans dehydrogenase 0.0103 0.0101 0.2388
Schistosoma mansoni protein kinase 0.0128 0.0133 0.0127
Mycobacterium ulcerans polyketide synthase 0.0085 0.0077 0.1832
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1531 0.1951 0.3192
Loa Loa (eye worm) hypothetical protein 0.774 1 1
Giardia lamblia Hypothetical protein 0.067 0.0836 0.2235
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Schistosoma mansoni hypothetical protein 0.0069 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0045 0.0025 0.0018
Trichomonas vaginalis WD repeat domain, putative 0.0071 0.0059 0.0087
Echinococcus granulosus adam 17 protease 0.0096 0.0091 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0351 0.0422 0.0682
Giardia lamblia Tenascin-like 0.014 0.0149 0.0346
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.014 0.0149 0.0234
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4732 0.6101 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0071 0.0059 0.0054
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0006
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0103 0.0101 0.1495
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0112 0.0112 0.0112
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.0025 0.0025
Echinococcus granulosus integrin beta 2 0.4551 0.5866 0.5863
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.037 0.0446 0.5174
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0121 0.0124 0.2932
Trichomonas vaginalis hypothetical protein 0.1531 0.1951 0.3192
Loa Loa (eye worm) apoptosis regulator protein 0.0059 0.0044 0.0037
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4732 0.6101 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0035 0.0012 0.0007
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0035 0.0012 0.0092
Echinococcus granulosus epidermal growth factor receptor 0.0403 0.049 0.0484
Toxoplasma gondii subtilisin SUB7 0.0351 0.0422 0.656
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0099 0.0095 0.0089
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0085 0.0077 0.1818
Echinococcus multilocularis discoidin domain receptor 0.0031 0.0008 0.0002
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0103 0.0101 0.1495
Toxoplasma gondii histone deacetylase SIR2-like 0.0099 0.0095 0.1408
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0035 0.0012 0.0005
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0012 0.0006
Toxoplasma gondii aspartyl protease ASP1 0.0035 0.0012 0.0092
Plasmodium falciparum plasmepsin II 0.0035 0.0012 0.0092
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0012 0.0092
Giardia lamblia hypothetical protein 0.014 0.0149 0.0346
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0012 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0006
Mycobacterium tuberculosis Possible oxidoreductase 0.0103 0.0101 0.2388
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0009 0.0003
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0232 0.0267 0.0261
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0011 0.0005
Echinococcus granulosus dual specificity 0.0081 0.0072 0.0067
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0081 0.0072 0.0801
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0103 0.0101 0.2388
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0103 0.0101 0.2388
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0081 0.0072 0.0551
Schistosoma mansoni dihydroceramide desaturase 0.0096 0.0091 0.0086
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0099 0.0095 0.1076
Toxoplasma gondii subtilisin SUB2 0.0351 0.0422 0.656
Brugia malayi SWIRM domain containing protein 0.0551 0.0681 0.0681
Loa Loa (eye worm) hypothetical protein 0.0532 0.0657 0.0651
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.037 0.0446 0.5174
Echinococcus granulosus protein will die slowly 0.0071 0.0059 0.0053
Echinococcus multilocularis Furin 1 0.1882 0.2406 0.2997
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0034 0.0011 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.1531 0.1951 0.3192
Loa Loa (eye worm) hypothetical protein 0.0099 0.0095 0.0089
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0016
Echinococcus multilocularis fibrillin 1 0.0142 0.0151 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Toxoplasma gondii SWIRM domain-containing protein 0.0043 0.0023 0.0264
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0085 0.0077 0.1832
Echinococcus multilocularis dual specificity 0.0081 0.0072 0.0083
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0031 0.0008 0.0002
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0739 0.0925 0.1148
Mycobacterium tuberculosis Polyketide synthase Pks2 0.008 0.0071 0.1683
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Plasmodium falciparum plasmepsin III 0.0035 0.0012 0.0092
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0031 0.0008 0.0184
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0351 0.0422 1
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0011 0.0005
Echinococcus multilocularis 0.6209 0.8016 1
Schistosoma mansoni hypothetical protein 0.0059 0.0044 0.0038
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.774 1 1
Giardia lamblia High cysteine protein 0.014 0.0149 0.0346
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.1531 0.1951 0.3192
Loa Loa (eye worm) TK/ALK protein kinase 0.0069 0.0057 0.005
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0043 0.0023 0.0017
Brugia malayi Will die slowly protein 0.0071 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0838 0.1053 0.1047
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0087 0.0079 0.188
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0031 0.0008 0.0167
Loa Loa (eye worm) hypothetical protein 0.0069 0.0057 0.005
Echinococcus multilocularis discoidin domain containing receptor 2 0.0031 0.0008 0.0002
Brugia malayi Protein kinase domain containing protein 0.0081 0.0072 0.0072
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.002 0.0014
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0087 0.0079 0.188
Echinococcus granulosus integrin alpha 3 0.0814 0.1022 0.1016
Trypanosoma cruzi UDP-galactopyranose mutase 0.0103 0.0101 0.0902
Echinococcus multilocularis adam 0.0443 0.0541 0.0668
Schistosoma mansoni chromatin regulatory protein sir2 0.067 0.0836 0.0831
Toxoplasma gondii type I fatty acid synthase, putative 0.0059 0.0043 0.059
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.037 0.0446 0.5174
Giardia lamblia High cysteine membrane protein Group 2 0.285 0.3661 1
Echinococcus multilocularis 0.0103 0.0101 0.0118
Schistosoma mansoni hypothetical protein 0.0032 0.0009 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1882 0.2406 0.3939
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0031 0.0008 0.0002
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0096 0.0091 0.0086
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0099 0.0095 0.0833
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0065 0.0051 0.1211
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0035 0.0012 0.0006
Giardia lamblia Sirtuin type 2 0.0099 0.0095 0.0199
Echinococcus multilocularis NMDA receptor 0.0034 0.0011 0.0006
Echinococcus multilocularis geminin 0.0152 0.0165 0.0198
Plasmodium falciparum plasmepsin VI 0.0035 0.0012 0.0092
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.002 0.0014
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0006
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4732 0.6101 0.7609
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.067 0.0836 0.1362
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1882 0.2406 0.2402
Trypanosoma cruzi UDP-galactopyranose mutase 0.0103 0.0101 0.0902
Echinococcus granulosus discoidin domain receptor 0.0031 0.0008 0.0002
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0103 0.0101 0.2388
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Toxoplasma gondii PA14 domain-containing protein 0.0031 0.0008 0.0029
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0007 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.002 0.0014
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.008 0.0071 0.1674
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0121 0.0124 0.2932
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1882 0.2406 0.3939
Brugia malayi Glutamate receptor 2 precursor 0.0034 0.0011 0.0011
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1302 0.1655 0.165
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0085 0.0077 0.1832
Toxoplasma gondii F5/8 type C domain-containing protein 0.0031 0.0008 0.0029
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0051 0.0033 0.0027
Onchocerca volvulus 0.0069 0.0057 0.0726
Echinococcus multilocularis glutamate receptor 2 0.0034 0.0011 0.0006
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0099 0.0095 0.1408
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0255 0.0297 0.0364
Entamoeba histolytica SWIRM domain protein 0.0043 0.0023 0.0166
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Giardia lamblia Tenascin-37 0.014 0.0149 0.0346
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0052 0.0034 0.0813
Echinococcus multilocularis protein will die slowly 0.0071 0.0059 0.0066
Loa Loa (eye worm) hypothetical protein 0.0551 0.0681 0.0674
Loa Loa (eye worm) subtilase 0.0351 0.0422 0.0415
Mycobacterium leprae Probable polyketide synthase Pks1 0.0085 0.0077 0.1818
Schistosoma mansoni hypothetical protein 0.0152 0.0165 0.0159
Echinococcus granulosus disintegrin and metalloproteinase 0.0096 0.0091 0.0086
Schistosoma mansoni chromatin regulatory protein sir2 0.067 0.0836 0.0831
Chlamydia trachomatis protoporphyrinogen oxidase 0.0103 0.0101 1
Echinococcus granulosus neuroendocrine convertase 2 0.489 0.6306 0.6304
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0099 0.0095 0.0089
Echinococcus granulosus Furin 1 0.1882 0.2406 0.2402
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.067 0.0836 0.1036
Schistosoma mansoni chromatin regulatory protein sir2 0.067 0.0836 0.0831
Mycobacterium ulcerans Sir2-like regulatory protein 0.0099 0.0095 0.2257
Toxoplasma gondii subtilisin SUB4 0.0351 0.0422 0.656
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Echinococcus multilocularis protein kinase c epsilon type 0.0087 0.008 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0255 0.0297 0.0291
Leishmania major silent information regulator 2, putative 0.067 0.0836 1
Trichomonas vaginalis conserved hypothetical protein 0.1531 0.1951 0.3192
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Echinococcus granulosus integrin alpha ps 0.0648 0.0807 0.0802
Toxoplasma gondii subtilisin SUB12 0.0351 0.0422 0.656
Mycobacterium ulcerans thioesterase TesA 0.0069 0.0056 0.1337
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0128 0.0133 0.0127
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0351 0.0422 1
Brugia malayi NAD-dependent deacetylase SIRT1 0.0099 0.0095 0.0095
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0351 0.0422 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0006
Toxoplasma gondii subtilisin SUB9 0.0351 0.0422 0.656
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Schistosoma mansoni amine oxidase 0.0103 0.0101 0.0095
Brugia malayi EGF-like domain containing protein 0.014 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.014 0.0149 0.0142
Toxoplasma gondii aspartyl protease ASP5 0.0354 0.0426 0.6621
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0099 0.0095 0.1043
Toxoplasma gondii F5/8 type C domain-containing protein 0.0031 0.0008 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.0012 0.0092
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0112 0.0112 0.0105
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0031 0.0008 0.0002
Echinococcus multilocularis discoidin domain containing receptor 2 0.0031 0.0008 0.0002
Loa Loa (eye worm) TK/EGFR protein kinase 0.0403 0.049 0.0483
Toxoplasma gondii subtilisin SUB11 0.0351 0.0422 0.656
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.067 0.0836 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0031 0.0008 0.0003
Toxoplasma gondii type I fatty acid synthase, putative 0.0085 0.0077 0.1125
Loa Loa (eye worm) metalloprotease 0.0064 0.005 0.0043
Echinococcus multilocularis serine:threonine protein kinase N2 0.008 0.007 0.0081
Giardia lamblia Neurogenic locus Notch protein precursor 0.014 0.0149 0.0346
Plasmodium falciparum plasmepsin I 0.0035 0.0012 0.0092
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0051 0.0033 0.0034
Brugia malayi celfurPC protein 0.6209 0.8016 0.8016
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.067 0.0836 1
Onchocerca volvulus 0.0069 0.0057 0.0726
Mycobacterium ulcerans polyketide synthase Pks13 0.0121 0.0124 0.2932
Plasmodium vivax plasmepsin IV, putative 0.0035 0.0012 0.0092
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0012 0.0006
Plasmodium falciparum subtilisin-like protease 3 0.0351 0.0422 0.656
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4732 0.6101 0.6098
Loa Loa (eye worm) acyl carrier protein 0.0038 0.0016 0.001
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0012 0.0005
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0351 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0059 0.0044 0.0037
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0034 0.0011 0.0006
Brugia malayi hypothetical protein 0.0946 0.1193 0.1193
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0758 0.095 0.095
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0095 0.1408
Plasmodium vivax aspartyl protease, putative 0.0035 0.0012 0.0092
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Plasmodium falciparum plasmepsin IX 0.0035 0.0012 0.0092
Leishmania major subtilisin-like serine peptidase 0.0351 0.0422 0.5011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0006
Entamoeba histolytica protein kinase domain containing protein 0.0081 0.0072 0.0767
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.008 0.0074
Onchocerca volvulus 0.0077 0.0067 0.0884
Trichomonas vaginalis conserved hypothetical protein 0.1531 0.1951 0.3192
Echinococcus granulosus discoidin domain containing receptor 2 0.0031 0.0008 0.0002
Loa Loa (eye worm) hypothetical protein 0.0351 0.0422 0.0415
Echinococcus granulosus fibrillin 1 0.0142 0.0151 0.0145
Brugia malayi hypothetical protein 0.0035 0.0012 0.0012
Plasmodium vivax subtilisin-like serine protease, putative 0.0351 0.0422 0.656
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.008 0.0071 0.1674
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0285 0.0336 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Loa Loa (eye worm) hypothetical protein 0.008 0.0071 0.0064
Brugia malayi amine oxidase, flavin-containing family protein 0.0146 0.0156 0.0156
Echinococcus granulosus discoidin domain containing receptor 2 0.0031 0.0008 0.0002
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.0012 0.0092
Echinococcus multilocularis epidermal growth factor receptor 0.0403 0.049 0.0604
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.012 0.0123 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0351 0.0422 0.0682
Plasmodium falciparum plasmepsin X 0.0035 0.0012 0.0092
Trichomonas vaginalis hypothetical protein 0.014 0.0149 0.0234
Schistosoma mansoni protein kinase 0.0128 0.0133 0.0127
Entamoeba histolytica SWIRM domain protein 0.0043 0.0023 0.0166
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Plasmodium vivax LCCL domain-containing protein 0.0031 0.0008 0.0029
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0232 0.0267 0.0261
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0012 0.0012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.0025 0.0018
Entamoeba histolytica hypothetical protein, conserved 0.0099 0.0095 0.1043
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Toxoplasma gondii F5/8 type C domain-containing protein 0.0031 0.0008 0.0029
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Echinococcus multilocularis integrin alpha ps 0.0281 0.0332 0.0407
Toxoplasma gondii histone lysine-specific demethylase 0.0103 0.0101 0.1495
Schistosoma mansoni tyrosine kinase 0.0403 0.049 0.0484
Trichomonas vaginalis conserved hypothetical protein 0.1531 0.1951 0.3192
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0012 0.0012
Echinococcus multilocularis integrin alpha ps 0.0587 0.0728 0.0901
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Loa Loa (eye worm) hypothetical protein 0.0061 0.0046 0.004
Loa Loa (eye worm) MH2 domain-containing protein 0.0107 0.0106 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0351 0.0422 0.0682
Plasmodium falciparum protoporphyrinogen oxidase 0.0103 0.0101 0.1495
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.002 0.0018
Plasmodium falciparum plasmepsin IV 0.0035 0.0012 0.0092
Toxoplasma gondii aspartyl protease 0.0035 0.0012 0.0092
Trypanosoma cruzi subtilisin peptidase 0.0351 0.0422 0.4876
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0067 0.0067
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0051 0.0033 0.0034
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0043 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0047 0.0028 0.0021
Onchocerca volvulus 0.014 0.0149 0.2094
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.067 0.0836 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0051 0.0033 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Brugia malayi Reprolysin 0.0136 0.0143 0.0143
Trypanosoma brucei SIR2-like protein 4, putative 0.0099 0.0095 0.0833
Schistosoma mansoni discoidin domain receptor 0.0031 0.0008 0.0002
Loa Loa (eye worm) hypothetical protein 0.014 0.0149 0.0142
Echinococcus granulosus geminin 0.0152 0.0165 0.0159
Brugia malayi angiogenesis inhibito 0.0135 0.0143 0.0143
Toxoplasma gondii subtilisin SUB1 0.0519 0.064 1
Loa Loa (eye worm) hypothetical protein 0.3008 0.3866 0.3862
Echinococcus granulosus glutamate receptor 2 0.0051 0.0033 0.0027
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0087 0.008 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0351 0.0422 0.0682
Brugia malayi hypothetical protein 0.0303 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0064 0.005 0.0043
Trypanosoma brucei subtilisin peptidase 0.0351 0.0422 0.4876
Echinococcus granulosus lysine specific histone demethylase 1A 0.0508 0.0625 0.0619
Echinococcus granulosus c-Jun N-terminal kinases 0.0255 0.0297 0.0291
Brugia malayi metalloprotease 0.0064 0.005 0.005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.002 0.002
Plasmodium vivax aspartyl protease, putative 0.0035 0.0012 0.0092
Entamoeba histolytica protein kinase, putative 0.0081 0.0072 0.0767
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.008 0.0071 0.0071
Schistosoma mansoni site-1 peptidase (S08 family) 0.0351 0.0422 0.0416
Loa Loa (eye worm) hypothetical protein 0.0343 0.0411 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0059 0.0044 0.0044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.002 0.0018
Schistosoma mansoni furin-1 (S08 family) 0.3359 0.4321 0.4318
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0085 0.0077 0.1818
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0085 0.0077 0.1832
Loa Loa (eye worm) hypothetical protein 0.0071 0.006 0.0053
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.067 0.0836 0.0831
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.002 0.0014
Leishmania major UDP-galactopyranose mutase 0.0103 0.0101 0.1142
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Schistosoma mansoni glutamate receptor NMDA 0.0285 0.0336 0.0331
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0237 0.0274 0.0268
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0012 0.0006
Giardia lamblia Tenascin precursor 0.014 0.0149 0.0346
Plasmodium vivax subtilisin-like protease 1 0.0519 0.064 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0005
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0059 0.061
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0096 0.0091 0.0107
Loa Loa (eye worm) integrin beta-2 0.6164 0.7957 0.7956
Schistosoma mansoni ATP-binding cassette transporter 0.0035 0.0012 0.0007
Loa Loa (eye worm) transcriptional regulator 0.0099 0.0095 0.0089
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0351 0.0422 0.0416
Schistosoma mansoni amine oxidase 0.0103 0.0101 0.0095
Schistosoma mansoni discoidin domain receptor 0.0031 0.0008 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0008 0.0001
Brugia malayi hypothetical protein 0.0035 0.0012 0.0012
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0085 0.0077 0.1832
Loa Loa (eye worm) hypothetical protein 0.0946 0.1193 0.1187
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0964 0.1217 0.1211
Echinococcus granulosus glutamate NMDA receptor subunit 0.0285 0.0336 0.0331
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0351 0.0422 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0031 0.0008 0.0003
Brugia malayi Furin-like cysteine rich region family protein 0.0403 0.049 0.049
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0099 0.0095 0.0833
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0027
Brugia malayi Protein kinase domain containing protein 0.0031 0.0008 0.0008
Onchocerca volvulus 0.0351 0.0422 0.6154
Brugia malayi hypothetical protein 0.0069 0.0057 0.0057
Onchocerca volvulus 0.0035 0.0012 0.006
Schistosoma mansoni site-1 peptidase (S08 family) 0.0351 0.0422 0.0416
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0011 0.0005
Brugia malayi SWIRM domain containing protein 0.0043 0.0023 0.0023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Loa Loa (eye worm) hypothetical protein 0.0758 0.095 0.0944
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0047 0.0028 0.0228
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.002 0.0014
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0051 0.0033 0.0034
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0005
Schistosoma mansoni hypothetical protein 0.0069 0.0057 0.0051
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0508 0.0625 0.0773
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0006
Plasmodium falciparum LCCL domain-containing protein 0.0031 0.0008 0.0029
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0077 0.0067 0.0061
Onchocerca volvulus 0.0551 0.0681 1
Brugia malayi EGF-like domain containing protein 0.014 0.0149 0.0149
Echinococcus multilocularis disintegrin and metalloproteinase 0.0096 0.0091 0.0107
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0095 0.0089
Giardia lamblia High cysteine protein 0.014 0.0149 0.0346
Mycobacterium ulcerans NAD-dependent deacetylase 0.0099 0.0095 0.2257
Mycobacterium tuberculosis Conserved hypothetical protein 0.0103 0.0101 0.2388
Giardia lamblia Furin precursor putative serine protease 0.1531 0.1951 0.5301
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0103 0.0101 0.1495
Trichomonas vaginalis conserved hypothetical protein 0.1531 0.1951 0.3192
Echinococcus multilocularis integrin alpha 3 0.0814 0.1022 0.1268
Schistosoma mansoni hypothetical protein 0.0031 0.0007 0.0001
Echinococcus granulosus lysine specific histone demethylase 1A 0.0103 0.0101 0.0095
Loa Loa (eye worm) reprolysin 0.0232 0.0267 0.0261
Echinococcus granulosus furin 0.774 1 1
Loa Loa (eye worm) integrin alpha pat-2 0.1535 0.1957 0.1951
Trichomonas vaginalis hypothetical protein 0.0031 0.0008 0.0003
Schistosoma mansoni septate junction protein 0.0036 0.0013 0.0007
Entamoeba histolytica hypothetical protein 0.0043 0.0023 0.0166
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0351 0.0422 0.0416
Brugia malayi neuroendocrine convertase 1 precursor 0.489 0.6306 0.6306
Mycobacterium tuberculosis Probable thioesterase TesA 0.0069 0.0056 0.1337
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.073 0.0913 0.1132
Loa Loa (eye worm) hypothetical protein 0.0508 0.0625 0.0619
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0232 0.0267 0.0261
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0051 0.0033 0.0027
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0081 0.0072 0.0551
Echinococcus multilocularis glutamate receptor 2 0.0051 0.0033 0.0034
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0051 0.0033 0.0027
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0077 0.0067 0.1594
Schistosoma mansoni hypothetical protein 0.0059 0.0044 0.0038
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0099 0.0095 0.0111
Brugia malayi Pepsin A precursor 0.0035 0.0012 0.0012
Mycobacterium ulcerans polyketide synthase 0.008 0.0071 0.1674
Loa Loa (eye worm) angiogenesis inhibito 0.0064 0.005 0.0043
Echinococcus granulosus membrane bound transcription factor site 1 0.0351 0.0422 0.0416
Leishmania major sir2-family protein-like protein 0.0099 0.0095 0.1076
Brugia malayi Disintegrin family protein 0.0096 0.0091 0.0091
Echinococcus multilocularis neuroendocrine convertase 2 0.489 0.6306 0.7865
Plasmodium vivax LCCL domain-containing protein 0.0031 0.0008 0.0029
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0034 0.0011 0.0006
Brugia malayi EGF-like domain containing protein 0.014 0.0149 0.0149
Brugia malayi transcriptional regulator, Sir2 family protein 0.0099 0.0095 0.0095
Loa Loa (eye worm) fatty acid synthase 0.0082 0.0073 0.0066
Loa Loa (eye worm) hypothetical protein 0.0096 0.0091 0.0085
Loa Loa (eye worm) hypothetical protein 0.0069 0.0057 0.005
Plasmodium falciparum plasmepsin VIII, putative 0.0035 0.0012 0.0092
Loa Loa (eye worm) glutamate receptor 1 0.0034 0.0011 0.0004
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0059 0.0044 0.0038
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0101 0.1495
Mycobacterium ulcerans fatty acid synthase Fas 0.0026 0.0001 0.0017
Toxoplasma gondii subtilisin SUB5 0.0351 0.0422 0.656
Loa Loa (eye worm) hypothetical protein 0.0135 0.0143 0.0136
Schistosoma mansoni integrin beta subunit 0.3605 0.464 0.4637
Plasmodium falciparum LCCL domain-containing protein 0.0031 0.0008 0.0029
Schistosoma mansoni hypothetical protein 0.0034 0.0011 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0006
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0232 0.0267 0.0326
Schistosoma mansoni hypothetical protein 0.0031 0.0008 0.0002
Plasmodium vivax plasmepsin V, putative 0.0388 0.0471 0.7327
Loa Loa (eye worm) hypothetical protein 0.0232 0.0267 0.0261
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0052 0.0034 0.0797
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Brugia malayi Subtilase family protein 0.0351 0.0422 0.0422
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0099 0.0095 0.1408
Mycobacterium leprae Polyketide synthase Pks13 0.0121 0.0124 0.292
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0099 0.0095 0.1043
Entamoeba histolytica hypothetical protein 0.0081 0.0072 0.0767
Trichomonas vaginalis conserved hypothetical protein 0.1531 0.1951 0.3192
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0099 0.0095 0.0833
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0099 0.0095 0.0199
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0026 0.0001 0.0017
Echinococcus multilocularis chromatin regulatory protein sir2 0.067 0.0836 0.1036
Schistosoma mansoni protein kinase 0.0128 0.0133 0.0127
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0351 0.0422 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0021 0.0241
Loa Loa (eye worm) hypothetical protein 0.0103 0.0101 0.0094
Loa Loa (eye worm) hypothetical protein 0.0136 0.0144 0.0137
Loa Loa (eye worm) proprotein convertase 2 0.1882 0.2406 0.2401
Trypanosoma brucei Silent information regulator 2 related protein 1 0.067 0.0836 1
Schistosoma mansoni apoptosis regulator bax 0.0059 0.0044 0.0038
Plasmodium falciparum subtilisin-like protease 2 0.0351 0.0422 0.656
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0034 0.0011 0.0005
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0064 0.005 0.1177
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1531 0.1951 0.3192
Schistosoma mansoni hypothetical protein 0.0059 0.0044 0.0038
Loa Loa (eye worm) transcriptional regulator 0.0099 0.0095 0.0089
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0012 0.0092
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Brugia malayi MH2 domain containing protein 0.0107 0.0106 0.0106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Brugia malayi Kelch motif family protein 0.0964 0.1217 0.1217
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0059 0.0044 0.0047
Mycobacterium ulcerans Type I modular polyketide synthase 0.008 0.0071 0.1674
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0087 0.0079 0.5
Loa Loa (eye worm) transcriptional regulator 0.067 0.0836 0.083
Loa Loa (eye worm) hypothetical protein 0.0146 0.0156 0.015
Loa Loa (eye worm) hypothetical protein 0.0103 0.0101 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Echinococcus granulosus nmda type glutamate receptor 0.012 0.0123 0.0117
Schistosoma mansoni btb and poz domain-containing protein 0.0031 0.0008 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0064 0.005 0.1162
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.067 0.0836 1
Mycobacterium ulcerans monoamine oxidase 0.0103 0.0101 0.2388
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0047 0.0028 0.0664
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.008 0.0071 0.1674
Schistosoma mansoni integrin alpha 0.1119 0.1418 0.1413
Trichomonas vaginalis conserved hypothetical protein 0.1531 0.1951 0.3192
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Echinococcus granulosus adam 0.0443 0.0541 0.0536
Loa Loa (eye worm) glutamate receptor 2 0.0034 0.0011 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.1531 0.1951 0.3192
Echinococcus granulosus fibrillin 2 0.014 0.0149 0.0143
Echinococcus multilocularis membrane bound transcription factor site 1 0.0351 0.0422 0.0519
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.008 0.0071 0.166
Loa Loa (eye worm) hypothetical protein 0.008 0.0071 0.0064
Echinococcus multilocularis integrin alpha ps 0.0648 0.0807 0.1
Entamoeba histolytica hypothetical protein 0.0047 0.0028 0.0228
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Brugia malayi hypothetical protein 0.0103 0.0101 0.0101
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0103 0.0101 0.1495
Loa Loa (eye worm) hypothetical protein 0.014 0.0149 0.0142
Brugia malayi ADAMTS-like protease 0.0135 0.0143 0.0143
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0034 0.0011 0.0005
Toxoplasma gondii histone deacetylase SIR2 0.0099 0.0095 0.1408
Mycobacterium ulcerans polyketide synthase Pks9 0.0052 0.0034 0.0813
Brugia malayi Integrin alpha pat-2 precursor 0.1119 0.1418 0.1418
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.002 0.0014
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0085 0.0077 0.1832
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0034 0.0011 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0101 0.1495
Echinococcus multilocularis nmda type glutamate receptor 0.012 0.0123 0.0146
Onchocerca volvulus 0.0071 0.0059 0.0765
Giardia lamblia Neurogenic locus notch-like protein 0.014 0.0149 0.0346
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0351 0.0422 0.4876
Mycobacterium ulcerans thioesterase 0.0069 0.0056 0.1337
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0095 0.0089
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0255 0.0297 0.0291
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0054 0.0037 0.0483
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0303 0.036 0.0354
Loa Loa (eye worm) hypothetical protein 0.0069 0.0057 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Brugia malayi ADAM-TS Spacer 1 family protein 0.0135 0.0143 0.0143
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0064 0.005 0.0044
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0099 0.0095 0.0111
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0025
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.008 0.0071 0.1674
Echinococcus granulosus MAM 0.0069 0.0057 0.0051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1882 0.2406 0.3939
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0051 0.0033 0.0034
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0351 0.0422 1
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0351 0.0422 1
Echinococcus granulosus integrin alpha ps 0.0281 0.0332 0.0326
Schistosoma mansoni glutamate receptor AMPA 0.0034 0.0011 0.0005
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0099 0.0095 0.0089
Brugia malayi hypothetical protein 0.0032 0.0009 0.0009
Echinococcus granulosus glutamate receptor subunit protein glur 0.0034 0.0011 0.0005
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0351 0.0422 0.0422
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0095 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0351 0.0422 0.0682
Mycobacterium ulcerans Type I modular polyketide synthase 0.008 0.0071 0.1674
Onchocerca volvulus 0.0109 0.0108 0.1491
Loa Loa (eye worm) sirtuin 4 0.0099 0.0095 0.0089
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0154 0.0167 0.0167
Brugia malayi Protein kinase domain containing protein 0.0069 0.0057 0.0057
Giardia lamblia Tenascin-X 0.014 0.0149 0.0346
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0095 0.0089
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0009 0.0004
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.008 0.0071 0.1683
Loa Loa (eye worm) hypothetical protein 0.0031 0.0008 0.0001
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.008 0.0071 0.166
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0081 0.0072 0.0066
Plasmodium vivax NAD-dependent deacetylase, putative 0.0099 0.0095 0.1408
Brugia malayi protein kinase C II. 0.0087 0.008 0.008
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0026 0 0.0006
Echinococcus multilocularis discoidin domain containing receptor 2 0.0031 0.0008 0.0002
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0069 0.0056 0.1322
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0508 0.0625 0.0619
Brugia malayi Stress-activated protein kinase jnk-1 0.0255 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0508 0.0625 0.0619
Schistosoma mansoni hypothetical protein 0.0071 0.0059 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.0422 0.0682
Echinococcus multilocularis MAM 0.0069 0.0057 0.0063
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0099 0.0095 0.2257
Schistosoma mansoni dock 0.0031 0.0008 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0008 0.0003
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0351 0.0422 1
Toxoplasma gondii subtilisin SUB8 0.0351 0.0422 0.656
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0103 0.0101 0.0095
Plasmodium vivax aspartyl protease, putative 0.0035 0.0012 0.0092
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0064 0.005 0.1177
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1882 0.2406 0.3939

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 12.5 ug ml-1 Antibacterial activity against Escherichia coli after 24 hrs by MTT method ChEMBL. 18313801

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.