Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0043 | 0.0293 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1534 | 0.4991 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0236 | 0.2681 | 0.872 |
Plasmodium vivax | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0043 | 0.0293 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0246 | 0.08 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.0029 | 0.0131 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.0578 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0043 | 0.03 | 0.0974 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0236 | 0.2681 | 0.2681 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.039 | 0.127 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0029 | 0.0131 | 1 |
Schistosoma mansoni | DNA ligase IV | 0.0029 | 0.0131 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0419 | 0.1365 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0209 | 0.2353 | 0.7653 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0236 | 0.2681 | 0.6651 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0039 | 0.0246 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0131 | 0.0425 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.0131 | 0.4364 |
Echinococcus multilocularis | GPCR, family 2 | 0.0066 | 0.0585 | 0.0585 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 0.3074 | 1 |
Brugia malayi | RNA binding protein | 0.0267 | 0.3074 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0267 | 0.3074 | 1 |
Brugia malayi | TAR-binding protein | 0.0267 | 0.3074 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0246 | 0.08 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0043 | 0.03 | 0.0743 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.0029 | 0.0131 | 0.0425 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0236 | 0.2681 | 0.872 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.039 | 0.127 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0408 | 0.1328 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.0375 | 0.0375 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0066 | 0.0585 | 0.0585 |
Loa Loa (eye worm) | RNA binding protein | 0.0267 | 0.3074 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0585 | 0.1902 |
Schistosoma mansoni | topbp1 | 0.0029 | 0.0131 | 0.0425 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.0029 | 0.0131 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.0408 | 0.1328 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0066 | 0.0585 | 0.0585 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0578 | 0.1881 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.0131 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.0578 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.0131 | 0.4364 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.0408 | 0.7057 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0236 | 0.2681 | 0.872 |
Brugia malayi | hypothetical protein | 0.0111 | 0.1135 | 0.3693 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0585 | 0.1902 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.0029 | 0.0131 | 0.0425 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.0029 | 0.0131 | 0.4364 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0578 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0111 | 0.1135 | 0.1135 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.0408 | 0.7057 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.0029 | 0.0131 | 0.226 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0066 | 0.0585 | 0.1902 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.2353 | 0.7653 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.0578 | 0.0578 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0236 | 0.2681 | 0.2681 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0043 | 0.03 | 0.03 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0066 | 0.0585 | 0.1451 |
Schistosoma mansoni | topbp1 | 0.0029 | 0.0131 | 0.0425 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0029 | 0.0131 | 0.4364 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0131 | 0.0425 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0102 | 0.1028 | 0.3344 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0131 | 0.0425 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 0.3074 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0066 | 0.0585 | 0.1902 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.028 | 0.0912 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.022 | 0.3799 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.1135 | 1 |
Brugia malayi | DKFZp564C0469 protein | 0.0029 | 0.0131 | 0.0425 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0052 | 0.0408 | 0.3595 |
Toxoplasma gondii | ATPase, AAA family protein | 0.0029 | 0.0131 | 0.0000078372 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.1009 | 0.3282 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.0029 | 0.0131 | 0.0131 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0143 | 0.1534 | 0.4991 |
Echinococcus multilocularis | expressed conserved protein | 0.0094 | 0.0933 | 0.0933 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.03 | 0.0974 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.01 | 0.1009 | 0.2503 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0111 | 0.1135 | 0.2817 |
Echinococcus multilocularis | tar DNA binding protein | 0.0267 | 0.3074 | 0.3074 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0052 | 0.0408 | 0.3595 |
Onchocerca volvulus | 0.0152 | 0.1647 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0585 | 0.1902 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 0.3074 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0131 | 0.0425 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 0.3074 | 1 |
Onchocerca volvulus | 0.0052 | 0.0408 | 0.183 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0209 | 0.2353 | 0.7653 |
Loa Loa (eye worm) | TAR-binding protein | 0.0267 | 0.3074 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 0.3074 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0293 | 0.0952 |
Plasmodium falciparum | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0043 | 0.0293 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0578 | 1 |
Toxoplasma gondii | mitochondrial inner membrane translocase subunit TIM17, putative | 0.0043 | 0.0293 | 0.3618 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.022 | 0.3799 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0251 | 0.287 | 0.9335 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.028 | 0.0912 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.1135 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0144 | 0.1542 | 0.1542 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.022 | 0.3799 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.0408 | 0.7057 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.028 | 0.0912 |
Treponema pallidum | DNA ligase (lig) | 0.0029 | 0.0131 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0578 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0345 | 0.4031 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.0578 | 0.1435 |
Brugia malayi | topoisomerase | 0.0029 | 0.0131 | 0.0425 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.0131 | 0.1151 |
Brugia malayi | MH2 domain containing protein | 0.0251 | 0.287 | 0.9335 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0585 | 0.1902 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0251 | 0.287 | 0.9335 |
Echinococcus multilocularis | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0043 | 0.0293 | 0.0293 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.0408 | 0.7057 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0052 | 0.0408 | 0.7057 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0052 | 0.0408 | 0.7057 |
Echinococcus multilocularis | protein patched | 0.0043 | 0.03 | 0.03 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0029 | 0.0131 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.0408 | 0.7057 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0052 | 0.0408 | 0.7057 |
Mycobacterium ulcerans | hypothetical protein | 0.0052 | 0.0408 | 0.7057 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.0131 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0242 | 0.0786 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0029 | 0.0131 | 0.4364 |
Echinococcus granulosus | expressed conserved protein | 0.0094 | 0.0933 | 0.2316 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.03 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0293 | 0.0952 |
Echinococcus granulosus | tar DNA binding protein | 0.0267 | 0.3074 | 0.7627 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.0131 | 0.4364 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.1534 | 0.4991 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.0131 | 0.4364 |
Echinococcus multilocularis | nibrin | 0.0029 | 0.0131 | 0.0131 |
Echinococcus granulosus | replication factor c subunit 1 | 0.0029 | 0.0131 | 0.0324 |
Echinococcus granulosus | nibrin | 0.0029 | 0.0131 | 0.0324 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.1135 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.01 | 0.1009 | 0.3282 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0246 | 0.08 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0052 | 0.0408 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0052 | 0.0408 | 0.7057 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0039 | 0.0246 | 0.7112 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0029 | 0.0131 | 0.4364 |
Onchocerca volvulus | 0.005 | 0.039 | 0.1713 | |
Brugia malayi | hypothetical protein | 0.0152 | 0.1647 | 0.5357 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.03 | 0.0974 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0246 | 0.08 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0052 | 0.0408 | 0.3595 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0039 | 0.0246 | 0.4252 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0043 | 0.0293 | 0.0952 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0029 | 0.0131 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.028 | 0.0912 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0408 | 0.1328 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0066 | 0.0585 | 0.1451 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0246 | 0.08 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0267 | 0.3074 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0236 | 0.2681 | 0.872 |
Brugia malayi | CHE-14 protein | 0.0043 | 0.03 | 0.0974 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0052 | 0.0408 | 0.7057 |
Echinococcus granulosus | GPCR family 2 | 0.0066 | 0.0585 | 0.1451 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0144 | 0.1542 | 0.3826 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.01 | 0.1009 | 0.8886 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.022 | 0.3799 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0236 | 0.2681 | 0.6651 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.0029 | 0.0131 | 0.0425 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0043 | 0.0293 | 0.0952 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0039 | 0.0246 | 0.4252 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0209 | 0.2353 | 0.7653 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1647 | 0.5357 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0242 | 0.0786 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0131 | 0.0425 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.01 | 0.1009 | 0.1009 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0052 | 0.0408 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0345 | 0.4031 | 0.4031 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0131 | 0.0425 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0066 | 0.0585 | 0.1902 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.1135 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0408 | 0.1328 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0043 | 0.03 | 0.0743 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0029 | 0.0131 | 0.4364 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.0029 | 0.0131 | 0.1151 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0131 | 0.0425 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.0408 | 0.7057 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.0408 | 0.1328 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.0578 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0131 | 0.0425 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.1135 | 0.3693 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0052 | 0.0408 | 0.7057 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0111 | 0.1135 | 0.3693 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.0408 | 0.1328 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0236 | 0.2681 | 0.872 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0039 | 0.0246 | 0.7112 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0585 | 0.1902 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0578 | 0.1881 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.0131 | 0.4364 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Displacement of [3H]clonidine from imidazoline 1 receptor in Sprague-Dawley rat kidney | ChEMBL. | 18517187 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.