Detailed information for compound 986041

Basic information

Technical information
  • TDR Targets ID: 986041
  • Name: 2,5-dimethyl-1-(4-methylphenyl)pyrrole-3-carb aldehyde
  • MW: 213.275 | Formula: C14H15NO
  • H donors: 0 H acceptors: 1 LogP: 2.95 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Cc1cc(n(c1C)c1ccc(cc1)C)C
  • InChi: 1S/C14H15NO/c1-10-4-6-14(7-5-10)15-11(2)8-13(9-16)12(15)3/h4-9H,1-3H3
  • InChiKey: YGUWNSYHYBHIIC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,5-dimethyl-1-(4-methylphenyl)-3-pyrrolecarboxaldehyde
  • AE-848/36959613
  • ZINC00332813
  • STK300004

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0209
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0209
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0085 0.0187
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0202 0.0136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0209
Schistosoma mansoni patched 1 0.0043 0.0187 0.0257
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0209
Mycobacterium tuberculosis Possible formate hydrogenlyase HycD (FHL) 0.008 0.0423 0.036
Treponema pallidum nitrogen fixation protein (rnfC) 0.0145 0.0838 1
Mycobacterium ulcerans NADH dehydrogenase subunit H 0.0296 0.1799 0.1744
Echinococcus granulosus lamin dm0 0.0027 0.0089 0.022
Echinococcus multilocularis expressed conserved protein 0.0093 0.0508 0.1254
Echinococcus granulosus acyl carrier protein mitochondrial 0.0045 0.0202 0.0498
Mycobacterium ulcerans polyketide synthase 0.0045 0.0202 0.0136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0209
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0651 0.4052 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0209
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0045 0.0202 0.0136
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0045 0.0202 0.0136
Schistosoma mansoni hypothetical protein 0.0041 0.0177 0.0233
Schistosoma mansoni hypothetical protein 0.0296 0.1799 0.4321
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0045 0.0202 0.0136
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.022
Onchocerca volvulus 0.0045 0.0202 0.063
Mycobacterium ulcerans putative regulatory protein 0.007 0.0359 0.0294
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.1587 1 1
Onchocerca volvulus 0.0027 0.0089 0.0084
Mycobacterium ulcerans Type I modular polyketide synthase 0.0045 0.0202 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0178
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0045 0.0202 0.0136
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit H 0.0296 0.1799 0.4348
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0045 0.0202 0.0136
Onchocerca volvulus 0.0026 0.0085 0.0062
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0085 0.0209
Mycobacterium ulcerans polyketide synthase Pks9 0.0045 0.0202 0.0136
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0045 0.0202 0.0136
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0085 0.0209
Mycobacterium ulcerans proteasome PrcA 0.1587 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0187 0.0289
Mycobacterium ulcerans polyketide synthase Pks13 0.0045 0.0202 0.0136
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0024 0.0072 0.042
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0045 0.0202 0.0136
Brugia malayi NADH dehydrogenase subunit 1 0.008 0.0423 0.1025
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0651 0.4052 1
Plasmodium falciparum acyl carrier protein 0.0045 0.0202 1
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0085 0.0062
Onchocerca volvulus 0.0045 0.0202 0.063
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0209
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0045 0.0202 0.0136
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0045 0.0202 0.0136
Onchocerca volvulus 0.0026 0.0085 0.0062
Schistosoma mansoni lamin 0.0027 0.0089 0.0011
Toxoplasma gondii type I fatty acid synthase, putative 0.0045 0.0202 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0045 0.0202 0.0136
Echinococcus multilocularis transfer RNA-Lys 0.007 0.0359 0.0885
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0045 0.0202 0.0136
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0045 0.0202 0.0136
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0546 1
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.0651 0.4052 0.4012
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.0651 0.4052 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0045 0.0202 0.0136
Loa Loa (eye worm) hypothetical protein 0.0315 0.192 0.4739
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0209
Plasmodium vivax acyl carrier protein, putative 0.0045 0.0202 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0209
Leishmania major protein kinase, putative 0.0024 0.0072 0.0014
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0045 0.0202 0.0136
Brugia malayi hypothetical protein 0.008 0.0423 0.1025
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0085 0.0209
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0187 0.0461
Mycobacterium leprae Possible regulatory protein 0.0024 0.0072 0.0006
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0045 0.0202 0.063
Schistosoma mansoni hypothetical protein 0.0041 0.0177 0.0233
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0651 0.4052 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0024 0.0072 0.0178
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0045 0.0202 1
Brugia malayi AMP-binding enzyme family protein 0.0045 0.0202 0.0476
Brugia malayi Blistered cuticle protein 3 0.0026 0.0085 0.0187
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0448 0.1106
Onchocerca volvulus 0.008 0.0423 0.1705
Brugia malayi hypothetical protein 0.0026 0.0085 0.0187
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0045 0.0202 0.0136
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.0651 0.4052 0.4012
Echinococcus granulosus peroxidasin 0.0026 0.0085 0.0209
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0187 0.0461
Mycobacterium ulcerans polyketide synthase 0.0045 0.0202 0.0136
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0045 0.0202 0.0136
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0024 0.0072 0.0178
Brugia malayi bHLH-PAS transcription factor 0.007 0.0359 0.0865
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0546 0.1348
Echinococcus multilocularis lamin dm0 0.0027 0.0089 0.022
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0045 0.0202 0.0136
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0085 0.0209
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0209
Echinococcus multilocularis lamin 0.0027 0.0089 0.022
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0816 0.2015
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0045 0.0202 0.0136
Echinococcus granulosus NADH dehydrogenase 0.0045 0.0202 0.0498
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0085 0.0062
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0024 0.0072 0.0178
Mycobacterium leprae Polyketide synthase Pks13 0.0045 0.0202 0.0136
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0045 0.0202 0.0136
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0349 0.2133 1
Schistosoma mansoni lamin 0.0027 0.0089 0.0011
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0045 0.0202 0.0136
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0045 0.0202 1
Echinococcus granulosus single minded 2 0.007 0.0359 0.0885
Entamoeba histolytica acyl-CoA synthetase, putative 0.0045 0.0202 0.2823
Echinococcus multilocularis AMP dependent ligase 0.0045 0.0202 0.0498
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0045 0.0202 0.0136
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0045 0.0202 0.0136
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0045 0.0202 0.034
Brugia malayi AMP-binding enzyme family protein 0.0045 0.0202 0.0476
Brugia malayi intermediate filament protein 0.0027 0.0089 0.0198
Loa Loa (eye worm) hypothetical protein 0.0084 0.0448 0.1106
Mycobacterium ulcerans acyl carrier protein 0.0045 0.0202 0.0136
Mycobacterium ulcerans acyl carrier protein 0.0045 0.0202 0.0136
Mycobacterium ulcerans hypothetical protein 0.0045 0.0202 0.0136
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0045 0.0202 0.0136
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0556 0.1188
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0651 0.4052 1
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0085 0.0062
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0045 0.0202 0.0498
Onchocerca volvulus 0.0027 0.0089 0.0084
Brugia malayi Peroxidasin 0.0026 0.0085 0.0187
Onchocerca volvulus Peroxidase homolog 0.0026 0.0085 0.0062
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.0651 0.4052 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0045 0.0202 0.0136
Schistosoma mansoni NADH dehydrogenase subunit 1 0.008 0.0423 0.0854
Schistosoma mansoni hypothetical protein 0.0041 0.0177 0.0233
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0202 0.0136
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0045 0.0202 0.0136
Loa Loa (eye worm) hypothetical protein 0.0043 0.0187 0.0461
Echinococcus granulosus aryl hydrocarbon receptor 0.0024 0.0072 0.0178
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0045 0.0202 0.0136
Brugia malayi hypothetical protein 0.0315 0.192 0.4727
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0045 0.0202 0.0136
Echinococcus granulosus AMP dependent ligase 0.0045 0.0202 0.0498
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0546 0.1348
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0045 0.0202 0.0136
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0651 0.4052 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0089 0.022
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0024 0.0072 0.0014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0202 0.0136
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0045 0.0202 0.0136
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.0651 0.4052 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0094 0.0514 0.1082
Onchocerca volvulus 0.008 0.0423 0.1705
Loa Loa (eye worm) hypoxia-induced factor 1 0.0291 0.1765 0.4356
Onchocerca volvulus 0.0026 0.0085 0.0062
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0187 0.0461
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0045 0.0202 0.0476
Loa Loa (eye worm) acyl carrier protein 0.0045 0.0202 0.0498
Mycobacterium ulcerans membrane protein ComEA 0.0145 0.0838 0.0777
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0045 0.0202 0.0136
Loa Loa (eye worm) hypothetical protein 0.0052 0.0248 0.0611
Brugia malayi hypoxia-induced factor 1 0.0291 0.1765 0.4343
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0209
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0045 0.0202 0.034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0209
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0651 0.4052 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0085 0.0187
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0045 0.0202 0.0136
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0045 0.0202 0.0326
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0009 0.0023
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0045 0.0202 0.0136
Toxoplasma gondii acyl carrier protein ACP 0.0045 0.0202 1
Echinococcus granulosus expressed conserved protein 0.0093 0.0508 0.1254
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0045 0.0202 0.0136
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0045 0.0202 0.0476
Onchocerca volvulus Fatty acid synthase homolog 0.0045 0.0202 0.063
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0085 0.0062
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0085 0.0187
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0085 0.0209
Onchocerca volvulus 0.0045 0.0202 0.063
Onchocerca volvulus 0.0084 0.0448 0.1826
Schistosoma mansoni acyl carrier protein 0.0045 0.0202 0.0295
Brugia malayi PAS domain containing protein 0.0094 0.0514 0.1249
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0024 0.0072 0.0178
Echinococcus multilocularis protein patched 0.0043 0.0187 0.0461
Echinococcus multilocularis musashi 0.0027 0.0089 0.022
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0045 0.0202 0.0136
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0045 0.0202 0.0498
Mycobacterium ulcerans polyketide synthase MbtD 0.0045 0.0202 0.0136
Mycobacterium tuberculosis Conserved hypothetical protein 0.0145 0.0838 0.0777
Mycobacterium ulcerans acyl-CoA synthetase 0.0045 0.0202 0.0136
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0045 0.0202 0.0476
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0045 0.0202 0.0136
Mycobacterium leprae Probable polyketide synthase Pks1 0.0045 0.0202 0.0136
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0448 0.1086
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0085 0.0187
Schistosoma mansoni hypothetical protein 0.0045 0.0202 0.0295
Schistosoma mansoni single-minded 0.0094 0.0514 0.1082
Mycobacterium leprae conserved hypothetical protein 0.0045 0.0202 0.0136
Onchocerca volvulus 0.007 0.0359 0.1391
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0045 0.0202 0.0136
Loa Loa (eye worm) NADH dehydrogenase subunit 1 0.008 0.0423 0.1045
Schistosoma mansoni hypothetical protein 0.0041 0.0177 0.0233
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) 0.0296 0.1799 0.1744
Loa Loa (eye worm) hypothetical protein 0.0027 0.0086 0.0212
Echinococcus multilocularis NADH dehydrogenase 0.0045 0.0202 0.0498
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0085 0.0187
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0045 0.0202 0.0476
Onchocerca volvulus Peroxidase homolog 0.0026 0.0085 0.0062
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0045 0.0202 0.0136
Mycobacterium ulcerans formate hydrogenlyase HycD 0.008 0.0423 0.036
Mycobacterium ulcerans Type I modular polyketide synthase 0.0045 0.0202 0.0136
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.0651 0.4052 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0209
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0045 0.0202 0.0136
Schistosoma mansoni intermediate filament proteins 0.0027 0.0089 0.0011
Treponema pallidum acyl carrier protein 0.0045 0.0202 0.1755
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0089 0.022
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.0651 0.4052 1
Echinococcus granulosus lamin 0.0027 0.0089 0.022
Leishmania major acyl carrier protein, putative 0.0045 0.0202 0.034
Loa Loa (eye worm) acyl carrier protein 0.0045 0.0202 0.0498
Loa Loa (eye worm) hypothetical protein 0.0045 0.0202 0.0498
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.0651 0.4052 1
Brugia malayi Phosphopantetheine attachment site family protein 0.0045 0.0202 0.0476
Echinococcus granulosus NADH dehydrogenase subunit 1 0.0296 0.1799 0.444
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0187 0.0461
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0816 0.2015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0045 0.0202 0.2823
Echinococcus granulosus intermediate filament protein 0.0027 0.0089 0.022
Chlamydia trachomatis acyl carrier protein 0.0045 0.0202 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0546 0.1348
Brugia malayi NADH dehydrogenase subunit 1, identical 0.008 0.0423 0.1025
Echinococcus multilocularis peroxidasin 0.0026 0.0085 0.0209
Echinococcus multilocularis protein dispatched 1 0.0049 0.0225 0.0555
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0045 0.0202 0.0136
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.0651 0.4052 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0045 0.0202 0.0136
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0089 0.0198
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0546 0.1328
Brugia malayi CHE-14 protein 0.0043 0.0187 0.044
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0045 0.0202 0.0136
Toxoplasma gondii type I fatty acid synthase, putative 0.0045 0.0202 1
Leishmania major protein kinase, putative 0.0024 0.0072 0.0014
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0448 0.0916
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0045 0.0202 0.0136
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0045 0.0202 0.0498
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0209
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0448 0.1106

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) OSM: Inhibition of Plasmodium falciparum 3D7 growth. IC50 values determined from 21 point dose response curves. Avery Group Griffith. ChEMBL. No reference
Inhibition (functional) OSM: Percent inhibition of Plasmodium falciparum K1 growth at 120 uM. Avery Group Griffith. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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