Detailed information for compound 986660

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 480.482 | Formula: C26H23F3N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.89 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCC2(CC1)C(=O)N([C@@H]2c1ccccc1)c1ccccn1)Nc1ccc(cc1)C(F)(F)F
  • InChi: 1S/C26H23F3N4O2/c27-26(28,29)19-9-11-20(12-10-19)31-24(35)32-16-13-25(14-17-32)22(18-6-2-1-3-7-18)33(23(25)34)21-8-4-5-15-30-21/h1-12,15,22H,13-14,16-17H2,(H,31,35)/t22-/m1/s1
  • InChiKey: JJYMDGAAHPIJQC-JOCHJYFZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0036 0.0124 0.0124
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0193 0.1659
Brugia malayi Bromodomain containing protein 0.0175 0.1647 0.1647
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0193 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0189 0.0256
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0052 0.0307 0.1802
Echinococcus granulosus expressed protein 0.004 0.0174 0.0174
Plasmodium vivax SET domain protein, putative 0.007 0.0495 0.3936
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0193 0.0149
Leishmania major trypanothione reductase 0.0055 0.0336 0.2097
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0204 0.0633
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0091 0.0091
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.004 0.0174 0.023
Mycobacterium tuberculosis Probable oxidoreductase 0.014 0.1263 0.4409
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.0905 0.0905
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0204 0.0283
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0215 0.0215
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.014 0.1263 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0126 0.1109 0.8705
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.004 0.0174 0.0174
Trypanosoma cruzi target of rapamycin kinase 3 0.0042 0.019 0.0651
Schistosoma mansoni peptidase Clp (S14 family) 0.0091 0.0731 0.0731
Brugia malayi RNA recognition motif domain containing protein 0.0254 0.2511 0.2511
Echinococcus multilocularis expressed protein 0.004 0.0174 0.0174
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0052 0.0307 0.1802
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.0307 0.2664
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0052 0.0307 0.1802
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0177 0.1673 0.1673
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0731 0.5
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0336 0.0336
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.004 0.0174 0.0174
Echinococcus multilocularis geminin 0.0198 0.1895 0.1895
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0155 0.0659
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.004 0.0174 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0307 0.0461
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0053 0.0308 0.0308
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0139 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0276 0.275 0.275
Echinococcus granulosus peregrin 0.0038 0.0151 0.0151
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0052 0.0307 0.2664
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0938 1 1
Schistosoma mansoni hypothetical protein 0.0058 0.0364 0.0364
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.004 0.0174 0.0174
Echinococcus multilocularis peregrin 0.0038 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.004 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0115 0.0995 0.0995
Echinococcus granulosus guanine nucleotide binding protein G protein 0.004 0.0174 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.016 0.0205
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0231 0.0231
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.056 0.5863 0.5863
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0052 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0091 0.0731 0.0731
Onchocerca volvulus 0.0042 0.0193 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0223 0.0315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0105 0.011
Loa Loa (eye worm) hypothetical protein 0.0042 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0099 0.0821 0.0821
Onchocerca volvulus 0.0042 0.0193 0.0178
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.014 0.1263 0.4409
Schistosoma mansoni hypothetical protein 0.0177 0.1673 0.1673
Brugia malayi glutathione reductase 0.0055 0.0336 0.0336
Schistosoma mansoni inositol monophosphatase 0.0043 0.0204 0.0204
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0193 0.0679
Schistosoma mansoni hypothetical protein 0.0033 0.0091 0.0091
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0204 0.1763
Giardia lamblia GTOR 0.0052 0.0307 1
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0336 0.2097
Echinococcus multilocularis peptidase Clp (S14 family) 0.006 0.0387 0.0387
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.004 0.0174 0.0174
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0052 0.0307 0.2774
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0193 0.0262
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.014 0.1263 0.4409
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.004 0.0174 0.0174
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.006 0.0387 0.2616
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0109 0.093 0.093
Onchocerca volvulus 0.007 0.0495 0.071
Schistosoma mansoni hypothetical protein 0.0383 0.3923 0.3923
Trypanosoma brucei PAB1-binding protein , putative 0.0128 0.1139 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0731 0.6158
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0938 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0139 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.004 0.0174 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0043 0.0001
Onchocerca volvulus 0.0552 0.5777 1
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.004 0.0174 0.023
Loa Loa (eye worm) glutathione reductase 0.0055 0.0336 0.0336
Brugia malayi hypothetical protein 0.0276 0.275 0.275
Loa Loa (eye worm) hypothetical protein 0.0383 0.3923 0.3923
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.004 0.0174 0.0174
Brugia malayi Latrophilin receptor protein 2 0.0177 0.1673 0.1673
Schistosoma mansoni bromodomain containing protein 0.0148 0.1348 0.1348
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0084 0.0651 0.0651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0072 0.0052
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0177 0.1673 0.1673
Trichomonas vaginalis set domain proteins, putative 0.0552 0.5777 1
Schistosoma mansoni hypothetical protein 0.0177 0.1673 0.1673
Brugia malayi RNA binding protein 0.0254 0.2511 0.2511
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0193 0.0262
Loa Loa (eye worm) hypothetical protein 0.0089 0.0712 0.0712
Plasmodium vivax glutathione reductase, putative 0.0055 0.0336 0.2444
Echinococcus multilocularis zinc finger protein 0.0046 0.0233 0.0233
Echinococcus granulosus methyl CpG binding domain protein 2 0.004 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0091
Echinococcus granulosus survival motor neuron protein 1 0.0276 0.275 0.275
Echinococcus granulosus histone lysine methyltransferase setb 0.0109 0.093 0.093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0938 1 1
Onchocerca volvulus 0.0042 0.0193 0.0178
Toxoplasma gondii ABC1 family protein 0.0042 0.0193 0.1089
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0193 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0189 0.0256
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0231 0.0231
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0042 0.0193 0.0193
Mycobacterium leprae Probable lipase LipE 0.0042 0.0193 0.0975
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0052 0.0307 0.1802
Loa Loa (eye worm) hypothetical protein 0.0042 0.0193 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0076 0.0058
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0126 0.1109 0.3798
Schistosoma mansoni tar DNA-binding protein 0.0254 0.2511 0.2511
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.004 0.0174 0.0174
Brugia malayi Bromodomain containing protein 0.0038 0.0151 0.0151
Brugia malayi hypothetical protein 0.0084 0.0651 0.0651
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.004 0.0174 0.0174
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0193 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0043 0.0001
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0336 0.0336
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.004 0.0174 0.023
Brugia malayi hypothetical protein 0.004 0.0174 0.0174
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0042 0.019 0.0651
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.004 0.0174 0.023
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0091 0.0731 0.0731
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.004 0.0174 0.0174
Trypanosoma cruzi PAB1-binding protein , putative 0.0128 0.1139 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0043 0.0001
Echinococcus granulosus guanine nucleotide binding protein subunit 0.004 0.0174 0.0174
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0938 1 1
Brugia malayi TAR-binding protein 0.0254 0.2511 0.2511
Brugia malayi PHD-finger family protein 0.0033 0.0091 0.0091
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0731 1
Schistosoma mansoni hypothetical protein 0.0056 0.0349 0.0349
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0495 0.0495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0118 0.0132
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0193 0.0193
Schistosoma mansoni tar DNA-binding protein 0.0254 0.2511 0.2511
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0189 0.0256
Echinococcus granulosus fetal alzheimer antigen falz 0.0053 0.0308 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.016 0.0205
Brugia malayi Inositol-1 0.0043 0.0204 0.0204
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0091 0.0133
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.007 0.0495 0.3936
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0193 0.1089
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.004 0.0174 0.0174
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.004 0.0174 0.0174
Entamoeba histolytica hypothetical protein 0.0084 0.0651 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.007 0.0495 0.0495
Brugia malayi hypothetical protein 0.0128 0.1139 0.1139
Mycobacterium tuberculosis Probable dehydrogenase 0.0126 0.1109 0.3798
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.056 0.5863 0.5863
Plasmodium falciparum ataxin-2 like protein, putative 0.0128 0.1139 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0177 0.1673 0.1673
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0177 0.1673 0.1673
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.004 0.0174 0.0174
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0215 0.0215
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0472 0.0472
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0731 1
Brugia malayi latrophilin 2 splice variant baaae 0.0383 0.3923 0.3923
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.006 0.0387 0.0924
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.004 0.0174 0.0174
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0254 0.2511 0.2511
Loa Loa (eye worm) hypothetical protein 0.0109 0.093 0.093
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0204 0.0796
Schistosoma mansoni zinc finger protein 0.0036 0.0124 0.0124
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0091 0.0091
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0109 0.093 0.093
Loa Loa (eye worm) hypothetical protein 0.004 0.0174 0.0174
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0177 0.1673 0.1673
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.004 0.0174 0.0174
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.004 0.0174 0.0174
Leishmania major hypothetical protein, conserved 0.0042 0.0193 0.0679
Schistosoma mansoni hypothetical protein 0.0198 0.1895 0.1895
Onchocerca volvulus 0.0056 0.0349 0.0453
Trypanosoma brucei ISWI complex protein 0.0036 0.0124 0.1051
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0307 0.0307
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.004 0.0174 0.0174
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0193 0.0149
Schistosoma mansoni hypothetical protein 0.0048 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0198 0.1895 0.1895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0072 0.0052
Schistosoma mansoni GTP-binding protein alpha subunit 0.004 0.0174 0.0174
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.004 0.0174 0.0174
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0091 0.0133
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0204 0.0796
Schistosoma mansoni trimeric G-protein alpha o subunit 0.004 0.0174 0.0174
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0204 0.12
Mycobacterium tuberculosis Conserved protein 0.0042 0.0193 0.0149
Toxoplasma gondii thioredoxin reductase 0.0055 0.0336 0.2444
Entamoeba histolytica hypothetical protein 0.0084 0.0651 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0052 0.0307 0.0307
Brugia malayi Pre-SET motif family protein 0.0485 0.5043 0.5043
Echinococcus granulosus tumor protein p63 0.0788 0.8354 0.8354
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0485 0.5043 0.5043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.016 0.0205
Schistosoma mansoni hypothetical protein 0.0177 0.1673 0.1673
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0731 0.5
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.004 0.0174 0.023
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0193 0.0975
Mycobacterium tuberculosis Conserved protein 0.0042 0.0193 0.0149
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0042 0.019 0.1634
Echinococcus granulosus tar DNA binding protein 0.0254 0.2511 0.2511
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.004 0.0174 0.0174
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0193 0.0193
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0349 0.0349
Loa Loa (eye worm) inositol-1 0.0043 0.0204 0.0204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0938 1 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0177 0.1673 0.1673
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.004 0.0174 0.0174
Loa Loa (eye worm) TAR-binding protein 0.0254 0.2511 0.2511
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.016 0.0205
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0215 0.0215
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0091 0.0731 0.6158
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.004 0.0174 0.0174
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0336 0.2444
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0204 0.0796
Echinococcus granulosus geminin 0.0198 0.1895 0.1895
Brugia malayi hypothetical protein 0.0083 0.0641 0.0641
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0193 0.0679
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.004 0.0174 0.023
Brugia malayi G-protein alpha subunit 0.004 0.0174 0.0174
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.004 0.0174 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0076 0.0058
Brugia malayi Pre-SET motif family protein 0.007 0.0495 0.0495
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0193 0.0149
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0091 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0189 0.0256
Onchocerca volvulus 0.004 0.0174 0.0146
Schistosoma mansoni tar DNA-binding protein 0.0254 0.2511 0.2511
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0189 0.0256
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0058 0.0364 0.0364
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0084 0.0651 0.0651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0307 0.0461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0938 1 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0773 0.0773
Echinococcus granulosus GPCR family 2 0.0177 0.1673 0.1673
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0938 1 1
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.004 0.0174 0.0174
Loa Loa (eye worm) G protein alpha subunit 3 0.004 0.0174 0.0174
Loa Loa (eye worm) RNA binding protein 0.0254 0.2511 0.2511
Loa Loa (eye worm) transcription factor SMAD2 0.0358 0.3648 0.3648
Schistosoma mansoni hypothetical protein 0.0177 0.1673 0.1673
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.007 0.0495 0.0495
Brugia malayi PHD-finger family protein 0.0058 0.0369 0.0369
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0126 0.1109 0.3798
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0336 0.0336
Loa Loa (eye worm) MH2 domain-containing protein 0.0358 0.3648 0.3648
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0126 0.1109 0.3798
Schistosoma mansoni zinc finger protein 0.0046 0.0233 0.0233
Mycobacterium tuberculosis Probable reductase 0.0126 0.1109 0.3798
Plasmodium falciparum thioredoxin reductase 0.0055 0.0336 0.2444
Leishmania major hypothetical protein, conserved 0.0128 0.1139 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0204 0.0283
Loa Loa (eye worm) beta-lactamase 0.0042 0.0193 0.0193
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0336 0.0722
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0204 0.0221
Brugia malayi beta-lactamase 0.0042 0.0193 0.0193
Trypanosoma brucei trypanothione reductase 0.0055 0.0336 0.2927
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0938 1 1
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.004 0.0174 0.0174
Brugia malayi MH2 domain containing protein 0.0358 0.3648 0.3648
Brugia malayi jmjC domain containing protein 0.0044 0.0215 0.0215
Brugia malayi Calcitonin receptor-like protein seb-1 0.056 0.5863 0.5863
Entamoeba histolytica hypothetical protein 0.0084 0.0651 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.004 0.0168 0.0168
Entamoeba histolytica hypothetical protein 0.0084 0.0651 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0193 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.016 0.0205
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0166 0.0166
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0193 0.0262
Echinococcus granulosus guanine nucleotide binding protein subunit 0.004 0.0174 0.0174
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0109 0.093 0.093
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0731 0.6158
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0664 0.0664
Plasmodium falciparum ataxin-2 like protein, putative 0.0128 0.1139 1
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.004 0.0174 0.0174
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0204 0.0204
Schistosoma mansoni GTP-binding protein alpha subunit 0.004 0.0174 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0307 0.0461
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0193 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.016 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.016 0.0205
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0052 0.0307 0.0307
Schistosoma mansoni methyl-cpg binding protein mbd 0.004 0.0168 0.0168
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.004 0.0174 0.0174
Schistosoma mansoni survival motor neuron protein 0.0056 0.0349 0.0349
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0126 0.1109 0.3798
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0067 0.0467 0.0467
Echinococcus granulosus guanine nucleotide binding protein G protein 0.004 0.0174 0.0174
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.006 0.0387 0.0924
Schistosoma mansoni transcription factor LCR-F1 0.0084 0.0651 0.0651
Echinococcus multilocularis GPCR, family 2 0.0177 0.1673 0.1673
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0193 0.0149
Loa Loa (eye worm) PHD-finger family protein 0.0048 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0042 0.0193 0.0193
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0053 0.0308 0.0308
Onchocerca volvulus 0.004 0.0174 0.0146
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0091 0.0731 0.0731
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0193 0.0149
Loa Loa (eye worm) hypothetical protein 0.0042 0.0193 0.0193
Echinococcus multilocularis survival motor neuron protein 1 0.0276 0.275 0.275
Loa Loa (eye worm) pigment dispersing factor receptor c 0.056 0.5863 0.5863
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0204 0.0204
Loa Loa (eye worm) bromodomain containing protein 0.0041 0.0184 0.0184
Onchocerca volvulus 0.0115 0.0995 0.159
Loa Loa (eye worm) hypothetical protein 0.004 0.0174 0.0174
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.0905 0.0905
Brugia malayi beta-lactamase family protein 0.0042 0.0193 0.0193
Onchocerca volvulus 0.004 0.0174 0.0146
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0091 0.0731 0.5514
Schistosoma mansoni cellular tumor antigen P53 0.0115 0.0995 0.0995
Brugia malayi Bromodomain containing protein 0.0089 0.071 0.071
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.004 0.0174 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0076 0.0058
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0268 0.2668 1
Toxoplasma gondii LsmAD domain-containing protein 0.0128 0.1139 1
Brugia malayi Thioredoxin reductase 0.0055 0.0336 0.0336
Schistosoma mansoni tar DNA-binding protein 0.0254 0.2511 0.2511
Loa Loa (eye worm) hypothetical protein 0.0056 0.0347 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0043 0.0001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0084 0.065 0.065
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0091 0.0091
Echinococcus granulosus zinc finger protein 0.0046 0.0233 0.0233
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.004 0.0174 0.0174
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0193 0.0262
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0731 0.6158
Schistosoma mansoni tar DNA-binding protein 0.0254 0.2511 0.2511
Loa Loa (eye worm) hypothetical protein 0.0165 0.1538 0.1538
Plasmodium falciparum phd finger protein, putative 0.0033 0.0091 0.0133
Loa Loa (eye worm) latrophilin receptor protein 2 0.0177 0.1673 0.1673
Brugia malayi jmjC domain containing protein 0.0107 0.0905 0.0905
Brugia malayi beta-lactamase family protein 0.0042 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0128 0.1139 0.1139
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0204 0.0283
Plasmodium vivax ataxin-2 like protein, putative 0.0128 0.1139 1
Mycobacterium tuberculosis Conserved protein 0.0042 0.0193 0.0149
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.004 0.0174 0.023
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.004 0.0174 0.0174
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0091 0.0133
Brugia malayi Probable ClpP-like protease 0.0091 0.0731 0.0731
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0731 1
Echinococcus granulosus peptidase Clp S14 family 0.006 0.0387 0.0387
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0052 0.0307 0.2774
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0091 0.0731 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.016 0.0779
Echinococcus multilocularis tar DNA binding protein 0.0254 0.2511 0.2511
Schistosoma mansoni inositol monophosphatase 0.0043 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.004 0.0174 0.0174
Schistosoma mansoni hypothetical protein 0.0084 0.0651 0.0651
Echinococcus multilocularis methyl CpG binding domain protein 2 0.004 0.0168 0.0168
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.004 0.0174 0.0174
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0193 0.0193
Plasmodium falciparum glutathione reductase 0.0055 0.0336 0.2444
Echinococcus multilocularis tumor protein p63 0.0788 0.8354 0.8354
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0193 0.0193
Trypanosoma cruzi PAB1-binding protein , putative 0.0128 0.1139 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0058 0.0364 0.0364
Trichomonas vaginalis esterase, putative 0.0042 0.0193 0.0262
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0084 0.065 0.065

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 83 % Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced activation at 10 uM by FLIPR assay ChEMBL. 19114307

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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