Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0429 | 0.4574 | 0.4574 |
Echinococcus granulosus | tumor protein p63 | 0.0744 | 0.8216 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0725 | 0.8 | 0.9736 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0725 | 0.8 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.0053 | 1 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0037 | 0.0034 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0053 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0276 | 0.2803 | 0.3476 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0053 | 0.5 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0061 | 0.0316 | 0.0345 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0053 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0061 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0429 | 0.4574 | 0.4574 |
Brugia malayi | MH1 domain containing protein | 0.0061 | 0.0316 | 0.0316 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0061 | 0.0316 | 0.0345 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0053 | 0.008 |
Schistosoma mansoni | smad | 0.0061 | 0.0316 | 0.0355 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0053 | 0.0053 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0053 | 1 |
Onchocerca volvulus | 0.0109 | 0.0868 | 0.5852 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0246 | 0.2451 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0061 | 0.0316 | 0.0316 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0053 | 1 |
Brugia malayi | hypothetical protein | 0.0159 | 0.1446 | 0.1446 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0053 | 0.0024 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0047 | 0.015 | 0.015 |
Onchocerca volvulus | 0.0159 | 0.1446 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.118 | 0.1438 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0061 | 0.0316 | 0.0316 |
Schistosoma mansoni | intermediate filament proteins | 0.0087 | 0.0619 | 0.0734 |
Echinococcus multilocularis | lamin dm0 | 0.0087 | 0.0619 | 0.0715 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0136 | 0.118 | 0.118 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0109 | 0.0868 | 0.1047 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0053 | 0.0053 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0087 | 0.0619 | 0.0619 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0725 | 0.8 | 0.9736 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.118 | 0.1438 |
Schistosoma mansoni | smad1 5 8 and | 0.0061 | 0.0316 | 0.0355 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0042 | 0.0096 | 0.0076 |
Echinococcus multilocularis | tumor protein p63 | 0.0744 | 0.8216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0078 | 0.0078 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0136 | 0.118 | 0.14 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0429 | 0.4574 | 0.4574 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0298 | 0.3059 | 0.3698 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0053 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0053 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0298 | 0.3059 | 0.3798 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.3003 | 0.3003 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0053 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0061 | 0.0316 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.118 | 0.1438 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0868 | 0.0868 |
Echinococcus granulosus | Smad4 | 0.0061 | 0.0316 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0096 | 0.0096 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0061 | 0.0316 | 0.0345 |
Brugia malayi | Smad1 | 0.0061 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | intermediate filament protein | 0.0087 | 0.0619 | 0.0619 |
Echinococcus multilocularis | smad | 0.0061 | 0.0316 | 0.0345 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0276 | 0.2803 | 0.3384 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0619 | 0.0619 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.118 | 0.1438 |
Echinococcus multilocularis | musashi | 0.0087 | 0.0619 | 0.0715 |
Schistosoma mansoni | thyroid hormone receptor | 0.0298 | 0.3059 | 0.3798 |
Echinococcus granulosus | lamin | 0.0087 | 0.0619 | 0.0715 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0053 | 0.0053 |
Schistosoma mansoni | smad1 5 8 and | 0.0061 | 0.0316 | 0.0355 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0053 | 0.0024 |
Schistosoma mansoni | lamin | 0.0087 | 0.0619 | 0.0734 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.0053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0053 | 0.0053 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0429 | 0.4574 | 0.4574 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0136 | 0.118 | 0.118 |
Schistosoma mansoni | lamin | 0.0087 | 0.0619 | 0.0734 |
Echinococcus multilocularis | lamin | 0.0087 | 0.0619 | 0.0715 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0078 | 0.0078 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0136 | 0.118 | 0.14 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0053 | 0.0053 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0038 | 0.0053 | 0.008 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0038 | 0.0053 | 0.008 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0136 | 0.118 | 0.14 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0053 | 0.0053 |
Echinococcus granulosus | intermediate filament protein | 0.0087 | 0.0619 | 0.0715 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0898 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0047 | 0.015 | 0.015 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0053 | 0.0024 |
Echinococcus granulosus | smad | 0.0061 | 0.0316 | 0.0345 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0293 | 0.3003 | 0.3003 |
Brugia malayi | MH2 domain containing protein | 0.0061 | 0.0316 | 0.0316 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0276 | 0.2803 | 0.3384 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0061 | 0.0316 | 0.0355 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.0053 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0053 | 0.0053 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0053 | 0.0024 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0038 | 0.0053 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0053 | 0.0053 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0038 | 0.0053 | 0.008 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0053 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0053 | 0.008 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0087 | 0.0619 | 0.0619 |
Schistosoma mansoni | Smad4 | 0.0061 | 0.0316 | 0.0355 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.0053 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0038 | 0.0053 | 0.008 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0053 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0898 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0053 | 0.008 |
Echinococcus multilocularis | Smad4 | 0.0061 | 0.0316 | 0.0345 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0042 | 0.0096 | 0.0076 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0038 | 0.0053 | 0.008 |
Brugia malayi | intermediate filament protein | 0.0087 | 0.0619 | 0.0619 |
Onchocerca volvulus | 0.0087 | 0.0619 | 0.4062 | |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0038 | 0.0053 | 0.008 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0136 | 0.118 | 0.118 |
Brugia malayi | MH1 domain containing protein | 0.0061 | 0.0316 | 0.0316 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0037 | 0.0034 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0061 | 0.0316 | 0.0355 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0061 | 0.0316 | 0.0345 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0053 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0053 | 0.0053 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0053 | 0.0053 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.3003 | 0.3727 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.118 | 0.118 |
Echinococcus granulosus | lamin dm0 | 0.0087 | 0.0619 | 0.0715 |
Echinococcus multilocularis | GPCR, family 2 | 0.0136 | 0.118 | 0.14 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0601 | 0.0601 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1446 | 0.1446 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.0053 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0136 | 0.118 | 0.14 |
Echinococcus granulosus | GPCR family 2 | 0.0136 | 0.118 | 0.14 |
Onchocerca volvulus | 0.0087 | 0.0619 | 0.4062 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 96 % | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 6.25 ug/mL by microplate alamar blue assay | ChEMBL. | 18930654 |
IZ (functional) | = 30 mm | Antimicrobial activity against Escherichia coli after 24 hrs by well diffusion method | ChEMBL. | 18930654 |
MIC (functional) | > 6.25 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate alamar blue assay | ChEMBL. | 18930654 |
MIC (functional) | = 0.34 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate alamar blue assay | ChEMBL. | 18930654 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.