Detailed information for compound 987404

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 386.403 | Formula: C22H18N4O3
  • H donors: 2 H acceptors: 2 LogP: 2.81 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1nc2NC(c3ccccc3)C3=C(Nc2c(=O)n1C)c1c(C3=O)cccc1
  • InChi: 1S/C22H18N4O3/c1-26-21(28)18-20(25-22(26)29-2)24-16(12-8-4-3-5-9-12)15-17(23-18)13-10-6-7-11-14(13)19(15)27/h3-11,16,23-24H,1-2H3
  • InChiKey: MZFKCSVHRCYYIS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi proprotein convertase 2 0.4771 0.4868 0.4868
Loa Loa (eye worm) fatty acid synthase 0.0084 0.0059 0.0057
Leishmania major subtilisin-like serine peptidase 0.0331 0.0312 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0001
Echinococcus granulosus glutamate NMDA receptor subunit 0.0291 0.0272 0.0348
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0023 0.0042
Echinococcus multilocularis serine:threonine protein kinase N2 0.0079 0.0055 0.007
Brugia malayi EGF-like domain containing protein 0.0208 0.0186 0.0186
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0328 0.031 0.9534
Loa Loa (eye worm) glutamate receptor 1 0.0035 0.0009 0.0006
Toxoplasma gondii subtilisin SUB7 0.0331 0.0312 0.9371
Mycobacterium ulcerans protoporphyrinogen oxidase 0.007 0.0044 0.0302
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0052 0.0027 0.0031
Schistosoma mansoni protein kinase 0.0131 0.0107 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0331 0.0312 0.0658
Mycobacterium ulcerans polyketide synthase Pks13 0.0125 0.0101 0.0686
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.7559 0.7729 1
Schistosoma mansoni integrin alpha-ps 0.0892 0.0889 0.1147
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.007 0.0044 0.0302
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0048 0.0023 0.0026
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0023 0.0042
Loa Loa (eye worm) transcriptional regulator 0.0048 0.0023 0.002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1828 0.1849 0.3922
Brugia malayi Will die slowly protein 0.0068 0.0043 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Mycobacterium leprae Possible secreted protease 0.0331 0.0312 1
Loa Loa (eye worm) hypothetical protein 0.0208 0.0186 0.0183
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0052 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.0034 0.0008 0.0005
Toxoplasma gondii subtilisin SUB10 0.0331 0.0312 0.9371
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0331 0.0312 1
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0062 0.0036 0.0044
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0331 0.0312 0.0312
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0048 0.0023 0.0027
Chlamydia trachomatis glutamine binding protein 0.0089 0.0064 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0023 0.0026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1828 0.1849 0.3922
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.007 0.0044 0.0054
Schistosoma mansoni hypothetical protein 0.0428 0.0412 0.053
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0328 0.031 0.9534
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0082 0.0058 0.1843
Brugia malayi Subtilase family protein 0.0331 0.0312 0.0312
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0023 0.0042
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0071 0.0046 0.1457
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0023 0.0042
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0331 0.0312 0.2125
Toxoplasma gondii subtilisin SUB1 0.0331 0.0312 0.9371
Trichomonas vaginalis conserved hypothetical protein 0.1497 0.1509 0.3201
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0023 0.0026
Echinococcus multilocularis translocator protein 0.1459 0.147 0.1992
Plasmodium falciparum plasmepsin V 0.0385 0.0368 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0053 0.0028 0.0877
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0023 0.0026
Mycobacterium tuberculosis Possible oxidoreductase 0.007 0.0044 0.1421
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0061 0.0036 0.1151
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0055 0.003 0.0819
Mycobacterium ulcerans Type I modular polyketide synthase 0.0082 0.0058 0.0392
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0048 0.0023 0.0731
Plasmodium falciparum subtilisin-like protease 2 0.0331 0.0312 0.8448
Echinococcus multilocularis adam 0.0583 0.0572 0.0772
Trypanosoma brucei subtilisin peptidase 0.0331 0.0312 0.9622
Echinococcus multilocularis fibrillin 2 0.0208 0.0186 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.1497 0.1509 0.3201
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0062 0.0077
Loa Loa (eye worm) AMP-binding enzyme family protein 0.008 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.0168 0.0145 0.0143
Loa Loa (eye worm) glutamate receptor 2 0.0035 0.0009 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.008 0.0055 0.1755
Toxoplasma gondii type I fatty acid synthase, putative 0.0061 0.0035 0.0987
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0052 0.0027 0.0031
Schistosoma mansoni amine oxidase 0.007 0.0044 0.0054
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0328 0.031 0.0652
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0088 0.0063 0.2002
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0088 0.0063 0.2002
Loa Loa (eye worm) hypothetical protein 0.0208 0.0186 0.0183
Brugia malayi hypothetical protein 0.0589 0.0578 0.0578
Trichomonas vaginalis conserved hypothetical protein 0.1497 0.1509 0.3201
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0087 0.0062 0.0059
Echinococcus granulosus adam 0.0583 0.0572 0.0736
Brugia malayi aspartic protease BmAsp-2, identical 0.0034 0.0008 0.0008
Loa Loa (eye worm) integrin alpha pat-2 0.2549 0.2589 0.2587
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0331 0.0312 0.0401
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0773 0.0766 0.0988
Echinococcus granulosus fibrillin 2 0.0208 0.0186 0.0237
Schistosoma mansoni site-1 peptidase (S08 family) 0.0331 0.0312 0.0401
Echinococcus granulosus protein kinase c epsilon type 0.0087 0.0062 0.0077
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0376 0.0359 0.0461
Loa Loa (eye worm) hypothetical protein 0.1257 0.1262 0.126
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1513 0.1525 0.1523
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1257 0.1262 0.1262
Echinococcus multilocularis integrin alpha ps 0.0958 0.0956 0.1294
Leishmania major UDP-galactopyranose mutase 0.007 0.0044 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0331 0.0312 0.0658
Loa Loa (eye worm) hypothetical protein 0.0119 0.0095 0.0092
Schistosoma mansoni glutamate receptor NMDA 0.0052 0.0027 0.0031
Echinococcus multilocularis neuroendocrine convertase 2 0.4771 0.4868 0.6603
Trichomonas vaginalis conserved hypothetical protein 0.1497 0.1509 0.3201
Brugia malayi Integrin alpha pat-2 precursor 0.1786 0.1806 0.1806
Loa Loa (eye worm) hypothetical protein 0.007 0.0044 0.0042
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0008 0.0007
Schistosoma mansoni dihydroceramide desaturase 0.0119 0.0095 0.012
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0035 0.0009 0.0007
Echinococcus granulosus chromatin regulatory protein sir2 0.0328 0.031 0.0397
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0023 0.0026
Echinococcus multilocularis membrane bound transcription factor site 1 0.0331 0.0312 0.042
Loa Loa (eye worm) metalloprotease 0.0079 0.0055 0.0052
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0131 0.0107 0.0142
Loa Loa (eye worm) transcriptional regulator 0.0328 0.031 0.0307
Onchocerca volvulus 0.0208 0.0186 0.1217
Toxoplasma gondii aspartyl protease ASP5 0.0351 0.0333 1
Echinococcus multilocularis glutamate receptor 2 0.0052 0.0027 0.0032
Brugia malayi aspartic protease BmAsp-1, identical 0.0034 0.0008 0.0008
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0331 0.0312 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0773 0.0766 0.1036
Giardia lamblia Sirtuin type 2 0.0048 0.0023 0.0071
Mycobacterium ulcerans monoamine oxidase 0.007 0.0044 0.0302
Brugia malayi Reprolysin 0.0168 0.0146 0.0146
Giardia lamblia Transcriptional regulator, Sir2 family 0.0048 0.0023 0.0071
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0023 0.0042
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0082 0.0058 0.1843
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0331 0.0312 0.0401
Onchocerca volvulus 0.0131 0.0107 0.0676
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Brugia malayi AMP-binding enzyme family protein 0.008 0.0055 0.0055
Giardia lamblia High cysteine protein 0.0208 0.0186 0.0648
Giardia lamblia Tenascin precursor 0.0208 0.0186 0.0648
Echinococcus multilocularis protein will die slowly 0.0068 0.0043 0.0054
Mycobacterium leprae Probable polyketide synthase Pks1 0.0088 0.0063 0.2002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0088 0.0063 0.0429
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0331 0.0312 0.0312
Plasmodium vivax subtilisin-like protease 2, putative 0.0331 0.0312 0.8448
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0033 0.0007 0.0006
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.1459 0.147 0.19
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0043 0.0017 0.044
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0008 0.0007
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0052 0.0027 0.0031
Brugia malayi transcriptional regulator, Sir2 family protein 0.0048 0.0023 0.0023
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0331 0.0312 1
Trichomonas vaginalis conserved hypothetical protein 0.0331 0.0312 0.0658
Loa Loa (eye worm) proprotein convertase 2 0.1828 0.1849 0.1846
Brugia malayi EGF-like domain containing protein 0.0208 0.0186 0.0186
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0119 0.0095 0.0125
Loa Loa (eye worm) hypothetical protein 0.1359 0.1367 0.1365
Loa Loa (eye worm) hypothetical protein 0.0098 0.0074 0.0071
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0089 0.0064 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1828 0.1849 0.3922
Schistosoma mansoni glutamate receptor NMDA 0.0291 0.0272 0.0348
Brugia malayi ADAM-TS Spacer 1 family protein 0.0168 0.0145 0.0145
Brugia malayi hypothetical protein 0.0034 0.0008 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0034 0.0008 0.0165
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4616 0.4709 0.6092
Echinococcus multilocularis integrin alpha ps 0.0892 0.0889 0.1202
Loa Loa (eye worm) hypothetical protein 0.0493 0.0479 0.0477
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0023 0.0404
Schistosoma mansoni glutamate receptor kainate 0.0035 0.0009 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Mycobacterium ulcerans Sir2-like regulatory protein 0.0048 0.0023 0.0155
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0066 0.004 0.1279
Trichomonas vaginalis conserved hypothetical protein 0.0331 0.0312 0.0658
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0287 0.0268 0.036
Echinococcus granulosus nmda type glutamate receptor 0.0123 0.0099 0.0125
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.007 0.0044 0.126
Loa Loa (eye worm) hypothetical protein 0.1459 0.147 0.1468
Mycobacterium ulcerans thioesterase 0.0071 0.0046 0.0313
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0008 0.0007
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0328 0.031 0.0397
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0287 0.0268 0.0343
Giardia lamblia Tenascin-37 0.0208 0.0186 0.0648
Schistosoma mansoni protein kinase 0.0131 0.0107 0.0135
Toxoplasma gondii subtilisin SUB9 0.0331 0.0312 0.9371
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0052 0.0027 0.0032
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0035 0.0009 0.0008
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0048 0.0023 0.0729
Echinococcus multilocularis NMDA receptor 0.0035 0.0009 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1828 0.1849 0.3922
Toxoplasma gondii subtilisin SUB5 0.0331 0.0312 0.9371
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0131 0.0107 0.0135
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0082 0.0058 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.1497 0.1509 0.3201
Echinococcus multilocularis glutamate receptor 2 0.0035 0.0009 0.0008
Giardia lamblia Furin precursor putative serine protease 0.1497 0.1509 0.5321
Echinococcus granulosus protein will die slowly 0.0068 0.0043 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.1497 0.1509 0.3201
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0125 0.0101 0.3228
Trypanosoma cruzi subtilisin peptidase 0.0331 0.0312 0.9622
Schistosoma mansoni amine oxidase 0.007 0.0044 0.0054
Loa Loa (eye worm) hypothetical protein 0.0079 0.0055 0.0052
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Loa Loa (eye worm) acyl carrier protein 0.0039 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.1459 0.147 0.1468
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0048 0.0023 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0331 0.0312 0.0658
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0119 0.0095 0.012
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0008 0.0007
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0023 0.0651
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1828 0.1849 0.3922
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0048 0.0023 0.0027
Echinococcus multilocularis protein kinase c epsilon type 0.0087 0.0062 0.0081
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0066 0.004 0.0275
Plasmodium vivax hypothetical protein, conserved 0.007 0.0044 0.1004
Giardia lamblia hypothetical protein 0.0208 0.0186 0.0648
Brugia malayi endoprotease bli-4 precursor 0.7559 0.7729 0.7729
Loa Loa (eye worm) aspartyl protease 6 0.0034 0.0008 0.0005
Loa Loa (eye worm) sirtuin 4 0.0048 0.0023 0.002
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0048 0.0023 0.0651
Loa Loa (eye worm) endoprotease bli-4 0.7559 0.7729 0.7728
Giardia lamblia Neurogenic locus Notch protein precursor 0.0208 0.0186 0.0648
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0052 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.007 0.0044 0.0042
Plasmodium vivax hypothetical protein, conserved 0.007 0.0044 0.1004
Loa Loa (eye worm) hypothetical protein 0.0331 0.0312 0.031
Echinococcus multilocularis 0.6062 0.6193 0.8401
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0048 0.0023 0.0027
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0082 0.0058 0.1843
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0048 0.0023 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.0044 0.1421
Brugia malayi hypothetical protein 0.1502 0.1514 0.1514
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0083 0.0058 0.1853
Echinococcus multilocularis protoporphyrinogen oxidase 0.007 0.0044 0.0056
Trypanosoma cruzi UDP-galactopyranose mutase 0.007 0.0044 0.0718
Loa Loa (eye worm) hypothetical protein 0.014 0.0117 0.0114
Toxoplasma gondii subtilisin SUB11 0.0331 0.0312 0.9371
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0062 0.0036 0.0036
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0082 0.0058 0.1827
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.007 0.0044 0.0302
Schistosoma mansoni chromatin regulatory protein sir2 0.0328 0.031 0.0397
Loa Loa (eye worm) hypothetical protein 0.0089 0.0064 0.0061
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0342 0.0324 1
Giardia lamblia High cysteine membrane protein Group 2 0.2788 0.2834 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0342 0.0324 0.0416
Mycobacterium ulcerans tryptophan-rich sensory protein 0.1459 0.147 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0019 0.0016
Echinococcus granulosus Furin 1 0.1828 0.1849 0.2389
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0331 0.0312 0.9622
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0291 0.0272 0.0365
Schistosoma mansoni hypothetical protein 0.0035 0.0009 0.0007
Trypanosoma cruzi UDP-galactopyranose mutase 0.007 0.0044 0.0718
Loa Loa (eye worm) hypothetical protein 0.1459 0.147 0.1468
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0008 0.0007
Loa Loa (eye worm) apoptosis regulator protein 0.0062 0.0036 0.0034
Brugia malayi ADAMTS-like protease 0.0168 0.0145 0.0145
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4616 0.4709 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0088 0.0063 0.2017
Brugia malayi hypothetical protein 0.0376 0.0359 0.0359
Schistosoma mansoni hypothetical protein 0.0062 0.0036 0.0044
Onchocerca volvulus 0.1459 0.147 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0098 0.0074 0.0074
Echinococcus granulosus disintegrin and metalloproteinase 0.0119 0.0095 0.012
Echinococcus multilocularis chromatin regulatory protein sir2 0.0328 0.031 0.0417
Loa Loa (eye worm) hypothetical protein 0.7559 0.7729 0.7728
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1828 0.1849 0.3922
Mycobacterium ulcerans dehydrogenase 0.007 0.0044 0.0302
Toxoplasma gondii histone lysine-specific demethylase 0.007 0.0044 0.126
Echinococcus granulosus adam 17 protease 0.0119 0.0095 0.012
Brugia malayi protein kinase C II. 0.0087 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0062 0.0036 0.0044
Loa Loa (eye worm) hypothetical protein 0.0208 0.0186 0.0183
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0114 0.009 0.0087
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0066 0.004 0.0275
Schistosoma mansoni integrin alpha 0.1786 0.1806 0.2334
Schistosoma mansoni hypothetical protein 0.1497 0.1509 0.195
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0123 0.0099 0.0131
Loa Loa (eye worm) TK/EGFR protein kinase 0.045 0.0435 0.0432
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0089 0.0064 0.2046
Echinococcus granulosus fibrillin 1 0.0209 0.0188 0.0239
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0023 0.0042
Mycobacterium ulcerans Type I modular polyketide synthase 0.0082 0.0058 0.0392
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0328 0.031 0.0417
Schistosoma mansoni serine/threonine protein kinase 0.0254 0.0234 0.0299
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.007 0.0044 0.1004
Loa Loa (eye worm) hypothetical protein 0.0034 0.0008 0.0005
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0035 0.0009 0.0007
Brugia malayi Eukaryotic aspartyl protease family protein 0.0034 0.0008 0.0008
Brugia malayi NAD-dependent deacetylase SIRT1 0.0048 0.0023 0.0023
Echinococcus multilocularis integrin alpha ps 0.0428 0.0412 0.0555
Schistosoma mansoni glutamate receptor kainate 0.0035 0.0009 0.0007
Toxoplasma gondii histone deacetylase SIR2-like 0.0048 0.0023 0.0605
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0035 0.0009 0.0008
Mycobacterium ulcerans polyketide synthase Pks9 0.0053 0.0028 0.019
Mycobacterium tuberculosis Probable thioesterase TesA 0.0071 0.0046 0.1473
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0035 0.0009 0.0007
Onchocerca volvulus 0.1459 0.147 1
Schistosoma mansoni hypothetical protein 0.0068 0.0043 0.0052
Echinococcus granulosus integrin alpha ps 0.0428 0.0412 0.053
Schistosoma mansoni chromatin regulatory protein sir2 0.0328 0.031 0.0397
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0062 0.0036 0.0046
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0062 0.0036 0.0044
Echinococcus granulosus glutamate receptor subunit protein glur 0.0035 0.0009 0.0007
Echinococcus granulosus serine:threonine protein kinase N2 0.0071 0.0046 0.0056
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1497 0.1509 0.3201
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0023 0.0042
Brugia malayi metalloprotease 0.0079 0.0055 0.0055
Schistosoma mansoni integrin beta subunit 0.5709 0.5831 0.7543
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0023 0.0042
Echinococcus multilocularis Furin 1 0.1828 0.1849 0.2505
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0008 0.0007
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0034 0.0008 0.0007
Onchocerca volvulus 0.1459 0.147 1
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0254 0.0234 0.0314
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0331 0.0312 0.2125
Brugia malayi SWIRM domain containing protein 0.0029 0.0003 0.0003
Echinococcus granulosus epidermal growth factor receptor 0.045 0.0435 0.0559
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0342 0.0324 0.0436
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0455 0.044 0.0566
Toxoplasma gondii subtilisin SUB12 0.0331 0.0312 0.9371
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0008 0.0007
Giardia lamblia High cysteine protein 0.0208 0.0186 0.0648
Brugia malayi neuroendocrine convertase 1 precursor 0.4771 0.4868 0.4868
Echinococcus multilocularis fibrillin 1 0.0209 0.0188 0.0251
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0331 0.0312 0.042
Echinococcus granulosus lysine specific histone demethylase 1A 0.007 0.0044 0.0054
Plasmodium falciparum subtilisin-like protease 1 0.0331 0.0312 0.8448
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0089 0.0064 0.5
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0088 0.0063 0.2017
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0048 0.0023 0.002
Schistosoma mansoni tyrosine kinase 0.045 0.0435 0.0559
Giardia lamblia Neurogenic locus notch-like protein 0.0208 0.0186 0.0648
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0048 0.0023 0.0404
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0079 0.0055 0.0067
Brugia malayi hypothetical protein 0.007 0.0044 0.0044
Echinococcus multilocularis integrin beta 2 0.7211 0.7372 1
Echinococcus granulosus furin 0.7559 0.7729 1
Trichomonas vaginalis WD repeat domain, putative 0.0068 0.0043 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.1497 0.1509 0.3201
Giardia lamblia Hypothetical protein 0.0328 0.031 0.1085
Toxoplasma gondii histone deacetylase SIR2 0.0048 0.0023 0.0605
Schistosoma mansoni chromatin regulatory protein sir2 0.0328 0.031 0.0397
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0034 0.0008 0.0007
Echinococcus granulosus integrin alpha 3 0.1322 0.1329 0.1717
Echinococcus multilocularis disintegrin and metalloproteinase 0.0119 0.0095 0.0125
Onchocerca volvulus 0.1459 0.147 1
Mycobacterium ulcerans polyketide synthase 0.0088 0.0063 0.0429
Onchocerca volvulus Fatty acid synthase homolog 0.0154 0.0131 0.0838
Brugia malayi Pepsin A precursor 0.0034 0.0008 0.0008
Plasmodium falciparum protoporphyrinogen oxidase 0.007 0.0044 0.1004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0008 0.0007
Echinococcus multilocularis 0.007 0.0044 0.0056
Echinococcus granulosus translocator protein 0.1459 0.147 0.19
Toxoplasma gondii type I fatty acid synthase, putative 0.0088 0.0063 0.1823
Onchocerca volvulus 0.008 0.0055 0.0319
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Onchocerca volvulus 0.0371 0.0354 0.2363
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0048 0.0023 0.0651
Echinococcus granulosus membrane bound transcription factor site 1 0.0331 0.0312 0.0401
Schistosoma mansoni site-1 peptidase (S08 family) 0.0331 0.0312 0.0401
Onchocerca volvulus 0.0148 0.0125 0.0801
Trichomonas vaginalis conserved hypothetical protein 0.1497 0.1509 0.3201
Brugia malayi SWIRM domain containing protein 0.0371 0.0354 0.0354
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0082 0.0058 0.1827
Echinococcus granulosus neuroendocrine convertase 2 0.4771 0.4868 0.6297
Schistosoma mansoni ATP-binding cassette transporter 0.0036 0.001 0.0009
Schistosoma mansoni memapsin-2 (A01 family) 0.0034 0.0008 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.1497 0.1509 0.3201
Trichomonas vaginalis conserved hypothetical protein 0.1497 0.1509 0.3201
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0034 0.0008 0.0271
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0328 0.031 0.9534
Onchocerca volvulus 0.0068 0.0043 0.0235
Mycobacterium leprae Polyketide synthase Pks13 0.0125 0.0101 0.3215
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4616 0.4709 0.6387
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0342 0.0324 1
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0331 0.0312 0.0401
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0331 0.0312 1
Brugia malayi Furin-like cysteine rich region family protein 0.045 0.0435 0.0435
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0083 0.0058 0.1853
Loa Loa (eye worm) hypothetical protein 0.0208 0.0186 0.0183
Brugia malayi EGF-like domain containing protein 0.0208 0.0186 0.0186
Mycobacterium ulcerans thioesterase TesA 0.0071 0.0046 0.0313
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0287 0.0268 0.0343
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0287 0.0268 0.0343
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0331 0.0312 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.0145 0.0143
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0048 0.0023 0.0071
Brugia malayi TspO/MBR family protein 0.1459 0.147 0.147
Loa Loa (eye worm) hypothetical protein 0.2943 0.2993 0.2991
Plasmodium vivax subtilisin-like serine protease, putative 0.0331 0.0312 0.8448
Plasmodium vivax protoporphyrinogen oxidase, putative 0.007 0.0044 0.1004
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0034 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.1459 0.147 0.1468
Schistosoma mansoni glutamate receptor kainate 0.0035 0.0009 0.0007
Toxoplasma gondii subtilisin SUB8 0.0331 0.0312 0.9371
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1497 0.1509 0.3201
Echinococcus multilocularis integrin alpha 3 0.1322 0.1329 0.18
Toxoplasma gondii hypothetical protein 0.0208 0.0186 0.5547
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Echinococcus granulosus lysine specific histone demethylase 1A 0.0342 0.0324 0.0416
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0035 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0034 0.0008 0.0005
Giardia lamblia Tenascin-like 0.0208 0.0186 0.0648
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0008 0.0007
Plasmodium vivax NAD-dependent deacetylase, putative 0.0048 0.0023 0.0404
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0208 0.0186 0.039
Onchocerca volvulus 0.0331 0.0312 0.2081
Schistosoma mansoni glutamate receptor AMPA 0.0035 0.0009 0.0007
Plasmodium falciparum subtilisin-like protease 3 0.0331 0.0312 0.8448
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.007 0.0044 0.1405
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0067 0.0042 0.1332
Loa Loa (eye worm) WD40 repeat protein 0.0068 0.0043 0.004
Schistosoma mansoni hypothetical protein 0.0062 0.0036 0.0044
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Brugia malayi Kelch motif family protein 0.1513 0.1525 0.1525
Schistosoma mansoni glutamate receptor AMPA 0.0035 0.0009 0.0007
Schistosoma mansoni furin-1 (S08 family) 0.3274 0.3332 0.4309
Loa Loa (eye worm) hypothetical protein 0.0342 0.0324 0.0321
Toxoplasma gondii aspartyl protease 0.0034 0.0008 0.0165
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0046 0.1402
Mycobacterium ulcerans NAD-dependent deacetylase 0.0048 0.0023 0.0155
Toxoplasma gondii subtilisin SUB4 0.0331 0.0312 0.9371
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Toxoplasma gondii subtilisin SUB2 0.0331 0.0312 0.9371
Loa Loa (eye worm) angiogenesis inhibito 0.0079 0.0055 0.0052
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0089 0.0064 0.0435
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Toxoplasma gondii aspartyl protease ASP1 0.0034 0.0008 0.0165
Loa Loa (eye worm) hypothetical protein 0.0287 0.0268 0.0265
Loa Loa (eye worm) hypothetical protein 0.1502 0.1514 0.1512
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0088 0.0063 0.0429
Giardia lamblia Tenascin-X 0.0208 0.0186 0.0648
Loa Loa (eye worm) hypothetical protein 0.0062 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0894 0.089 0.0888
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0331 0.0312 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0053 0.0028 0.019
Brugia malayi Glutamate receptor 1 precursor 0.0035 0.0009 0.0009
Plasmodium vivax subtilisin-like protease 1 0.0331 0.0312 0.8448
Plasmodium vivax plasmepsin V, putative 0.0385 0.0368 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0048 0.0023 0.0023
Brugia malayi hypothetical protein 0.0034 0.0008 0.0008
Brugia malayi transcriptional regulator, Sir2 family protein 0.0328 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.053 0.0517 0.0515
Brugia malayi celfurPC protein 0.6062 0.6193 0.6193
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4616 0.4709 1
Echinococcus multilocularis epidermal growth factor receptor 0.045 0.0435 0.0586
Trichomonas vaginalis hypothetical protein 0.0208 0.0186 0.039
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0159 0.0136 0.0136
Toxoplasma gondii aspartyl protease ASP3 0.0034 0.0008 0.0165
Loa Loa (eye worm) hypothetical protein 0.0066 0.0041 0.0038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Toxoplasma gondii subtilisin SUB6 0.0331 0.0312 0.9371
Schistosoma mansoni apoptosis regulator bax 0.0062 0.0036 0.0044
Brugia malayi EGF-like domain containing protein 0.0208 0.0186 0.0186
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0082 0.0058 0.0058
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0328 0.031 0.0652
Brugia malayi angiogenesis inhibito 0.0168 0.0145 0.0145
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0114 0.009 0.009
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0342 0.0324 1
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0331 0.0312 0.2125
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.2504 0.2542 0.3287
Schistosoma mansoni protein kinase 0.0131 0.0107 0.0135
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0027 0.0001 0.0019
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0371 0.0354 0.0351
Echinococcus granulosus glutamate receptor 2 0.0052 0.0027 0.0031
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.007 0.0044 0.1004
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1497 0.1509 0.3201
Loa Loa (eye worm) reprolysin 0.0287 0.0268 0.0265
Loa Loa (eye worm) integrin beta-2 0.9773 1 1
Brugia malayi Stress-activated protein kinase jnk-1 0.0254 0.0234 0.0234
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0052 0.0027 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.1497 0.1509 0.3201
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Loa Loa (eye worm) transcriptional regulator 0.0048 0.0023 0.002
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0328 0.031 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0052 0.0027 0.0032
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Echinococcus granulosus integrin alpha ps 0.0958 0.0956 0.1234
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0034 0.0008 0.0012
Mycobacterium ulcerans Type I modular polyketide synthase 0.0082 0.0058 0.0392
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0088 0.0063 0.2017
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1828 0.1849 0.2389
Loa Loa (eye worm) subtilase 0.0331 0.0312 0.031
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0008 0.0007
Mycobacterium ulcerans fatty acid synthase Fas 0.0027 0.0001 0.0004
Schistosoma mansoni integrin alpha-ps 0.053 0.0517 0.0666
Mycobacterium ulcerans oxidoreductase 0.007 0.0044 0.0302
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0254 0.0234 0.0231
Echinococcus granulosus integrin beta 2 0.7211 0.7372 0.9537
Trichomonas vaginalis hypothetical protein 0.1497 0.1509 0.3201
Echinococcus multilocularis nmda type glutamate receptor 0.0123 0.0099 0.0131
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0125 0.0101 0.3228
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0048 0.0023 0.0026
Mycobacterium ulcerans polyketide synthase 0.0082 0.0058 0.0392
Echinococcus multilocularis protein jagged 2 0.0208 0.0186 0.0249
Leishmania major silent information regulator 2, putative 0.0328 0.031 0.9909
Brugia malayi Disintegrin family protein 0.0119 0.0095 0.0095
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0089 0.0064 1
Loa Loa (eye worm) hypothetical protein 0.0342 0.0324 0.0321
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0328 0.031 1
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0034 0.0008 0.0165
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0026 0 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0331 0.0312 0.0658
Brugia malayi Glutamate receptor 2 precursor 0.0035 0.0009 0.0009
Echinococcus granulosus c-Jun N-terminal kinases 0.0254 0.0234 0.0299
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.0044 0.1004
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0034 0.0008 0.0005

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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