Detailed information for compound 986101

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 455.634 | Formula: C19H21NO4S4
  • H donors: 0 H acceptors: 3 LogP: 4.66 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSC(=S)SCC(=O)c1cccc(c1)S(=O)(=O)N(c1ccc(cc1)OC)C
  • InChi: 1S/C19H21NO4S4/c1-4-26-19(25)27-13-18(21)14-6-5-7-17(12-14)28(22,23)20(2)15-8-10-16(24-3)11-9-15/h5-12H,4,13H2,1-3H3
  • InChiKey: FIPYITCQUHBSCJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 9 Starlite/ChEMBL References
Homo sapiens histone deacetylase 3 References
Homo sapiens histone deacetylase 6 Starlite/ChEMBL References
Homo sapiens histone deacetylase 2 References
Homo sapiens histone deacetylase 1 Starlite/ChEMBL References
Homo sapiens histone deacetylase 10 References
Homo sapiens histone deacetylase 8 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum ko:K06067 histone deacetylase 1/2, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC3 Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deacetylase HDA2/Rpd3p Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Entamoeba histolytica histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 3 (HD3) Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 1 (HD1) Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum RPD3/HD1 histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K01463 Hdac3 [EC:3.5.1.-], putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase 1,histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC2 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Giardia lamblia Histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum histone deacetylase 1 histone deacetylase 8 286 aa 241 aa 44.8 %
Trypanosoma cruzi histone deacetylase, putative histone deacetylase 3 428 aa 374 aa 30.5 %
Trypanosoma brucei histone deacetylase 2 histone deacetylase 2 488 aa 427 aa 29.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis tubulin beta chain, putative 0.0217 0.0366 0.73
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.001 0.0018
Entamoeba histolytica tubulin family protein 0.0117 0.0182 0.3358
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0015 0.0144
Trypanosoma cruzi UDP-galactopyranose mutase 0.0385 0.0675 0.4678
Plasmodium falciparum tubulin epsilon chain, putative 0.0117 0.0182 0.0608
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0385 0.0675 0.5489
Echinococcus multilocularis Tubulin beta 2C chain 0.0117 0.0182 0.0374
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0028 0.0423
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0015 0.0012
Plasmodium falciparum protoporphyrinogen oxidase 0.0385 0.0675 0.2273
Brugia malayi Patched related family protein 10 0.0019 0.0003 0.0007
Plasmodium vivax telomerase reverse transcriptase, putative 0.08 0.1435 0.4842
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0024 0.0139
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0028 0.0423
Echinococcus multilocularis transient receptor potential ion channel A 0.0099 0.015 0.0304
Loa Loa (eye worm) hypothetical protein 0.0032 0.0028 0.0247
Echinococcus granulosus tubulin delta chain 0.0051 0.0061 0.0447
Entamoeba histolytica tubulin alpha chain, putative 0.0217 0.0366 0.6871
Echinococcus granulosus Tubulin beta 2C chain 0.0117 0.0182 0.1441
Mycobacterium ulcerans cell division protein FtsZ 0.0051 0.0061 0.0059
Schistosoma mansoni tubulin subunit epsilon 0.0117 0.0182 0.1441
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0166 0.0273 0.2646
Schistosoma mansoni patched 1 0.0131 0.0209 0.1662
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0028 0.0044
Trichomonas vaginalis tubulin gamma chain, putative 0.0117 0.0182 0.3568
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.001 0.0026
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0576 0.1024 0.2646
Loa Loa (eye worm) hypothetical protein 0.0385 0.0675 0.658
Echinococcus granulosus Tubulin beta 2C chain 0.0117 0.0182 0.1441
Echinococcus multilocularis expressed conserved protein 0.0287 0.0495 0.1042
Entamoeba histolytica hypothetical protein 0.0038 0.0038 0.0599
Echinococcus multilocularis epidermal growth factor receptor 0.0247 0.0422 0.0885
Plasmodium vivax hypothetical protein, conserved 0.0385 0.0675 0.2273
Giardia lamblia Beta tubulin 0.0117 0.0182 0.1228
Trichomonas vaginalis tubulin alpha chain, putative 0.0066 0.009 0.168
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0074 0.0105 0.1001
Schistosoma mansoni hypothetical protein 0.0409 0.0719 0.585
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0028 0.0423
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0015 0.0012
Leishmania major alpha tubulin 0.0217 0.0366 0.2499
Trichomonas vaginalis histone deacetylase, putative 0.0289 0.0499 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0117 0.0182 0.176
Echinococcus granulosus Tubulin alpha 1 chain 0.0217 0.0366 0.2949
Brugia malayi topoisomerase 0.0021 0.0007 0.0018
Trichomonas vaginalis ran, putative 0.0022 0.001 0.0052
Onchocerca volvulus 0.0029 0.0021 0.0035
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0159 0.026 0.0671
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0028 0.0423
Loa Loa (eye worm) tubulin gamma chain 0.0117 0.0182 0.176
Trypanosoma cruzi tubulin delta chain 0.0051 0.0061 0.0381
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Trypanosoma brucei alpha tubulin 0.0217 0.0366 0.2513
Echinococcus granulosus tubulin beta 4A class IVa 0.0117 0.0182 0.1441
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Echinococcus multilocularis peroxisome assembly protein 26 0.0217 0.0366 0.0765
Echinococcus granulosus tubulin alpha chain 0.0217 0.0366 0.2949
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Echinococcus granulosus histone deacetylase 8 0.0124 0.0196 0.1557
Trypanosoma cruzi epsilon tubulin, putative 0.0117 0.0182 0.1228
Toxoplasma gondii ABC1 family protein 0.0074 0.0105 0.0714
Echinococcus multilocularis multidrug resistance protein 1 0.0032 0.0028 0.0044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.0318 0.309
Mycobacterium ulcerans beta-lactamase 0.0074 0.0105 0.0102
Loa Loa (eye worm) hypothetical protein 0.0576 0.1024 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Leishmania major alpha tubulin 0.0217 0.0366 0.2499
Schistosoma mansoni histone deacetylase hda2 0.0268 0.046 0.3718
Loa Loa (eye worm) hypothetical protein 0.0159 0.026 0.2518
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0025 0.0014 0.0014
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0024 0.0036
Schistosoma mansoni tyrosine kinase 0.0147 0.0238 0.1899
Echinococcus multilocularis 0.0385 0.0675 0.1425
Entamoeba histolytica hypothetical protein 0.0038 0.0038 0.0599
Leishmania major alpha tubulin 0.0217 0.0366 0.2499
Echinococcus multilocularis protein dispatched 1 0.015 0.0243 0.0504
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.001 0.0021
Trypanosoma brucei epsilon tubulin 0.0117 0.0182 0.1228
Echinococcus multilocularis tubulin alpha chain 0.0217 0.0366 0.0765
Trypanosoma brucei ABC transporter, putative 0.003 0.0024 0.0119
Schistosoma mansoni hypothetical protein 0.0038 0.0038 0.0257
Schistosoma mansoni tar DNA-binding protein 0.0197 0.033 0.2656
Trichomonas vaginalis tubulin alpha chain, putative 0.0066 0.009 0.168
Echinococcus multilocularis sterol regulatory element binding protein 0.0131 0.0209 0.0431
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0043
Brugia malayi histone deacetylase 1 (HD1) 0.0289 0.0499 0.1288
Trypanosoma brucei beta tubulin 0.0117 0.0182 0.1228
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.003 0.0024 0.0139
Schistosoma mansoni hypothetical protein 0.0025 0.0014 0.006
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0105 0.0112
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0007 0.0000013315
Leishmania major alpha tubulin 0.0217 0.0366 0.2499
Mycobacterium ulcerans hypothetical protein 0.0074 0.0105 0.0102
Entamoeba histolytica tubulin alpha-1 chain 0.0217 0.0366 0.6871
Schistosoma mansoni transient receptor potential channel 0.0068 0.0092 0.0702
Onchocerca volvulus 0.0074 0.0105 0.0192
Echinococcus multilocularis tubulin alpha chain 0.0217 0.0366 0.0765
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Brugia malayi Tubulin beta-1 chain 0.0117 0.0182 0.0471
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0015 0.0144
Trypanosoma cruzi UDP-galactopyranose mutase 0.0385 0.0675 0.4678
Mycobacterium tuberculosis Conserved protein 0.0074 0.0105 0.0112
Schistosoma mansoni multidrug resistance protein 0.0032 0.0028 0.0171
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Loa Loa (eye worm) hypothetical protein 0.0102 0.0156 0.15
Onchocerca volvulus 0.0576 0.1024 0.1915
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0038 0.0067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0015 0.0015
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0015 0.0113
Loa Loa (eye worm) beta-tubulin 0.0117 0.0182 0.176
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0015 0.0035
Loa Loa (eye worm) hypothetical protein 0.0576 0.1024 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0385 0.0675 0.1425
Onchocerca volvulus 0.0032 0.0028 0.0047
Echinococcus granulosus tubulin alpha 3 chain 0.0217 0.0366 0.2949
Echinococcus multilocularis tubulin alpha 0.0117 0.0182 0.0374
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0131 0.0209 0.2022
Plasmodium vivax kinesin-5 0.0028 0.002 0.0057
Brugia malayi beta-tubulin, identical 0.0117 0.0182 0.0471
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0117
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0007 0.00000034564
Loa Loa (eye worm) tubulin beta-4 chain 0.0117 0.0182 0.176
Brugia malayi RNA binding protein 0.0197 0.033 0.0853
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0032 0.0028 0.0176
Loa Loa (eye worm) histone deacetylase 0.026 0.0446 0.4338
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.0318 0.0664
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0051 0.0061 0.0411
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.0092 0.0182
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0015 0.0144
Schistosoma mansoni tubulin subunit beta 0.0117 0.0182 0.1441
Chlamydia trachomatis DNA ligase 0.0021 0.0007 0.0014
Echinococcus multilocularis tubulin alpha 3 chain 0.0217 0.0366 0.0765
Loa Loa (eye worm) hypothetical protein 0.0385 0.0675 0.658
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Echinococcus multilocularis protein patched 0.0131 0.0209 0.0431
Schistosoma mansoni amine oxidase 0.0385 0.0675 0.5489
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0015 0.0035
Brugia malayi hypothetical protein 0.0385 0.0675 0.1744
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0576 0.1024 0.2646
Schistosoma mansoni hypothetical protein 0.0685 0.1224 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0117 0.0182 0.1255
Loa Loa (eye worm) tubulin beta chain 0.0051 0.0061 0.0576
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0028 0.0423
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0014 0.0137
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0105 0.0112
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0014 0.0137
Schistosoma mansoni hypothetical protein 0.0127 0.0201 0.159
Echinococcus granulosus histone deacetylase 6 0.026 0.0446 0.3606
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.001 0.0023
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0028 0.0423
Leishmania major hypothetical protein, conserved 0.0027 0.0017 0.0054
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0105 0.1991
Entamoeba histolytica fatty acid elongase, putative 0.0212 0.0357 0.6705
Echinococcus granulosus histone deacetylase 6 0.026 0.0446 0.3606
Echinococcus granulosus tubulin alpha 1C chain 0.0217 0.0366 0.2949
Echinococcus granulosus Niemann Pick C1 protein 0.0306 0.0529 0.4292
Echinococcus granulosus kinesin family 1 0.0214 0.036 0.2904
Echinococcus multilocularis Tubulin alpha 1 chain 0.0217 0.0366 0.0765
Brugia malayi Tubulin alpha-2 chain 0.0217 0.0366 0.0945
Mycobacterium tuberculosis Conserved protein 0.0074 0.0105 0.0112
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0306 0.0529 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.001 0.0018
Schistosoma mansoni tubulin subunit beta 0.0117 0.0182 0.1441
Loa Loa (eye worm) tubulin alpha-2 chain 0.0217 0.0366 0.3555
Entamoeba histolytica tubulin gamma chain 0.0117 0.0182 0.3358
Echinococcus granulosus tubulin alpha 0.0117 0.0182 0.1441
Entamoeba histolytica P-glycoprotein-2, putative 0.0032 0.0028 0.0399
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.0318 0.2559
Chlamydia trachomatis protoporphyrinogen oxidase 0.0385 0.0675 0.2272
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0028 0.0423
Brugia malayi Common central domain of tyrosinase family protein 0.0576 0.1024 0.2646
Entamoeba histolytica fatty acid elongase, putative 0.0212 0.0357 0.6705
Loa Loa (eye worm) hypothetical protein 0.0385 0.0675 0.658
Schistosoma mansoni amine oxidase 0.0385 0.0675 0.5489
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0007 0.0018
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Schistosoma mansoni tyrosinase precursor 0.0576 0.1024 0.836
Echinococcus granulosus insulin receptor 0.0147 0.0238 0.1899
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0028 0.0423
Brugia malayi DKFZp564C0469 protein 0.0021 0.0007 0.0018
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0028 0.0423
Toxoplasma gondii histone lysine-specific demethylase 0.0385 0.0675 0.4694
Echinococcus granulosus histone deacetylase 6 0.0268 0.046 0.3718
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.0318 0.0822
Echinococcus granulosus importin subunit beta 1 0.003 0.0024 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0061 0.1107
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0117
Entamoeba histolytica fatty acid elongase, putative 0.0212 0.0357 0.6705
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0028 0.0423
Entamoeba histolytica hypothetical protein 0.0025 0.0014 0.0129
Echinococcus multilocularis Tubulin beta 2C chain 0.0117 0.0182 0.0374
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0105 0.0102
Echinococcus granulosus multidrug resistance protein 1 0.0032 0.0028 0.0171
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0028 0.0423
Brugia malayi Tubulin alpha-2 chain 0.0217 0.0366 0.0945
Schistosoma mansoni tubulin subunit alpha 0.0217 0.0366 0.2949
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.001 0.0064
Brugia malayi Patched related family protein 12 0.0019 0.0003 0.0007
Echinococcus multilocularis transient receptor potential gamma protein 0.0102 0.0156 0.0318
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0061 0.0569
Brugia malayi CHE-14 protein 0.0131 0.0209 0.054
Brugia malayi protein C24B5.3 0.0019 0.0003 0.0007
Schistosoma mansoni tubulin subunit alpha 0.0217 0.0366 0.2949
Loa Loa (eye worm) BEN-1 protein 0.0117 0.0182 0.176
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1632 0.2961 0.2959
Loa Loa (eye worm) kinesin-like protein KLP2 0.0028 0.002 0.0165
Echinococcus multilocularis protoporphyrinogen oxidase 0.0385 0.0675 0.1425
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.001 0.0023
Loa Loa (eye worm) multidrug resistance protein 3 0.0032 0.0028 0.0247
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0017 0.0049
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0032 0.0028 0.0247
Echinococcus granulosus transient receptor potential gamma protein 0.0102 0.0156 0.1224
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0032 0.0028 0.0128
Brugia malayi multidrug resistance protein 3 0.0032 0.0028 0.0072
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0024 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0318 0.2559
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0385 0.0675 0.2273
Schistosoma mansoni tyrosine kinase 0.0247 0.0422 0.3408
Echinococcus granulosus tubulin subunit beta 0.0117 0.0182 0.1441
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0387 0.0678 0.4716
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.1632 0.2961 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0217 0.0366 0.0765
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0015 0.0012
Leishmania major alpha tubulin 0.0217 0.0366 0.2499
Trichomonas vaginalis tubulin gamma chain, putative 0.0117 0.0182 0.3568
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0028 0.0423
Plasmodium falciparum ABC transporter G family member 2 0.003 0.0024 0.0072
Trypanosoma brucei telomerase reverse transcriptase 0.08 0.1435 1
Echinococcus granulosus histone deacetylase 3 0.0289 0.0499 0.404
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Loa Loa (eye worm) ABC transporter 0.0026 0.0016 0.0127
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0003 0.0002
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0289 0.0499 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0032 0.0028 0.0423
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0105 0.1466
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0024 0.0151
Echinococcus multilocularis tubulin epsilon chain 0.0117 0.0182 0.0374
Schistosoma mansoni multidrug resistance protein 0.0032 0.0028 0.0171
Trichomonas vaginalis tubulin alpha chain, putative 0.0117 0.0182 0.3568
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0015 0.0113
Loa Loa (eye worm) tyrosinase 1 0.0576 0.1024 1
Echinococcus multilocularis snurportin 1 0.0324 0.0563 0.1185
Schistosoma mansoni alpha tubulin 0.0217 0.0366 0.2949
Giardia lamblia Delta tubulin 0.0051 0.0061 0.0381
Trypanosoma cruzi epsilon tubulin, putative 0.0117 0.0182 0.1228
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.001 0.0068
Plasmodium falciparum histone deacetylase 2 0.026 0.0446 0.1498
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0024 0.0139
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0007 0.0018
Plasmodium vivax ABC transporter G family member 2, putative 0.003 0.0024 0.0072
Onchocerca volvulus 0.0025 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0143
Schistosoma mansoni hypothetical protein 0.005 0.0061 0.0442
Loa Loa (eye worm) alpha-tubulin 0.0217 0.0366 0.3555
Trichomonas vaginalis tubulin epsilon chain, putative 0.0117 0.0182 0.3568
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0017 0.0049
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Giardia lamblia Epsilon tubulin 0.0051 0.0061 0.0381
Brugia malayi hypothetical protein 0.0038 0.0038 0.0099
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0385 0.0675 0.2273
Loa Loa (eye worm) TK/INSR protein kinase 0.0147 0.0238 0.2305
Loa Loa (eye worm) hypothetical protein 0.0217 0.0366 0.3555
Echinococcus granulosus epidermal growth factor receptor 0.046 0.0812 0.6615
Trichomonas vaginalis tubulin gamma chain, putative 0.0051 0.0061 0.1107
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0028 0.0423
Schistosoma mansoni hypothetical protein 0.0109 0.0168 0.1321
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0061 0.0157
Brugia malayi Telomerase reverse transcriptase 0.2129 0.3871 1
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0105 0.0346
Echinococcus granulosus tubulin alpha chain 0.0217 0.0366 0.2949
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0247 0.0422 0.3408
Trichomonas vaginalis abcb9, putative 0.0032 0.0028 0.0423
Trypanosoma brucei alpha tubulin 0.0217 0.0366 0.2513
Brugia malayi SWIRM domain containing protein 0.0385 0.0675 0.1744
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.008 0.0603
Loa Loa (eye worm) histone deacetylase 1 0.0289 0.0499 0.4854
Schistosoma mansoni histone deacetylase 1 2 3 0.0124 0.0196 0.1557
Leishmania major telomerase reverse transcriptase, putative 0.08 0.1435 1
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.1632 0.2961 0.2959
Toxoplasma gondii beta-1 tubulin, putative 0.0117 0.0182 0.1255
Mycobacterium ulcerans dehydrogenase 0.0385 0.0675 0.0672
Plasmodium vivax histone deacetylase, putative 0.0124 0.0196 0.0655
Schistosoma mansoni histone deacetylase 0.0289 0.0499 0.404
Schistosoma mansoni hypothetical protein 0.005 0.0061 0.0442
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.0563 0.548
Leishmania major p-glycoprotein 0.0032 0.0028 0.0128
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.0092 0.0182
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0311 0.0538 0.4363
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0038 0.0257
Echinococcus granulosus beta tubulin 0.0117 0.0182 0.1441
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Schistosoma mansoni ran 0.0022 0.001 0.0021
Brugia malayi RNA, U transporter 1 0.0086 0.0127 0.0328
Toxoplasma gondii histone deacetylase HDAC1 0.026 0.0446 0.3094
Echinococcus granulosus expressed conserved protein 0.0287 0.0495 0.4012
Entamoeba histolytica kinesin, putative 0.0028 0.002 0.024
Loa Loa (eye worm) hypothetical protein 0.0306 0.0529 0.5155
Schistosoma mansoni tubulin subunit gamma 0.0117 0.0182 0.1441
Loa Loa (eye worm) hypothetical protein 0.0385 0.0675 0.658
Entamoeba histolytica histone deacetylase, putative 0.0289 0.0499 0.9412
Schistosoma mansoni tar DNA-binding protein 0.0197 0.033 0.2656
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0105 0.0804
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0051 0.0061 0.0411
Echinococcus multilocularis Tubulin beta 2C chain 0.0117 0.0182 0.0374
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.1632 0.2961 1
Trypanosoma cruzi beta tubulin, putative 0.0117 0.0182 0.1228
Echinococcus multilocularis tubulin alpha chain 0.0217 0.0366 0.0765
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0061 0.0442
Brugia malayi Transient-receptor-potential like protein 0.0038 0.0038 0.0099
Echinococcus granulosus tubulin gamma 1 chain 0.0117 0.0182 0.1441
Trypanosoma brucei histone deacetylase 4 0.026 0.0446 0.3073
Echinococcus multilocularis multidrug resistance protein 1 0.0023 0.001 0.0007
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.0007 0.0000032962
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0217 0.0366 0.73
Schistosoma mansoni cpg binding protein 0.0029 0.0021 0.0117
Echinococcus multilocularis Niemann Pick C1 protein 0.0437 0.077 0.1627
Plasmodium falciparum alpha tubulin 2 0.0217 0.0366 0.1228
Plasmodium vivax histone deacetylase 2, putative 0.026 0.0446 0.1498
Schistosoma mansoni tar DNA-binding protein 0.0197 0.033 0.2656
Loa Loa (eye worm) hypothetical protein 0.0385 0.0675 0.658
Trypanosoma cruzi tubulin delta chain 0.0051 0.0061 0.0381
Trypanosoma cruzi histone deacetylase, putative 0.026 0.0446 0.3073
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1632 0.2961 0.2959
Giardia lamblia Alpha-tubulin 0.0217 0.0366 0.2513
Echinococcus multilocularis tubulin delta chain 0.0051 0.0061 0.0116
Brugia malayi Cell division protein ftsZ 0.0051 0.0061 0.0159
Echinococcus multilocularis Tubulin beta 2C chain 0.0117 0.0182 0.0374
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0007 0.0015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0061 0.0442
Brugia malayi Protein kinase domain containing protein 0.0147 0.0238 0.0615
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0028 0.0171
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Plasmodium falciparum tubulin gamma chain 0.0117 0.0182 0.0608
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0043
Plasmodium vivax delta tubulin, putative 0.0051 0.0061 0.0199
Loa Loa (eye worm) hypothetical protein 0.0161 0.0263 0.2552
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0038 0.0257
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0105 0.0686
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2578 0.4696 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0385 0.0675 0.5489
Brugia malayi Histone deacetylase family protein 0.026 0.0446 0.1152
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.001 0.0026
Trypanosoma cruzi alpha tubulin, putative 0.0217 0.0366 0.2513
Trypanosoma brucei alpha tubulin 0.0217 0.0366 0.2513
Schistosoma mansoni tubulin subunit beta 0.0117 0.0182 0.1441
Trypanosoma brucei tubulin gamma chain 0.0117 0.0182 0.1228
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0197 0.033 0.3206
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0014 0.0047
Trichomonas vaginalis tubulin beta chain, putative 0.0117 0.0182 0.3568
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0038 0.0038 0.0067
Entamoeba histolytica tubulin family protein 0.0117 0.0182 0.3358
Plasmodium falciparum alpha tubulin 1 0.0217 0.0366 0.1228
Schistosoma mansoni histone deacetylase 4 5 0.026 0.0446 0.3606
Schistosoma mansoni multidrug resistance protein 0.0032 0.0028 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.0209 0.4114
Onchocerca volvulus 0.0576 0.1024 0.1915
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0385 0.0675 0.2273
Echinococcus multilocularis epidermal growth factor receptor 0.046 0.0812 0.1717
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0015 0.0012
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0017 0.0072
Schistosoma mansoni tubulin subunit delta 0.0051 0.0061 0.0447
Trichomonas vaginalis histone deacetylase, putative 0.0289 0.0499 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0289 0.0499 1
Loa Loa (eye worm) tubulin alpha chain 0.0217 0.0366 0.3555
Schistosoma mansoni tyrosine kinase 0.046 0.0812 0.6615
Schistosoma mansoni hypothetical protein 0.0324 0.0563 0.4565
Loa Loa (eye worm) hypothetical protein 0.0064 0.0086 0.0818
Brugia malayi tubulin alpha-2 chain 0.0217 0.0366 0.0945
Entamoeba histolytica ABC transporter, putative 0.003 0.0024 0.0324
Echinococcus multilocularis tubulin subunit TubB 0.0217 0.0366 0.0765
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0015 0.0038
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0105 0.0112
Loa Loa (eye worm) hypothetical protein 0.0289 0.0499 0.4854
Entamoeba histolytica P-glyco protein 6, putative 0.0032 0.0028 0.0399
Schistosoma mansoni hypothetical protein 0.0127 0.0201 0.159
Trichomonas vaginalis histone deacetylase, putative 0.0289 0.0499 1
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0007 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0105 0.0804
Trypanosoma cruzi zeta tubulin, putative 0.0051 0.0061 0.0381
Brugia malayi ShTK domain containing protein 0.0576 0.1024 0.2646
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0032 0.0028 0.0423
Brugia malayi hypothetical protein 0.0021 0.0007 0.0018
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0024 0.0036
Mycobacterium leprae cell division protein FtsZ 0.0051 0.0061 0.0815
Schistosoma mansoni tyrosine kinase 0.0247 0.0422 0.3408
Brugia malayi ABC transporter family protein 0.0026 0.0016 0.004
Echinococcus granulosus dnaJ subfamily B 0.0409 0.0719 0.585
Onchocerca volvulus 0.0576 0.1024 0.1915
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0105 0.1991
Echinococcus multilocularis histone deacetylase 1 0.0289 0.0499 0.1049
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0068 0.0459
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Schistosoma mansoni hypothetical protein 0.005 0.0061 0.0442
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0289 0.0499 1
Echinococcus granulosus GPCR family 2 0.005 0.0061 0.0442
Trypanosoma cruzi histone deacetylase, putative 0.026 0.0446 0.3073
Giardia lamblia Gamma tubulin 0.0117 0.0182 0.1228
Echinococcus multilocularis hypothetical protein 0.0217 0.0366 0.0765
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0043
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.08 0.1435 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0007 0.0000032962
Onchocerca volvulus 0.0074 0.0105 0.0192
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0105 0.0686
Echinococcus multilocularis histone deacetylase 6 0.0268 0.046 0.0965
Mycobacterium tuberculosis Possible oxidoreductase 0.0385 0.0675 0.0725
Schistosoma mansoni tubulin subunit beta 0.0051 0.0061 0.0447
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.2022
Schistosoma mansoni tar DNA-binding protein 0.0197 0.033 0.2656
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0105 0.1991
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0007 0.0000032962
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0159 0.026 0.2518
Schistosoma mansoni tyrosinase precursor 0.0576 0.1024 0.836
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0117 0.0182 0.0374
Echinococcus granulosus snurportin 1 0.0324 0.0563 0.4565
Trypanosoma brucei alpha tubulin, putative 0.0066 0.009 0.0578
Loa Loa (eye worm) hypothetical protein 0.0385 0.0675 0.658
Loa Loa (eye worm) TK/EGFR protein kinase 0.046 0.0812 0.7922
Schistosoma mansoni kinesin eg-5 0.0028 0.002 0.0103
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Brugia malayi TAR-binding protein 0.0197 0.033 0.0853
Treponema pallidum cell division protein FtsZ 0.0051 0.0061 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0117
Echinococcus granulosus lysine specific histone demethylase 1A 0.0385 0.0675 0.5489
Schistosoma mansoni transient receptor potential channel 0.0102 0.0156 0.1224
Echinococcus multilocularis multidrug resistance protein 1 0.0032 0.0028 0.0044
Schistosoma mansoni hypothetical protein 0.005 0.0061 0.0442
Trichomonas vaginalis tubulin, putative 0.0066 0.009 0.168
Trichomonas vaginalis tubulin epsilon chain, putative 0.0217 0.0366 0.73
Onchocerca volvulus Histone deacetylase 10 homolog 0.0124 0.0196 0.0363
Echinococcus granulosus tubulin beta 1 chain 0.0117 0.0182 0.1441
Schistosoma mansoni ABC transporter 0.0026 0.0016 0.0071
Plasmodium falciparum histone deacetylase 1 0.0289 0.0499 0.1677
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0024 0.0139
Schistosoma mansoni hypothetical protein 0.0186 0.031 0.2486
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.0092 0.0702
Brugia malayi hypothetical protein 0.0027 0.0017 0.0045
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Brugia malayi Tubulin alpha chain 0.0217 0.0366 0.0945
Brugia malayi protein C24B5.3 0.0019 0.0003 0.0007
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0032 0.0028 0.0029
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0061 0.0115
Leishmania major alpha tubulin 0.0217 0.0366 0.2499
Brugia malayi Calcitonin receptor-like protein seb-1 0.0159 0.026 0.0671
Loa Loa (eye worm) tubulin alpha 2 0.0166 0.0273 0.2646
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0105 0.0686
Chlamydia trachomatis oxoacyl-ACP synthase III 0.1632 0.2961 1
Trichomonas vaginalis histone deacetylase, putative 0.0289 0.0499 1
Trichomonas vaginalis tubulin, putative 0.0117 0.0182 0.3568
Loa Loa (eye worm) histone deacetylase 11 0.0124 0.0196 0.1897
Schistosoma mansoni tubulin subunit beta 0.0117 0.0182 0.1441
Brugia malayi Tubulin alpha chain 0.0051 0.0061 0.0159
Brugia malayi alpha-tubulin 0.0217 0.0366 0.0945
Loa Loa (eye worm) tubulin alpha 2 0.0166 0.0273 0.2646
Echinococcus granulosus multidrug resistance protein 1 0.0032 0.0028 0.0171
Leishmania major histone deacetylase, putative 0.026 0.0446 0.306
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0028 0.0423
Plasmodium vivax tubulin alpha chain, putative 0.0217 0.0366 0.1228
Echinococcus multilocularis 0.0142 0.023 0.0475
Trypanosoma brucei histone deacetylase 1 0.0289 0.0499 0.3442
Giardia lamblia ABC transporter 0.0029 0.0023 0.011
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.08 0.1435 1
Giardia lamblia Beta tubulin 0.0117 0.0182 0.1228
Mycobacterium tuberculosis Cell division protein FtsZ 0.0051 0.0061 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0318 0.2559
Loa Loa (eye worm) hypothetical protein 0.0074 0.0105 0.1001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0105 0.0271
Trypanosoma brucei histone deacetylase, putative 0.026 0.0446 0.3073
Plasmodium vivax hypothetical protein, conserved 0.0385 0.0675 0.2273
Trypanosoma cruzi zeta tubulin, putative 0.0051 0.0061 0.0381
Echinococcus multilocularis beta tubulin 0.0117 0.0182 0.0374
Echinococcus granulosus alpha tubulin 0.0217 0.0366 0.2949
Trypanosoma cruzi histone deacetylase, putative 0.0124 0.0196 0.1326
Brugia malayi beta-lactamase 0.0074 0.0105 0.0271
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0028 0.0423
Leishmania major alpha tubulin 0.0217 0.0366 0.2499
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0028 0.0423
Plasmodium falciparum tubulin beta chain 0.0117 0.0182 0.0608
Brugia malayi histone deacetylase 11 0.0124 0.0196 0.0507
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Trichomonas vaginalis histone deacetylase, putative 0.0289 0.0499 1
Trypanosoma brucei epsilon tubulin 0.0117 0.0182 0.1228
Echinococcus granulosus TRP transient receptor potential channel 0.0038 0.0038 0.0257
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.001 0.0018
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.5472 1 1
Entamoeba histolytica P-glycoprotein-5 0.0032 0.0028 0.0399
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0017 0.0072
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021 0.0007 0.0031
Plasmodium falciparum telomerase reverse transcriptase 0.08 0.1435 0.4842
Plasmodium vivax histone deacetylase, putative 0.026 0.0446 0.1498
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0015 0.0035
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0024 0.0121
Plasmodium vivax tubulin alpha chain, putative 0.0217 0.0366 0.1228
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0007 0.0000013315
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0003 0.0001
Trichomonas vaginalis tubulin beta chain, putative 0.0066 0.009 0.168
Echinococcus granulosus histone deacetylase 7 0.026 0.0446 0.3606
Mycobacterium tuberculosis Conserved hypothetical protein 0.0385 0.0675 0.0725
Brugia malayi RNA recognition motif domain containing protein 0.0197 0.033 0.0853
Toxoplasma gondii alpha tubulin TUBA1 0.0217 0.0366 0.2536
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0147 0.0238 0.1899
Trichomonas vaginalis histone deacetylase, putative 0.0289 0.0499 1
Echinococcus multilocularis histone deacetylase 0.026 0.0446 0.0936
Echinococcus granulosus tubulin subunit TubB 0.0217 0.0366 0.2949
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0166 0.0273 0.5411
Echinococcus multilocularis histone deacetylase 8 0.0124 0.0196 0.0404
Echinococcus multilocularis Tubulin alpha 1 chain 0.0217 0.0366 0.0765
Echinococcus granulosus epidermal growth factor receptor 0.0247 0.0422 0.3408
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.0092 0.0702
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0028 0.0423
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0015 0.0012
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0024 0.0021
Loa Loa (eye worm) tubulin alpha 2 0.01 0.0152 0.1463
Brugia malayi Kinesin motor domain containing protein 0.0028 0.002 0.005
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0051 0.0061 0.0184
Trypanosoma brucei zeta tubulin 0.0051 0.0061 0.0381
Plasmodium vivax multidrug resistance protein 1, putative 0.0032 0.0028 0.0085
Loa Loa (eye worm) hypothetical protein 0.0151 0.0245 0.2371
Plasmodium vivax importin-beta 2, putative 0.003 0.0024 0.0073
Brugia malayi Furin-like cysteine rich region family protein 0.046 0.0812 0.2098
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0043
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Echinococcus granulosus multidrug resistance protein 1 0.0032 0.0028 0.0171
Leishmania major alpha tubulin 0.0217 0.0366 0.2499
Brugia malayi Niemann-Pick C1 protein precursor 0.0306 0.0529 0.1367
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0028 0.0423
Schistosoma mansoni tubulin subunit beta 0.0117 0.0182 0.1441
Echinococcus granulosus cpg binding protein 0.003 0.0024 0.0142
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0105 0.1001
Echinococcus multilocularis Tubulin beta 2C chain 0.0117 0.0182 0.0374
Echinococcus granulosus peroxisome assembly protein 26 0.0217 0.0366 0.2949
Schistosoma mansoni tyrosine kinase 0.0245 0.0417 0.3369
Echinococcus multilocularis beta tubulin 0.0117 0.0182 0.0374
Trichomonas vaginalis abcb9, putative 0.0032 0.0028 0.0423
Plasmodium vivax tubulin gamma chain, putative 0.0117 0.0182 0.0608
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Trypanosoma cruzi ABC transporter, putative 0.003 0.0024 0.0119
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.0007 0.0000031024
Trypanosoma brucei ATP-binding cassette protein, putative 0.003 0.0024 0.0119
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0385 0.0675 1
Trichomonas vaginalis tubulin beta chain, putative 0.0217 0.0366 0.73
Trichomonas vaginalis tubulin gamma chain, putative 0.0117 0.0182 0.3568
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.1632 0.2961 0.3185
Loa Loa (eye worm) hypothetical protein 0.0074 0.0105 0.1001
Brugia malayi hypothetical protein 0.0021 0.0007 0.0018
Giardia lamblia Beta tubulin 0.0117 0.0182 0.1228
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0043
Giardia lamblia Telomerase catalytic subunit 0.08 0.1435 1
Schistosoma mansoni tubulin subunit beta 0.0117 0.0182 0.1441
Brugia malayi Patched related family protein 4 0.0019 0.0003 0.0007
Entamoeba histolytica P-glycoprotein 5, putative 0.0032 0.0028 0.0399
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0017 0.0072
Schistosoma mansoni tubulin subunit alpha 0.0051 0.0061 0.0447
Trypanosoma brucei epsilon tubulin 0.0117 0.0182 0.1228
Trichomonas vaginalis tubulin alpha chain, putative 0.0066 0.009 0.168
Loa Loa (eye worm) histone deacetylase 3 0.0289 0.0499 0.4854
Trypanosoma brucei beta tubulin 0.0117 0.0182 0.1228
Echinococcus granulosus Niemann Pick C1 protein 0.0437 0.077 0.6269
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0105 0.0804
Schistosoma mansoni tyrosine kinase 0.0147 0.0238 0.1899
Echinococcus granulosus tar DNA binding protein 0.0197 0.033 0.2656
Trichomonas vaginalis tubulin, putative 0.0051 0.0061 0.1107
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0028 0.0171
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Loa Loa (eye worm) TAR-binding protein 0.0197 0.033 0.3206
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0015 0.0012
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0028 0.0171
Mycobacterium ulcerans monoamine oxidase 0.0385 0.0675 0.0672
Echinococcus multilocularis histone deacetylase 3 0.0289 0.0499 0.1049
Brugia malayi Patched protein homolog 1 0.0019 0.0003 0.0007
Entamoeba histolytica P-glycoprotein-2 0.0032 0.0028 0.0399
Echinococcus granulosus transient receptor potential ion channel A 0.0099 0.015 0.1172
Echinococcus multilocularis histone deacetylase 6 0.026 0.0446 0.0936
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0061 0.1107
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0032 0.0027 0.0234
Schistosoma mansoni histone deacetylase 0.0289 0.0499 0.404
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0028 0.0044
Echinococcus multilocularis tubulin alpha 1C chain 0.0217 0.0366 0.0765
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0061 0.0115
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0475 0.0839 0.0902
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0015 0.0015
Trypanosoma cruzi tubulin gamma chain 0.0117 0.0182 0.1228
Leishmania major alpha tubulin 0.0217 0.0366 0.2499
Toxoplasma gondii beta tubulin 0.0117 0.0182 0.1255
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.0318 0.0664
Echinococcus granulosus tubulin alpha chain 0.0217 0.0366 0.2949
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0024 0.0121
Trypanosoma brucei histone deacetylase 3 0.026 0.0446 0.3073
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.1632 0.2961 1
Brugia malayi Histone deacetylase family protein 0.026 0.0446 0.1152
Echinococcus granulosus tubulin alpha chain 0.0217 0.0366 0.2949
Echinococcus granulosus Tubulin beta 2C chain 0.0117 0.0182 0.1441
Brugia malayi beta-lactamase family protein 0.0074 0.0105 0.0271
Brugia malayi hypothetical protein 0.0019 0.0003 0.0007
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0028 0.0044
Mycobacterium ulcerans oxidoreductase 0.0385 0.0675 0.0672
Plasmodium falciparum importin beta, putative 0.003 0.0024 0.0073
Brugia malayi Histone deacetylase 1 0.0289 0.0499 0.1288
Mycobacterium ulcerans hypothetical protein 0.0025 0.0015 0.0012
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0576 0.1024 0.2646
Leishmania major delta tubulin, putative 0.0051 0.0061 0.0364
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0051 0.0061 0.1107
Leishmania major epsilon tubulin, putative 0.0117 0.0182 0.1213
Schistosoma mansoni alpha tubulin 0.0217 0.0366 0.2949
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0015 0.0012
Toxoplasma gondii RNA-directed DNA polymerase 0.08 0.1435 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0576 0.1024 1
Loa Loa (eye worm) alpha-tubulin 0.0217 0.0366 0.3555
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0028 0.0044
Loa Loa (eye worm) hypothetical protein 0.005 0.0061 0.0569
Schistosoma mansoni hypothetical protein 0.0127 0.0201 0.159
Trichomonas vaginalis tubulin epsilon chain, putative 0.0117 0.0182 0.3568
Echinococcus multilocularis tubulin alpha chain 0.0217 0.0366 0.0765
Leishmania major zeta tubulin, putative 0.0051 0.0061 0.0364
Echinococcus multilocularis tar DNA binding protein 0.0197 0.033 0.0689
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0151 0.0245 0.4839
Echinococcus granulosus Tubulin alpha 1 chain 0.0217 0.0366 0.2949
Loa Loa (eye worm) hypothetical protein 0.0136 0.0218 0.2108
Echinococcus granulosus Tubulin beta 2C chain 0.0117 0.0182 0.1441
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0028 0.0171
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.001 0.0005
Trichomonas vaginalis abcb9, putative 0.0032 0.0028 0.0423
Trichomonas vaginalis tubulin beta chain, putative 0.0217 0.0366 0.73
Brugia malayi Tubulin gamma chain 0.0117 0.0182 0.0471
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Trichomonas vaginalis tubulin beta chain, putative 0.0217 0.0366 0.73
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0385 0.0675 0.5489
Trypanosoma brucei alpha tubulin 0.0217 0.0366 0.2513
Loa Loa (eye worm) hypothetical protein 0.0124 0.0196 0.1897
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0105 0.0112
Schistosoma mansoni cpg binding protein 0.003 0.0024 0.0142
Loa Loa (eye worm) hypothetical protein 0.0074 0.0105 0.1001
Trichomonas vaginalis tubulin beta chain, putative 0.0217 0.0366 0.73
Trypanosoma cruzi histone deacetylase 1, putative 0.0289 0.0499 0.3442
Schistosoma mansoni histone deacetylase 4 5 0.026 0.0446 0.3606
Brugia malayi hypothetical protein 0.0019 0.0003 0.0007
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Plasmodium vivax histone deacetylase 1, putative 0.0289 0.0499 0.1677
Schistosoma mansoni ran 0.0022 0.001 0.0021
Brugia malayi Tubulin beta chain 0.0051 0.0061 0.0159
Echinococcus multilocularis tubulin beta 1 chain 0.0117 0.0182 0.0374
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Leishmania major UDP-galactopyranose mutase 0.0385 0.0675 0.4668
Echinococcus multilocularis histone deacetylase 7 0.026 0.0446 0.0936
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.0318 0.2559
Schistosoma mansoni cpg binding protein 0.003 0.0024 0.0142
Echinococcus multilocularis insulin receptor 0.0147 0.0238 0.0493
Leishmania major histone deacetylase, putative 0.026 0.0446 0.306
Trypanosoma cruzi histone deacetylase, putative 0.0124 0.0196 0.1326
Leishmania major alpha tubulin 0.0217 0.0366 0.2499
Brugia malayi Tubulin beta chain 0.0066 0.009 0.0231
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Trypanosoma brucei beta tubulin 0.0117 0.0182 0.1228
Trypanosoma cruzi histone deacetylase, putative 0.026 0.0446 0.3073
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0105 0.0112
Brugia malayi Myosin head containing protein 0.0019 0.0003 0.0007
Echinococcus multilocularis tubulin gamma 1 chain 0.0117 0.0182 0.0374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0318 0.2559
Echinococcus granulosus Tubulin alpha 1 chain 0.0217 0.0366 0.2949
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0147 0.0238 0.0493
Schistosoma mansoni tubulin subunit alpha 0.0217 0.0366 0.2949
Plasmodium vivax tubulin epsilon chain, putative 0.0117 0.0182 0.0608
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0024 0.0036
Entamoeba histolytica fatty acid elongase, putative 0.0212 0.0357 0.6705
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0028 0.0423
Schistosoma mansoni importin beta-1 0.003 0.0024 0.0142
Loa Loa (eye worm) BEN-1 protein 0.0117 0.0182 0.176
Echinococcus granulosus sterol regulatory element binding protein 0.0131 0.0209 0.1662
Loa Loa (eye worm) tubulin alpha chain 0.0217 0.0366 0.3555
Schistosoma mansoni hypothetical protein 0.0127 0.0201 0.159
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.003 0.0024 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0197 0.033 0.2656
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.003 0.0024 0.0149
Entamoeba histolytica P-glycoprotein-1 0.0032 0.0028 0.0399
Echinococcus granulosus beta tubulin 0.0117 0.0182 0.1441
Entamoeba histolytica hypothetical protein 0.0038 0.0038 0.0599
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0105 0.1991
Echinococcus multilocularis importin subunit beta 1 0.003 0.0024 0.0037
Loa Loa (eye worm) hypothetical protein 0.0074 0.0105 0.1001
Brugia malayi histone deacetylase 3 (HD3) 0.0289 0.0499 0.1288
Plasmodium falciparum multidrug resistance protein 1 0.0032 0.0028 0.0085
Loa Loa (eye worm) tubulin alpha-3 chain 0.0151 0.0245 0.2371
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Brugia malayi Importin beta-1 subunit 0.003 0.0024 0.0063
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0032 0.0028 0.0084
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Loa Loa (eye worm) hypothetical protein 0.0035 0.0032 0.0288
Toxoplasma gondii histone deacetylase HDAC4 0.0124 0.0196 0.1353
Entamoeba histolytica fatty acid elongase, putative 0.0212 0.0357 0.6705
Plasmodium falciparum kinesin-5 0.0028 0.002 0.0057
Brugia malayi amine oxidase, flavin-containing family protein 0.0385 0.0675 0.1744
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0003 0.0001
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.0168 0.0433
Echinococcus granulosus Tubulin beta 2C chain 0.0117 0.0182 0.1441
Leishmania major histone deacetylase, putative 0.0289 0.0499 0.3431
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0021 0.0183
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Echinococcus granulosus tubulin alpha chain 0.0217 0.0366 0.2949
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0017 0.0049
Toxoplasma gondii histone deacetylase HDAC2 0.0289 0.0499 0.3462
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.2929 0.5338 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0028 0.0423
Schistosoma mansoni tyrosine kinase 0.0245 0.0417 0.3369
Echinococcus granulosus tubulin alpha 3 chain 0.0217 0.0366 0.2949
Echinococcus multilocularis Tubulin alpha 1 chain 0.0217 0.0366 0.0765
Trichomonas vaginalis tubulin epsilon chain, putative 0.0051 0.0061 0.1107
Giardia lamblia Alpha-tubulin 0.0217 0.0366 0.2513
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0028 0.0423
Mycobacterium tuberculosis Conserved protein 0.0074 0.0105 0.0112
Loa Loa (eye worm) hypothetical protein 0.0038 0.0038 0.0349
Echinococcus granulosus tubulin epsilon chain 0.0117 0.0182 0.1441
Schistosoma mansoni transient receptor potential channel 4 0.0102 0.0156 0.1224
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.5086 0.9294 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0105 0.1001
Schistosoma mansoni hypothetical protein 0.0685 0.1224 1
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0017 0.0102
Schistosoma mansoni tyrosine kinase 0.0245 0.0417 0.3369
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0066 0.009 0.168
Echinococcus multilocularis ATP binding cassette sub family B 0.0032 0.0027 0.0042
Brugia malayi beta-lactamase family protein 0.0074 0.0105 0.0271
Trichomonas vaginalis tubulin, putative 0.0066 0.009 0.168
Brugia malayi ABC transporter family protein 0.0032 0.0028 0.0072
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0043
Echinococcus multilocularis geminin 0.0685 0.1224 0.2596
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0015 0.0038
Trypanosoma brucei zeta tubulin, putative 0.0051 0.0061 0.0381
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0105 0.0112
Echinococcus granulosus tubulin alpha 1C chain 0.0217 0.0366 0.2949
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0007 0.0031
Trichomonas vaginalis tubulin epsilon chain, putative 0.0217 0.0366 0.73
Toxoplasma gondii kinesin motor domain-containing protein 0.0028 0.002 0.0118
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0015 0.0038
Echinococcus multilocularis tubulin subunit beta 0.0117 0.0182 0.0374
Leishmania major histone deacetylase, putative 0.0289 0.0499 0.3431
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0576 0.1024 0.2646
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0028 0.0423
Toxoplasma gondii histone deacetylase HDAC5 0.0124 0.0196 0.1353
Plasmodium falciparum histone deacetylase, putative 0.026 0.0446 0.1498
Brugia malayi hypothetical protein 0.0019 0.0003 0.0007
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0014 0.0137
Loa Loa (eye worm) hypothetical protein 0.0144 0.0232 0.2242
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0385 0.0675 0.0672
Onchocerca volvulus 0.0576 0.1024 0.1915
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Mycobacterium ulcerans lipase LipD 0.0074 0.0105 0.0102
Plasmodium vivax tubulin beta chain, putative 0.0117 0.0182 0.0608
Trypanosoma cruzi histone deacetylase 1, putative 0.0289 0.0499 0.3442
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Loa Loa (eye worm) tubulin beta-1 chain 0.0117 0.0182 0.176
Onchocerca volvulus 0.0066 0.009 0.0163
Echinococcus multilocularis tubulin alpha chain 0.0217 0.0366 0.0765
Trypanosoma brucei beta tubulin 0.0117 0.0182 0.1228
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0028 0.0044
Echinococcus granulosus histone deacetylase 0.026 0.0446 0.3606
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0032 0.0027 0.0161
Echinococcus multilocularis kinesin family 1 0.0214 0.036 0.0754
Loa Loa (eye worm) tubulin beta chain 0.0117 0.0182 0.176
Schistosoma mansoni histone deacetylase hda2 0.0124 0.0196 0.1557
Loa Loa (eye worm) beta-lactamase 0.0074 0.0105 0.1001
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.001 0.0018
Leishmania major alpha tubulin 0.0217 0.0366 0.2499
Loa Loa (eye worm) hypothetical protein 0.0166 0.0273 0.2646
Loa Loa (eye worm) RNA binding protein 0.0197 0.033 0.3206
Loa Loa (eye worm) hypothetical protein 0.0109 0.0168 0.1616
Leishmania major gamma-tubulin 0.0117 0.0182 0.1213
Entamoeba histolytica P-glycoprotein-2 0.0032 0.0028 0.0399
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0032 0.0028 0.0176
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0028 0.0423
Echinococcus granulosus geminin 0.0685 0.1224 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0105 0.1991
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.0719 0.1518
Trypanosoma brucei tubulin delta chain 0.0051 0.0061 0.0381
Mycobacterium leprae Probable lipase LipE 0.0074 0.0105 0.1466
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.003 0.0024 0.0101
Giardia lamblia Histone deacetylase 0.0289 0.0499 0.3442
Loa Loa (eye worm) hypothetical protein 0.0032 0.0028 0.0247
Echinococcus granulosus Protein patched homolog 1 0.0131 0.0209 0.1662
Giardia lamblia Kinesin-5 0.0028 0.002 0.0088
Leishmania major beta tubulin 0.0117 0.0182 0.1213
Trichomonas vaginalis tubulin beta chain, putative 0.0217 0.0366 0.73
Schistosoma mansoni transient receptor potential channel 0.0068 0.0092 0.0702
Toxoplasma gondii beta-tubulin, putative 0.0117 0.0182 0.1255
Loa Loa (eye worm) histone deacetylase 7A 0.026 0.0446 0.4338
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0105 0.0102
Onchocerca volvulus 0.0021 0.0007 0.0008
Leishmania major hypothetical protein, conserved 0.0074 0.0105 0.0669
Plasmodium falciparum tubulin delta chain, putative 0.0051 0.0061 0.0199
Echinococcus granulosus histone deacetylase 1 0.0289 0.0499 0.404
Entamoeba histolytica Ran family GTPase 0.0022 0.001 0.0049
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0028 0.0423
Trichomonas vaginalis tubulin alpha chain, putative 0.0117 0.0182 0.3568
Brugia malayi CXXC zinc finger family protein 0.0029 0.0021 0.0055
Trichomonas vaginalis taga, putative 0.0032 0.0028 0.0423
Schistosoma mansoni smdr2 0.0032 0.0028 0.0171
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0024 0.0021
Leishmania major importin beta-1 subunit, putative 0.0025 0.0014 0.0029
Echinococcus multilocularis cpg binding protein 0.003 0.0024 0.0037
Onchocerca volvulus 0.0385 0.0675 0.126
Trichomonas vaginalis esterase, putative 0.0074 0.0105 0.1991
Leishmania major alpha tubulin 0.0217 0.0366 0.2499
Trypanosoma brucei histone deacetylase 2 0.0124 0.0196 0.1326
Trypanosoma brucei beta tubulin 0.0117 0.0182 0.1228
Brugia malayi hypothetical protein 0.0019 0.0003 0.0007
Brugia malayi Patched family protein 0.0019 0.0003 0.0007
Trypanosoma cruzi ATP-binding cassette protein, putative 0.003 0.0024 0.0119
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0105 0.0209
Brugia malayi tubulin alpha chain - mouse 0.0217 0.0366 0.0945
Entamoeba histolytica hypothetical protein 0.0038 0.0038 0.0599
Schistosoma mansoni alpha tubulin 0.0217 0.0366 0.2949
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0105 0.0112
Echinococcus multilocularis tubulin alpha 3 chain 0.0217 0.0366 0.0765
Loa Loa (eye worm) hypothetical protein 0.003 0.0024 0.0212
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.001 0.0049
Toxoplasma gondii histone deacetylase HDAC3 0.0289 0.0499 0.3462
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0385 0.0675 0.2273
Loa Loa (eye worm) ShTK domain-containing protein 0.0576 0.1024 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.001 0.0025
Echinococcus multilocularis GPCR, family 2 0.005 0.0061 0.0115
Toxoplasma gondii alpha-tubulin I, putative 0.0217 0.0366 0.2536
Echinococcus multilocularis histone deacetylase 6 0.026 0.0446 0.0936
Echinococcus multilocularis Niemann Pick C1 protein 0.0306 0.0529 0.1114
Onchocerca volvulus 0.0074 0.0105 0.0192
Brugia malayi Latrophilin receptor protein 2 0.005 0.0061 0.0157

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of HDAC in human HeLa cells ChEMBL. 18558669
IC50 (binding) = 0.11 uM Inhibition of nuclear HDAC isolated from human HeLa cells ChEMBL. 18558669
IC50 (binding) = 2.04 uM Inhibition of recombinant HDAC6 expressed in HEK293 cells ChEMBL. 18558669
IC50 (binding) = 5.33 uM Inhibition of recombinant HDAC1 expressed in HEK293 cells ChEMBL. 18558669
Inhibition (functional) = 43 % Cytotoxicity against human HeLa cells at 50 uM after 72 hrs by alamar blue assay ChEMBL. 18558669

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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