Detailed information for compound 987030

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 413.768 | Formula: C19H12ClN3O6
  • H donors: 1 H acceptors: 3 LogP: 4.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc2c(c1)OCO2)N/N=C/c1ccc(o1)c1ccc(cc1Cl)[N+](=O)[O-]
  • InChi: 1S/C19H12ClN3O6/c20-15-8-12(23(25)26)2-4-14(15)16-6-3-13(29-16)9-21-22-19(24)11-1-5-17-18(7-11)28-10-27-17/h1-9H,10H2,(H,22,24)/b21-9+
  • InChiKey: MSTGQDXCEMPLCD-ZVBGSRNCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Brugia malayi NAD-dependent deacetylase SIRT1 0.0064 0.0081 0.0081
Onchocerca volvulus 0.0083 0.0113 0.0338
Toxoplasma gondii histone deacetylase SIR2-like 0.0064 0.0081 0.1944
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Schistosoma mansoni chromatin regulatory protein sir2 0.0437 0.0705 0.0704
Echinococcus granulosus furin 0.5987 1 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.0089 0.1248
Schistosoma mansoni hypothetical protein 0.1193 0.1972 0.1972
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0064 0.0081 0.0102
Giardia lamblia Furin precursor putative serine protease 0.1193 0.1972 0.5329
Echinococcus granulosus lysine specific histone demethylase 1A 0.0484 0.0784 0.0784
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0016 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.1193 0.1972 0.323
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.3661 0.6104 0.7629
Trichomonas vaginalis conserved hypothetical protein 0.1193 0.1972 0.323
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0437 0.0705 1
Toxoplasma gondii histone deacetylase SIR2 0.0064 0.0081 0.1944
Plasmodium falciparum subtilisin-like protease 1 0.0264 0.0415 1
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0264 0.0415 0.0519
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Plasmodium vivax subtilisin-like protease 2, putative 0.0264 0.0415 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0437 0.0705 0.1153
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Echinococcus multilocularis serine:threonine protein kinase N2 0.0077 0.0103 0.0128
Loa Loa (eye worm) endoprotease bli-4 0.5987 1 1
Loa Loa (eye worm) hypothetical protein 0.0484 0.0784 0.0783
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0098 0.0138 0.3315
Brugia malayi protein kinase C II. 0.0084 0.0115 0.0114
Echinococcus granulosus epidermal growth factor receptor 0.0339 0.0541 0.0541
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0437 0.0705 1
Loa Loa (eye worm) sirtuin 4 0.0064 0.0081 0.0081
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0064 0.0081 0.1144
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.3661 0.6104 0.6104
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0064 0.0081 0.0132
Plasmodium vivax hypothetical protein, conserved 0.0098 0.0138 0.3315
Chlamydia trachomatis protoporphyrinogen oxidase 0.0098 0.0138 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Trypanosoma brucei SIR2-like protein 4, putative 0.0064 0.0081 0.1144
Echinococcus multilocularis neuroendocrine convertase 2 0.3783 0.6309 0.7885
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0041 0.0042 0.0042
Brugia malayi SWIRM domain containing protein 0.0525 0.0853 0.0852
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Toxoplasma gondii subtilisin SUB4 0.0264 0.0415 1
Schistosoma mansoni furin-1 (S08 family) 0.259 0.4311 0.4311
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0437 0.0705 0.1153
Echinococcus granulosus chromatin regulatory protein sir2 0.0437 0.0705 0.0705
Plasmodium falciparum protoporphyrinogen oxidase 0.0098 0.0138 0.3315
Entamoeba histolytica SWIRM domain protein 0.0041 0.0042 0.0585
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1457 0.2414 0.2414
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0264 0.0415 0.5354
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0264 0.0415 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0437 0.0705 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0116 0.0169 0.0168
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Toxoplasma gondii subtilisin SUB10 0.0264 0.0415 1
Echinococcus multilocularis membrane bound transcription factor site 1 0.0264 0.0415 0.0519
Echinococcus multilocularis protoporphyrinogen oxidase 0.0098 0.0138 0.0173
Brugia malayi Subtilase family protein 0.0264 0.0415 0.0414
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0064 0.0081 0.0132
Schistosoma mansoni chromatin regulatory protein sir2 0.0064 0.0081 0.0081
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0116 0.0169 0.0168
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0098 0.0138 0.1702
Toxoplasma gondii subtilisin SUB7 0.0264 0.0415 1
Trichomonas vaginalis conserved hypothetical protein 0.0264 0.0415 0.0679
Loa Loa (eye worm) hypothetical protein 0.0064 0.0081 0.0081
Loa Loa (eye worm) WD40 repeat protein 0.0068 0.0087 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0064 0.0081 0.1944
Echinococcus granulosus protein will die slowly 0.0068 0.0087 0.0087
Toxoplasma gondii histone lysine-specific demethylase 0.0098 0.0138 0.3315
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0064 0.0081 0.0132
Mycobacterium ulcerans monoamine oxidase 0.0098 0.0138 0.1702
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0437 0.0705 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1457 0.2414 0.3953
Trichomonas vaginalis hypothetical protein 0.1193 0.1972 0.323
Plasmodium vivax subtilisin-like serine protease, putative 0.0264 0.0415 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0437 0.0705 0.0881
Echinococcus multilocularis epidermal growth factor receptor 0.0339 0.0541 0.0676
Schistosoma mansoni chromatin regulatory protein sir2 0.0064 0.0081 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0264 0.0415 0.0679
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0098 0.0138 0.1702
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0264 0.0415 0.0415
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0098 0.0138 0.1702
Echinococcus granulosus protein kinase c epsilon type 0.0084 0.0115 0.0115
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Brugia malayi neuroendocrine convertase 1 precursor 0.3783 0.6309 0.6309
Giardia lamblia High cysteine membrane protein Group 2 0.2204 0.3664 1
Trichomonas vaginalis conserved hypothetical protein 0.0264 0.0415 0.0679
Plasmodium falciparum subtilisin-like protease 2 0.0264 0.0415 1
Trichomonas vaginalis conserved hypothetical protein 0.1193 0.1972 0.323
Loa Loa (eye worm) proprotein convertase 2 0.1457 0.2414 0.2413
Trichomonas vaginalis conserved hypothetical protein 0.0264 0.0415 0.0679
Schistosoma mansoni amine oxidase 0.0098 0.0138 0.0138
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0264 0.0415 0.5354
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0098 0.0138 0.3315
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0098 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.1193 0.1972 0.323
Giardia lamblia Transcriptional regulator, Sir2 family 0.0064 0.0081 0.0109
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0064 0.0081 0.0132
Onchocerca volvulus 0.0525 0.0853 1
Loa Loa (eye worm) transcriptional regulator 0.0064 0.0081 0.0081
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.5987 1 1
Schistosoma mansoni protein kinase 0.0133 0.0196 0.0196
Brugia malayi transcriptional regulator, Sir2 family protein 0.0064 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0525 0.0853 0.0852
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0264 0.0415 0.5886
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0098 0.0138 0.3315
Trypanosoma cruzi subtilisin peptidase 0.0264 0.0415 0.5354
Schistosoma mansoni amine oxidase 0.0098 0.0138 0.0138
Loa Loa (eye worm) TK/EGFR protein kinase 0.0339 0.0541 0.054
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0064 0.0081 0.0132
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0064 0.0081 0.0109
Toxoplasma gondii subtilisin SUB12 0.0264 0.0415 1
Plasmodium vivax subtilisin-like protease 1 0.0264 0.0415 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0064 0.0081 0.0081
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0084 0.0115 0.0114
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0064 0.0081 0.0081
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0264 0.0415 0.0414
Entamoeba histolytica hypothetical protein 0.0041 0.0042 0.0585
Trypanosoma brucei subtilisin peptidase 0.0264 0.0415 0.5886
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1457 0.2414 0.3953
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Schistosoma mansoni chromatin regulatory protein sir2 0.0064 0.0081 0.0081
Trypanosoma cruzi UDP-galactopyranose mutase 0.0098 0.0138 0.0912
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0016 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Leishmania major UDP-galactopyranose mutase 0.0098 0.0138 0.1951
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0264 0.0415 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0064 0.0081 0.0102
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0264 0.0415 0.5354
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1239 0.2049 0.2048
Trichomonas vaginalis conserved hypothetical protein 0.0264 0.0415 0.0679
Brugia malayi transcriptional regulator, Sir2 family protein 0.0064 0.0081 0.0081
Echinococcus granulosus neuroendocrine convertase 2 0.3783 0.6309 0.6309
Trichomonas vaginalis conserved hypothetical protein 0.1193 0.1972 0.323
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0016 0.0001 0.0001
Brugia malayi SWIRM domain containing protein 0.0041 0.0042 0.0041
Mycobacterium tuberculosis Possible oxidoreductase 0.0098 0.0138 0.1702
Loa Loa (eye worm) hypothetical protein 0.0098 0.0138 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0042 0.0068
Toxoplasma gondii subtilisin SUB1 0.0264 0.0415 1
Schistosoma mansoni SWI/SNF complex-related 0.0041 0.0042 0.0042
Echinococcus multilocularis 0.4794 0.8001 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1193 0.1972 0.323
Plasmodium falciparum plasmepsin V 0.0127 0.0185 0.4454
Plasmodium vivax plasmepsin V, putative 0.0127 0.0185 0.4454
Plasmodium vivax NAD-dependent deacetylase, putative 0.0064 0.0081 0.1944
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3661 0.6104 1
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0264 0.0415 1
Trichomonas vaginalis WD repeat domain, putative 0.0068 0.0087 0.0141
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0064 0.0081 0.1144
Brugia malayi transcriptional regulator, Sir2 family protein 0.0437 0.0705 0.0704
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0264 0.0415 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0437 0.0705 0.0704
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Toxoplasma gondii aspartyl protease ASP5 0.0115 0.0167 0.4
Mycobacterium ulcerans dehydrogenase 0.0098 0.0138 0.1702
Echinococcus multilocularis 0.0098 0.0138 0.0173
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0225 0.0351 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.1193 0.1972 0.323
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Brugia malayi hypothetical protein 0.0098 0.0138 0.0137
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0133 0.0196 0.0245
Mycobacterium leprae Possible secreted protease 0.0264 0.0415 1
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0264 0.0415 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1457 0.2414 0.3953
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Toxoplasma gondii subtilisin SUB5 0.0264 0.0415 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0064 0.0081 0.0132
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Schistosoma mansoni tyrosine kinase 0.0339 0.0541 0.0541
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1193 0.1972 0.323
Brugia malayi Furin-like cysteine rich region family protein 0.0339 0.0541 0.054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0016 0.0001 0.0001
Plasmodium falciparum subtilisin-like protease 3 0.0264 0.0415 1
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1193 0.1972 0.323
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0484 0.0784 0.0784
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3661 0.6104 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0016 0.0001 0.0001
Mycobacterium ulcerans oxidoreductase 0.0098 0.0138 0.1702
Loa Loa (eye worm) hypothetical protein 0.0264 0.0415 0.0414
Loa Loa (eye worm) subtilase 0.0264 0.0415 0.0414
Entamoeba histolytica hypothetical protein, conserved 0.0064 0.0081 0.1144
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0484 0.0784 0.098
Giardia lamblia Sirtuin type 2 0.0064 0.0081 0.0109
Toxoplasma gondii subtilisin SUB9 0.0264 0.0415 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0098 0.0138 0.0912
Toxoplasma gondii subtilisin SUB6 0.0264 0.0415 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0064 0.0081 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.1193 0.1972 0.323
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0064 0.0081 0.1144
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0064 0.0081 0.0102
Plasmodium vivax hypothetical protein, conserved 0.0098 0.0138 0.3315
Schistosoma mansoni protein kinase 0.0133 0.0196 0.0196
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0098 0.0138 0.3315
Echinococcus granulosus lysine specific histone demethylase 1A 0.0098 0.0138 0.0138
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0064 0.0081 0.0132
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0133 0.0196 0.0196
Toxoplasma gondii SWIRM domain-containing protein 0.0041 0.0042 0.0995
Echinococcus multilocularis protein kinase c epsilon type 0.0084 0.0115 0.0143
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Mycobacterium tuberculosis Conserved hypothetical protein 0.0098 0.0138 0.1702
Loa Loa (eye worm) transcriptional regulator 0.0064 0.0081 0.0081
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0264 0.0415 1
Entamoeba histolytica SWIRM domain protein 0.0041 0.0042 0.0585
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0264 0.0415 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0064 0.0081 0.0081
Brugia malayi Will die slowly protein 0.0068 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.2326 0.3869 0.3869
Brugia malayi amine oxidase, flavin-containing family protein 0.0139 0.0207 0.0206
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Giardia lamblia Hypothetical protein 0.0437 0.0705 0.1829
Schistosoma mansoni site-1 peptidase (S08 family) 0.0264 0.0415 0.0415
Toxoplasma gondii subtilisin SUB11 0.0264 0.0415 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1457 0.2414 0.3953
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0064 0.0081 0.1144
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0001 0.0001
Leishmania major silent information regulator 2, putative 0.0437 0.0705 1
Echinococcus multilocularis Furin 1 0.1457 0.2414 0.3017
Trichomonas vaginalis conserved hypothetical protein 0.1193 0.1972 0.323
Schistosoma mansoni site-1 peptidase (S08 family) 0.0264 0.0415 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.1193 0.1972 0.323
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0042 0.0068
Schistosoma mansoni chromatin regulatory protein sir2 0.0437 0.0705 0.0704
Loa Loa (eye worm) hypothetical protein 0.0484 0.0784 0.0783
Entamoeba histolytica protein kinase, putative 0.0018 0.0003 0.003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Echinococcus granulosus membrane bound transcription factor site 1 0.0264 0.0415 0.0415
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0264 0.0415 1
Schistosoma mansoni protein kinase 0.0133 0.0196 0.0196
Echinococcus multilocularis protein will die slowly 0.0068 0.0087 0.0109
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0016 0.0001 0.0001
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0437 0.0705 1
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0115 0.0114
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0064 0.0081 0.0132
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0064 0.0081 0.1944
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0264 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0041 0.0042 0.0041
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0064 0.0081 0.1944
Brugia malayi celfurPC protein 0.4794 0.8001 0.8001
Leishmania major sir2-family protein-like protein 0.0064 0.0081 0.1144
Loa Loa (eye worm) hypothetical protein 0.5987 1 1
Leishmania major subtilisin-like serine peptidase 0.0264 0.0415 0.5886
Brugia malayi proprotein convertase 2 0.3783 0.6309 0.6309
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0264 0.0415 1
Toxoplasma gondii subtilisin SUB8 0.0264 0.0415 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0437 0.0705 0.0705
Toxoplasma gondii subtilisin SUB2 0.0264 0.0415 1
Trichomonas vaginalis conserved hypothetical protein 0.1193 0.1972 0.323
Echinococcus granulosus serine:threonine protein kinase N2 0.0069 0.0089 0.0089
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0264 0.0415 0.0414
Onchocerca volvulus 0.0264 0.0415 0.4287
Echinococcus granulosus Furin 1 0.1457 0.2414 0.2414
Echinococcus multilocularis chromatin regulatory protein sir2 0.0437 0.0705 0.0881
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1457 0.2414 0.3953
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0264 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0098 0.0138 0.0137
Schistosoma mansoni hypothetical protein 0.0068 0.0087 0.0087
Loa Loa (eye worm) transcriptional regulator 0.0437 0.0705 0.0704
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0064 0.0081 0.0081
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1457 0.2414 0.3953
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0264 0.0415 0.0679
Trichomonas vaginalis conserved hypothetical protein 0.1193 0.1972 0.323
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0041 0.0042 0.0053
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0098 0.0138 0.3315
Loa Loa (eye worm) hypothetical protein 0.0139 0.0207 0.0206

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.