Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3111 | 0.5169 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0056 | 0 | 0.5 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0131 | 0.3909 | 0.6494 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0171 | 0.602 | 1 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0131 | 0.3909 | 0.3909 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0056 | 0 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0171 | 0.602 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0066 | 0.0551 | 0.0916 |
Leishmania major | adenine aminohydrolase | 0.0171 | 0.602 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0171 | 0.602 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0056 | 0 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3111 | 0.5169 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.602 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0171 | 0.602 | 1 |
Mycobacterium ulcerans | DNA-3-methyladenine glycosylase I TagA | 0.0175 | 0.621 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0056 | 0 | 0.5 |
Trichomonas vaginalis | DNA-3-methyladenine glycosylase, putative | 0.0175 | 0.621 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0056 | 0 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0171 | 0.602 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0171 | 0.602 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0056 | 0 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.3909 | 0.6494 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0056 | 0 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0056 | 0 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0171 | 0.602 | 1 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0171 | 0.602 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0171 | 0.602 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0064 | 0.045 | 0.0747 |
Trichomonas vaginalis | DNA-3-methyladenine glycosylase, putative | 0.0175 | 0.621 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0171 | 0.602 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.0171 | 0.602 | 0.602 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.3909 | 0.6494 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0131 | 0.3909 | 0.6494 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0171 | 0.602 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0131 | 0.3909 | 0.6494 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0056 | 0 | 0.5 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0131 | 0.3909 | 0.6494 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0131 | 0.3909 | 0.3909 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3111 | 0.5169 |
Echinococcus multilocularis | adenosine deaminase | 0.0171 | 0.602 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0171 | 0.602 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0171 | 0.602 | 0.602 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3111 | 0.5169 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.7 uM | Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs | ChEMBL. | 18502136 |
IC50 (functional) | = 1.78 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 after 72 hrs by microplate alamar blue assay | ChEMBL. | 18502136 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18502136 | |
Trypanosoma brucei gambiense | 18502136 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.