Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0233 | 0.6244 | 0.6244 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0089 | 0.0711 | 0.075 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0129 | 0.2234 | 0.2358 |
Onchocerca volvulus | 0.0129 | 0.2234 | 1 | |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0317 | 0.9471 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0331 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0317 | 0.9471 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0119 | 0.1877 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0119 | 0.1877 | 0.1877 |
Brugia malayi | Cathepsin L-like precursor | 0.0129 | 0.2234 | 0.2358 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0089 | 0.0711 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0331 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0129 | 0.2234 | 0.1738 |
Brugia malayi | Cathepsin L-like precursor | 0.0129 | 0.2234 | 0.2358 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0331 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0331 | 1 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0317 | 0.9471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0129 | 0.2234 | 0.1738 |
Loa Loa (eye worm) | ctsf protein | 0.0129 | 0.2234 | 0.1738 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0119 | 0.1877 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0331 | 1 | 1 |
Onchocerca volvulus | 0.0129 | 0.2234 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0119 | 0.1877 | 0.1982 |
Brugia malayi | Cathepsin L-like precursor | 0.0129 | 0.2234 | 0.2358 |
Echinococcus granulosus | cathepsin l1 | 0.0129 | 0.2234 | 0.2358 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Leishmania major | cathepsin L-like protease | 0.0129 | 0.2234 | 0.0438 |
Echinococcus granulosus | cathepsin b | 0.0317 | 0.9471 | 1 |
Onchocerca volvulus | 0.0129 | 0.2234 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0331 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0129 | 0.2234 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0089 | 0.0711 | 0.075 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0129 | 0.2234 | 0.2358 |
Onchocerca volvulus | Cathepsin L homolog | 0.0129 | 0.2234 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0331 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0331 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0331 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0119 | 0.1877 | 0.1332 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0129 | 0.2234 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0129 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0089 | 0.0711 | 0.075 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0331 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0089 | 0.0711 | 0.075 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.0711 | 0.3182 |
Toxoplasma gondii | cathepsin CPL | 0.0129 | 0.2234 | 1 |
Leishmania major | cathepsin L-like protease | 0.0129 | 0.2234 | 0.0438 |
Brugia malayi | Cathepsin L-like precursor | 0.0129 | 0.2234 | 0.2358 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0129 | 0.2234 | 0.2358 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.9471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Echinococcus granulosus | cathepsin b | 0.0317 | 0.9471 | 1 |
Leishmania major | cathepsin L-like protease | 0.0331 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0129 | 0.2234 | 0.2358 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0317 | 0.9471 | 0.9471 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0129 | 0.2234 | 0.2358 |
Brugia malayi | Cathepsin L-like precursor | 0.0129 | 0.2234 | 0.2358 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0089 | 0.0711 | 0.075 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0331 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0331 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0291 | 0.8477 | 0.8477 |
Leishmania major | cysteine peptidase A (CPA) | 0.0129 | 0.2234 | 0.0438 |
Onchocerca volvulus | 0.0129 | 0.2234 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0129 | 0.2234 | 1 |
Onchocerca volvulus | 0.0129 | 0.2234 | 1 | |
Onchocerca volvulus | 0.0129 | 0.2234 | 1 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0129 | 0.2234 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0317 | 0.9471 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0129 | 0.2234 | 0.1738 |
Loa Loa (eye worm) | fibroinase | 0.0129 | 0.2234 | 0.1738 |
Giardia lamblia | Cathepsin B precursor | 0.0119 | 0.1877 | 0.5 |
Onchocerca volvulus | 0.0129 | 0.2234 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0129 | 0.2234 | 0.0438 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0317 | 0.9471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.0711 | 0.3182 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0317 | 0.9471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Plasmodium vivax | vivapain-2 | 0.0129 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0119 | 0.1877 | 0.8406 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0129 | 0.2234 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0317 | 0.9471 | 1 |
Leishmania major | cathepsin L-like protease | 0.0129 | 0.2234 | 0.0438 |
Plasmodium vivax | vivapain-2 | 0.0129 | 0.2234 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0129 | 0.2234 | 0.2358 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.2234 | 0.1738 |
Brugia malayi | Cathepsin L-like precursor | 0.0129 | 0.2234 | 0.2358 |
Echinococcus multilocularis | cysteine protease | 0.0129 | 0.2234 | 0.2358 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0331 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0129 | 0.2234 | 1 |
Leishmania major | cathepsin L-like protease | 0.0331 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0129 | 0.2234 | 0.2358 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0129 | 0.2234 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0129 | 0.2234 | 0.2358 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0331 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0331 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0119 | 0.1877 | 0.1877 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0129 | 0.2234 | 0.2234 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0089 | 0.0711 | 0.075 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0129 | 0.2234 | 0.2358 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0129 | 0.2234 | 0.2358 |
Leishmania major | cathepsin L-like protease | 0.0129 | 0.2234 | 0.0438 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.2234 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 61 % | Antimicrobial activity against Mycobacterium tuberculosis assessed as growth inhibition at 100 uM after 8 days under aerobic condition by alamar blue assay | ChEMBL. | 19099398 |
Inhibition (functional) | = 79 % | Antimicrobial activity against Mycobacterium tuberculosis assessed as growth inhibition at 100 uM after 11 days under anaerobic condition by luminescence-based low oxygen recovery assay | ChEMBL. | 19099398 |
MIC (functional) | > 128 uM | Antimicrobial activity against Mycobacterium tuberculosis after 8 days in aerobic condition by alamar blue assay | ChEMBL. | 19099398 |
MIC (functional) | > 128 uM | Antimicrobial activity against Mycobacterium tuberculosis after 11 days under anaerobic condition by luminescence-based low oxygen recovery assay | ChEMBL. | 19099398 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.