TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 458.913 | Formula: C23H24ClFN4O3
H donors: 2 H acceptors: 2 LogP: 4.36 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2ncc(c(c2cc1OCCN1CCCC1)Nc1ccc(c(c1)Cl)F)C(=O)N
InChi: 1S/C23H24ClFN4O3/c1-31-20-12-19-15(11-21(20)32-9-8-29-6-2-3-7-29)22(16(13-27-19)23(26)30)28-14-4-5-18(25)17(24)10-14/h4-5,10-13H,2-3,6-9H2,1H3,(H2,26,30)(H,27,28)
InChiKey: KYZYGNRBSALYHE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	colony stimulating factor 1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	Get druggable targets OG5_132967	All targets in OG5_132967

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0497	0.124
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (probably LuxR/UhpA-family)	0.0668	0.8261	1
Mycobacterium leprae	Probable lipase LipE	0.0078	0.0854	0.0842
Toxoplasma gondii	NAC domain-containing protein	0.004	0.0385	0.4512
Echinococcus granulosus	methyl CpG binding domain protein 2	0.002	0.0125	0.0133
Brugia malayi	Inositol-1	0.0043	0.0414	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0854	0.2238
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0106	0.0148
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0205	0.0205
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0405	0.043
Echinococcus granulosus	neuropeptide s receptor	0.0535	0.6599	0.7019
Echinococcus granulosus	microtubule associated protein 2	0.0686	0.8492	0.9033
Echinococcus granulosus	Niemann Pick C1 protein	0.014	0.1634	0.1738
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0106	0.0106
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0414	0.4169
Echinococcus granulosus	Immunoglobulin	0.0014	0.0053	0.0057
Onchocerca volvulus	Glucosylceramidase homolog	0.0196	0.234	0.7515
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0043	0.0414	0.114
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0278	0.0296
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0414	0.4169
Schistosoma mansoni	cell adhesion molecule	0.0019	0.0111	0.0118
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0078	0.0854	0.0939
Trichomonas vaginalis	penicillin-binding protein, putative	0.0078	0.0854	0.2352
Mycobacterium tuberculosis	Possible transcriptional regulatory protein	0.0668	0.8261	1
Echinococcus multilocularis	transcription factor btf3	0.004	0.0385	0.0385
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0205	0.0218
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0098	0.1106	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3631	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0125
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0042	0.0399	0.0425
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0263	0.028
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0106	0.0113
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0069	0.0745	0.0745
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.234	0.6445
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0173	0.0975
Onchocerca volvulus		0.0175	0.2074	0.6591
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.234	0.6445
Echinococcus multilocularis	Immunoglobulin	0.0014	0.0053	0.0053
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0542	0.0577
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3631	1
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0098	0.255
Trichomonas vaginalis	glucosylceramidase, putative	0.0207	0.2473	0.681
Brugia malayi	Bromodomain containing protein	0.0087	0.0967	0.2554
Mycobacterium ulcerans	lipase LipD	0.0078	0.0854	0.0926
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0125
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0098	0.0015
Mycobacterium tuberculosis	Conserved protein	0.0078	0.0854	0.0939
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0173	0.0334
Mycobacterium tuberculosis	Conserved protein	0.0078	0.0854	0.0939
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0173	0.0092
Echinococcus granulosus	geminin	0.0758	0.9401	1
Trichomonas vaginalis	set domain proteins, putative	0.0253	0.3057	0.8418
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0173	0.0092
Toxoplasma gondii	ABC1 family protein	0.0078	0.0854	1
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0019	0.0111	0.0118
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0222	0.2671	0.7316
Schistosoma mansoni	hypothetical protein	0.0048	0.0479	0.051
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0038	0.0358	0.0228
Echinococcus granulosus	roundabout 2	0.0019	0.0111	0.0118
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0078	0.0854	0.0939
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0854	0.2238
Loa Loa (eye worm)	inositol-1	0.0043	0.0414	0.1008
Trichomonas vaginalis	penicillin-binding protein, putative	0.0078	0.0854	0.2352
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0435	0.1066
Leishmania major	basic transcription factor 3a, putative	0.004	0.0385	0.3789
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0405	0.1114
Echinococcus multilocularis	expressed conserved protein	0.0092	0.1032	0.1032
Echinococcus granulosus	GPCR family 2	0.0018	0.0106	0.0113
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0405	0.043
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0014	0.0053	0.0057
Echinococcus multilocularis	Immunoglobulin	0.0014	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0854	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0854	0.2238
Trichomonas vaginalis	esterase, putative	0.0078	0.0854	0.2352
Schistosoma mansoni	inositol monophosphatase	0.0043	0.0414	0.044
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0414	0.4169
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0125
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3631	1
Mycobacterium ulcerans	putative regulatory protein	0.0668	0.8261	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0043	0.0414	0.0414
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0854	1
Schistosoma mansoni	hypothetical protein	0.004	0.0386	0.041
Echinococcus multilocularis	neuropeptide receptor A26	0.0535	0.6599	0.6599
Schistosoma mansoni	inositol monophosphatase	0.0043	0.0414	0.044
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0173	0.0092
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.234	0.6445
Brugia malayi	Pre-SET motif family protein	0.0032	0.0278	0.0627
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0078	0.0854	0.0854
Schistosoma mansoni	microtubule-associated protein tau	0.0686	0.8492	0.9033
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0173	0.0092
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0479	0.0479
Schistosoma mansoni	hypothetical protein	0.004	0.0386	0.041
Echinococcus granulosus	transcription factor btf3	0.004	0.0385	0.041
Mycobacterium tuberculosis	Probable transcriptional regulatory protein	0.0668	0.8261	1
Plasmodium vivax	basic transcription factor 3b, putative	0.004	0.0385	0.4512
Trypanosoma cruzi	transcription factor btf3, putative	0.004	0.0385	0.3789
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0405	0.0981
Echinococcus multilocularis	neuroglian	0.0014	0.0053	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0385	0.1061
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0042	0.0399	0.0399
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0542	0.1366
Schistosoma mansoni	hypothetical protein	0.0758	0.9401	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0078	0.0854	0.0939
Plasmodium falciparum	basic transcription factor 3b, putative	0.004	0.0385	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0405	0.0981
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0854	0.2238
Schistosoma mansoni	hypothetical protein	0.0018	0.0106	0.0113
Echinococcus granulosus	beta LACTamase domain containing family member	0.0078	0.0854	0.0908
Brugia malayi	beta-lactamase family protein	0.0078	0.0854	0.2238
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0173	0.1565
Echinococcus granulosus	zinc finger protein	0.0023	0.0162	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0235	0.2829	0.7758
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0542	0.0577
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3631	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0542	0.0542
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0602	0.1532
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0299	0.3631	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0098	0.1106	0.1106
Mycobacterium tuberculosis	Probable lipase LipE	0.0078	0.0854	0.0939
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0106	0.0106
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0078	0.0854	0.0939
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0542	0.1366
Schistosoma mansoni	zinc finger protein	0.0018	0.0099	0.0106
Brugia malayi	CHE-14 protein	0.0042	0.0405	0.0981
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0111	0.0161
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0078	0.0854	0.2238
Mycobacterium leprae	conserved hypothetical protein	0.0078	0.0854	0.0842
Echinococcus granulosus	expressed conserved protein	0.0092	0.1032	0.1097
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0052	0.0526	0.0559
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0299	0.3631	1
Trypanosoma brucei	transcription factor BTF3, putative	0.004	0.0385	0.3789
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0106	0.0106
Trypanosoma cruzi	transcription factor btf3, putative	0.004	0.0385	0.3789
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0173	0.1565
Schistosoma mansoni	hypothetical protein	0.0018	0.0106	0.0113
Onchocerca volvulus		0.0253	0.3057	1
Schistosoma mansoni	hypothetical protein	0.004	0.0386	0.041
Loa Loa (eye worm)	beta-lactamase	0.0078	0.0854	0.2238
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.002	0.0127	0.0206
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0479	0.051
Echinococcus granulosus	histone lysine methyltransferase setb	0.0052	0.0526	0.0559
Echinococcus granulosus	neuroglian	0.0014	0.0053	0.0057
Onchocerca volvulus		0.0078	0.0854	0.2361
Schistosoma mansoni	hypothetical protein	0.004	0.0386	0.041
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0125	0.0133
Mycobacterium ulcerans	nitrate/nitrite response regulator protein NarL	0.0668	0.8261	1
Loa Loa (eye worm)	bromodomain containing protein	0.002	0.0134	0.0225
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0278	0.0296
Schistosoma mansoni	hypothetical protein	0.0758	0.9401	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0069	0.0745	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0111	0.0161
Echinococcus multilocularis	neuropeptide s receptor	0.0535	0.6599	0.6599
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0385	0.1061
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0052	0.0526	0.0559
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3631	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0602	0.1532
Brugia malayi	beta-lactamase	0.0078	0.0854	0.2238
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0014	0.0053	0.0057
Schistosoma mansoni	zinc finger protein	0.0023	0.0162	0.0172
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0173	0.0092
Entamoeba histolytica	transcription factor BTF3, putative	0.004	0.0385	0.3484
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0278	0.0278
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0479	0.119
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.234	0.6445
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0905	0.238
Onchocerca volvulus		0.0078	0.0854	0.2361
Mycobacterium tuberculosis	Possible nitrate/nitrite response transcriptional regulatory protein NarL	0.0668	0.8261	1
Echinococcus multilocularis	zinc finger protein	0.0023	0.0162	0.0162
Trichomonas vaginalis	D-aminoacylase, putative	0.0078	0.0854	0.2352
Onchocerca volvulus		0.0032	0.0278	0.0363
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0173	0.0092
Echinococcus multilocularis	geminin	0.0758	0.9401	0.9401
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1106	0.2942
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0038	0.0358	0.0332
Mycobacterium ulcerans	two component transcriptional regulator	0.0668	0.8261	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0052	0.0526	0.0526
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0078	0.0854	0.0908
Echinococcus granulosus	neuropeptide receptor A26	0.0535	0.6599	0.7019
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0602	0.1532
Giardia lamblia	Replication factor C, subunit 1	0.001	0	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0078	0.0854	0.0908
Echinococcus granulosus	survival motor neuron protein 1	0.0235	0.2829	0.3009
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0501	0.6172	0.6565
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0173	0.0975
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0205	0.0218
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0106	0.0113
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0043	0.0414	0.0387
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0098	0.115
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0173	0.0106
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0278	0.3253
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0043	0.0414	0.4848
Echinococcus granulosus	inositol monophosphatase 1	0.0043	0.0414	0.044
Plasmodium vivax	hypothetical protein, conserved	0.0078	0.0854	1
Mycobacterium leprae	PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	0.0668	0.8261	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0469	0.1162
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0385	0.1061
Schistosoma mansoni	vesicular amine transporter	0.0014	0.0053	0.0057
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0014	0.0053	0.0053
Loa Loa (eye worm)	ICD-1 protein	0.004	0.0385	0.0928
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0173	0.0106
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0125	0.0133
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0173	0.0334
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.234	0.6445
Mycobacterium tuberculosis	Probable hydrolase	0.0078	0.0854	0.0939
Mycobacterium ulcerans	esterase/lipase LipP	0.0078	0.0854	0.0926
Trichomonas vaginalis	D-aminoacylase, putative	0.0078	0.0854	0.2352
Mycobacterium ulcerans	hypothetical protein	0.0668	0.8261	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.234	0.6445
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0098	0.5
Schistosoma mansoni	hypothetical protein	0.0018	0.0106	0.0113
Onchocerca volvulus		0.0078	0.0854	0.2361
Echinococcus granulosus	twitchin	0.0014	0.0053	0.0057
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0542	0.0542
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.1125	0.1197
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0175	0.2074	0.5647
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0173	0.0092
Brugia malayi	beta-lactamase family protein	0.0078	0.0854	0.2238
Onchocerca volvulus		0.0048	0.0479	0.1062
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0173	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0854	0.2238
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0542	0.0577
Mycobacterium tuberculosis	Probable esterase LipL	0.0078	0.0854	0.0939
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0125
Echinococcus multilocularis	roundabout 2	0.0019	0.0111	0.0111
Mycobacterium ulcerans	beta-lactamase	0.0078	0.0854	0.0926
Schistosoma mansoni	hypothetical protein	0.0018	0.0106	0.0113
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0106	0.0148
Echinococcus multilocularis	protein patched	0.0042	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0125
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3631	1
Entamoeba histolytica	hypothetical protein	0.004	0.0385	0.3484
Schistosoma mansoni	transcription factor btf3	0.004	0.0385	0.041
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0854	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.0334
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0372	0.0892
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0497	0.6118	0.7379
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0173	0.0092
Brugia malayi	hypothetical protein	0.0175	0.2074	0.5647
Trypanosoma brucei	hypothetical protein, conserved	0.0078	0.0854	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0111	0.0161
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0043	0.0414	0.114
Mycobacterium tuberculosis	Possible two component transcriptional regulatory protein (probably LuxR-family)	0.0668	0.8261	1
Schistosoma mansoni	patched 1	0.0042	0.0405	0.043
Schistosoma mansoni	hypothetical protein	0.0018	0.0099	0.0106
Schistosoma mansoni	nephrin	0.0014	0.0053	0.0057
Brugia malayi	Pre-SET motif family protein	0.0222	0.2671	0.7316
Leishmania major	hypothetical protein, conserved	0.0078	0.0854	1
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0043	0.0414	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.002	0.0127	0.0206
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0078	0.0854	0.0926
Echinococcus multilocularis	Niemann Pick C1 protein	0.014	0.1634	0.1634
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0173	0.1565
Plasmodium vivax	SET domain protein, putative	0.0032	0.0278	0.3253
Echinococcus multilocularis	microtubule associated protein 2	0.0686	0.8492	0.8492
Mycobacterium ulcerans	two component transcriptional regulatory protein DevR	0.0668	0.8261	1
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0043	0.0414	0.3743
Schistosoma mansoni	hypothetical protein	0.0039	0.0372	0.0396
Trichomonas vaginalis	glucosylceramidase, putative	0.0207	0.2473	0.681
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (LuxR-family)	0.0668	0.8261	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0542	0.0577
Brugia malayi	Bromodomain containing protein	0.0044	0.0434	0.1063
Echinococcus granulosus	Niemann Pick C1 protein	0.0098	0.1106	0.1177
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0106	0.0148
Schistosoma mansoni	bromodomain containing protein	0.0073	0.0797	0.0848
Trichomonas vaginalis	inositol monophosphatase, putative	0.0043	0.0414	0.114
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0372	0.0892
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0173	0.0975
Brugia malayi	Niemann-Pick C1 protein precursor	0.0098	0.1106	0.2942
Brugia malayi	PHD-finger family protein	0.0029	0.0239	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0523	0.1313
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.002	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0526	0.132
Echinococcus granulosus	defective proboscis extension response	0.0014	0.0053	0.0057
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0078	0.0854	0.2238
Loa Loa (eye worm)	PHD-finger family protein	0.0024	0.0177	0.0345
Trichomonas vaginalis	D-aminoacylase, putative	0.0078	0.0854	0.2352
Mycobacterium tuberculosis	Conserved protein	0.0078	0.0854	0.0939
Mycobacterium ulcerans	hypothetical protein	0.0078	0.0854	0.0926
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0602	0.1532
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.234	0.6445
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.0334
Brugia malayi	hypothetical protein	0.0235	0.2829	0.7758
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.0334
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0542	0.0577
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0414	0.4169
Echinococcus multilocularis	survival motor neuron protein 1	0.0235	0.2829	0.2829
Brugia malayi	beta-NAC-like protein	0.004	0.0385	0.0928
Schistosoma mansoni	hypothetical protein	0.0024	0.0177	0.0188
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0106	0.0148

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 0.48 uM	Antiproliferative activity against mouse 3T3 cells expressing human CSF1R after 72 hrs by Celltiter assay	ChEMBL.	19112018
IC50 (binding)	= 0.013 uM	Inhibition of His-tagged CSF1R catalytic domain expressed in baculovirus by HTRF assay	ChEMBL.	19112018

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL480646

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 986322