Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | integrin alpha 3 | 0.0113 | 0.0031 | 0.0069 |
Echinococcus granulosus | neuropeptide s receptor | 0.0494 | 0.2332 | 0.5185 |
Echinococcus granulosus | neuropeptide receptor | 0.0658 | 0.3322 | 0.7386 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0494 | 0.2332 | 0.5185 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0234 | 0.0759 | 0.1285 |
Schistosoma mansoni | neuropeptide receptor | 0.0658 | 0.3322 | 0.3322 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0148 | 0.024 | 0.0406 |
Mycobacterium leprae | 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) | 0.1152 | 0.631 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0658 | 0.3322 | 0.7386 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0112 | 0.0022 | 0.0037 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.1086 | 0.5912 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0342 | 0.1414 | 0.2392 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0109 | 0.0006 | 0.0013 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0852 | 0.4498 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0852 | 0.4498 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1086 | 0.5912 | 1 |
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | 0.1152 | 0.631 | 0.5 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0109 | 0.0006 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.0658 | 0.3322 | 0.7386 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 0.1152 | 0.631 | 0.5 |
Echinococcus granulosus | integrin alpha 3 | 0.0113 | 0.0031 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0048 | 0.0081 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0494 | 0.2332 | 0.5185 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.0759 | 0.1285 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0022 | 0.0037 |
Schistosoma mansoni | hypothetical protein | 0.0307 | 0.1199 | 0.1199 |
Schistosoma mansoni | integrin alpha | 0.0148 | 0.024 | 0.024 |
Echinococcus granulosus | sodium channel protein | 0.0109 | 0.0006 | 0.0013 |
Trypanosoma brucei | RNA helicase, putative | 0.0307 | 0.1199 | 0.5 |
Onchocerca volvulus | 0.0392 | 0.1716 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0392 | 0.1716 | 0.2902 |
Schistosoma mansoni | hypothetical protein | 0.0234 | 0.0759 | 0.0759 |
Brugia malayi | solute carrier family 40, member 1 | 0.0392 | 0.1716 | 0.2902 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0494 | 0.2332 | 0.5185 |
Schistosoma mansoni | serine-type protease inhibitor | 0.1762 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0342 | 0.1414 | 0.2392 |
Echinococcus multilocularis | sodium channel protein | 0.0109 | 0.0006 | 0.0013 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0228 | 0.0724 | 0.1225 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 200 uM | Inhibition of 5-lipoxygenase | ChEMBL. | 9544564 |
IC50 (binding) | > 200 uM | Inhibition of COX1 | ChEMBL. | 9544564 |
Inhibition (functional) | = 50 % | Antagonist activity at human FXR expressed in human HepG2 cells assessed as inhibition of CDCA-induced transactivation of SHP gene at 50 uM by measuring relative luciferase activity by transient transfection reporter assay relative to control | ChEMBL. | 22365756 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.