Detailed information for compound 986519

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 480.548 | Formula: C26H23F3N4S
  • H donors: 2 H acceptors: 2 LogP: 6.64 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1nc(c([nH]1)c1ccnc(c1)NC1CCCc2c1cccc2)c1cccc(c1)C(F)(F)F
  • InChi: 1S/C26H23F3N4S/c1-34-25-32-23(17-8-4-9-19(14-17)26(27,28)29)24(33-25)18-12-13-30-22(15-18)31-21-11-5-7-16-6-2-3-10-20(16)21/h2-4,6,8-10,12-15,21H,5,7,11H2,1H3,(H,30,31)(H,32,33)
  • InChiKey: ZPZCIOHWBPWKQV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Brugia malayi celfurPC protein 0.7851 0.8002 0.8002
Brugia malayi GH02984p 0.0038 0.0006 0.0005
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.002 0.0402
Loa Loa (eye worm) hypothetical protein 0.9803 1 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.0153 0.0124 0.0155
Schistosoma mansoni septate junction protein 0.0061 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0035 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.1952 0.1965 0.3214
Onchocerca volvulus 0.0078 0.0047 0.0616
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0081 0.005 0.0771
Toxoplasma gondii subtilisin SUB10 0.0431 0.0408 1
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0108 0.0077 0.0096
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0094 0.0063 0.0094
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0671 0.0654 0.0817
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0006 0.0006
Onchocerca volvulus 0.0038 0.0006 0.0032
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0081 0.005 0.1183
Loa Loa (eye worm) hypothetical protein 0.0097 0.0066 0.0066
Trichomonas vaginalis hypothetical protein 0.0052 0.002 0.0023
Echinococcus granulosus lysine specific histone demethylase 1A 0.0671 0.0654 0.0654
Loa Loa (eye worm) transcriptional regulator 0.0094 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0118 0.0087 0.0087
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2383 0.2406 0.3939
Schistosoma mansoni protein kinase 0.0134 0.0104 0.0104
Toxoplasma gondii subtilisin SUB2 0.0431 0.0408 1
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.006 0.0028 0.0662
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0638 0.062 0.1007
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0298 0.0272 0.3759
Echinococcus granulosus Furin 1 0.2383 0.2406 0.2406
Toxoplasma gondii aspartyl protease 0.0038 0.0006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0038 0.0006 0.0006
Onchocerca volvulus 0.0097 0.0066 0.0883
Echinococcus granulosus adam 0.01 0.0069 0.0069
Schistosoma mansoni protein arginine n-methyltransferase 0.0108 0.0077 0.0077
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0017 0.0021
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.007 0.0038 0.0481
Plasmodium vivax aspartyl protease, putative 0.0038 0.0006 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0003 0.0003
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0045 0.0013 0.0013
Schistosoma mansoni discoidin domain receptor 0.0052 0.002 0.002
Echinococcus granulosus protein arginine N methyltransferase 8 0.0191 0.0162 0.0162
Schistosoma mansoni discoidin domain receptor 0.0052 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.381 0.3866 0.3866
Echinococcus multilocularis Furin 1 0.2383 0.2406 0.3007
Echinococcus granulosus chromatin regulatory protein sir2 0.0638 0.062 0.062
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0134 0.0104 0.0104
Plasmodium vivax aspartyl protease, putative 0.0038 0.0006 0.0055
Echinococcus granulosus growth factor receptor bound protein 2 0.013 0.01 0.01
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0086 0.0055 0.1314
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Loa Loa (eye worm) hypothetical protein 0.0036 0.0003 0.0003
Plasmodium falciparum plasmepsin I 0.0038 0.0006 0.0055
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0017 0.0021
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0038 0.0006 0.0055
Loa Loa (eye worm) integrin beta-2 0.1999 0.2012 0.2012
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0136 0.0106 0.2216
Schistosoma mansoni chromatin regulatory protein sir2 0.0094 0.0063 0.0063
Brugia malayi SWIRM domain containing protein 0.0728 0.0712 0.0711
Brugia malayi hypothetical protein 0.0036 0.0003 0.0003
Loa Loa (eye worm) acyl carrier protein 0.0039 0.0006 0.0006
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0075 0.0044 0.0044
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0054 0.0023 0.0473
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0191 0.0162 0.0162
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0052 0.002 0.0025
Echinococcus multilocularis inhibitor of apoptosis protein 0.0107 0.0077 0.0096
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0153 0.0124 0.1088
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0431 0.0408 0.6202
Loa Loa (eye worm) hypothetical protein 0.0038 0.0006 0.0006
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0462 0.044 0.6764
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0083 0.0051 0.1225
Schistosoma mansoni hypothetical protein 0.0055 0.0023 0.0023
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0191 0.0162 0.0257
Mycobacterium leprae Possible secreted protease 0.0431 0.0408 1
Loa Loa (eye worm) transcriptional regulator 0.0094 0.0063 0.0063
Schistosoma mansoni chromatin regulatory protein sir2 0.0638 0.062 0.062
Loa Loa (eye worm) TK/ALK protein kinase 0.0097 0.0066 0.0066
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0107 0.0077 0.0076
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5993 0.61 0.61
Echinococcus granulosus lysine specific histone demethylase 1A 0.0136 0.0106 0.0106
Echinococcus granulosus epidermal growth factor receptor 0.0636 0.0618 0.0618
Loa Loa (eye worm) proprotein convertase 2 0.2383 0.2406 0.2406
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0114 0.0084 0.0083
Schistosoma mansoni chromatin regulatory protein sir2 0.0638 0.062 0.062
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0094 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0193 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0108 0.0077 0.0077
Plasmodium vivax subtilisin-like protease 1 0.0431 0.0408 1
Giardia lamblia Furin precursor putative serine protease 0.1952 0.1965 0.5355
Echinococcus multilocularis epidermal growth factor receptor 0.0636 0.0618 0.0773
Mycobacterium ulcerans thioesterase TesA 0.007 0.0038 0.0458
Loa Loa (eye worm) hypothetical protein 0.0298 0.0272 0.0272
Loa Loa (eye worm) TK/EGFR protein kinase 0.0636 0.0618 0.0618
Plasmodium falciparum subtilisin-like protease 1 0.0431 0.0408 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0115 0.0084 0.0105
Toxoplasma gondii subtilisin SUB9 0.0431 0.0408 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0136 0.0106 0.2546
Echinococcus multilocularis integrin alpha 3 0.0116 0.0085 0.0106
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0232 0.0204 0.0204
Echinococcus multilocularis fibrillin 2 0.0041 0.0009 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0232 0.0204 0.0204
Onchocerca volvulus 0.0431 0.0408 0.5713
Onchocerca volvulus Fatty acid synthase homolog 0.0151 0.0122 0.1667
Echinococcus multilocularis c4b binding protein beta chain 0.0036 0.0003 0.0004
Schistosoma mansoni integrin alpha 0.0151 0.0121 0.0121
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Toxoplasma gondii bicoid-interacting protein BIN3 0.0108 0.0077 0.1816
Brugia malayi hypothetical protein 0.0038 0.0006 0.0005
Brugia malayi Carm1-pending protein 0.0108 0.0077 0.0076
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0013 0.0013
Toxoplasma gondii aspartyl protease ASP3 0.0038 0.0006 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0136 0.0106 0.2546
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0006 0.0006
Brugia malayi Furin-like cysteine rich region family protein 0.0636 0.0618 0.0617
Brugia malayi hypothetical protein 0.0307 0.0281 0.0281
Schistosoma mansoni integrin alpha-ps 0.0068 0.0036 0.0036
Loa Loa (eye worm) sirtuin 4 0.0094 0.0063 0.0063
Plasmodium falciparum plasmepsin VII 0.0038 0.0006 0.0055
Brugia malayi Integrin alpha pat-2 precursor 0.0151 0.0121 0.012
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0094 0.0063 0.0149
Schistosoma mansoni integrin alpha-ps 0.0035 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0055 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Leishmania major UDP-galactopyranose mutase 0.0136 0.0106 0.0779
Mycobacterium tuberculosis Probable thioesterase TesA 0.007 0.0038 0.0905
Loa Loa (eye worm) transcriptional regulator 0.0638 0.062 0.062
Echinococcus multilocularis 0.7851 0.8002 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0012 0.0012
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0017 0.0021
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5993 0.61 1
Brugia malayi hypothetical protein 0.0036 0.0003 0.0003
Echinococcus granulosus membrane bound transcription factor site 1 0.0431 0.0408 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Echinococcus multilocularis high affinity choline transporter 1 0.0038 0.0006 0.0007
Toxoplasma gondii type I fatty acid synthase, putative 0.006 0.0028 0.0606
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0017 0.0017
Toxoplasma gondii aspartyl protease ASP5 0.0388 0.0364 0.8907
Loa Loa (eye worm) hypothetical protein 0.0671 0.0654 0.0654
Leishmania major subtilisin-like serine peptidase 0.0431 0.0408 0.6202
Brugia malayi Angiotensin-converting enzyme family protein 0.0642 0.0624 0.0623
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.002 0.002
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0108 0.0077 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0431 0.0408 0.0661
Schistosoma mansoni chromatin regulatory protein sir2 0.0094 0.0063 0.0063
Schistosoma mansoni dock 0.0052 0.002 0.002
Brugia malayi Kelch motif family protein 0.0338 0.0313 0.0312
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0049 0.0017 0.0017
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0086 0.0055 0.1314
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0094 0.0063 0.0079
Loa Loa (eye worm) hypothetical protein 0.0041 0.0009 0.0009
Echinococcus granulosus furin 0.9803 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0094 0.0063 0.0642
Echinococcus granulosus c-Jun N-terminal kinases 0.0232 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0083 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0001
Plasmodium falciparum LCCL domain-containing protein 0.0052 0.002 0.0402
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0638 0.062 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0094 0.0063 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.1952 0.1965 0.3214
Brugia malayi Pepsin A precursor 0.0038 0.0006 0.0005
Echinococcus granulosus fibrillin 2 0.0041 0.0009 0.0009
Schistosoma mansoni protein kinase 0.0134 0.0104 0.0104
Toxoplasma gondii subtilisin SUB11 0.0431 0.0408 1
Echinococcus multilocularis 0.0136 0.0106 0.0133
Toxoplasma gondii PA14 domain-containing protein 0.0052 0.002 0.0402
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2383 0.2406 0.2406
Plasmodium falciparum plasmepsin X 0.0038 0.0006 0.0055
Toxoplasma gondii histone deacetylase SIR2-like 0.0094 0.0063 0.1476
Brugia malayi P38 map kinase family protein 2 0.0153 0.0124 0.0123
Plasmodium vivax hypothetical protein, conserved 0.0094 0.0063 0.1476
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Loa Loa (eye worm) Carm1-pending protein 0.0108 0.0077 0.0077
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0431 0.0408 1
Toxoplasma gondii SWIRM domain-containing protein 0.0057 0.0025 0.0534
Onchocerca volvulus Putative cubilin 0.004 0.0008 0.0059
Onchocerca volvulus 0.0174 0.0145 0.1997
Echinococcus granulosus sodium:glucose cotransporter 2 0.0149 0.0119 0.0119
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0136 0.0106 0.2546
Schistosoma mansoni hypothetical protein 0.0206 0.0178 0.0178
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.002 0.002
Echinococcus granulosus mitogen activated protein kinase 14 0.0153 0.0124 0.0124
Echinococcus multilocularis neuroendocrine convertase 2 0.6193 0.6306 0.788
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0012 0.0012
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0136 0.0106 0.2546
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0108 0.0077 0.0874
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0036 0.0003 0.0003
Echinococcus multilocularis C type lectin domian containing protein 0.0036 0.0003 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2383 0.2406 0.3939
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Schistosoma mansoni inositol transporter 0.0149 0.0119 0.0119
Plasmodium falciparum plasmepsin V 0.0426 0.0403 0.9864
Loa Loa (eye worm) hypothetical protein 0.0055 0.0023 0.0023
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0094 0.0063 0.1515
Schistosoma mansoni glutamate receptor NMDA 0.0272 0.0245 0.0245
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0017 0.0021
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Trichomonas vaginalis conserved hypothetical protein 0.1952 0.1965 0.3214
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0638 0.062 0.0774
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0108 0.0077 0.0117
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0136 0.0106 0.2216
Echinococcus multilocularis protein kinase c epsilon type 0.0182 0.0154 0.0192
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0638 0.062 1
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0057 0.0025 0.0025
Giardia lamblia High cysteine membrane protein Group 2 0.3609 0.3661 1
Echinococcus granulosus neuroendocrine convertase 2 0.6193 0.6306 0.6306
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0471 0.0449 0.0449
Loa Loa (eye worm) hypothetical protein 0.0036 0.0003 0.0003
Schistosoma mansoni site-1 peptidase (S08 family) 0.0431 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0038 0.0006 0.0006
Leishmania major silent information regulator 2, putative 0.0638 0.062 1
Loa Loa (eye worm) hypothetical protein 0.0307 0.0281 0.0281
Brugia malayi Calcium binding EGF domain containing protein 0.004 0.0008 0.0007
Toxoplasma gondii subtilisin SUB8 0.0431 0.0408 1
Brugia malayi Sex muscle abnormal protein 5 0.013 0.01 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Brugia malayi Stress-activated protein kinase jnk-1 0.0232 0.0204 0.0203
Echinococcus granulosus sodium:glucose cotransporter 0.0149 0.0119 0.0119
Mycobacterium ulcerans polyketide synthase Pks13 0.0122 0.0092 0.1844
Trichomonas vaginalis conserved hypothetical protein 0.1952 0.1965 0.3214
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0182 0.0154 0.0154
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0094 0.0063 0.0094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1952 0.1965 0.3214
Onchocerca volvulus Deterin homolog 0.0107 0.0077 0.1036
Loa Loa (eye worm) hypothetical protein 0.0136 0.0106 0.0106
Trypanosoma cruzi UDP-galactopyranose mutase 0.0136 0.0106 0.0779
Loa Loa (eye worm) endoprotease bli-4 0.9803 1 1
Schistosoma mansoni integrin beta subunit 0.1167 0.1161 0.1161
Loa Loa (eye worm) hypothetical protein 0.0036 0.0003 0.0003
Brugia malayi NAD-dependent deacetylase SIRT1 0.0094 0.0063 0.0062
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0052 0.0021 0.0024
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0081 0.005 0.0771
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0006 0.0006
Giardia lamblia Hypothetical protein 0.0638 0.062 0.1673
Loa Loa (eye worm) hypothetical protein 0.0035 0.0003 0.0003
Echinococcus granulosus protein kinase c iota type 0.0032 0.0000089972 0.0000089972
Loa Loa (eye worm) fatty acid synthase 0.0083 0.0052 0.0052
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5993 0.61 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0153 0.0124 0.0155
Echinococcus multilocularis mitogen activated protein kinase 11 0.0153 0.0124 0.0155
Echinococcus granulosus glutamate NMDA receptor subunit 0.0272 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0097 0.0066 0.0066
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0017 0.0017
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0116 0.0086 0.0085
Mycobacterium ulcerans polyketide synthase 0.0081 0.005 0.075
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.002 0.0402
Chlamydia trachomatis protoporphyrinogen oxidase 0.0136 0.0106 1
Toxoplasma gondii subtilisin SUB6 0.0431 0.0408 1
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.259 0.2618 0.2618
Trichomonas vaginalis conserved hypothetical protein 0.1952 0.1965 0.3214
Toxoplasma gondii histone lysine-specific demethylase 0.0136 0.0106 0.2546
Schistosoma mansoni furin-1 (S08 family) 0.4241 0.4308 0.4308
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Giardia lamblia hypothetical protein 0.0057 0.0025 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0431 0.0408 0.0661
Brugia malayi EGF-like domain containing protein 0.0041 0.0009 0.0008
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0431 0.0408 0.0408
Mycobacterium ulcerans NAD-dependent deacetylase 0.0094 0.0063 0.1098
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0107 0.0077 0.0076
Leishmania major arginine N-methyltransferase, type I 0.0108 0.0077 0.0247
Schistosoma mansoni high-affinity choline transporter 0.0038 0.0006 0.0006
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0122 0.0092 0.2226
Echinococcus multilocularis fibrillin 1 0.0043 0.0011 0.0014
Brugia malayi EGF-like domain containing protein 0.0041 0.0009 0.0008
Echinococcus granulosus glutamate receptor 2 0.0049 0.0017 0.0017
Trichomonas vaginalis hypothetical protein 0.0041 0.0009 0.0005
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0052 0.002 0.0023
Schistosoma mansoni growth factor receptor-bound protein 0.013 0.01 0.01
Plasmodium vivax LCCL domain-containing protein 0.0052 0.002 0.0402
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0153 0.0124 0.1088
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0017 0.0017
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0191 0.0162 0.3924
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0006 0.0055
Toxoplasma gondii histone deacetylase SIR2 0.0094 0.0063 0.1476
Brugia malayi aspartic protease BmAsp-2, identical 0.0038 0.0006 0.0005
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0094 0.0063 0.0642
Schistosoma mansoni chromatin regulatory protein sir2 0.0094 0.0063 0.0063
Mycobacterium tuberculosis Possible oxidoreductase 0.0136 0.0106 0.258
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0134 0.0104 0.013
Echinococcus granulosus inhibitor of apoptosis protein 0.0107 0.0077 0.0077
Onchocerca volvulus 0.0097 0.0066 0.0883
Schistosoma mansoni atypical protein kinase C 0.0032 0.0000089972 0.0000089972
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Loa Loa (eye worm) hypothetical protein 0.0431 0.0408 0.0408
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0431 0.0408 0.0408
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0462 0.044 0.6764
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0108 0.0077 0.0247
Loa Loa (eye worm) hypothetical protein 0.0041 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.1952 0.1965 0.1965
Trichomonas vaginalis conserved hypothetical protein 0.1952 0.1965 0.3214
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0081 0.005 0.1192
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.002 0.0025
Echinococcus multilocularis serine:threonine protein kinase N2 0.0167 0.0138 0.0172
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0006 0.0005
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0052 0.002 0.0445
Brugia malayi transcriptional regulator, Sir2 family protein 0.0094 0.0063 0.0062
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0006 0.0006
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0094 0.0063 0.0094
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0094 0.0063 0.0642
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0638 0.062 0.062
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0038 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0006 0.0059
Brugia malayi GCC2 and GCC3 family protein 0.0045 0.0013 0.0012
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0086 0.0055 0.0909
Brugia malayi proprotein convertase 2 0.6193 0.6306 0.6305
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0097 0.0066 0.0066
Schistosoma mansoni inhibitor of apoptosis protein 0.0107 0.0077 0.0077
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0431 0.0408 1
Echinococcus multilocularis integrin alpha ps 0.0068 0.0036 0.0045
Echinococcus granulosus mitogen activated protein kinase 11 0.0153 0.0124 0.0124
Echinococcus granulosus nmda type glutamate receptor 0.0115 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0094 0.0063 0.0063
Echinococcus multilocularis MAM 0.0097 0.0066 0.0082
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0038 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0078 0.0047 0.0046
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0041 0.0009 0.0005
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0059 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0431 0.0408 0.0661
Mycobacterium ulcerans oxidoreductase 0.0136 0.0106 0.2216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0003 0.0003
Mycobacterium ulcerans dehydrogenase 0.0136 0.0106 0.2216
Onchocerca volvulus 0.0038 0.0006 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2383 0.2406 0.3939
Toxoplasma gondii subtilisin SUB7 0.0431 0.0408 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0006 0.0006
Echinococcus multilocularis protein arginine methyltransferase 0.0191 0.0162 0.0203
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0052 0.002 0.0023
Plasmodium falciparum plasmepsin VI 0.0038 0.0006 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0057 0.0025 0.0025
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0191 0.0162 0.0162
Trypanosoma cruzi UDP-galactopyranose mutase 0.0136 0.0106 0.0779
Schistosoma mansoni hypothetical protein 0.0107 0.0077 0.0077
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0431 0.0408 1
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0272 0.0245 0.0306
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0094 0.0063 0.0094
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0108 0.0077 0.0117
Brugia malayi hypothetical protein 0.0036 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0097 0.0066 0.0066
Trichomonas vaginalis hypothetical protein 0.1952 0.1965 0.3214
Loa Loa (eye worm) hypothetical protein 0.0038 0.0006 0.0006
Onchocerca volvulus 0.0041 0.0009 0.0074
Echinococcus granulosus protein arginine N methyltransferase 7 0.0108 0.0077 0.0077
Schistosoma mansoni c4b-binding protein beta chain 0.0036 0.0003 0.0003
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0638 0.062 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0136 0.0106 0.2216
Brugia malayi Subtilase family protein 0.0431 0.0408 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Schistosoma mansoni inositol transporter 0.0149 0.0119 0.0119
Mycobacterium tuberculosis Conserved hypothetical protein 0.0136 0.0106 0.258
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2383 0.2406 0.3939
Brugia malayi hypothetical protein 0.0059 0.0027 0.0026
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0638 0.062 0.1007
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0065 0.0033 0.0317
Loa Loa (eye worm) hypothetical protein 0.004 0.0008 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.0017 0.0017
Toxoplasma gondii subtilisin SUB4 0.0431 0.0408 1
Trichomonas vaginalis conserved hypothetical protein 0.1952 0.1965 0.3214
Brugia malayi SWIRM domain containing protein 0.0057 0.0025 0.0024
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0108 0.0077 0.1816
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0689 0.0672 0.0672
Plasmodium vivax hypothetical protein, conserved 0.0136 0.0106 0.2546
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0431 0.0408 1
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0094 0.0063 0.1476
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0025 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0003 0.0003
Brugia malayi Sushi domain 0.0036 0.0003 0.0003
Schistosoma mansoni amine oxidase 0.0136 0.0106 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.0154 0.0154
Schistosoma mansoni chromatin regulatory protein sir2 0.0094 0.0063 0.0063
Brugia malayi transcriptional regulator, Sir2 family protein 0.0638 0.062 0.0619
Loa Loa (eye worm) hypothetical protein 0.0036 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0136 0.0106 0.0106
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0431 0.0408 1
Plasmodium falciparum plasmepsin IX 0.0038 0.0006 0.0055
Echinococcus granulosus integrin alpha ps 0.0068 0.0036 0.0036
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0638 0.062 1
Onchocerca volvulus 0.0728 0.0712 1
Trichomonas vaginalis conserved hypothetical protein 0.1952 0.1965 0.3214
Loa Loa (eye worm) subtilase 0.0431 0.0408 0.0408
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0094 0.0063 0.0063
Brugia malayi pregnancy-associated plasma protein-A 0.0036 0.0003 0.0003
Mycobacterium ulcerans monoamine oxidase 0.0136 0.0106 0.2216
Onchocerca volvulus 0.0052 0.002 0.023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Echinococcus multilocularis mitogen activated protein kinase 14 0.0153 0.0124 0.0155
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Plasmodium vivax aspartyl protease, putative 0.0038 0.0006 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.1952 0.1965 0.3214
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0086 0.0055 0.1314
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0094 0.0063 0.0094
Echinococcus granulosus sodium:myo inositol cotransporter 0.0149 0.0119 0.0119
Mycobacterium leprae Polyketide synthase Pks13 0.0122 0.0092 0.1863
Loa Loa (eye worm) hypothetical protein 0.0118 0.0088 0.0088
Echinococcus multilocularis nmda type glutamate receptor 0.0115 0.0084 0.0105
Schistosoma mansoni tyrosine kinase 0.0636 0.0618 0.0618
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0041 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0138 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0728 0.0712 0.0712
Schistosoma mansoni apoptosis regulator bax 0.0055 0.0023 0.0023
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0108 0.0077 0.0247
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0052 0.002 0.0023
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0006 0.0006
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0094 0.0063 0.0079
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0116 0.0086 0.0086
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0081 0.005 0.1192
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0136 0.0106 0.2546
Onchocerca volvulus 0.0206 0.0178 0.2466
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0057 0.0025 0.0031
Brugia malayi Protein arginine N-methyltransferase 0.0108 0.0077 0.0076
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0191 0.0162 0.0257
Echinococcus granulosus serine:threonine protein kinase N2 0.0149 0.0119 0.0119
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0078 0.0047 0.1118
Plasmodium falciparum subtilisin-like protease 3 0.0431 0.0408 1
Echinococcus multilocularis discoidin domain receptor 0.0052 0.002 0.0025
Toxoplasma gondii type I fatty acid synthase, putative 0.0086 0.0055 0.1274
Echinococcus multilocularis adam 0.01 0.0069 0.0086
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0066 0.0034 0.0798
Plasmodium vivax hypothetical protein, conserved 0.0136 0.0106 0.2546
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0081 0.005 0.1183
Echinococcus granulosus high affinity choline transporter 1 0.0038 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.1952 0.1965 0.3214
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.005 0.075
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0431 0.0408 1
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0431 0.0408 0.051
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.002 0.0402
Trichomonas vaginalis WD repeat domain, putative 0.0206 0.0178 0.0283
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0086 0.0055 0.0909
Plasmodium falciparum protoporphyrinogen oxidase 0.0136 0.0106 0.2546
Loa Loa (eye worm) hypothetical protein 0.0041 0.0009 0.0009
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0107 0.0077 0.0077
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0298 0.0272 0.3759
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0107 0.0077 0.0096
Plasmodium vivax plasmepsin IV, putative 0.0038 0.0006 0.0055
Loa Loa (eye worm) aspartyl protease 6 0.0038 0.0006 0.0006
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0081 0.005 0.075
Leishmania major arginine N-methyltransferase-like protein 0.0191 0.0162 0.1781
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0108 0.0077 0.0117
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0149 0.0119 0.0149
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0108 0.0077 0.1816
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0038 0.0006 0.0055
Brugia malayi hypothetical protein 0.0036 0.0003 0.0003
Echinococcus granulosus C type lectin domian containing protein 0.0036 0.0003 0.0003
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0094 0.0063 0.0079
Loa Loa (eye worm) hypothetical protein 0.0036 0.0003 0.0003
Echinococcus granulosus MAM 0.0097 0.0066 0.0066
Giardia lamblia Transcriptional regulator, Sir2 family 0.0094 0.0063 0.0149
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0108 0.0077 0.0247
Giardia lamblia Sirtuin type 2 0.0094 0.0063 0.0149
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.005 0.075
Brugia malayi aspartic protease BmAsp-1, identical 0.0038 0.0006 0.0005
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0431 0.0408 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0191 0.0162 0.0257
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Loa Loa (eye worm) hypothetical protein 0.0107 0.0077 0.0077
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0081 0.005 0.1183
Toxoplasma gondii subtilisin SUB1 0.0431 0.0408 1
Loa Loa (eye worm) DEAH box polypeptide 35 0.0033 0.0001 0.0001
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0083 0.0051 0.5
Echinococcus multilocularis protein jagged 2 0.0041 0.0009 0.0011
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0431 0.0408 0.0408
Echinococcus multilocularis integrin alpha ps 0.0068 0.0036 0.0045
Loa Loa (eye worm) sex muscle abnormal protein 5 0.013 0.01 0.01
Plasmodium falciparum plasmepsin II 0.0038 0.0006 0.0055
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0338 0.0313 0.0313
Brugia malayi Eukaryotic aspartyl protease family protein 0.0038 0.0006 0.0005
Brugia malayi Integrin beta pat-3 precursor 0.1999 0.2012 0.2012
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0156 0.0126 0.0126
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Onchocerca volvulus 0.0038 0.0006 0.0032
Echinococcus multilocularis integrin beta 2 0.1474 0.1476 0.1844
Toxoplasma gondii subtilisin SUB5 0.0431 0.0408 1
Brugia malayi Will die slowly protein 0.0206 0.0178 0.0177
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0094 0.0063 0.0063
Loa Loa (eye worm) reprolysin 0.0045 0.0013 0.0013
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0431 0.0408 0.0408
Mycobacterium ulcerans polyketide synthase 0.0086 0.0055 0.0887
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0038 0.0006 0.0007
Brugia malayi EGF-like domain containing protein 0.0041 0.0009 0.0008
Plasmodium falciparum plasmepsin III 0.0038 0.0006 0.0055
Echinococcus granulosus protein kinase c epsilon type 0.0182 0.0154 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0431 0.0408 1
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0136 0.0106 0.2234
Trichomonas vaginalis conserved hypothetical protein 0.0431 0.0408 0.0661
Echinococcus granulosus c4b binding protein beta chain 0.0036 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0052 0.002 0.002
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0431 0.0408 0.0408
Echinococcus multilocularis protoporphyrinogen oxidase 0.0136 0.0106 0.0133
Echinococcus multilocularis solute carrier family 5 0.0149 0.0119 0.0149
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0191 0.0162 0.3924
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0038 0.0006 0.0006
Echinococcus granulosus discoidin domain receptor 0.0052 0.002 0.002
Plasmodium falciparum plasmepsin VIII, putative 0.0038 0.0006 0.0055
Brugia malayi Protein kinase domain containing protein 0.0052 0.002 0.0019
Brugia malayi hypothetical protein 0.0097 0.0066 0.0065
Brugia malayi amine oxidase, flavin-containing family protein 0.0193 0.0165 0.0164
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0108 0.0077 0.0247
Brugia malayi hypothetical protein 0.0036 0.0003 0.0003
Brugia malayi hypothetical protein 0.0036 0.0003 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Echinococcus multilocularis growth factor receptor bound protein 2 0.013 0.01 0.0125
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0107 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0036 0.0003 0.0003
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0462 0.044 0.6764
Loa Loa (eye worm) hypothetical protein 0.0045 0.0013 0.0013
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1952 0.1965 0.3214
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0136 0.0106 0.0106
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0065 0.0033 0.034
Echinococcus granulosus integrin alpha 3 0.0116 0.0085 0.0085
Trypanosoma cruzi subtilisin peptidase 0.0431 0.0408 0.6202
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Entamoeba histolytica hypothetical protein 0.0298 0.0272 0.416
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0012 0.0012
Plasmodium falciparum LCCL domain-containing protein 0.0052 0.002 0.0402
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0052 0.002 0.0025
Entamoeba histolytica PH domain containing protein kinase, putative 0.0149 0.0119 0.1587
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055 0.0023 0.0023
Toxoplasma gondii aspartyl protease ASP1 0.0038 0.0006 0.0055
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0086 0.0055 0.0887
Loa Loa (eye worm) apoptosis regulator protein 0.0055 0.0023 0.0023
Trypanosoma brucei subtilisin peptidase 0.0431 0.0408 0.6202
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0638 0.062 1
Echinococcus granulosus solute carrier family 5 0.0149 0.0119 0.0119
Plasmodium vivax subtilisin-like protease 2, putative 0.0431 0.0408 1
Onchocerca volvulus 0.0146 0.0116 0.1592
Brugia malayi protein kinase C II. 0.0182 0.0154 0.0153
Schistosoma mansoni sodium/solute symporter 0.0038 0.0006 0.0006
Onchocerca volvulus 0.0107 0.0077 0.1036
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0149 0.0119 0.0149
Mycobacterium ulcerans thioesterase 0.007 0.0038 0.0458
Echinococcus granulosus protein will die slowly 0.0206 0.0178 0.0178
Onchocerca volvulus 0.0052 0.002 0.023
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0094 0.0063 0.0094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2383 0.2406 0.3939
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0298 0.0272 0.3759
Loa Loa (eye worm) hypothetical protein 0.0045 0.0013 0.0013
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0191 0.0162 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0065 0.0033 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.0431 0.0408 0.0661
Brugia malayi hypothetical protein 0.0298 0.0272 0.0272
Echinococcus granulosus Protein kinase C brain isozyme 0.0035 0.0003 0.0003
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0094 0.0063 0.1476
Brugia malayi hypothetical protein 0.0036 0.0003 0.0003
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0094 0.0063 0.0094
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0232 0.0204 0.0255
Loa Loa (eye worm) integrin alpha pat-2 0.0232 0.0205 0.0205
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0108 0.0077 0.0096
Plasmodium falciparum plasmepsin IV 0.0038 0.0006 0.0055
Plasmodium vivax NAD-dependent deacetylase, putative 0.0094 0.0063 0.1476
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0094 0.0063 0.0094
Schistosoma mansoni btb and poz domain-containing protein 0.0052 0.002 0.002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2383 0.2406 0.3939
Schistosoma mansoni SWI/SNF complex-related 0.0057 0.0025 0.0025
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0083 0.0051 0.5
Schistosoma mansoni chromatin regulatory protein sir2 0.0638 0.062 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0023
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0122 0.0092 0.2226
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0006 0.0007
Echinococcus granulosus protein arginine methyltransferase 0.0191 0.0162 0.0162
Echinococcus multilocularis protein will die slowly 0.0206 0.0178 0.0223
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0083 0.0051 0.0794
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0045 0.0013 0.0016
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0153 0.0124 0.1088
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.001 0.0169
Echinococcus granulosus fibrillin 1 0.0043 0.0011 0.0011
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0108 0.0077 0.0247
Brugia malayi Protein kinase domain containing protein 0.0097 0.0066 0.0065
Brugia malayi neuroendocrine convertase 1 precursor 0.6193 0.6306 0.6305
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0006 0.0006
Schistosoma mansoni memapsin-2 (A01 family) 0.0038 0.0006 0.0006
Schistosoma mansoni growth factor receptor-bound protein 0.013 0.01 0.01
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0298 0.0272 0.416
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0048 0.0016 0.0346
Loa Loa (eye worm) WD40 repeat protein 0.0206 0.0178 0.0178
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0689 0.0672 0.0839
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0671 0.0654 0.0654
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0094 0.0063 0.0094
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0006 0.0006
Toxoplasma gondii subtilisin SUB12 0.0431 0.0408 1
Plasmodium vivax subtilisin-like serine protease, putative 0.0431 0.0408 1
Echinococcus multilocularis membrane bound transcription factor site 1 0.0431 0.0408 0.051
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0052 0.002 0.002
Echinococcus granulosus methyltransferase protein 5 0.0108 0.0077 0.0077
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0049 0.0017 0.0021
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0078 0.0047 0.0047
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0006 0.0006
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.002 0.002
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0642 0.0624 0.0624
Plasmodium vivax plasmepsin V, putative 0.0426 0.0403 0.9864
Toxoplasma gondii hypothetical protein 0.0041 0.0009 0.0129
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055 0.0023 0.0023
Plasmodium vivax LCCL domain-containing protein 0.0052 0.002 0.0402
Brugia malayi EGF-like domain containing protein 0.0041 0.0009 0.0008
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.002 0.0025
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0013 0.0013
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0431 0.0408 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.005 0.075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0431 0.0408 0.0661
Mycobacterium leprae Probable polyketide synthase Pks1 0.0086 0.0055 0.0909
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0006 0.0006
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0108 0.0077 0.0247
Schistosoma mansoni hypothetical protein 0.0097 0.0066 0.0066
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0153 0.0124 0.1088
Loa Loa (eye worm) hypothetical protein 0.0114 0.0084 0.0084
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0153 0.0124 0.0124
Echinococcus granulosus integrin beta 2 0.1474 0.1476 0.1476
Trichomonas vaginalis conserved hypothetical protein 0.1952 0.1965 0.3214
Schistosoma mansoni protein kinase 0.0134 0.0104 0.0104
Schistosoma mansoni amine oxidase 0.0136 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0671 0.0654 0.0654
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1952 0.1965 0.3214
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.9803 1 1
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0191 0.0162 0.3924
Brugia malayi hypothetical protein 0.0136 0.0106 0.0106
Brugia malayi hypothetical protein 0.0038 0.0006 0.0005
Schistosoma mansoni hypothetical protein 0.0052 0.002 0.002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0006 0.0006
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0052 0.002 0.002
Plasmodium falciparum subtilisin-like protease 2 0.0431 0.0408 1
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0108 0.0077 0.0077
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0081 0.005 0.0049
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5993 0.61 0.7624
Echinococcus multilocularis chromatin regulatory protein sir2 0.0638 0.062 0.0774
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0191 0.0162 0.0203
Schistosoma mansoni site-1 peptidase (S08 family) 0.0431 0.0408 0.0408
Mycobacterium ulcerans Sir2-like regulatory protein 0.0094 0.0063 0.1098
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0107 0.0077 0.0077
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0086 0.0055 0.0887
Schistosoma mansoni hypothetical protein 0.0055 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0025 0.0032
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055 0.0023 0.0029

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.248 uM Inhibition of p38alpha ChEMBL. 18578517
IC50 (functional) = 10.3 uM Inhibition of IL1-beta release in human whole blood ChEMBL. 18578517
IC50 (functional) = 21.2 uM Inhibition of TNFalpha release in human whole blood ChEMBL. 18578517

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 18578517

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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