TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 388.246 | Formula: C18H21BN2O5S
H donors: 1 H acceptors: 3 LogP: 1.42 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)S(=O)(=O)c1ccc(cc1)Oc1ccc2c(c1)COB2O
InChi: 1S/C18H21BN2O5S/c1-20-8-10-21(11-9-20)27(23,24)17-5-2-15(3-6-17)26-16-4-7-18-14(12-16)13-25-19(18)22/h2-7,12,22H,8-11,13H2,1H3
InChiKey: XRFULAKZXAYUMU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 4D, cAMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.0645	0.0645
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0283	0.4105	1
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.012	0.2268
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0059	0.0059
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.4105	0.9219
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.012	0.2268
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.012	0.0773
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0049	0.0528	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1492	0.1495
Entamoeba histolytica	modulator of drug activity B homolog, putative	0.0019	0.007	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1492	0.1495
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Echinococcus multilocularis	lysine specific demethylase 5A	0.0057	0.0645	0.064
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0199	0.0194
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0019	0.0057	0.0052
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0059	0.1122
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0059	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0049	0.0528	0.0526
Treponema pallidum	fructose-bisphosphate aldolase	0.0283	0.4105	1
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0578	0.0573
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.0682	0.0677
Echinococcus granulosus	expressed protein	0.0361	0.5305	0.5302
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0057	0.0052
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0064	0.0064
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0054
Echinococcus multilocularis	microtubule associated protein 2	0.0668	1	1
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0057	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0057	0.0052
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0578	0.0578
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0059	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Echinococcus multilocularis	expressed protein	0.0361	0.5305	0.5302
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0528	0.1073
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0019	0.0058	0.0053
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.0682	0.0677
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0023	0.012	0.0331
Entamoeba histolytica	hypothetical protein	0.0019	0.007	0.0032
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0059	0.0054
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0528	0.1073
Echinococcus granulosus	zinc finger protein	0.0021	0.0088	0.0082
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0059	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0664	0.9948	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0112	0.1492	0.1492
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0057	0.0052
Brugia malayi	Carboxylesterase family protein	0.0112	0.1492	0.1495
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0019	0.0058	0.0053
Echinococcus granulosus	acetylcholinesterase	0.0664	0.9948	0.9948
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0049	0.0528	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0057	0.0052
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0057	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0043	0.043	0.0426
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.4105	0.9219
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.4105	0.9219
Brugia malayi	Carboxylesterase family protein	0.0664	0.9948	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0342	0.0338
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0059	0.0054
Echinococcus multilocularis	neuroligin	0.0112	0.1492	0.1488
Brugia malayi	Bromodomain containing protein	0.0037	0.0341	0.0337
Onchocerca volvulus		0.0046	0.048	0.2175
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.008	0.1005	0.1005
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0098	0.1275	0.1276
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0057	0.0645	0.064
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0057	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1492	0.1495
Loa Loa (eye worm)	carboxylesterase	0.0112	0.1492	0.1495
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0057	0.0057
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0112	0.1492	0.1488
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0019	0.007	0.003
Echinococcus granulosus	mitogen activated protein kinase	0.0049	0.0528	0.0523
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0049	0.0528	0.3539
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0578	0.0573
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0026	0.002
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0057	0.0052
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.4105	0.9219
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0676	0.0676
Brugia malayi	hypothetical protein	0.0019	0.0057	0.0052
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0059	0.1122
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0182	0.2559	0.2555
Echinococcus granulosus	mitogen activated protein kinase 3	0.0049	0.0528	0.0523
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.4105	0.9219
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0035	0.003
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1483	0.1485
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Loa Loa (eye worm)	hypothetical protein	0.008	0.1005	0.1006
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0059	0.0004
Brugia malayi	MAP kinase sur-1	0.0049	0.0528	0.0526
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0023	0.012	0.0331
Echinococcus multilocularis	acetylcholinesterase	0.0664	0.9948	0.9948
Brugia malayi	Carboxylesterase family protein	0.0112	0.1492	0.1495
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0023	0.012	0.0331
Schistosoma mansoni	cpg binding protein	0.0028	0.0199	0.0199
Echinococcus multilocularis	zinc finger protein	0.0021	0.0088	0.0082
Entamoeba histolytica	hypothetical protein	0.0023	0.012	0.0154
Schistosoma mansoni	cpg binding protein	0.0031	0.0251	0.0251
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0057	0.0052
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.012	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0019	0.007	0.003
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0098	0.1275	0.1276
Loa Loa (eye worm)	RGS-3 protein	0.0019	0.0057	0.0052
Echinococcus multilocularis	carboxylesterase 5A	0.0664	0.9948	0.9948
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0112	0.1492	0.7832
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.1483	0.1478
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0112	0.1492	0.1488
Echinococcus multilocularis	L aminoadipate semialdehyde	0.008	0.1005	0.1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Echinococcus multilocularis	mitogen activated protein kinase	0.0049	0.0528	0.0523
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.4105	0.9219
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Echinococcus granulosus	neuroligin	0.0112	0.1492	0.1488
Echinococcus granulosus	dna polymerase eta	0.0019	0.0059	0.0054
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Entamoeba histolytica	iron-sulfur flavoprotein, putative	0.0019	0.007	0.0032
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0306	0.03
Brugia malayi	PHD-finger family protein	0.0026	0.0167	0.0162
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0057	0.0057
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0112	0.1492	0.1492
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.012	0.0773
Onchocerca volvulus		0.0112	0.1492	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0049	0.0528	0.0523
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Onchocerca volvulus		0.0112	0.1492	1
Echinococcus granulosus	lysine specific demethylase 5A	0.006	0.0697	0.0692
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0046	0.048	0.0475
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0057	0.0052
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0138	0.1889	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Trypanosoma brucei	protein kinase, putative	0.0049	0.0528	1
Schistosoma mansoni	hypothetical protein	0.0281	0.4071	0.4071
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Echinococcus granulosus	L aminoadipate semialdehyde	0.008	0.1005	0.1
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0064	0.0064
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0306	0.03
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0019	0.0064	0.0059
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0112	0.1483	1
Echinococcus granulosus	polycomb protein SCMH1	0.0046	0.048	0.0475
Schistosoma mansoni	BC026374 protein (S09 family)	0.0112	0.1492	0.1492
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0305	0.4448	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0664	0.9948	0.9948
Echinococcus multilocularis	cpg binding protein	0.0031	0.0251	0.0246
Brugia malayi	PXA domain containing protein	0.0019	0.0057	0.0052
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0098	0.1275	0.127
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0019	0.0064	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0046	0.048	0.0477
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0528	0.1073
Loa Loa (eye worm)	acetylcholinesterase 1	0.0664	0.9948	1
Brugia malayi	Bromodomain containing protein	0.0074	0.0909	0.0909
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0132	0.0126
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0015	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1492	0.1495
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0059	0.0054
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0057	0.0052
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0035	0.0035
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0064	0.0064
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0112	0.1492	0.1492
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0578	0.0573
Echinococcus granulosus	cpg binding protein	0.0031	0.0251	0.0246
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0057	0.0057
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.4105	0.9219
Schistosoma mansoni	phd/f-box containing protein	0.0015	0.0006	0.0006
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0057	0.0052
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0112	0.1492	0.1492
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.1483	0.1478
Loa Loa (eye worm)	carboxylesterase	0.0664	0.9948	1
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0132	0.0132
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0112	0.1492	0.7832
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0046	0.048	0.048
Trichomonas vaginalis	FMN-dependent NADH-azoreductase, putative	0.0019	0.007	0.003
Leishmania major	hypothetical protein, conserved	0.0015	0.0006	0.0108
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0057	0.0057
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0112	0.1492	0.7832
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0112	0.1492	0.1488
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0057	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0821	0.082
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.0528	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.0528	1
Brugia malayi	PXA domain containing protein	0.0019	0.0057	0.0052
Schistosoma mansoni	gliotactin	0.0112	0.1492	0.1492
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0057	0.0052
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0015	0.0006	0.0108
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0019	0.0064	0.0059
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0615	0.4123
Loa Loa (eye worm)	mbt repeat family protein	0.0046	0.048	0.0477
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0019	0.0064	0.0059
Trypanosoma brucei	unspecified product	0.0019	0.0059	0.1122
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Brugia malayi	mbt repeat family protein	0.0046	0.048	0.0477
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0132	0.0126
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0138	0.1889	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0578	0.0573
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0182	0.2559	0.2555
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0057	0.0052
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0035	0.0035
Loa Loa (eye worm)	MBCTL1	0.0053	0.0578	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1492	0.1495
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0019	0.0057	0.0052
Brugia malayi	jmjC domain containing protein	0.0057	0.0645	0.0643
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0035	0.003
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0046	0.048	0.2175
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0019	0.0064	0.0059
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0112	0.1483	0.1483
Schistosoma mansoni	phosphatidylserine receptor	0.0015	0.0006	0.0006
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0057	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1492	0.1495
Brugia malayi	hypothetical protein	0.0019	0.0057	0.0052
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.4105	0.9219
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0006	0.0108
Brugia malayi	jmjC domain containing protein	0.006	0.0697	0.0696
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0059	0.1122
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Schistosoma mansoni	hypothetical protein	0.002	0.0079	0.0079
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0079	0.0074
Schistosoma mansoni	jumonji domain containing protein	0.0015	0.0006	0.0006
Giardia lamblia	Fructose-bisphosphate aldolase	0.0283	0.4105	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0035	0.003
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0059	0.1122
Giardia lamblia	NADPH oxidoreductase, putative	0.0019	0.007	0.0027
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Schistosoma mansoni	cpg binding protein	0.0031	0.0251	0.0251
Giardia lamblia	NADPH oxidoreductase, putative	0.0019	0.007	0.0027
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0112	0.1492	0.3269
Echinococcus granulosus	SAM and MBT domain containing protein	0.0046	0.048	0.0475
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0049	0.0528	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0057	0.0052
Echinococcus multilocularis	acetylcholinesterase	0.0664	0.9948	0.9948
Schistosoma mansoni	hypothetical protein	0.0396	0.5835	0.5835
Brugia malayi	Carboxylesterase family protein	0.0664	0.9948	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0377	0.0373
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0059	0.0054
Onchocerca volvulus		0.0112	0.1492	1
Loa Loa (eye worm)	PXA domain-containing protein	0.0019	0.0057	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0026	0.002
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0697	0.0697
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0006	0.0108
Echinococcus granulosus	para nitrobenzyl esterase	0.0112	0.1492	0.1488
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.1483	0.1478
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.048	0.048
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0059	0.0005
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0059	0.0054
Echinococcus granulosus	BC026374 protein S09 family	0.0112	0.1492	0.1488
Echinococcus multilocularis	dnaJ subfamily B	0.0396	0.5835	0.5833
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0199	0.0194
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0019	0.0057	0.0057
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Giardia lamblia	NADPH oxidoreductase, putative	0.0019	0.007	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0664	0.9948	1
Schistosoma mansoni	acetylcholinesterase	0.0112	0.1492	0.1492
Echinococcus multilocularis	regulator of G protein signaling	0.0019	0.0057	0.0052
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.1483	0.1478
Brugia malayi	Carboxylesterase family protein	0.0112	0.1492	0.1495
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.008	0.1005	0.1006
Mycobacterium ulcerans	carboxylesterase, LipT	0.0112	0.1492	0.7832
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.0057	0.0052
Echinococcus granulosus	Regulator of G protein signaling 20	0.0019	0.0057	0.0052
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0023	0.012	0.5
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0019	0.007	0.003
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0528	0.1073
Schistosoma mansoni	zinc finger protein	0.0021	0.0088	0.0088
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0059	0.0054
Brugia malayi	mbt repeat family protein	0.0046	0.048	0.0477
Echinococcus multilocularis	polycomb protein SCMH1	0.0046	0.048	0.0475
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0057	0.0057
Onchocerca volvulus		0.008	0.1005	0.6235
Echinococcus granulosus	acetylcholinesterase	0.0664	0.9948	0.9948
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0035	0.003
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0059	0.0059
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0059	0.0059
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0019	0.0057	0.0052
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0057	0.0645	0.064
Onchocerca volvulus		0.0112	0.1492	1
Schistosoma mansoni	protein phosphatase 2C	0.0015	0.0006	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.0057	0.0052
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0697	0.0697
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0578	0.0576
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0057	0.0052
Schistosoma mansoni	bromodomain containing protein	0.0063	0.0735	0.0735
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0049	0.0528	1
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0112	0.1483	0.3518
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.012	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1492	0.1495
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0057	0.0052
Echinococcus multilocularis	para nitrobenzyl esterase	0.0112	0.1492	0.1488
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0528	0.0528
Trichomonas vaginalis	spcc417.12 protein, putative	0.0112	0.1492	0.3269
Schistosoma mansoni	microtubule-associated protein tau	0.0668	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0098	0.1275	0.127
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0057	0.0057
Echinococcus granulosus	dnaJ subfamily B	0.0396	0.5835	0.5833
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0057	0.0052
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0026	0.0026
Brugia malayi	Carboxylesterase family protein	0.0112	0.1492	0.1495
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0059	0.1122
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0023	0.012	0.5
Giardia lamblia	Kinase, CMGC MAPK	0.0049	0.0528	0.116
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0057	0.0057
Onchocerca volvulus		0.0112	0.1492	1
Loa Loa (eye worm)	carboxylesterase	0.0112	0.1492	0.1495
Leishmania major	DNA polymerase eta, putative	0.0019	0.0059	0.1122
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.048	0.048
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0059	0.1122
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0057	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.007	0.003
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0283	0.4105	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0026	0.0026
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0059	0.1122
Brugia malayi	hypothetical protein	0.0112	0.1492	0.1495
Trichomonas vaginalis	modulator of drug activity B, putative	0.0019	0.007	0.003
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0138	0.1889	1
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0057	0.0057
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0057	0.0057
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0697	0.0696
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0305	0.4448	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0578	0.0576
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0057	0.0052
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0057	0.0057
Echinococcus granulosus	carboxylesterase 5A	0.0664	0.9948	0.9948
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0049	0.0528	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10 uM	Inhibition of PDE4 in human U937 cells assessed as accumulation of [3H]adenosine by scintillation counting	ChEMBL.	19303290
IC50 (functional)	> 10 uM	Antiinflammatory activity in human PBMC assessed as inhibition of phytohemagglutininin-induced IL10 release after 48 hrs by FACS Array analysis	ChEMBL.	19303290
IC50 (functional)	> 10 uM	Antiinflammatory activity in human PBMC assessed as inhibition of phytohemagglutininin-induced IL5 release after 48 hrs by FACS Array analysis	ChEMBL.	19303290
IC50 (functional)	> 10 uM	Antiinflammatory activity in human PBMC assessed as inhibition of phytohemagglutininin-induced IFN-gamma release after 24 hrs by FACSArray analysis	ChEMBL.	19303290
IC50 (functional)	> 10 uM	Antiinflammatory activity in human PBMC assessed as inhibition of phytohemagglutininin-induced IL2 release after 24 hrs by FACS Array analysis	ChEMBL.	19303290
IC50 (functional)	> 10 uM	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release in after 24 hrs by FACS Array analysis	ChEMBL.	19303290

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	19303290

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL483990

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 986059